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Diseases of hemostasis
SuperPath
Pathway network
for
Diseases of hemostasis
SuperPath
20
Pathways
in the
Diseases of hemostasis
SuperPath
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
Defective factor XII causes hereditary angioedema
Common Pathway of Fibrin Clot Formation
Diseases of hemostasis
Defective F8 cleavage by thrombin
Defective F9 activation
Formation of Fibrin Clot (Clotting Cascade)
Intrinsic Pathway of Fibrin Clot Formation
Blood Coagulation Signaling Pathways
Defective F8 binding to von Willebrand factor
Extrinsic Pathway of Fibrin Clot Formation
Extrinsic Prothrombin Activation Pathway
Defective F9 secretion
Thrombin/protease-activated receptor (PAR) pathway
Blood clotting cascade
Defective gamma-carboxylation of F9
Defective F8 sulfation at Y1699
Complement and coagulation cascades
Defective factor VIII causes hemophilia A
Defective factor IX causes hemophilia B
83
Genes
in the
Diseases of hemostasis
SuperPath
F2
F8
F9
F10
VWF
F12
F11
KLKB1
GP1BA
GP5
GP9
GP1BB
F5
FGB
SERPINC1
PROC
PROS1
F3
F7
SERPING1
F13B
SERPIND1
SERPINA5
THBD
TFPI
GGCX
TPST2
TPST1
FGA
FGG
A2M
KNG1
F2R
F13A1
SERPINE2
SERPINE1
PLG
PLAU
PLAT
SERPINF2
PROCR
PF4
PF4V1
PRTN3
CD177
PRCP
C1QBP
SERPINB2
GP6
COL4A1
TFPI2
KLK1
MASP2
CLU
CLTC
CPB2
CR1
CR2
CD55
CFD
CFH
CFI
LMAN1
CD46
SERPINA1
PLAUR
MASP1
BDKRB1
CFB
C1QA
C1QB
C1QC
C1R
C1S
C2
C3
C3AR1
C4B
C5AR1
C6
C7
C8G
C9
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Diseases of hemostasis
SuperPath