FGFR1 mutant receptor activation

Pathway network for the FGFR1 mutant receptor activation SuperPath

Sources:

Reactome

Pathways in the FGFR1 mutant receptor activation SuperPath

#	Name	Source	Genes
1	FGFR1 mutant receptor activation	Reactome	BCR CEP43 CNTRL CPSF6 CUX1 ERLIN2 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR1OP2 GAB2 GRB2 LRRFIP1 MYO18A PIK3CA PIK3R1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 (see all 30) (see less)
2	Signaling by FGFR1 in disease	Reactome	BCR CEP43 CNTRL CPSF6 CUX1 ERLIN2 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR1OP2 FRS2 GAB1 GAB2 GRB2 HRAS KRAS LRRFIP1 MYO18A NRAS PIK3CA PIK3R1 PLCG1 SOS1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 (see all 37) (see less)
3	Signaling by cytosolic FGFR1 fusion mutants	Reactome	BCR CEP43 CNTRL CPSF6 CUX1 FGFR1OP2 GAB2 GRB2 LRRFIP1 MYO18A PIK3CA PIK3R1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 (see all 18) (see less)
4	Signaling by plasma membrane FGFR1 fusions	Reactome	ERLIN2 FGFR1
5	Signaling by FGFR1 amplification mutants	Reactome	FGFR1

Gene overlap in member pathways for FGFR1 mutant receptor activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	4
2	CPSF6	Cleavage And Polyadenylation Specific Factor 6	Protein Coding	3
3	CNTRL	Centriolin	Protein Coding	3
4	CEP43	Centrosomal Protein 43	Protein Coding	3
5	ERLIN2	ER Lipid Raft Associated 2	Protein Coding	3
6	CUX1	Cut Like Homeobox 1	Protein Coding	3
7	FGFR1OP2	FGFR1 Oncogene Partner 2	Protein Coding	3
8	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
9	MYO18A	Myosin XVIIIA	Protein Coding	3
10	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
11	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
12	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	3
13	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
14	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
15	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
16	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	3
17	ZMYM2	Zinc Finger MYM-Type Containing 2	Protein Coding	3
18	TRIM24	Tripartite Motif Containing 24	Protein Coding	3
19	LRRFIP1	LRR Binding FLII Interacting Protein 1	Protein Coding	3
20	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	3
21	FGF1	Fibroblast Growth Factor 1	Protein Coding	2
22	FGF2	Fibroblast Growth Factor 2	Protein Coding	2
23	FGF4	Fibroblast Growth Factor 4	Protein Coding	2
24	FGF5	Fibroblast Growth Factor 5	Protein Coding	2
25	FGF6	Fibroblast Growth Factor 6	Protein Coding	2
26	FGF8	Fibroblast Growth Factor 8	Protein Coding	2
27	FGF9	Fibroblast Growth Factor 9	Protein Coding	2
28	FGF20	Fibroblast Growth Factor 20	Protein Coding	2
29	FGF23	Fibroblast Growth Factor 23	Protein Coding	2
30	FGF17	Fibroblast Growth Factor 17	Protein Coding	2
31	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
32	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
33	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
34	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
35	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
36	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
37	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1

Disorders associated with FGFR1 mutant receptor activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bone development disease	Direct
2	Leukemia, chronic myeloid	Direct
3	Subacute leukemia	Direct
4	Myelodysplastic/myeloproliferative neoplasm	Direct
5	Leukemia, acute lymphoblastic	Direct
6	Osteoglophonic dysplasia	Enrichment	FGFR1	4.13
7	Trigonocephaly 1	Enrichment	FGFR1	4.13
8	Hartsfield syndrome	Enrichment	FGFR1	4.13
9	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	4.13
10	Spastic paraplegia 18b, autosomal recessive	Enrichment	ERLIN2	3.83
11	Hereditary spastic paraplegia 18	Enrichment	ERLIN2	3.83
12	Spastic paraplegia 18a, autosomal dominant	Enrichment	ERLIN2	3.83
13	Recessive intellectual disability-motor dysfunction-multiple joint contractures syndrome	Enrichment	ERLIN2	3.83
14	Pfeiffer syndrome	Enrichment	FGFR1	3.83
15	Jackson-weiss syndrome	Enrichment	FGFR1	3.83
16	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	3.83
17	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	3.83
18	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	3.83
19	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	3.66
20	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	3.66
21	Primary lateral sclerosis, juvenile	Enrichment	ERLIN2	3.53
22	Holoprosencephaly	Enrichment	FGFR1	3.43
23	Primary hypereosinophilic syndrome	Enrichment	FGFR1	3.43
24	Holoprosencephaly 1	Enrichment	FGFR1	3.35
25	Pilomyxoid astrocytoma	Enrichment	FGFR1	3.29
26	Hypogonadotropic hypogonadism	Enrichment	FGFR1	3.18
27	Septooptic dysplasia	Enrichment	FGFR1	3.05
28	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	2.99
29	Gliosarcoma	Enrichment	FGFR1	2.93
30	Microform holoprosencephaly	Enrichment	FGFR1	2.93
31	Lobar holoprosencephaly	Enrichment	FGFR1	2.93
32	Giant cell glioblastoma	Enrichment	FGFR1	2.90
33	Semilobar holoprosencephaly	Enrichment	FGFR1	2.88
34	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	2.88
35	Tooth agenesis	Enrichment	FGFR1	2.79
36	Kallmann syndrome	Enrichment	FGFR1	2.77
37	Hereditary spastic paraplegia	Enrichment	ERLIN2	2.21
38	Congenital nervous system abnormality	Enrichment	ERLIN2	1.81
39	Nervous system disease	Enrichment	ERLIN2	1.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FGFR1 mutant receptor activation

Pathway Network for FGFR1 mutant receptor activation

Pathway network for the FGFR1 mutant receptor activation SuperPath

Member Pathways for FGFR1 mutant receptor activation

Pathways in the FGFR1 mutant receptor activation SuperPath

Gene overlap in member pathways for FGFR1 mutant receptor activation SuperPath

Associated Genes for FGFR1 mutant receptor activation

Associated Disorders for FGFR1 mutant receptor activation

Disorders associated with FGFR1 mutant receptor activation SuperPath

STRING Interaction Network for FGFR1 mutant receptor activation

Sources for FGFR1 mutant receptor activation