CDK-mediated phosphorylation and removal of Cdc6

Pathway network for the CDK-mediated phosphorylation and removal of Cdc6 SuperPath

Sources:

Reactome

Pathways in the CDK-mediated phosphorylation and removal of Cdc6 SuperPath

#	Name	Source	Genes
1	CDK-mediated phosphorylation and removal of Cdc6	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNA1 CCNA2 CCNE1 CCNE2 CDC16 CDC23 CDC26 CDC27 CDC6 CDK2 FZR1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 60) (see less)
2	S Phase	Reactome	ADRM1 AKT1 AKT2 AKT3 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CABLES1 CCNA1 CCNA2 CCND1 CCNE1 CCNE2 CCNH CDC16 CDC23 CDC25A CDC25B CDC26 CDC27 CDC45 CDC6 CDCA5 CDK2 CDK4 CDK7 CDKN1A CDKN1B CDT1 CKS1B CUL1 DNA2 E2F1 E2F4 E2F5 ESCO1 ESCO2 FEN1 FZR1 GINS1 GINS2 GINS3 GINS4 GMNN GSK3B LIG1 LIN37 LIN52 LIN54 LIN9 MAX MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PDS5A PDS5B POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTK6 RAD21 RB1 RBBP4 RBL2 RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SEM1 SKP1 SKP2 SMC1A SMC3 STAG1 STAG2 TFDP1 TFDP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S WAPL WEE1 (see all 150) (see less)
3	Synthesis of DNA	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNA1 CCNA2 CCNE1 CCNE2 CDC16 CDC23 CDC26 CDC27 CDC45 CDC6 CDK2 CDT1 CUL1 DNA2 FEN1 FZR1 GINS1 GINS2 GINS3 GINS4 GMNN LIG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SEM1 SKP1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 108) (see less)
4	Switching of origins to a post-replicative state	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNA1 CCNA2 CCNE1 CCNE2 CDC16 CDC23 CDC26 CDC27 CDC6 CDK2 CDT1 CUL1 FZR1 GMNN MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RBX1 RPS27A SEM1 SKP1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 79) (see less)
5	Regulation of mitotic cell cycle	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CDK2 CUL1 FBXO5 FZR1 MAD2L1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RB1 RPS27A SEM1 SKP1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 75) (see less)
6	APC/C-mediated degradation of cell cycle proteins	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CDK2 CUL1 FBXO5 FZR1 MAD2L1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RB1 RPS27A SEM1 SKP1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 75) (see less)
7	Regulation of APC/C activators between G1/S and early anaphase	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BTRC BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CDK2 CUL1 FBXO5 FZR1 MAD2L1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEM1 SKP1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 68) (see less)
8	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 64) (see less)
9	APC/C:Cdc20 mediated degradation of mitotic proteins	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CCNB1 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 NEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 63) (see less)
10	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 NEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 61) (see less)
11	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB CDC16 CDC20 CDC23 CDC26 CDC27 FZR1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RB1 RPS27A SEM1 SKP2 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 61) (see less)
12	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B BUB3 CCNA1 CCNA2 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 MAD2L1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 60) (see less)
13	Orc1 removal from chromatin	Reactome	ADRM1 CCNA1 CCNA2 CDC6 CDK2 CDT1 CUL1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RBX1 RPS27A SEM1 SKP1 SKP2 UBA52 UBB UBC (see all 58) (see less)
14	APC/C:Cdc20 mediated degradation of Securin	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDC26 CDC27 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTTG1 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 55) (see less)
15	Autodegradation of Cdh1 by Cdh1:APC/C	Reactome	ADRM1 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC16 CDC23 CDC26 CDC27 FZR1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEM1 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S (see all 54) (see less)
16	Phosphorylation of the APC/C	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CDC16 CDC23 CDC26 CDC27 CDK1 PLK1 UBE2C UBE2D1 UBE2E1 UBE2S (see all 20) (see less)
17	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 FZR1 UBE2C UBE2D1 UBE2E1 UBE2S (see all 20) (see less)
18	Establishment of Sister Chromatid Cohesion	Reactome	CDCA5 ESCO1 ESCO2 PDS5A PDS5B RAD21 SMC1A SMC3 STAG1 STAG2 WAPL (see all 11) (see less)

Gene overlap in member pathways for CDK-mediated phosphorylation and removal of Cdc6 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	16
2	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	16
3	ANAPC16	Anaphase Promoting Complex Subunit 16	Protein Coding	16
4	CDC26	Cell Division Cycle 26	Protein Coding	16
5	ANAPC15	Anaphase Promoting Complex Subunit 15	Protein Coding	16
6	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	16
7	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	16
8	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	16
9	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	16
10	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	16
11	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	16
12	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	16
13	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	16
14	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	16
15	CDC23	Cell Division Cycle 23	Protein Coding	16
16	CDC16	Cell Division Cycle 16	Protein Coding	16
17	CDC27	Cell Division Cycle 27	Protein Coding	16
18	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	15
19	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	15
20	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	15
21	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	15
22	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	15
23	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	15
24	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	15
25	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	15
26	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	15
27	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	15
28	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	15
29	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	15
30	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	15
31	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	15
32	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	15
33	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	15
34	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	15
35	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	15
36	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	15
37	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	15
38	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	15
39	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	15
40	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	15
41	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	15
42	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	15
43	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	15
44	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	15
45	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	15
46	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	15
47	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	15
48	RPS27A	Ribosomal Protein S27a	Protein Coding	15
49	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	15
50	UBB	Ubiquitin B	Protein Coding	15
51	UBC	Ubiquitin C	Protein Coding	15
52	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	15
53	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	15
54	CCNA2	Cyclin A2	Protein Coding	12
55	CCNA1	Cyclin A1	Protein Coding	12
56	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	10
57	CDC20	Cell Division Cycle 20	Protein Coding	10
58	CDK2	Cyclin Dependent Kinase 2	Protein Coding	8
59	CDK1	Cyclin Dependent Kinase 1	Protein Coding	8
60	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	7
61	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	7
62	CUL1	Cullin 1	Protein Coding	7
63	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	7
64	BUB1B	BUB1 Mitotic Checkpoint Serine/Threonine Kinase B	Protein Coding	7
65	BUB3	BUB3 Mitotic Checkpoint Protein	Protein Coding	7
66	PLK1	Polo Like Kinase 1	Protein Coding	6
67	CCNB1	Cyclin B1	Protein Coding	6
68	PTTG1	PTTG1 Regulator Of Sister Chromatid Separation, Securin	Protein Coding	6
69	CDC6	Cell Division Cycle 6	Protein Coding	5
70	NEK2	NIMA Related Kinase 2	Protein Coding	5
71	CCNE1	Cyclin E1	Protein Coding	4
72	CCNE2	Cyclin E2	Protein Coding	4
73	ORC6	Origin Recognition Complex Subunit 6	Protein Coding	4
74	ORC3	Origin Recognition Complex Subunit 3	Protein Coding	4
75	MCM2	Minichromosome Maintenance Complex Component 2	Protein Coding	4
76	MCM3	Minichromosome Maintenance Complex Component 3	Protein Coding	4
77	MCM4	Minichromosome Maintenance Complex Component 4	Protein Coding	4
78	MCM5	Minichromosome Maintenance Complex Component 5	Protein Coding	4
79	MCM6	Minichromosome Maintenance Complex Component 6	Protein Coding	4
80	MCM7	Minichromosome Maintenance Complex Component 7	Protein Coding	4
81	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	4
82	ORC2	Origin Recognition Complex Subunit 2	Protein Coding	4
83	ORC4	Origin Recognition Complex Subunit 4	Protein Coding	4
84	ORC5	Origin Recognition Complex Subunit 5	Protein Coding	4
85	RB1	RB Transcriptional Corepressor 1	Protein Coding	4
86	CDT1	Chromatin Licensing And DNA Replication Factor 1	Protein Coding	4
87	MCM8	Minichromosome Maintenance 8 Homologous Recombination Repair Factor	Protein Coding	4
88	RBX1	Ring-Box 1	Protein Coding	4
89	GMNN	Geminin DNA Replication Inhibitor	Protein Coding	3
90	FBXO5	F-Box Protein 5	Protein Coding	3
91	AURKA	Aurora Kinase A	Protein Coding	3
92	CDC14A	Cell Division Cycle 14A	Protein Coding	3
93	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	3
94	AURKB	Aurora Kinase B	Protein Coding	3
95	STAG1	STAG1 Cohesin Complex Component	Protein Coding	2
96	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	2
97	STAG2	STAG2 Cohesin Complex Component	Protein Coding	2
98	CDCA5	Cell Division Cycle Associated 5	Protein Coding	2
99	ESCO1	Establishment Of Sister Chromatid Cohesion N-Acetyltransferase 1	Protein Coding	2
100	ESCO2	Establishment Of Sister Chromatid Cohesion N-Acetyltransferase 2	Protein Coding	2
101	DNA2	DNA Replication Helicase/Nuclease 2	Protein Coding	2
102	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	2
103	PDS5B	PDS5 Cohesin Associated Factor B	Protein Coding	2
104	WAPL	WAPL Cohesin Release Factor	Protein Coding	2
105	PDS5A	PDS5 Cohesin Associated Factor A	Protein Coding	2
106	POLA2	DNA Polymerase Alpha 2, Accessory Subunit	Protein Coding	2
107	LIG1	DNA Ligase 1	Protein Coding	2
108	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	2
109	GINS2	GINS Complex Subunit 2	Protein Coding	2
110	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	2
111	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	2
112	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	2
113	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	2
114	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	2
115	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	2
116	PRIM1	DNA Primase Subunit 1	Protein Coding	2
117	PRIM2	DNA Primase Subunit 2	Protein Coding	2
118	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	2
119	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	2
120	RAD21	RAD21 Cohesin Complex Component	Protein Coding	2
121	RFC1	Replication Factor C Subunit 1	Protein Coding	2
122	RFC2	Replication Factor C Subunit 2	Protein Coding	2
123	RFC3	Replication Factor C Subunit 3	Protein Coding	2
124	RFC4	Replication Factor C Subunit 4	Protein Coding	2
125	RFC5	Replication Factor C Subunit 5	Protein Coding	2
126	RPA1	Replication Protein A1	Protein Coding	2
127	RPA2	Replication Protein A2	Protein Coding	2
128	RPA3	Replication Protein A3	Protein Coding	2
129	GINS3	GINS Complex Subunit 3	Protein Coding	2
130	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	2
131	CDC45	Cell Division Cycle 45	Protein Coding	2
132	GINS4	GINS Complex Subunit 4	Protein Coding	2
133	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	2
134	GINS1	GINS Complex Subunit 1	Protein Coding	2
135	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
136	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
137	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
138	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
139	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
140	CKS1B	CDC28 Protein Kinase Regulatory Subunit 1B	Protein Coding	1
141	LIN54	Lin-54 DREAM MuvB Core Complex Component	Protein Coding	1
142	E2F1	E2F Transcription Factor 1	Protein Coding	1
143	E2F4	E2F Transcription Factor 4	Protein Coding	1
144	E2F5	E2F Transcription Factor 5	Protein Coding	1
145	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
146	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
147	LIN9	Lin-9 DREAM MuvB Core Complex Component	Protein Coding	1
148	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
149	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
150	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	1
151	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
152	LIN37	Lin-37 DREAM MuvB Core Complex Component	Protein Coding	1
153	PTK6	Protein Tyrosine Kinase 6	Protein Coding	1
154	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
155	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
156	CCND1	Cyclin D1	Protein Coding	1
157	TFDP1	Transcription Factor Dp-1	Protein Coding	1
158	TFDP2	Transcription Factor Dp-2	Protein Coding	1
159	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	1
160	CCNH	Cyclin H	Protein Coding	1
161	LIN52	Lin-52 DREAM MuvB Core Complex Component	Protein Coding	1
162	CABLES1	Cdk5 And Abl Enzyme Substrate 1	Protein Coding	1
163	CDC25A	Cell Division Cycle 25A	Protein Coding	1
164	CDC25B	Cell Division Cycle 25B	Protein Coding	1

Disorders associated with CDK-mediated phosphorylation and removal of Cdc6 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meier-gorlin syndrome 1	Enrichment	CDC45, CDC6, CDT1, GMNN, MCM7, ORC1, ORC4, ORC6	16.00
2	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	7.48
3	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	7.48
4	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	5.05
5	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	4.04
6	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	3.73
7	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B, BUB3	3.28
8	Isolated split hand-split foot malformation	Enrichment	BTRC, SEM1	3.17
9	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	3.09
10	Roberts-sc phocomelia syndrome	Enrichment	ESCO2	3.09
11	Holoprosencephaly 13, x-linked	Enrichment	STAG2	3.09
12	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	3.09
13	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	3.09
14	Juberg-hayward syndrome	Enrichment	ESCO2	3.09
15	Mullegama-klein-martinez syndrome	Enrichment	STAG2	3.09
16	Intellectual developmental disorder, autosomal dominant 47	Enrichment	STAG1	3.09
17	Mungan syndrome	Enrichment	RAD21	3.09
18	Xq25 microduplication syndrome	Enrichment	STAG2	3.09
19	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.83
20	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.83
21	Deafness, autosomal recessive 32, with or without immotile sperm	Enrichment	CDC14A	2.83
22	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	2.83
23	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.83
24	Autosomal recessive nonsyndromic deafness 32	Enrichment	CDC14A	2.83
25	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.79
26	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	2.61
27	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	2.49
28	Familial colorectal cancer type x	Enrichment	POLD1, POLE	2.48
29	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, MAX, POLD1, POLE, RB1	2.46
30	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.40
31	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.40
32	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.40
33	Lactose intolerance, adult type	Enrichment	MCM6	2.37
34	Meier-gorlin syndrome 3	Enrichment	ORC6	2.37
35	Meier-gorlin syndrome 2	Enrichment	ORC4	2.37
36	Meier-gorlin syndrome 4	Enrichment	CDT1	2.37
37	Anisometropia	Enrichment	MCM7	2.37
38	Immunodeficiency 54	Enrichment	MCM4	2.37
39	Deafness, autosomal dominant 70	Enrichment	MCM2	2.37
40	Meier-gorlin syndrome 8	Enrichment	MCM5	2.37
41	Premature ovarian failure 10	Enrichment	MCM8	2.37
42	Meier-gorlin syndrome 5	Enrichment	CDC6	2.37
43	Premature chromatid separation trait	Enrichment	BUB1B	2.35
44	Retinitis pigmentosa 67	Enrichment	NEK2	2.35
45	Trilateral retinoblastoma	Enrichment	RB1	2.35
46	Lung oat cell carcinoma	Enrichment	RB1	2.35
47	Polymicrogyria	Enrichment	AKT3, PSMC3	2.29
48	Seckel syndrome	Enrichment	DNA2, PRIM1	2.27
49	Meier-gorlin syndrome 6	Enrichment	GMNN	2.23
50	Rett syndrome, congenital variant	Enrichment	SMC1A	2.19
51	Deafness, autosomal recessive 63	Enrichment	ANAPC15	2.13
52	Birk-aharoni syndrome	Enrichment	PSMC1	2.10
53	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	2.10
54	17q24.2 microdeletion syndrome	Enrichment	PSMD12	2.10
55	Submucosal cleft palate	Enrichment	UBB	2.10
56	Cleft hard palate	Enrichment	UBB	2.10
57	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.10
58	Van esch-o'driscoll syndrome	Enrichment	POLA1	2.10
59	Colorectal cancer 10	Enrichment	POLD1	2.10
60	Seckel syndrome 8	Enrichment	DNA2	2.10
61	Colorectal cancer 12	Enrichment	POLE	2.10
62	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.10
63	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	2.10
64	Immunodeficiency 120	Enrichment	POLD1	2.10
65	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6	Enrichment	DNA2	2.10
66	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.10
67	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.10
68	Immunodeficiency 96	Enrichment	LIG1	2.10
69	Meier-gorlin syndrome 7	Enrichment	CDC45	2.10
70	Rothmund-thomson syndrome, type 4	Enrichment	DNA2	2.10
71	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.10
72	Immunodeficiency 122	Enrichment	POLD3	2.10
73	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.05
74	Familial retinoblastoma	Enrichment	RB1	2.05
75	Proteus syndrome	Enrichment	AKT1	1.96
76	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.96
77	Melanoma, cutaneous malignant 3	Enrichment	CDK4	1.96
78	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	1.96
79	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.96
80	Neuroendocrine tumor	Enrichment	CDKN1B	1.96
81	Polydactyly-macrocephaly syndrome	Enrichment	MAX	1.96
82	Cowden syndrome 6	Enrichment	AKT1	1.96
83	Capillary hemangioma	Enrichment	AKT3	1.96
84	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.96
85	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.92
86	Uvula, bifid	Enrichment	UBB	1.92
87	Cleft soft palate	Enrichment	UBB	1.92
88	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.92
89	Thyroid hemiagenesis	Enrichment	PSMD3	1.92
90	Retinoblastoma	Enrichment	RB1	1.87
91	Osteogenic sarcoma	Enrichment	RB1	1.87
92	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.87
93	Hypotrichosis 8	Enrichment	RB1	1.87
94	Squamous cell carcinoma	Enrichment	RB1	1.87
95	Bone osteosarcoma	Enrichment	RB1	1.87
96	Alobar holoprosencephaly	Enrichment	STAG2	1.86
97	Colorectal cancer	Enrichment	AKT1, CCND1, POLD1, POLE	1.80
98	Rothmund-thomson syndrome, type 2	Enrichment	DNA2	1.80
99	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	1.80
100	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	1.80
101	Immunodeficiency 55	Enrichment	GINS1	1.80
102	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	1.80
103	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	1.80
104	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	1.80
105	Astigmatism	Enrichment	MCM7	1.77
106	Enophthalmos	Enrichment	MCM7	1.77
107	Small cell cancer of the lung	Enrichment	RB1	1.75
108	Lynch syndrome 4	Enrichment	RB1	1.75
109	2q23.1 microduplication syndrome	Enrichment	ORC4	1.67
110	Farsightedness	Enrichment	MCM7	1.67
111	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B	1.66
112	Burkitt lymphoma	Enrichment	MYC	1.66
113	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.66
114	Senior-loken syndrome 7	Enrichment	AKT3	1.66
115	Bardet-biedl syndrome 16	Enrichment	AKT3	1.66
116	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.63
117	Patent ductus arteriosus	Enrichment	PSMC3	1.63
118	Partington syndrome	Enrichment	POLA1	1.63
119	Childhood apraxia of speech	Enrichment	RFC3	1.63
120	Wieacker-wolff syndrome	Enrichment	CCNH	1.48
121	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.48
122	Dedifferentiated liposarcoma	Enrichment	CDK4	1.48
123	Well-differentiated liposarcoma	Enrichment	CDK4	1.48
124	Ear malformation	Enrichment	CDC14A	1.46
125	Bladder cancer	Enrichment	CDKN1A, RB1	1.39
126	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.36
127	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.36
128	Mantle cell lymphoma	Enrichment	CCND1	1.36
129	Primary hyperparathyroidism	Enrichment	CDKN1B	1.36
130	Lip and oral cavity carcinoma	Enrichment	RB1	1.28
131	Capillary malformations, congenital	Enrichment	CCNH	1.27
132	Von hippel-lindau syndrome	Enrichment	CCND1	1.27
133	Hemimegalencephaly	Enrichment	AKT3	1.27
134	Nk-cell enteropathy	Enrichment	AURKB	1.24
135	Lung cancer susceptibility 3	Enrichment	RB1	1.21
136	Isolated growth hormone deficiency, type ia	Enrichment	DNA2	1.21
137	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.19
138	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.19
139	Hemangioma, capillary infantile	Enrichment	CCNH	1.19
140	Basal cell carcinoma 1	Enrichment	CCNH	1.19
141	Breast adenocarcinoma	Enrichment	AKT1	1.19
142	Sensorineural hearing loss	Enrichment	CDC14A	1.16
143	Patent foramen ovale	Enrichment	PSMC3	1.16
144	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.13
145	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	1.13
146	Megacolon	Enrichment	AKT3	1.13
147	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	1.10
148	Azoospermia	Enrichment	MCM8	1.09
149	Congenital nervous system abnormality	Enrichment	SMC1A	1.08
150	Nervous system disease	Enrichment	SMC1A	1.08
151	Myocardial infarction	Enrichment	PSMA6	1.08
152	Combined immunodeficiency	Enrichment	POLD1	1.07
153	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.07
154	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.07
155	Autism spectrum disorder	Enrichment	SMC3	1.07
156	Microphthalmia	Enrichment	MCM7	1.05
157	Arteriovenous malformation	Enrichment	CCNH	1.02
158	Cowden syndrome	Enrichment	AKT1	1.02
159	Microcephaly	Enrichment	SMC1A	1.02
160	Ovarian cancer	Enrichment	AKT1, CDKN1B, RB1	0.99
161	Leukemia, chronic lymphocytic	Enrichment	CCND1	0.98
162	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	0.98
163	Rare genetic deafness	Enrichment	CDC14A	0.96
164	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CDC14A	0.91
165	Meningioma	Enrichment	AKT1	0.90
166	Primary autosomal recessive microcephaly	Enrichment	MCM7	0.89
167	Parkinson's disease	Enrichment	RFC1	0.85
168	Pheochromocytoma	Enrichment	MAX	0.84
169	Williams-beuren syndrome	Enrichment	RFC2	0.83
170	Melanoma, cutaneous malignant 1	Enrichment	CDK4	0.76
171	Polycystic liver disease	Enrichment	CDC25A	0.76
172	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	0.76
173	Parkinson disease, late-onset	Enrichment	RFC1	0.76
174	Pancreatic cancer	Enrichment	POLD1	0.74
175	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MCM2	0.70
176	Breast cancer	Enrichment	AKT1, CKS1B	0.70
177	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.68
178	Myeloma, multiple	Enrichment	AURKA	0.65
179	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.65
180	Type 2 diabetes mellitus	Enrichment	AKT2	0.43
181	Gastric cancer	Enrichment	CDK4	0.42
182	Hereditary breast carcinoma	Enrichment	AKT1	0.41
183	Complex neurodevelopmental disorder	Enrichment	PSMD12	0.41
184	Retinitis pigmentosa	Enrichment	NEK2	0.21
185	Hereditary retinal dystrophy	Enrichment	NEK2	0.13
186	Fundus dystrophy	Enrichment	NEK2	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CDK-mediated phosphorylation and removal of Cdc6

Pathway Network for CDK-mediated phosphorylation and removal of Cdc6

Pathway network for the CDK-mediated phosphorylation and removal of Cdc6 SuperPath

Member Pathways for CDK-mediated phosphorylation and removal of Cdc6

Pathways in the CDK-mediated phosphorylation and removal of Cdc6 SuperPath

Gene overlap in member pathways for CDK-mediated phosphorylation and removal of Cdc6 SuperPath

Associated Genes for CDK-mediated phosphorylation and removal of Cdc6

Associated Disorders for CDK-mediated phosphorylation and removal of Cdc6

Disorders associated with CDK-mediated phosphorylation and removal of Cdc6 SuperPath

STRING Interaction Network for CDK-mediated phosphorylation and removal of Cdc6

Sources for CDK-mediated phosphorylation and removal of Cdc6