Arf1 pathway

No Pathway Network information available for Arf1 pathway

Pathways in the Arf1 pathway SuperPath

#	Name	Source	Genes
1	Arf1 pathway	PubChem	ACTR2 ACTR3 AP2A1 AP2M1 ARF1 ARFGAP1 ARFGEF1 ARFIP2 ARHGAP10 ASAP1 CD4 CLTA CLTB COPA CYTH1 CYTH2 EREG GBF1 GGA3 GIT1 GOSR2 KDELR1 PAPOLA PIP5K1A PLD2 RAC1 USO1 YKT6 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYTH1	Cytohesin 1	Protein Coding	1
2	CLTB	Clathrin Light Chain B	Protein Coding	1
3	EREG	Epiregulin	Protein Coding	1
4	ARFGEF1	ARF Guanine Nucleotide Exchange Factor 1	Protein Coding	1
5	KDELR1	KDEL Endoplasmic Reticulum Protein Retention Receptor 1	Protein Coding	1
6	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	1
7	CYTH2	Cytohesin 2	Protein Coding	1
8	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
9	PLD2	Phospholipase D2	Protein Coding	1
10	PAPOLA	Poly(A) Polymerase Alpha	Protein Coding	1
11	CD4	CD4 Molecule	Protein Coding	1
12	GGA3	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3	Protein Coding	1
13	ARHGAP10	Rho GTPase Activating Protein 10	Protein Coding	1
14	GIT1	GIT ArfGAP 1	Protein Coding	1
15	ASAP1	ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	1
16	RAC1	Rac Family Small GTPase 1	Protein Coding	1
17	ACTR2	Actin Related Protein 2	Protein Coding	1
18	ARFGAP1	ARF GTPase Activating Protein 1	Protein Coding	1
19	ACTR3	Actin Related Protein 3	Protein Coding	1
20	ARF1	ARF GTPase 1	Protein Coding	1
21	ARFIP2	ARF Interacting Protein 2	Protein Coding	1
22	YKT6	YKT6 Vesicular SNARE Protein	Protein Coding	1
23	GBF1	Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1	Protein Coding	1
24	COPA	Coat Protein Complex I Subunit Alpha	Protein Coding	1
25	GOSR2	Golgi SNAP Receptor Complex Member 2	Protein Coding	1
26	USO1	USO1 Vesicle Transport Factor	Protein Coding	1
27	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	1
28	CLTA	Clathrin Light Chain A	Protein Coding	1

Disorders associated with Arf1 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1, PIP5K1A	5.39
2	Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures	Enrichment	ARFGEF1	2.69
3	Okt4 epitope deficiency	Enrichment	CD4	2.69
4	Charcot-marie-tooth disease, axonal, type 2gg	Enrichment	GBF1	2.69
5	Autoinflammation and autoimmunity, systemic, with immune dysregulation	Enrichment	COPA	2.69
6	Immunodeficiency 79	Enrichment	CD4	2.69
7	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.69
8	Cataract 11, multiple types	Enrichment	GBF1	2.38
9	Anterior segment dysgenesis 1	Enrichment	GBF1	2.38
10	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.38
11	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.38
12	Nephrotic syndrome, type 17	Enrichment	GGA3	2.38
13	Joubert syndrome 21	Enrichment	ARFGEF1	2.38
14	Epilepsy, progressive myoclonic, 6	Enrichment	GOSR2	2.21
15	Muscular dystrophy, congenital, with or without seizures	Enrichment	GOSR2	2.21
16	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.73
17	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.73
18	Progressive myoclonus epilepsy	Enrichment	GOSR2	1.69
19	Myoclonic epilepsy of unverricht and lundborg	Enrichment	GOSR2	1.54
20	Periventricular nodular heterotopia	Enrichment	ARF1	1.54
21	Deafness, autosomal recessive	Enrichment	GOSR2	0.91
22	Autosomal recessive nonsyndromic deafness	Enrichment	GOSR2	0.91
23	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GOSR2	0.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Arf1 pathway

Member Pathways for Arf1 pathway

Pathways in the Arf1 pathway SuperPath

Associated Genes for Arf1 pathway

Associated Disorders for Arf1 pathway

Disorders associated with Arf1 pathway SuperPath

STRING Interaction Network for Arf1 pathway

Sources for Arf1 pathway