Melanin biosynthesis

No Pathway Network information available for Melanin biosynthesis

#	Name	Source	Genes
1	Melanin biosynthesis	Reactome	DCT OCA2 SLC45A2 TYR TYRP1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DCT	Dopachrome Tautomerase	Protein Coding	1
2	OCA2	OCA2 Melanosomal Transmembrane Protein	Protein Coding	1
3	SLC45A2	Solute Carrier Family 45 Member 2	Protein Coding	1
4	TYR	Tyrosinase	Protein Coding	1
5	TYRP1	Tyrosinase Related Protein 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oculocutaneous albinism	Enrichment	OCA2, SLC45A2, TYR, TYRP1	10.55
2	Albinism	Enrichment	DCT, OCA2, TYR, TYRP1	10.47
3	Albinism, oculocutaneous, type ii	Enrichment	OCA2, TYRP1	5.96
4	Albinism, ocular, type i	Enrichment	TYR, TYRP1	5.79
5	Albinism, oculocutaneous, type iv	Enrichment	SLC45A2	3.43
6	Albinism, oculocutaneous, type ib	Enrichment	TYR	3.43
7	Skin/hair/eye pigmentation, variation in, 5	Enrichment	SLC45A2	3.43
8	Skin/hair/eye pigmentation, variation in, 3	Enrichment	TYR	3.43
9	Skin melanoma	Enrichment	SLC45A2	3.43
10	Minimal pigment oculocutaneous albinism type 1	Enrichment	TYR	3.43
11	Hypopigmentation of the skin	Enrichment	TYR	3.43
12	Albinism, oculocutaneous, type iii	Enrichment	TYRP1	3.13
13	Skin/hair/eye pigmentation, variation in, 1	Enrichment	OCA2	3.13
14	Albinism, oculocutaneous, type ia	Enrichment	TYR	3.13
15	Skin/hair/eye pigmentation, variation in, 11	Enrichment	TYRP1	3.13
16	Oculocutaneous albinism, type viii	Enrichment	DCT	3.13
17	Melanoma, cutaneous malignant 8	Enrichment	TYR	3.13
18	Hypophosphatasia	Enrichment	OCA2	3.13
19	Angelman syndrome due to maternal 15q11q13 deletion	Enrichment	OCA2	3.13
20	Hypophosphatasia, infantile	Enrichment	OCA2	2.96
21	Schaaf-yang syndrome	Enrichment	OCA2	2.83
22	Prader-willi syndrome	Enrichment	OCA2	2.59
23	Waardenburg syndrome, type 2e	Enrichment	TYR	2.59
24	Optic nerve disease	Enrichment	TYR	2.43
25	Myopia	Enrichment	TYR	2.26
26	Skin disease	Enrichment	TYR	2.09
27	Strabismus	Enrichment	TYR	2.00
28	Eye disease	Enrichment	TYR	1.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Melanin biosynthesis