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Homologous DNA Pairing and Strand Exchange
SuperPath
Pathway network
for
Homologous DNA Pairing and Strand Exchange
SuperPath
12
Pathways
in the
Homologous DNA Pairing and Strand Exchange
SuperPath
Defective homologous recombination repair (HRR) due to BRCA2 loss of function
HDR through Single Strand Annealing (SSA)
Diseases of DNA repair
Homologous DNA Pairing and Strand Exchange
Diseases of Base Excision Repair
Diseases of DNA Double-Strand Break Repair
Defective Base Excision Repair Associated with NEIL1
HDR through Homologous Recombination (HRR)
Fanconi anemia pathway
Fanconi Anemia Pathway
Impaired BRCA2 binding to RAD51
Presynaptic phase of homologous DNA pairing and strand exchange
108
Genes
in the
Homologous DNA Pairing and Strand Exchange
SuperPath
ATR
RPA1
RPA2
ATRIP
RAD50
TOPBP1
HUS1
MRE11
NBN
ATM
RAD1
RAD9A
RAD17
RFC2
RFC3
RFC4
RFC5
RPA3
BLM
BRCA1
TOP3A
RMI1
BRIP1
KAT5
RMI2
RAD9B
DNA2
BARD1
RAD51
RBBP8
BRCA2
WRN
RHNO1
EXO1
SEM1
RAD51C
RAD51B
RAD51D
XRCC2
PALB2
RAD51AP1
CHEK1
NEIL1
XRCC3
ERCC1
ERCC4
MUTYH
NTHL1
OGG1
NEIL3
EME1
EME2
SLX1A
RPS27A
UBA52
UBB
UBC
SLX1B
MUS81
SLX4
FANCD2
USP1
WDR48
FANCF
UBE2T
FANCG
FANCA
FANCC
FAAP100
FANCM
CENPS-CORT
CENPS
FANCB
FAAP24
FANCE
FANCI
FANCL
FAN1
ABL1
RAD52
MSH6
MLH1
MSH2
MSH3
PMS2
POLD3
SPIDR
GEN1
PCNA
POLK
RTEL1
POLE3
POLD1
POLD2
POLE
POLE2
POLH
POLE4
POLD4
RFC1
HES1
BHLHE40
H2AX
FAAP20
CENPX
POLN
DCLRE1B
DCLRE1A
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Homologous DNA Pairing and Strand Exchange
SuperPath