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Regulation of activated PAK-2p34 by proteasome mediated degradation
SuperPath
Pathway network
for
Regulation of activated PAK-2p34 by proteasome mediated degradation
SuperPath
130
Pathways
in the
Regulation of activated PAK-2p34 by proteasome mediated degradation
SuperPath
ABC transporters in lipid homeostasis
Metabolism of polyamines
Regulation of PAK-2p34 activity by PS-GAP/RHG10
APC/C-mediated degradation of cell cycle proteins
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Autodegradation of Cdh1 by Cdh1:APC/C
Hh mutants abrogate ligand secretion
RUNX3 regulates YAP1-mediated transcription
Ubiquitin-dependent degradation of Cyclin D
Autodegradation of the E3 ubiquitin ligase COP1
HuR (ELAVL1) binds and stabilizes mRNA
Regulation of PTEN stability and activity
WNT5A-dependent internalization of FZD4
Beta-catenin independent WNT signaling
Regulation of RUNX2 expression and activity
SCF(Skp2)-mediated degradation of p27/p21
superpathway of polyamine biosynthesis II
Degradation of DVL
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Defective CFTR causes cystic fibrosis
RUNX2 regulates genes involved in cell migration
Parkinson's Disease Pathway
Signaling by NOTCH4
RUNX3 Regulates Immune Response and Cell Migration
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Repression of WNT target genes
p53-Dependent G1/S DNA damage checkpoint
Degradation of AXIN
Degradation of GLI1 by the proteasome
Transcriptional regulation by RUNX2
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX3 regulates WNT signaling
Degradation of beta-catenin by the destruction complex
Negative regulation of NOTCH4 signaling
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Phosphorylation of the APC/C
RUNX3 regulates BCL2L11 (BIM) transcription
spermine and spermidine degradation I
Regulation of APC/C activators between G1/S and early anaphase
FCERI mediated NF-kB activation
Degradation of GLI2 by the proteasome
Ca2+ pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Regulation of mRNA stability by proteins that bind AU-rich elements
RUNX3 regulates p14-ARF
Mitochondrial ABC transporters
Orc1 removal from chromatin
Fc epsilon receptor (FCERI) signaling
Germ layer formation at gastrulation
p53-Independent DNA Damage Response
Regulation of RAS by GAPs
Hedgehog 'on' state
Release of Hh-Np from the secreting cell
PCP/CE pathway
SCF-beta-TrCP mediated degradation of Emi1
Regulation of Apoptosis
Calcineurin activates NFAT
The role of GTSE1 in G2/M progression after G2 checkpoint
NOTCH4 Intracellular Domain Regulates Transcription
AUF1 (hnRNP D0) binds and destabilizes mRNA
Somitogenesis
Formation of intermediate mesoderm
Regulation of activated PAK-2p34 by proteasome mediated degradation
Activation of NF-kappaB in B cells
Formation of paraxial mesoderm
MAPK6/MAPK4 signaling
Gastrulation
Formation of axial mesoderm
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Cyclin A:Cdk2-associated events at S phase entry
Formation of lateral plate mesoderm
Formation of definitive endoderm
Signaling by the B Cell Receptor (BCR)
Parkin-ubiquitin proteasomal system pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Downstream signaling events of B Cell Receptor (BCR)
Regulation of mitotic cell cycle
Regulation of gene expression by Hypoxia-inducible Factor
Vpu mediated degradation of CD4
p53-Dependent G1 DNA Damage Response
Hedgehog ligand biogenesis
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
ABC-family proteins mediated transport
Activation of SMO
Cross-presentation of soluble exogenous antigens (endosomes)
Transcriptional regulation by RUNX3
PAOs oxidise polyamines to amines
RUNX3 regulates RUNX1-mediated transcription
Hh mutants are degraded by ERAD
Asymmetric localization of PCP proteins
RUNX3 regulates CDKN1A transcription
Dectin-1 mediated noncanonical NF-kB signaling
APC/C:Cdc20 mediated degradation of Securin
Defective ABCB6 causes MCOPCB7
Cyclin E associated events during G1/S transition
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Defective ABCA12 causes ARCI4B
Immune response Antigen presentation by MHC class I
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
p53-Independent G1/S DNA damage checkpoint
RUNX3 regulates NOTCH signaling
Proteasome degradation
Establishment of Sister Chromatid Cohesion
Vif-mediated degradation of APOBEC3G
Switching of origins to a post-replicative state
Epithelial-Mesenchymal Transition (EMT) during gastrulation
Regulation of ornithine decarboxylase (ODC)
putrescine biosynthesis III
Signaling by TCF7L2 mutants
CDK-mediated phosphorylation and removal of Cdc6
ABC transporter disorders
Synthesis of DNA
S Phase
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
GLI3 is processed to GLI3R by the proteasome
Cellular response to hypoxia
KSRP (KHSRP) binds and destabilizes mRNA
Interconversion of polyamines
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
UCH proteinases
TNFR2 non-canonical NF-kB pathway
NOTCH4 Activation and Transmission of Signal to the Nucleus
Role of LAT2/NTAL/LAB on calcium mobilization
RAS signaling downstream of NF1 loss-of-function variants
G1/S DNA Damage Checkpoints
NIK-->noncanonical NF-kB signaling
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of RUNX3 expression and activity
978
Genes
in the
Regulation of activated PAK-2p34 by proteasome mediated degradation
SuperPath
PSMC1
PSMC2
PSMC3
PSMC4
PSMC5
PSMC6
PSMD1
PSMD2
PSMD3
PSMD4
PSMD5
PSMD6
PSMD7
PSMD8
PSMD9
PSMD10
PSMD11
PSMD12
PSMD13
PSMD14
PSMA1
PSMA2
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PSME3
PSMB8
PSMB9
PSMB10
PSME1
PSME2
SEM1
PSMF1
UBB
UBC
RPS27A
UBA52
PSMA8
PSMB11
PSME4
CUL1
SKP1
UBE2D1
RBX1
CCNA2
CCNA1
BTRC
ANAPC10
UBE2C
ANAPC16
CDC26
ANAPC15
UBE2S
ANAPC2
ANAPC4
ANAPC5
ANAPC7
ANAPC11
ANAPC1
UBE2E1
CDC23
CDC16
CDC27
CDK2
CCNE1
FZR1
SKP2
CDK1
CDC20
AKT1
CTNNB1
LEF1
CDKN1A
CCNE2
RUNX3
EP300
SHH
CCND1
KRAS
TCF7
TCF7L2
SMAD3
CCNB1
IHH
GSK3B
TP53
SMURF1
CBFB
CREBBP
CHUK
FBXW11
MAD2L1
PLK1
RB1
BUB1B
BUB3
SMURF2
MAP3K7
CDKN1B
CHEK2
CDC25A
RBPJ
NOTCH1
SMAD4
PTTG1
OS9
ERLEC1
DERL2
SEL1L
VCP
CDK4
PRKCA
AKT3
STUB1
AKT2
PRKCB
WNT5A
NFATC1
PPP3CA
PPP3CB
PPP3R1
CALM1
CALM2
CALM3
TCF7L1
FBXW7
CDKN2A
MDM2
MAMLD1
SNW1
KAT2A
MAML3
MAML2
KAT2B
MAML1
MYC
RELA
TBXT
PAK2
NEK2
DHH
YAP1
ATM
COP1
DVL2
ARRB2
FZD4
FZD2
FZD5
HES1
YWHAZ
CSNK1A1
MALT1
IKBKB
NFKB1
NFKBIA
UBE2D2
CARD11
IKBKG
BCL10
TGFB1
CDC6
HRAS
NRAS
BMP4
ABCA12
ODC1
SMOX
FBXO5
AURKA
CDC14A
TEAD4
TEAD2
AP2M1
AP2S1
CLTA
CLTB
CLTC
AP2A1
AP2A2
AP2B1
ITPR1
ITPR2
ITPR3
RAC1
FZD3
CKS1B
PTK6
MDM4
PHF20
CHEK1
TUBA4A
TUBA3C
TUBA8
TUBB1
TUBB2A
JAG1
NOTCH4
EXOSC8
EXOSC6
DCP2
DIS3
EXOSC7
EXOSC2
EXOSC3
EXOSC1
EXOSC9
EXOSC4
EXOSC5
SUFU
PRKACA
PRKACB
PRKACG
RASGRP1
LYN
MAP3K14
HSPA1A
HSPA1B
HSPA8
ABCB6
ORC6
ORC3
MCM2
MCM3
MCM4
MCM5
MCM6
MCM7
ORC1
ORC2
ORC4
ORC5
CDT1
MCM8
NFATC2
NFATC3
SMAD2
EOMES
ABCA3
ABCD1
APOA1
ABCG5
ABCG8
PAOX
SAT1
AURKB
SYVN1
WWTR1
XPO1
TNFSF13
PRKCG
PRICKLE1
DVL1
DVL3
AGO3
AGO4
TNRC6B
SCRIB
AGO1
AGO2
TNRC6A
MOV10
ROR1
ROR2
PARD6A
VANGL2
TNRC6C
WNT11
FZD1
FZD6
FZD7
FZD8
RUNX2
CUL3
ERLIN1
CFTR
ERLIN2
RNF5
DERL1
DERL3
RNF185
CASP1
CASP8
GPR37
HSPA4
PRKN
SEPTIN5
SNCA
SNCAIP
TUBB7P
UBE2L3
UCHL1
HEY1
HEY2
XRN1
DCP1A
YWHAB
MAPKAPK2
CTBP1
CTBP2
ZNF385A
PCBP4
GLI2
GLI3
SRC
RUNX1
HDAC4
FOXO3
FCER1A
MS4A2
FCER1G
PDPK1
HSPB1
FYN
GRB2
PIK3R1
SOS1
SYK
GSC
MIXL1
FOXH1
FKBP1A
PPIA
TUBA1B
TUBB3
TUBB4A
TUBB4B
TUBA3E
TUBA3D
TUBB8
TUBB2B
TUBA1A
TUBAL3
TUBB6
TUBA1C
DLL3
MESP2
EPHA4
DLL1
MSGN1
LFNG
TBX6
NFKBIB
NFKBIE
REL
FGFR1
GATA4
FOXA2
CDK7
LIN54
E2F1
E2F4
E2F5
LIN9
MAX
MNAT1
LIN37
RBBP4
RBL2
TFDP1
TFDP2
WEE1
CCNH
LIN52
CABLES1
UBA1
EPAS1
HIF1A
HIF3A
NFKB2
RELB
UBA3
UBE2M
UBE2D3
ELOC
ELOB
GMNN
ABCA7
ABCA10
ABCA9
ABCA2
ABCD2
ABCA6
ABCA5
PEX19
ABCD3
ABCG4
PEX3
ABCG1
AZIN2
NQO1
OAZ1
OAZ2
AZIN1
OAZ3
SMS
SRM
ARHGAP10
HHAT
CCN2
TEAD1
TEAD3
ELAVL1
PRKCD
SET
NUP214
ANP32A
NEDD4
TNKS2
RNF146
TNKS
GNB5
DAAM1
PLCB1
GNAO1
GNAT2
GNB1
GNB2
GNB3
GNG3
GNG4
GNG5
GNG7
GNG10
GNG11
GNGT1
GNGT2
RHOA
PDE6A
PDE6G
PDE6B
NLK
GNG13
PFN1
PLCB2
PLCB3
GNG2
WNT4
PRKG1
PRKG2
GNG12
RAC2
RAC3
GNB4
RYK
WNT1
WNT5B
CAMK2A
GNG8
PPARGC1A
WWP1
PPARGC1B
DLX5
DLX6
ESR1
ESRRA
NR3C1
MSX2
NKX3-2
HIVEP3
BMP2
STAT1
TWIST1
ITGA5
MMP13
ITGBL1
ADAM10
TACC3
FLT4
NCSTN
HES5
NOTCH2
APH1A
DLL4
PSENEN
PSEN1
PSEN2
ACTA2
APH1B
ITGA4
ITGAL
RORC
SPP1
TNPO1
ZFP36
TLE5
HDAC1
TLE1
TLE2
TLE3
TLE4
AXIN1
GLI1
ITCH
NUMB
MAPK1
MAPK3
BCL2L11
RASGRP2
TAB1
RASGRP4
TAB2
TAB3
PEDS1-UBE2V1
PRKCQ
TRAF6
UBE2N
UBE2V1
CDC34
TNFSF13B
TNFRSF13C
BIRC2
BIRC3
LTA
LTB
LTBR
TNFSF12-TNFSF13
TNFRSF12A
TRAF2
TRAF3
TNFSF11
TNFSF14
TNFSF12
TNFRSF11A
CD40
CD40LG
MAPK14
EIF4G1
PABPC1
HNRNPD
PARN
MAPK11
ZFP36L1
KHSRP
BRD2
ABCB8
ABCB7
ABCB10
AHCYL1
JUN
PAK1
PIK3CA
PIK3CB
PIK3R2
PLCG2
SHC1
BTK
VAV1
LAT2
GAB2
TBPL2
TRIM33
POU5F1
SOX2
NANOG
SPRED1
SPRED2
SPRED3
NF1
KIF3A
EVC2
GRK2
EVC
IQCE
GAS1
GAS8
ARRB1
CDON
PTCH1
SMO
EFCAB7
BOC
NOTUM
GPC5
SCUBE2
ADAM17
DISP2
HSP90AA1
HSP90AB1
FGF2
FOXC1
FOXC2
WNT3A
NOG
FOXF1
GATA6
FOXA1
NOTO
SOX17
SNAI1
CXCR4
CDH1
CDC25B
RASGRP3
UBE2J2
TUBB
RNF19A
HSPA1L
HSPA2
HSPA5
HSPA6
HSPA7
HSPA9
HSPA14
UBE2J1
SIAH1
SIAH2
UBE2G1
UBE2G2
TUBA4B
CASK
UBE2L6
CITED2
EPO
HIGD1A
ARNT
VEGFA
CA9
ABCC9
ABCC2
ABCC6
KCNJ11
ABCB4
ZFHX3
HLA-A
HLA-B
HLA-C
UCHL3
H2AC4
STAG1
STAG2
CDCA5
ESCO1
ESCO2
PDS5B
WAPL
PDS5A
RAD21
SMC1A
SMC3
POLD3
DNA2
FEN1
POLA2
LIG1
PCNA
GINS2
POLE3
POLA1
POLD1
POLD2
POLE
POLE2
PRIM1
PRIM2
POLE4
POLD4
RFC1
RFC2
RFC3
RFC4
RFC5
RPA1
RPA2
RPA3
GINS3
CDC45
GINS4
GINS1
EGLN2
EGLN3
WTIP
EGLN1
VHL
CUL2
AJUBA
LIMD1
AMD1
AGMAT
WWP2
CSNK2A1
CSNK2A2
CSNK2B
OTUD3
MKRN1
FRK
XIAP
PTEN
TRIM27
PREX2
USP13
HECW1
DACT1
KLHL12
ATXN10
EPRS1
ATXN3
PARK7
PINK1
ATXN1
ATXN2
ATXN7
SLC6A3
SYT11
TUBE1
TUBG1
TUBG2
TUBGCP2
TUBGCP3
TUBGCP5
TUBGCP6
UBD
AXIN2
HDAC6
RBM14-RBM4
RBM14
TWIST2
SP7
COL1A1
UCMA
SATB2
ABL1
ZNF521
AR
LGALS3
SMAD1
SMAD6
MAF
BAX
BGLAP
SOX9
YES1
PPM1D
HDAC3
HAND2
FBXL7
FRAT1
AMER1
FRAT2
APC
ZRANB1
PPP2CA
PPP2CB
PPP2R1A
PPP2R1B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
VAV3
FOS
LAT
ITK
LCP2
MAP3K1
PLCG1
MAPK8
MAPK9
MAPK10
MAP2K7
MAP2K4
TEC
TXK
VAV2
GRAP2
RASA4
DAB2IP
RASA3
RASA1
RASA2
RASAL3
KBTBD7
RASAL1
SYNGAP1
RASAL2
DZIP1
GPR161
ULK3
SPOPL
KIF7
HHIP
CDC73
SPOP
OMA1
OPA1
MAPRE1
GTSE1
FKBPL
CCNB2
CDC42EP2
CDC42EP3
IGF2BP1
CDC42EP5
ETV4
FOXO1
DNAJB1
PAK3
MAPK4
MAPK6
RAG1
RAG2
NCOA3
MAPKAPK5
CDC14B
CCND3
KALRN
SEPTIN7
CDC42
NFE2L2
PIK3AP1
DAPP1
BLNK
SH3KBP1
NCK1
PIK3CD
PTPN6
BLK
STIM1
TRPC1
ORAI2
ORAI1
CD19
CD22
CD79A
CD79B
CD4
P4HB
ABCC5
ABCC4
ABCA8
EIF2S1
EIF2S3
ABCF1
ABCB9
ABCA4
ABCB5
ABCC1
ABCB1
ABCC11
ABCC3
EIF2S2
ABCC10
FCGR1A
MRC1
CD207
MRC2
B2M
CALR
CANX
CD3D
CD3E
CD3G
CD247
CD8A
CD8B
PDIA3
TAP1
TAP2
TAPBP
TRA
TRB
HSP90B1
TRAP1
SEC61B
SEC61G
TRBV17
TRBV11-3
TRBV11-2
TRBV11-1
TRAV24
TRAJ18
TRAC
SEC61A1
SEC61A2
H2AX
H2AZ1
HLA-E
HLA-F
HLA-G
HLA-H
HLA-J
IFNG
RPN1
RPN2
UBA7
UBE2B
APOBEC3G
CUL5
ABCA1
LMBRD1
ABCD4
ABCC8
ABCB11
HIF1AN
MCRS1
ADRM1
MBD6
SENP8
INO80C
ASXL1
H2AC1
KDM1B
FOXK1
INO80E
TFPT
H2AC8
H2AC7
HCFC1
H2AC21
FOXK2
SMAD7
NEDD8
NFRKB
UCHL5
INO80
INO80D
ASXL2
MBD5
BARD1
ACTB
TGFBR1
TGFBR2
H2AC19
YY1
ACTR5
BAP1
H2AC13
H2AC15
H2AC14
H2AC16
H2AC6
H2AC17
H2AC18
H2AC20
INO80B
OGT
H2AC12
ACTL6A
RUVBL1
H2AC11
H2AC25
ACTR8
USP15
EDAR
EDARADD
EDA
TNFRSF13B
FASLG
TNFRSF9
TNFRSF11B
EDA2R
TNFRSF17
TNF
TNFRSF1A
TNFRSF1B
TNFSF4
TNFRSF4
TNFRSF25
TNFSF9
TNFRSF14
TNFRSF6B
TNFRSF18
TNFSF18
CD27
TNFRSF8
TNFSF8
CD70
TNFSF15
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Regulation of activated PAK-2p34 by proteasome mediated degradation
SuperPath