Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

No Pathway Network information available for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Pathways in the Hypoxic and oxygen homeostasis regulation of HIF-1-alpha SuperPath

#	Name	Source	Genes
1	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	PubChem	ARNT CDKN2A COPS5 CUL2 EGLN2 ELOB ELOC HIF1A HIF1AN HIF3A HSP90AA1 NAA10 OS9 RACK1 RBX1 TP53 VHL (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NAA10	N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit	Protein Coding	1
2	OS9	OS9 Endoplasmic Reticulum Lectin	Protein Coding	1
3	HIF1AN	Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor	Protein Coding	1
4	EGLN2	Egl-9 Family Hypoxia Inducible Factor 2	Protein Coding	1
5	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
6	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
7	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
8	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
9	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
10	HIF3A	Hypoxia Inducible Factor 3 Subunit Alpha	Protein Coding	1
11	ELOB	Elongin B	Protein Coding	1
12	ELOC	Elongin C	Protein Coding	1
13	CUL2	Cullin 2	Protein Coding	1
14	RBX1	Ring-Box 1	Protein Coding	1
15	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
16	COPS5	COP9 Signalosome Subunit 5	Protein Coding	1
17	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with Hypoxic and oxygen homeostasis regulation of HIF-1-alpha SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	4.66
2	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	4.66
3	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A, VHL	4.51
4	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	4.51
5	Lip and oral cavity carcinoma	Enrichment	CDKN2A, TP53	4.01
6	Pancreatic cancer	Enrichment	CDKN2A, TP53	3.36
7	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, TP53, VHL	3.26
8	Bladder cancer	Enrichment	CDKN2A, TP53	3.23
9	Bone marrow failure syndrome 5	Enrichment	TP53	2.90
10	Papilloma of choroid plexus	Enrichment	TP53	2.90
11	Basal cell carcinoma 7	Enrichment	TP53	2.90
12	Anaplastic thyroid carcinoma	Enrichment	TP53	2.90
13	Ductal carcinoma in situ	Enrichment	TP53	2.90
14	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.90
15	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.90
16	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.90
17	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.90
18	Choroid plexus cancer	Enrichment	TP53	2.90
19	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.90
20	Retinal hemangioblastoma	Enrichment	VHL	2.90
21	Gastric cancer	Enrichment	CDKN2A, TP53	2.89
22	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.60
23	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.60
24	Ogden syndrome	Enrichment	NAA10	2.60
25	Microphthalmia, syndromic 1	Enrichment	NAA10	2.60
26	Cervical cancer	Enrichment	TP53	2.60
27	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.60
28	Lymphoma, hodgkin, classic	Enrichment	TP53	2.60
29	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.60
30	Congenital fibrosarcoma	Enrichment	TP53	2.60
31	Li-fraumeni syndrome 1	Enrichment	TP53	2.60
32	Sarcoma	Enrichment	TP53	2.60
33	Cervix carcinoma	Enrichment	TP53	2.60
34	Hodgkin's lymphoma	Enrichment	TP53	2.60
35	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.60
36	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.60
37	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	2.43
38	Osteogenic sarcoma	Enrichment	TP53	2.43
39	Nasopharyngeal carcinoma	Enrichment	TP53	2.43
40	Primary polycythemia	Enrichment	VHL	2.43
41	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.43
42	Anaplastic astrocytoma	Enrichment	TP53	2.43
43	Squamous cell carcinoma	Enrichment	TP53	2.43
44	Adenocarcinoma	Enrichment	TP53	2.43
45	Bone osteosarcoma	Enrichment	TP53	2.43
46	Enchondromatosis	Enrichment	HIF1A	2.43
47	Small cell cancer of the lung	Enrichment	TP53	2.30
48	Erythrocytosis, familial, 2	Enrichment	VHL	2.30
49	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.30
50	Au-kline syndrome	Enrichment	VHL	2.30
51	Lung sarcomatoid carcinoma	Enrichment	TP53	2.30
52	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.30
53	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.20
54	Fanconi anemia, complementation group d2	Enrichment	VHL	2.20
55	Von hippel-lindau syndrome	Enrichment	VHL	2.20
56	Rhabdomyosarcoma 2	Enrichment	TP53	2.20
57	Lymphoma	Enrichment	TP53	2.20
58	Acute megakaryocytic leukemia	Enrichment	TP53	2.20
59	Ovarian cancer	Enrichment	CDKN2A, TP53	2.16
60	Breast adenocarcinoma	Enrichment	TP53	2.13
61	Lung squamous cell carcinoma	Enrichment	CDKN2A	2.13
62	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	VHL	2.13
63	Esophageal cancer	Enrichment	TP53	2.06
64	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.06
65	Renal cell carcinoma, papillary, 1	Enrichment	VHL	2.06
66	Essential thrombocythemia	Enrichment	TP53	2.06
67	Gallbladder cancer	Enrichment	TP53	2.06
68	Glioma susceptibility 1	Enrichment	TP53	2.00
69	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.00
70	Adult hepatocellular carcinoma	Enrichment	TP53	1.95
71	Primary hyperaldosteronism	Enrichment	TP53	1.95
72	Leukemia, chronic lymphocytic	Enrichment	TP53	1.90
73	Melanoma	Enrichment	CDKN2A	1.90
74	Familial colorectal cancer	Enrichment	TP53	1.90
75	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.86
76	Myelodysplastic syndrome	Enrichment	TP53	1.86
77	Pheochromocytoma	Enrichment	VHL	1.76
78	Lung cancer susceptibility 3	Enrichment	TP53	1.76
79	Renal cell carcinoma, nonpapillary	Enrichment	VHL	1.73
80	Rhabdomyosarcoma	Enrichment	TP53	1.70
81	Gliosarcoma	Enrichment	TP53	1.70
82	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.68
83	Giant cell glioblastoma	Enrichment	TP53	1.68
84	Diffuse large b-cell lymphoma	Enrichment	TP53	1.63
85	Hepatoblastoma	Enrichment	TP53	1.58
86	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.58
87	Hepatocellular carcinoma	Enrichment	TP53	1.56
88	Diamond-blackfan anemia 1	Enrichment	TP53	1.55
89	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	1.55
90	Prostate cancer	Enrichment	TP53	1.45
91	Fanconi anemia, complementation group a	Enrichment	VHL	1.37
92	Diamond-blackfan anemia	Enrichment	TP53	1.35
93	Leukemia, acute myeloid	Enrichment	TP53	1.31
94	Hereditary breast carcinoma	Enrichment	TP53	1.27
95	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.18
96	Myeloma, multiple	Enrichment	TP53	1.17
97	Breast cancer	Enrichment	TP53	1.05
98	Colorectal cancer	Enrichment	TP53	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Pathway Network for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Member Pathways for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Pathways in the Hypoxic and oxygen homeostasis regulation of HIF-1-alpha SuperPath

Associated Genes for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Associated Disorders for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Disorders associated with Hypoxic and oxygen homeostasis regulation of HIF-1-alpha SuperPath

STRING Interaction Network for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Sources for Hypoxic and oxygen homeostasis regulation of HIF-1-alpha