Inositol phosphate metabolism

Pathway network for the Inositol phosphate metabolism SuperPath

Sources:

Reactome
PubChem

Pathways in the Inositol phosphate metabolism SuperPath

#	Name	Source	Genes
1	Inositol phosphate metabolism	Reactome	CALM1 CALM2 CALM3 IMPA1 IMPA2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5D INPP5J INPPL1 ISYNA1 ITPK1 ITPKA ITPKB ITPKC MINPP1 MIOX MTMR7 MTMR9 OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PTEN SYNJ1 (see all 39) (see less)
2	Synthesis of IP3 and IP4 in the cytosol	Reactome	CALM1 CALM2 CALM3 INPP5B INPP5D INPP5J INPPL1 ITPK1 ITPKA ITPKB ITPKC OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PTEN SYNJ1 (see all 28) (see less)
3	Synthesis of IP2, IP, and Ins in the cytosol	Reactome	IMPA1 IMPA2 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5J ISYNA1 MIOX MTMR7 MTMR9 OCRL SYNJ1 (see all 14) (see less)
4	myo-inositol de novo biosynthesis	PubChem	IMPA1 IMPA2 ISYNA1

Gene overlap in member pathways for Inositol phosphate metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	INPP5J	Inositol Polyphosphate-5-Phosphatase J	Protein Coding	3
2	IMPA1	Inositol Monophosphatase 1	Protein Coding	3
3	IMPA2	Inositol Monophosphatase 2	Protein Coding	3
4	INPP5B	Inositol Polyphosphate-5-Phosphatase B	Protein Coding	3
5	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	3
6	ISYNA1	Inositol-3-Phosphate Synthase 1	Protein Coding	3
7	SYNJ1	Synaptojanin 1	Protein Coding	3
8	PLCD3	Phospholipase C Delta 3	Protein Coding	2
9	PLD4	Phospholipase D Family Member 4	Protein Coding	2
10	PLCH1	Phospholipase C Eta 1	Protein Coding	2
11	PLCB1	Phospholipase C Beta 1	Protein Coding	2
12	INPP1	Inositol Polyphosphate-1-Phosphatase	Protein Coding	2
13	INPP4A	Inositol Polyphosphate-4-Phosphatase Type I A	Protein Coding	2
14	INPP5A	Inositol Polyphosphate-5-Phosphatase A	Protein Coding	2
15	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	2
16	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	2
17	ITPK1	Inositol-Tetrakisphosphate 1-Kinase	Protein Coding	2
18	ITPKA	Inositol-Trisphosphate 3-Kinase A	Protein Coding	2
19	ITPKB	Inositol-Trisphosphate 3-Kinase B	Protein Coding	2
20	PLCE1	Phospholipase C Epsilon 1	Protein Coding	2
21	PLCB2	Phospholipase C Beta 2	Protein Coding	2
22	PLCB3	Phospholipase C Beta 3	Protein Coding	2
23	PLCB4	Phospholipase C Beta 4	Protein Coding	2
24	PLCD1	Phospholipase C Delta 1	Protein Coding	2
25	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
26	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
27	MIOX	Myo-Inositol Oxygenase	Protein Coding	2
28	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
29	MTMR9	Myotubularin Related Protein 9	Protein Coding	2
30	CALM1	Calmodulin 1	Protein Coding	2
31	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	2
32	CALM2	Calmodulin 2	Protein Coding	2
33	CALM3	Calmodulin 3	Protein Coding	2
34	PLCD4	Phospholipase C Delta 4	Protein Coding	2
35	INPP4B	Inositol Polyphosphate-4-Phosphatase Type II B	Protein Coding	2
36	PLCZ1	Phospholipase C Zeta 1	Protein Coding	2
37	MTMR7	Myotubularin Related Protein 7	Protein Coding	2
38	PLCH2	Phospholipase C Eta 2	Protein Coding	2
39	MINPP1	Multiple Inositol-Polyphosphate Phosphatase 1	Protein Coding	1

Disorders associated with Inositol phosphate metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.36
2	Dent disease 2	Enrichment	INPP5B, OCRL	6.00
3	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.51
4	Thyroid cancer, nonmedullary, 2	Enrichment	MINPP1, PTEN	3.78
5	Follicular thyroid carcinoma	Enrichment	MINPP1, PTEN	3.78
6	Intellectual developmental disorder, autosomal recessive 59	Enrichment	IMPA1	3.66
7	Developmental and epileptic encephalopathy 53	Enrichment	SYNJ1	2.99
8	Neurodevelopmental disorder with growth impairment, quadriparesis, and poor or absent speech	Enrichment	INPP4A	2.99
9	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	2.99
10	Long qt syndrome	Enrichment	CALM1, CALM2	2.73
11	Parkinson disease 20, early-onset	Enrichment	SYNJ1	2.69
12	Vacterl association with hydrocephalus	Enrichment	PTEN	2.69
13	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.69
14	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.69
15	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.69
16	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.69
17	Papillary tumor of the pineal region	Enrichment	PTEN	2.69
18	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.69
19	Long qt syndrome 16	Enrichment	CALM3	2.69
20	Glioma susceptibility 2	Enrichment	PTEN	2.69
21	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.69
22	Holoprosencephaly 14	Enrichment	PLCH1	2.69
23	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.69
24	Long qt syndrome 15	Enrichment	CALM2	2.69
25	Systemic lupus erythematosus 18	Enrichment	PLD4	2.69
26	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.69
27	Dent disease	Enrichment	OCRL	2.51
28	Atypical juvenile parkinsonism	Enrichment	SYNJ1	2.51
29	West syndrome	Enrichment	PLCB1, SYNJ1	2.43
30	Schneckenbecken dysplasia	Enrichment	INPPL1	2.38
31	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.38
32	Spermatogenic failure 17	Enrichment	PLCZ1	2.38
33	Long qt syndrome 14	Enrichment	CALM1	2.38
34	Ocular melanoma	Enrichment	PLCB4	2.38
35	Vacterl with hydrocephalus	Enrichment	PTEN	2.38
36	Juvenile polyposis of infancy	Enrichment	PTEN	2.38
37	Pontocerebellar hypoplasia, type 7	Enrichment	MINPP1	2.24
38	Dyskeratosis congenita, autosomal dominant 1	Enrichment	INPP4A	2.21
39	Opsismodysplasia	Enrichment	INPPL1	2.21
40	Nephrotic syndrome, type 3	Enrichment	PLCE1	2.21
41	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.21
42	Dyskeratosis congenita, autosomal dominant 2	Enrichment	INPP4A	2.14
43	Auriculocondylar syndrome 1	Enrichment	PLCB4	2.08
44	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	2.08
45	Glioma	Enrichment	PTEN	2.08
46	Pontocerebellar hypoplasia, type 16	Enrichment	MINPP1	2.07
47	Familial papillary or follicular thyroid carcinoma	Enrichment	MINPP1	2.07
48	Macrocephaly/autism syndrome	Enrichment	PTEN	1.99
49	Hemangioma	Enrichment	PTEN	1.99
50	Acute megakaryocytic leukemia	Enrichment	PTEN	1.99
51	Hemimegalencephaly	Enrichment	PTEN	1.99
52	Pectus excavatum	Enrichment	INPP4A	1.95
53	Early-onset parkinson's disease	Enrichment	SYNJ1	1.91
54	Melanoma, uveal	Enrichment	PLCB4	1.91
55	Cowden syndrome 1	Enrichment	PTEN	1.91
56	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.91
57	Autosomal recessive non-syndromic intellectual disability	Enrichment	IMPA1	1.89
58	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.84
59	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.79
60	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.73
61	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.73
62	Cowden syndrome	Enrichment	PTEN	1.73
63	Melanoma	Enrichment	PTEN	1.69
64	Meningioma, familial	Enrichment	PTEN	1.65
65	Uterine corpus cancer	Enrichment	PTEN	1.65
66	Meningioma	Enrichment	PTEN	1.61
67	Developmental and epileptic encephalopathy 1	Enrichment	SYNJ1	1.59
68	Rhabdomyosarcoma	Enrichment	PTEN	1.49
69	Sudden infant death syndrome	Enrichment	CALM2	1.46
70	Alobar holoprosencephaly	Enrichment	PLCH1	1.46
71	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.41
72	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.39
73	Endometrial cancer	Enrichment	PTEN	1.37
74	Pontocerebellar hypoplasia	Enrichment	MINPP1	1.30
75	Undetermined early-onset epileptic encephalopathy	Enrichment	SYNJ1	1.25
76	Bladder cancer	Enrichment	PTEN	1.23
77	Prostate cancer	Enrichment	PTEN	1.23
78	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	1.17
79	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	1.09
80	Centralopathic epilepsy	Enrichment	PLCB1	1.07
81	Gastric cancer	Enrichment	PTEN	1.07
82	Nephrotic syndrome	Enrichment	PLCE1	1.07
83	Hereditary breast carcinoma	Enrichment	PTEN	1.06
84	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.97
85	Microcephaly	Enrichment	INPP4A	0.92
86	Breast cancer	Enrichment	PTEN	0.84
87	Ovarian cancer	Enrichment	PTEN	0.72
88	Congenital nervous system abnormality	Enrichment	PTEN	0.70
89	Nervous system disease	Enrichment	PTEN	0.70
90	Autism spectrum disorder	Enrichment	PTEN	0.69
91	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Inositol phosphate metabolism

Pathway Network for Inositol phosphate metabolism

Pathway network for the Inositol phosphate metabolism SuperPath

Member Pathways for Inositol phosphate metabolism

Pathways in the Inositol phosphate metabolism SuperPath

Gene overlap in member pathways for Inositol phosphate metabolism SuperPath

Associated Genes for Inositol phosphate metabolism

Associated Disorders for Inositol phosphate metabolism

Disorders associated with Inositol phosphate metabolism SuperPath

STRING Interaction Network for Inositol phosphate metabolism

Sources for Inositol phosphate metabolism