1 |
|
Gene expression (Transcription)
|
1546 |
1.740 |
SuperPathway |
- Gene expression (Transcription)
|
Genes names |
- Piwi Like RNA-Mediated Gene Silencing 1
- Piwi Like RNA-Mediated Gene Silencing 2
- Piwi Like RNA-Mediated Gene Silencing 4
|
Pathways |
- Gene expression (Transcription)
|
|
2 |
|
Gene Silencing by RNA
|
190 |
1.740 |
SuperPathway |
|
Genes names |
- Piwi Like RNA-Mediated Gene Silencing 1
- Piwi Like RNA-Mediated Gene Silencing 2
- Piwi Like RNA-Mediated Gene Silencing 4
|
Pathways |
|
|
3 |
|
RNA Polymerase I Promoter Opening
|
509 |
1.622 |
Genes names |
- N-Acetyltransferase 8B (Putative, Gene/Pseudogene)
|
Pathways |
- Epigenetic regulation of gene expression
- Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Binding of TCF/LEF:CTNNB1 to target gene promoters
|
|
4 |
|
Formation of HIV elongation complex in the absence of HIV Tat
|
180 |
1.419 |
Genes names |
- Piwi Like RNA-Mediated Gene Silencing 1
- Piwi Like RNA-Mediated Gene Silencing 2
- Piwi Like RNA-Mediated Gene Silencing 4
|
Pathways |
- TP53 Regulates Transcription of DNA Repair Genes
- RNA polymerase II transcribes snRNA genes
|
|
5 |
|
TP53 Regulates Transcription of Cell Cycle Genes
|
48 |
1.380 |
SuperPathway |
- TP53 Regulates Transcription of Cell Cycle Genes
|
Pathways |
- TP53 Regulates Transcription of Cell Cycle Genes
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
|
|
6 |
|
TP53 Regulates Transcription of Cell Death Genes
|
44 |
1.263 |
SuperPathway |
- TP53 Regulates Transcription of Cell Death Genes
|
Pathways |
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 Regulates Transcription of Cell Death Genes
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
|
|
7 |
|
Olfactory Signaling Pathway
|
621 |
1.129 |
Genes names |
- Olfactory Receptor Family 10 Subfamily A Member 6 (Gene/Pseudogene)
- Olfactory Receptor Family 11 Subfamily H Member 7 (Gene/Pseudogene)
- Olfactory Receptor Family 4 Subfamily C Member 45 (Gene/Pseudogene)
- Olfactory Receptor Family 52 Subfamily E Member 1 (Gene/Pseudogene)
- Olfactory Receptor Family 5 Subfamily AL Member 1 (Gene/Pseudogene)
- Olfactory Receptor Family 8 Subfamily K Member 3 (Gene/Pseudogene)
|
|
8 |
|
PERK regulates gene expression
|
32 |
1.123 |
SuperPathway |
- PERK regulates gene expression
|
Pathways |
- PERK regulates gene expression
- ATF4 activates genes in response to endoplasmic reticulum stress
|
|
9 |
|
RUNX1 regulates transcription of genes involved in BCR signaling
|
8 |
1.123 |
SuperPathway |
- RUNX1 regulates transcription of genes involved in BCR signaling
|
Pathways |
- RUNX1 regulates transcription of genes involved in interleukin signaling
- RUNX1 regulates transcription of genes involved in BCR signaling
|
|
10 |
|
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
|
7 |
1.123 |
SuperPathway |
- RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
|
Pathways |
- RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
- RUNX2 regulates genes involved in differentiation of myeloid cells
|
|
11 |
|
Metabolism of steroids
|
194 |
1.091 |
Genes names |
- Insulin Induced Gene 1
- Insulin Induced Gene 2
|
Pathways |
- Activation of gene expression by SREBF (SREBP)
|
|
12 |
|
NR1H2 and NR1H3-mediated signaling
|
47 |
1.075 |
Pathways |
- NR1H2 and NR1H3 regulate gene expression to control bile acid homeostasis
- NR1H3 and NR1H2 regulate gene expression linked to cholesterol transport and efflux
- NR1H2 and NR1H3 regulate gene expression linked to lipogenesis
- NR1H2 and NR1H3 regulate gene expression linked to gluconeogenesis
- NR1H2 and NR1H3 regulate gene expression to limit cholesterol uptake
- NR1H2 and NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
|
|
13 |
|
Metabolism
|
2121 |
1.031 |
Genes names |
- Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)
- Glucosylceramidase Beta 3 (Gene/Pseudogene)
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
- Insulin Induced Gene 1
- Insulin Induced Gene 2
|
|
14 |
|
YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
15 |
0.941 |
SuperPathway |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
Pathways |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
|
15 |
|
p53 transcriptional gene network
|
95 |
0.941 |
SuperPathway |
- p53 transcriptional gene network
|
Pathways |
- p53 transcriptional gene network
|
|
16 |
|
Gene regulatory network modelling somitogenesis
|
12 |
0.941 |
SuperPathway |
- Gene regulatory network modelling somitogenesis
|
Pathways |
- Gene regulatory network modelling somitogenesis
|
|
17 |
|
Transcription_Role of VDR in regulation of genes involved in osteoporosis
|
45 |
0.941 |
SuperPathway |
- Transcription_Role of VDR in regulation of genes involved in osteoporosis
|
Pathways |
- Transcription_Role of VDR in regulation of genes involved in osteoporosis
|
|
18 |
|
RUNX1 regulates transcription of genes involved in WNT signaling
|
6 |
0.941 |
SuperPathway |
- RUNX1 regulates transcription of genes involved in WNT signaling
|
Pathways |
- RUNX1 regulates transcription of genes involved in WNT signaling
|
|
19 |
|
Antiviral mechanism by IFN-stimulated genes
|
80 |
0.941 |
SuperPathway |
- Antiviral mechanism by IFN-stimulated genes
|
Pathways |
- Antiviral mechanism by IFN-stimulated genes
|
|
20 |
|
Lissencephaly gene (LIS1) in neuronal migration and development
|
28 |
0.941 |
SuperPathway |
- Lissencephaly gene (LIS1) in neuronal migration and development
|
Pathways |
- Lissencephaly gene (LIS1) in neuronal migration and development
|
|
21 |
|
Transcriptional activation of p53 responsive genes
|
4 |
0.941 |
SuperPathway |
- Transcriptional activation of p53 responsive genes
|
Pathways |
- Transcriptional activation of p53 responsive genes
|
|
22 |
|
PPARA activates gene expression
|
145 |
0.941 |
SuperPathway |
- PPARA activates gene expression
|
Pathways |
- PPARA activates gene expression
|
|
23 |
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
72 |
0.941 |
SuperPathway |
- Regulation of nuclear beta catenin signaling and target gene transcription
|
Pathways |
- Regulation of nuclear beta catenin signaling and target gene transcription
|
|
24 |
|
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
|
8 |
0.941 |
SuperPathway |
- RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
|
Pathways |
- RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
|
|
25 |
|
IL-2 Gene Expression in Activated and Quiescent T-Cells
|
35 |
0.941 |
SuperPathway |
- IL-2 Gene Expression in Activated and Quiescent T-Cells
|
Pathways |
- IL-2 Gene Expression in Activated and Quiescent T-Cells
|
|
26 |
|
Circadian rhythm genes
|
2 |
0.941 |
|
27 |
|
TP53 Regulates Metabolic Genes
|
87 |
0.941 |
SuperPathway |
- TP53 Regulates Metabolic Genes
|
Pathways |
- TP53 Regulates Metabolic Genes
|
|
28 |
|
Retinoblastoma gene in cancer
|
86 |
0.941 |
SuperPathway |
- Retinoblastoma gene in cancer
|
Pathways |
- Retinoblastoma gene in cancer
|
|
29 |
|
Hematopoietic stem cell gene regulation by GABP alpha/beta complex
|
20 |
0.941 |
SuperPathway |
- Hematopoietic stem cell gene regulation by GABP alpha/beta complex
|
Pathways |
- Hematopoietic stem cell gene regulation by GABP alpha/beta complex
|
|
30 |
|
Genes targeted by miRNAs in adipocytes
|
13 |
0.941 |
SuperPathway |
- Genes targeted by miRNAs in adipocytes
|
Pathways |
- Genes targeted by miRNAs in adipocytes
|
|
31 |
|
Genes associated with the development of rheumatoid arthritis
|
18 |
0.941 |
SuperPathway |
- Genes associated with the development of rheumatoid arthritis
|
Pathways |
- Genes associated with the development of rheumatoid arthritis
|
|
32 |
|
Genes controlling nephrogenesis
|
44 |
0.941 |
SuperPathway |
- Genes controlling nephrogenesis
|
Pathways |
- Genes controlling nephrogenesis
|
|
33 |
|
Rett syndrome causing genes
|
48 |
0.941 |
SuperPathway |
- Rett syndrome causing genes
|
Pathways |
- Rett syndrome causing genes
|
|
34 |
|
Deregulation of Rab and Rab effector genes in bladder cancer
|
16 |
0.941 |
SuperPathway |
- Deregulation of Rab and Rab effector genes in bladder cancer
|
Pathways |
- Deregulation of Rab and Rab effector genes in bladder cancer
|
|
35 |
|
Male infertility
|
52 |
0.922 |
Genes names |
- Piwi Like RNA-Mediated Gene Silencing 1
- Piwi Like RNA-Mediated Gene Silencing 2
- Piwi Like RNA-Mediated Gene Silencing 3
- Piwi Like RNA-Mediated Gene Silencing 4
|
|
36 |
|
Regulation of beta-cell development
|
41 |
0.877 |
Pathways |
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
- Regulation of gene expression in early pancreatic precursor cells
- Regulation of gene expression in beta cells
|
|
37 |
|
22q11.2 copy number variation syndrome
|
130 |
0.799 |
Genes names |
- DiGeorge Syndrome Critical Region Gene 2
- DiGeorge Syndrome Critical Region Gene 5
- DiGeorge Syndrome Critical Region Gene 6 Like
|
|
38 |
|
Circadian Clock
|
85 |
0.760 |
Pathways |
- RORA activates gene expression
- NR1D1 (REV-ERBA) represses gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
|
39 |
|
Transcriptional Regulation by NPAS4
|
34 |
0.760 |
Pathways |
- Regulation of NPAS4 gene transcription
- Regulation of NPAS4 gene expression
- NPAS4 regulates expression of target genes
|
|
40 |
|
FOXO-mediated transcription
|
65 |
0.760 |
Pathways |
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell death genes
|
|
41 |
|
Nuclear events mediated by NFE2L2
|
199 |
0.760 |
Pathways |
- NFE2L2 regulates pentose phosphate pathway genes
- NFE2L2 regulating TCA cycle genes
- Regulation of NFE2L2 gene expression
|
|
42 |
|
Unfolded Protein Response (UPR)
|
94 |
0.760 |
Pathways |
- CREB3 factors activate genes
- ATF6 (ATF6-alpha) activates chaperone genes
- XBP1(S) activates chaperone genes
|
|
43 |
|
Regulation of activated PAK-2p34 by proteasome mediated degradation
|
978 |
0.760 |
Pathways |
- RUNX2 regulates genes involved in cell migration
- Repression of WNT target genes
- Regulation of gene expression by Hypoxia-inducible Factor
|
|
44 |
|
Vitamin D receptor pathway
|
185 |
0.652 |
Genes names |
- Cellular Repressor Of E1A Stimulated Genes 2
- Maternally Expressed 8, Small Nucleolar RNA Host Gene
|
|
45 |
|
Overview of interferons-mediated signaling pathway
|
168 |
0.652 |
Genes names |
- Interferon Lambda 4 (Gene/Pseudogene)
- Interferon Stimulated Exonuclease Gene 20
|
|
46 |
|
miRNA role in immune response in sepsis
|
62 |
0.652 |
Genes names |
- MIR155 Host Gene
- MIR223 Host Gene
|
|
47 |
|
Innate Immune System
|
2025 |
0.652 |
Genes names |
- Cellular Repressor Of E1A Stimulated Genes 1
- Interferon Stimulated Exonuclease Gene 20
|
|
48 |
|
Metapathway biotransformation Phase I and II
|
296 |
0.652 |
Genes names |
- Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
|
|
49 |
|
Metal ion SLC transporters
|
47 |
0.620 |
Pathways |
- MTF1 activates gene expression
- Zinc influx into cells by the SLC39 gene family
|
|
50 |
|
Alzheimer's disease and miRNA effects
|
267 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
51 |
|
OSX and miRNAs in tooth development
|
33 |
0.461 |
|
52 |
|
PKMTs methylate histone lysines
|
86 |
0.461 |
Genes names |
- SET Domain And Mariner Transposase Fusion Gene
|
|
53 |
|
VEGF Pathway (Tocris)
|
58 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
54 |
|
Amyotrophic lateral sclerosis (ALS)
|
36 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
55 |
|
Oxidative stress response
|
32 |
0.461 |
Genes names |
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
|
|
56 |
|
Nuclear receptors meta-pathway
|
315 |
0.461 |
Genes names |
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
|
|
57 |
|
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics
|
20 |
0.461 |
|
58 |
|
MAPK-Erk Pathway
|
275 |
0.461 |
Genes names |
- Polycystin 1 Like 2 (Gene/Pseudogene)
|
|
59 |
|
Chks in Checkpoint Regulation
|
186 |
0.461 |
|
60 |
|
Oxysterols derived from cholesterol
|
36 |
0.461 |
|
61 |
|
Aflatoxin activation and detoxification
|
19 |
0.461 |
Genes names |
- Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)
|
|
62 |
|
Translational Control
|
190 |
0.461 |
Genes names |
- Piwi Like RNA-Mediated Gene Silencing 1
|
|
63 |
|
Metabolism of proteins
|
1970 |
0.461 |
Genes names |
- N-Acetyltransferase 8B (Putative, Gene/Pseudogene)
|
|
64 |
|
Prion disease pathway
|
32 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
65 |
|
Sphingolipid metabolism
|
90 |
0.461 |
Genes names |
- Glucosylceramidase Beta 3 (Gene/Pseudogene)
|
|
66 |
|
Cytokine Signaling in Immune system
|
732 |
0.461 |
Genes names |
- Interferon Stimulated Exonuclease Gene 20
|
|
67 |
|
Apoptotic Pathways in Synovial Fibroblasts
|
731 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
68 |
|
Digestion and absorption
|
27 |
0.461 |
Genes names |
- Pancreatic Lipase Related Protein 2 (Gene/Pseudogene)
|
|
69 |
|
ncRNAs involved in Wnt signaling in hepatocellular carcinoma
|
220 |
0.461 |
|
70 |
|
Processing of Capped Intron-Containing Pre-mRNA
|
745 |
0.461 |
Genes names |
- Interferon Stimulated Exonuclease Gene 20 Like 2
|
|
71 |
|
NF-kappaB Pathway
|
152 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
72 |
|
GPCRs, other
|
100 |
0.461 |
Genes names |
- Olfactory Receptor Family 1 Subfamily E Member 3 (Gene/Pseudogene)
|
|
73 |
|
Senescence and autophagy in cancer
|
105 |
0.461 |
Genes names |
- Cellular Repressor Of E1A Stimulated Genes 1
|
|
74 |
|
rRNA processing in the nucleus and cytosol
|
205 |
0.461 |
Genes names |
- Interferon Stimulated Exonuclease Gene 20 Like 2
|
|
75 |
|
Toll-like receptor signaling pathway
|
285 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
76 |
|
Corticotropin-releasing hormone signaling pathway
|
91 |
0.461 |
Genes names |
- Caspase 12 (Gene/Pseudogene)
|
|
77 |
|
Interferon gamma signaling
|
203 |
0.461 |
Genes names |
- Interferon Stimulated Exonuclease Gene 20
|
|
78 |
|
Glutathione conjugation
|
47 |
0.461 |
Genes names |
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
|
|
79 |
|
Integration of energy metabolism
|
108 |
0.439 |
Pathways |
- ChREBP activates metabolic gene expression
|
|
80 |
|
Transcriptional regulation of pluripotent stem cells
|
24 |
0.439 |
Pathways |
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
|
|
81 |
|
PIP3 activates AKT signaling
|
310 |
0.439 |
Pathways |
- Regulation of PTEN gene transcription
|
|
82 |
|
Bisphosphonate Pathway, Pharmacodynamics
|
22 |
0.439 |
Pathways |
- RalA downstream regulated genes
|
|
83 |
|
Transcriptional Regulation by MECP2
|
62 |
0.439 |
Pathways |
- MECP2 regulates transcription of genes involved in GABA signaling
|
|
84 |
|
ECM proteoglycans
|
121 |
0.439 |
Pathways |
- MED and pseudoachondroplasia genes
|
|
85 |
|
Interleukin-12 family signaling
|
57 |
0.439 |
Pathways |
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
|
|
86 |
|
Human Early Embryo Development
|
7 |
0.439 |
Pathways |
- POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
|
|
87 |
|
RNA Polymerase II Transcription Initiation And Promoter Clearance
|
205 |
0.439 |
Pathways |
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
|
|
88 |
|
Bardet-Biedl syndrome
|
103 |
0.439 |
Pathways |
- Genes related to primary cilium development (based on CRISPR)
|
|
89 |
|
Tumor suppressor activity of SMARCB1
|
31 |
0.439 |
Pathways |
- GLI proteins bind promoters of Hh responsive genes to promote transcription
|
|
90 |
|
Regulation of CDH11 Expression and Function
|
145 |
0.439 |
Pathways |
- Regulation of CDH11 gene transcription
|
|
91 |
|
ESR-mediated signaling
|
298 |
0.439 |
Pathways |
- Estrogen-dependent gene expression
|
|
92 |
|
Assembly of the pre-replicative complex
|
316 |
0.439 |
Pathways |
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
|
|