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Chondroitin sulfate/dermatan sulfate metabolism
SuperPath
Pathway network
for
Chondroitin sulfate/dermatan sulfate metabolism
SuperPath
13
Pathways
in the
Chondroitin sulfate/dermatan sulfate metabolism
SuperPath
Defective CHSY1 causes TPBS
Diseases associated with glycosaminoglycan metabolism
Defective CHST14 causes EDS, musculocontractural type
Defective CHST3 causes SEDCJD
Chondroitin sulfate/dermatan sulfate metabolism
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
A tetrasaccharide linker sequence is required for GAG synthesis
dermatan sulfate biosynthesis (late stages)
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Defective B4GALT7 causes EDS, progeroid type
64
Genes
in the
Chondroitin sulfate/dermatan sulfate metabolism
SuperPath
CSPG5
VCAN
NCAN
CSPG4
DCN
BGN
BCAN
GPC6
GPC2
GPC4
GPC5
GPC3
GPC1
HSPG2
AGRN
SDC1
SDC2
SDC4
SDC3
CHST14
CHSY1
B4GALT7
B3GALT6
B3GAT3
CHST3
HEXA
HEXB
UST
DSE
CHST15
B3GAT2
CHST13
B3GAT1
HYAL1
CHSY3
IDS
IDUA
ARSB
CHST11
CHPF2
CSGALNACT2
CHST12
CSGALNACT1
CHST7
XYLT1
XYLT2
CHPF
CHST9
HYAL3
DSEL
KERA
ACAN
SLC26A2
EXT1
EXT2
FMOD
B4GALT1
LUM
CHST6
OMD
OGN
PRELP
ST3GAL3
PAPSS2
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Chondroitin sulfate/dermatan sulfate metabolism
SuperPath