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Activation of the pre-replicative complex
SuperPath
Pathway network
for
Activation of the pre-replicative complex
SuperPath
13
Pathways
in the
Activation of the pre-replicative complex
SuperPath
DNA replication
Unwinding of DNA
ATR signaling pathway
DNA strand elongation
Cell cycle Start of DNA replication in early S phase
Lagging Strand Synthesis
Removal of the Flap Intermediate
DNA replication initiation
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
Processive synthesis on the lagging strand
Cell Cycle Control of Chromosomal Replication
Activation of the pre-replicative complex
112
Genes
in the
Activation of the pre-replicative complex
SuperPath
POLA1
RPA1
RPA2
POLA2
MCM2
MCM7
PRIM1
PRIM2
RPA3
MCM3
MCM4
MCM5
MCM6
CDC45
CDC6
CDK2
ORC6
ORC3
ORC1
ORC2
ORC4
ORC5
POLD1
POLD2
POLD4
MCM8
POLD3
PCNA
MCM10
RFC2
RFC3
RFC4
RFC5
CDC7
DBF4
POLE
POLE2
CDT1
DNA2
FEN1
GMNN
RFC1
LIG1
POLE4
RPA4
GINS2
GINS3
GINS4
GINS1
CHEK1
CDC25A
RAD1
ATRIP
CDC25C
ATR
PPP2CA
HUS1
RAD17
RAD9A
CLSPN
POLE3
UBA52
UBC
NBN
FANCD2
BRCA2
CCNA2
PLK1
RAD51
TOPBP1
YWHAZ
YWHAB
MDM2
PPP2R1A
PPP2R2B
TIPIN
SMARCAL1
TIMELESS
CEP164
CCNE1
E2F1
H1-0
H1-2
H1-3
H1-4
H1-5
H1-6
H1-1
PPP2CB
TFDP1
H1-10
CBX5
DBF4B
H1-8
RAD9B
CDK10
CDK19
CDK3
CDK4
CDK5
CDK6
CDK7
CDK8
CDK9
CHEK2
POLB
POLG
POLH
POLK
POLQ
POLR1A
TENT4A
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Activation of the pre-replicative complex
SuperPath