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Intrinsic Pathway for Apoptosis
SuperPath
Pathway network
for
Intrinsic Pathway for Apoptosis
SuperPath
14
Pathways
in the
Intrinsic Pathway for Apoptosis
SuperPath
Intrinsic Pathway for Apoptosis
Activation, myristolyation of BID and translocation to mitochondria
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Apoptotic factor-mediated response
Activation of PUMA and translocation to mitochondria
Activation of BMF and translocation to mitochondria
Cytochrome c-mediated apoptotic response
Activation of NOXA and translocation to mitochondria
Activation of BAD and translocation to mitochondria
Release of apoptotic factors from the mitochondria
Activation of BH3-only proteins
Activation of BIM and translocation to mitochondria
SMAC, XIAP-regulated apoptotic response
55
Genes
in the
Intrinsic Pathway for Apoptosis
SuperPath
CYCS
DIABLO
BID
BCL2L11
E2F1
BBC3
APAF1
XIAP
PMAIP1
SEPTIN4
MAPK8
BAD
BCL2
TFDP1
TFDP2
TP53
CASP3
CASP7
CASP9
BMF
AKT3
CDKN2A
YWHAQ
DYNLL2
GSDME
AKT1
AKT2
CARD8
PPP1R13B
SFN
APIP
UACA
PPP3CC
PPP3R1
MAPK1
MAPK3
AVEN
BAK1
BAX
C1QBP
TP53BP2
TP73
YWHAB
YWHAE
YWHAG
YWHAH
YWHAZ
GSDMD
TP63
DYNLL1
GZMB
NMT1
BCL2L1
STAT3
CASP8
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Intrinsic Pathway for Apoptosis
SuperPath