Mesodermal commitment pathway

No Pathway Network information available for Mesodermal commitment pathway

Pathways in the Mesodermal commitment pathway SuperPath

#	Name	Source	Genes
1	Mesodermal commitment pathway	WikiPathways	ACACA ACVR1 ACVR2A ACVR2B ADAM19 AEBP2 AHDC1 AMH ARID5B ARL4A ASCC3 ATP8B2 AXIN1 AXIN2 BCORL1 BHLHE40 BMP4 BMP7 BMPR1A BMPR2 C1QBP C9orf72 CCDC6 CCDC88A CCND1 CEP250 CHRD CRTC1 CSRP2 CTBP2 CUL4B DDAH1 DIP2A DKK1 DLL1 DNMT3B ELK4 ELP4 EMSY EOMES EPB41L5 EXT1 EXT2 FGF8 FGFR1 FOXA1 FOXA2 FOXC1 FOXC2 FOXH1 FZD4 FZD5 FZD8 GATA3 GATA6 GDF3 GRHL2 HAND1 HES7 HMGA2 HNF4A HPRT1 HTT INHBA JAK2 JARID2 KDM6A KLF4 KLF5 LATS1 LEF1 LEFTY1 LEFTY2 MACF1 MBTD1 MEIS1 MIR302C MIXL1 MSGN1 MTF2 NABP2 NANOG NCAPG2 NFE2L2 NLK NODAL NOG PARP8 PAX6 PBX1 PBX3 PHF6 PIAS1 PITX2 PLCH1 POU5F1 PPP2CA PRKACA PRKAR1A RARB RARG RGS10 RPL38 SCHIP1 SESN1 SETD2 SLC2A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SNAI1 SOX17 SOX2 SOX21 SRF TBX1 TBX3 TBX6 TCF4 TCF7L1 TEAD1 TEAD2 TET1 TEX56P TOX TOX3 TRERF1 TRIM28 TRIM5 TRIM71 TWSG1 UBR5 VAV3 WDCP WDFY2 WDHD1 WNT3 WNT3A YAP1 ZFHX4 ZIC2 ZIC3 ZIC5 ZNF281 ZNF462 (see all 147) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PARP8	Poly(ADP-Ribose) Polymerase Family Member 8	Protein Coding	1
2	PLCH1	Phospholipase C Eta 1	Protein Coding	1
3	SLC2A12	Solute Carrier Family 2 Member 12	Protein Coding	1
4	GDF3	Growth Differentiation Factor 3	Protein Coding	1
5	HAND1	Heart And Neural Crest Derivatives Expressed 1	Protein Coding	1
6	KLF4	KLF Transcription Factor 4	Protein Coding	1
7	ACVR2B	Activin A Receptor Type 2B	Protein Coding	1
8	NOG	Noggin	Protein Coding	1
9	ACVR2A	Activin A Receptor Type 2A	Protein Coding	1
10	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	1
11	ACVR1	Activin A Receptor Type 1	Protein Coding	1
12	WNT3A	Wnt Family Member 3A	Protein Coding	1
13	FOXH1	Forkhead Box H1	Protein Coding	1
14	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
15	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
16	ZIC5	Zic Family Zinc Finger 5	Protein Coding	1
17	TRIM5	Tripartite Motif Containing 5	Protein Coding	1
18	HES7	Hes Family BHLH Transcription Factor 7	Protein Coding	1
19	TEAD2	TEA Domain Transcription Factor 2	Protein Coding	1
20	CUL4B	Cullin 4B	Protein Coding	1
21	PHF6	PHD Finger Protein 6	Protein Coding	1
22	ARID5B	AT-Rich Interaction Domain 5B	Protein Coding	1
23	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
24	FZD8	Frizzled Class Receptor 8	Protein Coding	1
25	FZD4	Frizzled Class Receptor 4	Protein Coding	1
26	EOMES	Eomesodermin	Protein Coding	1
27	AXIN2	Axin 2	Protein Coding	1
28	AXIN1	Axin 1	Protein Coding	1
29	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	1
30	TET1	Tet Methylcytosine Dioxygenase 1	Protein Coding	1
31	CCDC6	Coiled-Coil Domain Containing 6	Protein Coding	1
32	GRHL2	Grainyhead Like Transcription Factor 2	Protein Coding	1
33	NANOG	Nanog Homeobox	Protein Coding	1
34	ZIC3	Zic Family Zinc Finger 3	Protein Coding	1
35	ZIC2	Zic Family Zinc Finger 2	Protein Coding	1
36	WNT3	Wnt Family Member 3	Protein Coding	1
37	KDM6A	Lysine Demethylase 6A	Protein Coding	1
38	C1QBP	Complement C1q Binding Protein	Protein Coding	1
39	LEFTY2	Left-Right Determination Factor 2	Protein Coding	1
40	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	1
41	TBX3	T-Box Transcription Factor 3	Protein Coding	1
42	TCF4	Transcription Factor 4	Protein Coding	1
43	TBX6	T-Box Transcription Factor 6	Protein Coding	1
44	TBX1	T-Box Transcription Factor 1	Protein Coding	1
45	KLF5	KLF Transcription Factor 5	Protein Coding	1
46	SRF	Serum Response Factor	Protein Coding	1
47	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
48	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
49	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	1
50	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	1
51	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
52	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
53	SOX17	SRY-Box Transcription Factor 17	Protein Coding	1
54	BCORL1	BCL6 Corepressor Like 1	Protein Coding	1
55	RGS10	Regulator Of G Protein Signaling 10	Protein Coding	1
56	CCND1	Cyclin D1	Protein Coding	1
57	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
58	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
59	ZNF462	Zinc Finger Protein 462	Protein Coding	1
60	TWSG1	Twisted Gastrulation BMP Signaling Modulator 1	Protein Coding	1
61	EMSY	EMSY Transcriptional Repressor, BRCA2 Interacting	Protein Coding	1
62	TRERF1	Transcriptional Regulating Factor 1	Protein Coding	1
63	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
64	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
65	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
66	NCAPG2	Non-SMC Condensin II Complex Subunit G2	Protein Coding	1
67	POU5F1	POU Class 5 Homeobox 1	Protein Coding	1
68	PITX2	Paired Like Homeodomain 2	Protein Coding	1
69	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
70	PBX1	PBX Homeobox 1	Protein Coding	1
71	PAX6	Paired Box 6	Protein Coding	1
72	NODAL	Nodal Growth Differentiation Factor	Protein Coding	1
73	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
74	MIR302C	MicroRNA 302c	RNA Gene	1
75	MEIS1	Meis Homeobox 1	Protein Coding	1
76	SMAD6	SMAD Family Member 6	Protein Coding	1
77	SMAD4	SMAD Family Member 4	Protein Coding	1
78	SMAD3	SMAD Family Member 3	Protein Coding	1
79	SMAD2	SMAD Family Member 2	Protein Coding	1
80	SMAD1	SMAD Family Member 1	Protein Coding	1
81	JARID2	Jumonji And AT-Rich Interaction Domain Containing 2	Protein Coding	1
82	JAK2	Janus Kinase 2	Protein Coding	1
83	INHBA	Inhibin Subunit Beta A	Protein Coding	1
84	MSGN1	Mesogenin 1	Protein Coding	1
85	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	1
86	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
87	FOXA2	Forkhead Box A2	Protein Coding	1
88	FOXA1	Forkhead Box A1	Protein Coding	1
89	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	1
90	HTT	Huntingtin	Protein Coding	1
91	SETD2	SET Domain Containing 2, Histone Lysine Methyltransferase	Protein Coding	1
92	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
93	TOX3	TOX High Mobility Group Box Family Member 3	Protein Coding	1
94	AHDC1	AT-Hook DNA Binding Motif Containing 1	Protein Coding	1
95	AMH	Anti-Mullerian Hormone	Protein Coding	1
96	ELP4	Elongator Acetyltransferase Complex Subunit 4	Protein Coding	1
97	GATA6	GATA Binding Protein 6	Protein Coding	1
98	GATA3	GATA Binding Protein 3	Protein Coding	1
99	DDAH1	Dimethylarginine Dimethylaminohydrolase 1	Protein Coding	1
100	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	1
101	DIP2A	Disco Interacting Protein 2 Homolog A	Protein Coding	1
102	FOXC2	Forkhead Box C2	Protein Coding	1
103	FOXC1	Forkhead Box C1	Protein Coding	1
104	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
105	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
106	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
107	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	1
108	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	1
109	C9orf72	C9orf72-SMCR8 Complex Subunit	Protein Coding	1
110	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	1
111	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
112	CSRP2	Cysteine And Glycine Rich Protein 2	Protein Coding	1
113	ASCC3	Activating Signal Cointegrator 1 Complex Subunit 3	Protein Coding	1
114	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
115	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
116	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
117	TOX	Thymocyte Selection Associated High Mobility Group Box	Protein Coding	1
118	ADAM19	ADAM Metallopeptidase Domain 19	Protein Coding	1
119	CHRD	Chordin	Protein Coding	1
120	MIXL1	Mix Paired-Like Homeobox	Protein Coding	1
121	TRIM71	Tripartite Motif Containing 71	Protein Coding	1
122	AEBP2	AE Binding Protein 2	Protein Coding	1
123	WDFY2	WD Repeat And FYVE Domain Containing 2	Protein Coding	1
124	CEP250	Centrosomal Protein 250	Protein Coding	1
125	WDHD1	WD Repeat And HMG-Box DNA Binding Protein 1	Protein Coding	1
126	SOX21	SRY-Box Transcription Factor 21	Protein Coding	1
127	LEFTY1	Left-Right Determination Factor 1	Protein Coding	1
128	ARL4A	ARF Like GTPase 4A	Protein Coding	1
129	WDCP	WD Repeat And Coiled Coil Containing	Protein Coding	1
130	ZFHX4	Zinc Finger Homeobox 4	Protein Coding	1
131	NABP2	Nucleic Acid Binding Protein 2	Protein Coding	1
132	FZD5	Frizzled Class Receptor 5	Protein Coding	1
133	RPL38	Ribosomal Protein L38	Protein Coding	1
134	EPB41L5	Erythrocyte Membrane Protein Band 4.1 Like 5	Protein Coding	1
135	ATP8B2	ATPase Phospholipid Transporting 8B2	Protein Coding	1
136	CCDC88A	Coiled-Coil And HOOK Domain Protein 88A	Protein Coding	1
137	MBTD1	Mbt Domain Containing 1	Protein Coding	1
138	NLK	Nemo Like Kinase	Protein Coding	1
139	UBR5	Ubiquitin Protein Ligase E3 Component N-Recognin 5	Protein Coding	1
140	PBX3	PBX Homeobox 3	Protein Coding	1
141	TEX56P	Testis Expressed 56, Pseudogene	Pseudogene	1
142	SCHIP1	Schwannomin Interacting Protein 1	Protein Coding	1
143	SESN1	Sestrin 1	Protein Coding	1
144	ZNF281	Zinc Finger Protein 281	Protein Coding	1
145	MACF1	Microtubule Actin Crosslinking Factor 1	Protein Coding	1
146	MTF2	Metal Response Element Binding Transcription Factor 2	Protein Coding	1
147	ELK4	ETS Transcription Factor ELK4	Protein Coding	1

Disorders associated with Mesodermal commitment pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Microform holoprosencephaly	Enrichment	DLL1, FGF8, FGFR1, FOXH1, NODAL, ZIC2	7.97
2	Lobar holoprosencephaly	Enrichment	DLL1, FGF8, FGFR1, FOXH1, NODAL, ZIC2	7.97
3	Alobar holoprosencephaly	Enrichment	DLL1, FGF8, FOXH1, NODAL, PLCH1, ZIC2	7.79
4	Semilobar holoprosencephaly	Enrichment	DLL1, FGF8, FGFR1, FOXH1, NODAL, ZIC2	7.61
5	Peters-plus syndrome	Enrichment	BMP4, ELP4, FOXC1, PAX6, PITX2	7.47
6	Microphthalmia/coloboma 12	Enrichment	ELP4, FZD5, PAX6, RARB, YAP1	6.78
7	Coloboma of macula	Enrichment	ELP4, FZD5, PAX6, RARB, YAP1	6.42
8	Septopreoptic holoprosencephaly	Enrichment	DLL1, FGF8, FOXH1, NODAL, ZIC2	6.42
9	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1, FGF8, FOXH1, NODAL, ZIC2	6.42
10	Holoprosencephaly	Enrichment	FGF8, FGFR1, ZIC2	4.91
11	Coloboma of optic nerve	Enrichment	ELP4, FZD5, PAX6	4.61
12	Holoprosencephaly 1	Enrichment	FGF8, FGFR1, ZIC2	4.61
13	Anterior segment dysgenesis 5	Enrichment	BMP4, ELP4, PAX6	4.61
14	Visceral heterotaxy	Enrichment	ACVR2B, LEFTY2, NODAL, ZIC3	4.08
15	Keratitis, hereditary	Enrichment	ELP4, PAX6	3.93
16	Exostoses, multiple, type i	Enrichment	EXT1, EXT2	3.93
17	Foveal hypoplasia 1	Enrichment	ELP4, PAX6	3.93
18	Axenfeld-rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities	Enrichment	FOXC1, PITX2	3.93
19	Optic nerve hypoplasia, bilateral	Enrichment	ELP4, PAX6	3.93
20	Fibrodysplasia ossificans progressiva	Enrichment	ACVR1, BMPR2	3.93
21	Axenfeld-rieger syndrome	Enrichment	FOXC1, PITX2	3.93
22	Juvenile polyposis syndrome	Enrichment	BMPR1A, SMAD4	3.46
23	Osteoporosis, juvenile	Enrichment	DKK1, WNT3A	3.46
24	Anterior segment dysgenesis	Enrichment	FOXC1, PAX6, PITX2	3.29
25	Aniridia 1	Enrichment	ELP4, PAX6	3.16
26	Eyelid coloboma	Enrichment	FZD5, PAX6	3.16
27	Lens coloboma	Enrichment	FZD5, PAX6	3.16
28	Congenital heart defects, multiple types, 4	Enrichment	BMP7, GATA6	2.94
29	Aniridia	Enrichment	FOXC1, PAX6	2.94
30	Coloboma of choroid and retina	Enrichment	FZD5, PAX6	2.94
31	Persistent truncus arteriosus	Enrichment	GATA6, TBX1	2.94
32	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A, SMAD4	2.94
33	Macs syndrome	Enrichment	GDF3, PAX6, SOX2	2.91
34	Microphthalmia	Enrichment	PAX6, RARB, SOX2	2.78
35	Conotruncal heart malformations	Enrichment	GATA6, TBX1	2.77
36	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	ELP4, PAX6	2.77
37	Spondylocostal dysostosis, autosomal recessive	Enrichment	HES7, TBX6	2.77
38	Spastic paraplegia 4, autosomal dominant	Enrichment	PHF6, TCF4	2.50
39	Myeloma, multiple	Enrichment	BCORL1, CCND1, LATS1, YAP1	2.50
40	Tooth agenesis, selective, 1	Enrichment	AXIN2, BMPR2	2.40
41	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	2.40
42	Cat eye syndrome	Enrichment	FZD5, PAX6	2.30
43	Heritable pulmonary arterial hypertension	Enrichment	BMPR2, SOX17	2.22
44	Autism spectrum disorder	Enrichment	DIP2A, KDM6A, PBX1, SETD2, TCF4	2.18
45	Epicanthus	Enrichment	ACVR1, TCF4	2.14
46	Septooptic dysplasia	Enrichment	FGFR1, SOX2	2.14
47	Pulmonary hypertension, primary, 1	Enrichment	BMPR2, SOX17	2.08
48	Stereotypic movement disorder	Enrichment	JARID2, TCF4	2.08
49	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3, SMAD6	2.01
50	Chiari malformation type i	Enrichment	DKK1	1.97
51	Osteoglophonic dysplasia	Enrichment	FGFR1	1.97
52	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	1.97
53	Chondrosarcoma	Enrichment	EXT1	1.97
54	Trigonocephaly 1	Enrichment	FGFR1	1.97
55	Velocardiofacial syndrome	Enrichment	TBX1	1.97
56	Axenfeld-rieger syndrome, type 1	Enrichment	PITX2	1.97
57	Stapes ankylosis with broad thumbs and toes	Enrichment	NOG	1.97
58	Tarsal-carpal coalition syndrome	Enrichment	NOG	1.97
59	Hypertelorism and tetralogy of fallot	Enrichment	FOXC1	1.97
60	Borjeson-forssman-lehmann syndrome	Enrichment	PHF6	1.97
61	Shukla-vernon syndrome	Enrichment	BCORL1	1.97
62	Kabuki syndrome 2	Enrichment	KDM6A	1.97
63	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	1.97
64	Heterotaxy, visceral, 1, x-linked	Enrichment	ZIC3	1.97
65	Carney complex, type 1	Enrichment	PRKAR1A	1.97
66	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	1.97
67	Brachydactyly, type b2	Enrichment	NOG	1.97
68	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	1.97
69	Anterior segment dysgenesis 4	Enrichment	PITX2	1.97
70	Ectodermal dysplasia/short stature syndrome	Enrichment	GRHL2	1.97
71	Symphalangism, proximal, 1a	Enrichment	NOG	1.97
72	Ring dermoid of cornea	Enrichment	PITX2	1.97
73	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	1.97
74	Caudal duplication anomaly	Enrichment	AXIN1	1.97
75	Multiple synostoses syndrome 1	Enrichment	NOG	1.97
76	Vesicoureteral reflux 3	Enrichment	SOX17	1.97
77	Aniridia 2	Enrichment	ELP4	1.97
78	Microphthalmia, isolated 7	Enrichment	GDF3	1.97
79	Radioulnar synostosis, nonsyndromic	Enrichment	SMAD6	1.97
80	Atrioventricular septal defect 5	Enrichment	GATA6	1.97
81	Khan-khan-katsanis syndrome	Enrichment	NCAPG2	1.97
82	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	1.97
83	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	1.97
84	Intellectual developmental disorder, autosomal dominant 70	Enrichment	SETD2	1.97
85	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Enrichment	PBX1	1.97
86	Silver-russell syndrome 5	Enrichment	HMGA2	1.97
87	Heterotaxy, visceral, 5, autosomal	Enrichment	NODAL	1.97
88	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	1.97
89	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	1.97
90	Microphthalmia, syndromic 6	Enrichment	BMP4	1.97
91	Orofacial cleft 11	Enrichment	BMP4	1.97
92	Myxoma, intracardiac	Enrichment	PRKAR1A	1.97
93	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	1.97
94	Developmental delay with variable intellectual disability and dysmorphic facies	Enrichment	JARID2	1.97
95	Ovary adenocarcinoma	Enrichment	INHBA	1.97
96	Xia-gibbs syndrome	Enrichment	AHDC1	1.97
97	Stature quantitative trait locus 9	Enrichment	HMGA2	1.97
98	Klippel-feil syndrome 3, autosomal dominant	Enrichment	GDF3	1.97
99	Microphthalmia, syndromic 12	Enrichment	RARB	1.97
100	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.97
101	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.97
102	Microphthalmia/coloboma 11	Enrichment	FZD5	1.97
103	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	1.97
104	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	1.97
105	Atrial septal defect 9	Enrichment	GATA6	1.97
106	Corneal dystrophy, posterior polymorphous, 4	Enrichment	GRHL2	1.97
107	Hartsfield syndrome	Enrichment	FGFR1	1.97
108	Hereditary multiple osteochondromas	Enrichment	EXT1	1.97
109	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.97
110	Lopes-maciel-rodan syndrome	Enrichment	HTT	1.97
111	Hydrocephalus, congenital, 4	Enrichment	TRIM71	1.97
112	Holoprosencephaly 14	Enrichment	PLCH1	1.97
113	Exostosis	Enrichment	EXT1	1.97
114	Peho-like syndrome	Enrichment	CCDC88A	1.97
115	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	1.97
116	Luscan-lumish syndrome	Enrichment	SETD2	1.97
117	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.97
118	Rabin-pappas syndrome	Enrichment	SETD2	1.97
119	Intellectual developmental disorder, autosomal recessive 81	Enrichment	ASCC3	1.97
120	Heritable thoracic aortic disease	Enrichment	SMAD4	1.97
121	Pulmonary hypertension, primary, 7	Enrichment	SOX17	1.97
122	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	1.97
123	Neurodevelopmental disorder with speech delay and behavioral abnormalities	Enrichment	UBR5	1.97
124	Huntington disease-like syndrome due to c9orf72 expansions	Enrichment	C9orf72	1.97
125	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	1.97
126	Primary pulmonary hypertension	Enrichment	BMPR2	1.97
127	Pulmonary hypertension	Enrichment	BMPR2	1.97
128	Wilms tumor 7	Enrichment	TRIM28	1.97
129	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	1.97
130	Oligoasthenoteratozoospermia	Enrichment	BCORL1	1.97
131	Hereditary multiple exostoses	Enrichment	EXT1	1.97
132	Juvenile huntington disease	Enrichment	HTT	1.97
133	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.97
134	Autosomal dominant spondylocostal dysostosis	Enrichment	TBX6	1.97
135	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	1.97
136	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4	1.92
137	Inherited cancer-predisposing syndrome	Enrichment	AXIN2, BMPR1A, EXT2, PRKAR1A, SMAD4	1.84
138	Colorectal cancer	Enrichment	AXIN2, CCND1, NFE2L2, SMAD4	1.83
139	Heart, malformation of	Enrichment	NODAL, SMAD6	1.80
140	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF8, FGFR1	1.80
141	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1, JARID2, TCF4	1.77
142	Craniosynostosis	Enrichment	SMAD6, ZNF462	1.71
143	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.67
144	Exostoses, multiple, type ii	Enrichment	EXT2	1.67
145	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.67
146	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	1.67
147	Maturity-onset diabetes of the young, type 1	Enrichment	HNF4A	1.67
148	Myhre syndrome	Enrichment	SMAD4	1.67
149	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.67
150	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	1.67
151	Ulnar-mammary syndrome	Enrichment	TBX3	1.67
152	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	1.67
153	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.67
154	Axenfeld-rieger syndrome, type 3	Enrichment	FOXC1	1.67
155	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	ZIC3	1.67
156	Intellectual developmental disorder, x-linked, syndromic, cabezas type	Enrichment	CUL4B	1.67
157	Tetraamelia syndrome 1	Enrichment	WNT3	1.67
158	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.67
159	Atrial fibrillation, familial, 1	Enrichment	PITX2	1.67
160	Deafness, autosomal dominant 28	Enrichment	GRHL2	1.67
161	Chromosome 22q11.2 duplication syndrome	Enrichment	TBX1	1.67
162	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.67
163	Holoprosencephaly 5	Enrichment	ZIC2	1.67
164	Lymphedema-distichiasis syndrome	Enrichment	FOXC2	1.67
165	Salivary gland adenoma, pleomorphic	Enrichment	HMGA2	1.67
166	Pfeiffer syndrome	Enrichment	FGFR1	1.67
167	Jackson-weiss syndrome	Enrichment	FGFR1	1.67
168	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	1.67
169	Spondylocostal dysostosis 4, autosomal recessive	Enrichment	HES7	1.67
170	Thrombocythemia 3	Enrichment	JAK2	1.67
171	Heterotaxy, visceral, 4, autosomal	Enrichment	ACVR2B	1.67
172	Cardiomyopathy, dilated, 1ff	Enrichment	KLF5	1.67
173	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.67
174	Abdominal obesity-metabolic syndrome 3	Enrichment	AHDC1	1.67
175	Cone-rod dystrophy and hearing loss 2	Enrichment	CEP250	1.67
176	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	1.67
177	Anterior segment dysgenesis 3	Enrichment	FOXC1	1.67
178	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	1.67
179	Lissencephaly 9 with complex brainstem malformation	Enrichment	MACF1	1.67
180	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	1.67
181	Usher syndrome, type iv	Enrichment	PRKAR1A	1.67
182	Pettigrew syndrome	Enrichment	CUL4B	1.67
183	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	1.67
184	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	1.67
185	Split hand-foot malformation	Enrichment	LEF1	1.67
186	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	1.67
187	Seizures, scoliosis, and macrocephaly/microcephaly syndrome	Enrichment	EXT2	1.67
188	Acrodysostosis	Enrichment	PRKAR1A	1.67
189	Microphthalmia/coloboma 6	Enrichment	GDF3	1.67
190	Fibrolamellar carcinoma	Enrichment	PRKACA	1.67
191	Aortic valve disease 2	Enrichment	SMAD6	1.67
192	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.67
193	Proximal symphalangism	Enrichment	NOG	1.67
194	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.67
195	Polycythemia	Enrichment	JAK2	1.67
196	Craniosynostosis 7	Enrichment	SMAD6	1.67
197	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A	1.67
198	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.67
199	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.67
200	Weiss-kruszka syndrome	Enrichment	ZNF462	1.67
201	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.67
202	Radioulnar synostosis	Enrichment	SMAD6	1.67
203	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	PBX1	1.67
204	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.67
205	12q14 microdeletion syndrome	Enrichment	HMGA2	1.67
206	Hypereosinophilic syndrome	Enrichment	JAK2	1.67
207	Hyperinsulinism	Enrichment	HNF4A	1.67
208	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF4A	1.67
209	Pulmonary venoocclusive disease	Enrichment	BMPR2	1.67
210	Renal hypoplasia, bilateral	Enrichment	PBX1	1.67
211	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.67
212	Juvenile polyposis of infancy	Enrichment	BMPR1A	1.67
213	Sleep apnea	Enrichment	AHDC1	1.67
214	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	1.67
215	Malignant peritoneal mesothelioma	Enrichment	LATS1	1.67
216	Metopic ridging-ptosis-facial dysmorphism syndrome	Enrichment	ZNF462	1.67
217	Tooth agenesis	Enrichment	AXIN2, FGFR1	1.63
218	Ovarian cancer	Enrichment	AXIN2, BMPR1A, EXT1, EXT2	1.62
219	Kallmann syndrome	Enrichment	FGF8, FGFR1	1.59
220	Familial atrial fibrillation	Enrichment	GATA6, PITX2	1.56
221	Tetralogy of fallot	Enrichment	GATA6, TBX1	1.50
222	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.49
223	Spondylocostal dysostosis 5	Enrichment	TBX6	1.49
224	Gillespie syndrome	Enrichment	PAX6	1.49
225	Polycythemia vera	Enrichment	JAK2	1.49
226	Lesch-nyhan syndrome	Enrichment	HPRT1	1.49
227	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	1.49
228	Hyperuricemia, hprt-related	Enrichment	HPRT1	1.49
229	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.49
230	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.49
231	Dedifferentiated liposarcoma	Enrichment	HMGA2	1.49
232	Loeys-dietz syndrome 1	Enrichment	SMAD2	1.49
233	Familial vesicoureteral reflux	Enrichment	SOX17	1.49
234	End stage renal disease	Enrichment	GATA3	1.49
235	Tetraamelia syndrome	Enrichment	WNT3	1.49
236	Well-differentiated liposarcoma	Enrichment	HMGA2	1.49
237	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2	1.49
238	Isolated klippel-feil syndrome	Enrichment	GDF3	1.49
239	Trichorhinophalangeal syndrome, type ii	Enrichment	EXT1	1.37
240	Erythrocytosis, familial, 1	Enrichment	JAK2	1.37
241	Huntington disease	Enrichment	HTT	1.37
242	Microphthalmia, syndromic 3	Enrichment	SOX2	1.37
243	Budd-chiari syndrome	Enrichment	JAK2	1.37
244	Potocki-shaffer syndrome	Enrichment	EXT2	1.37
245	Persistent mullerian duct syndrome, types i and ii	Enrichment	AMH	1.37
246	Pitt-hopkins syndrome	Enrichment	TCF4	1.37
247	Maturity-onset diabetes of the young, type 3	Enrichment	HNF4A	1.37
248	Carney complex variant	Enrichment	PRKAR1A	1.37
249	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.37
250	Mantle cell lymphoma	Enrichment	CCND1	1.37
251	Multiple synostoses syndrome	Enrichment	NOG	1.37
252	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	1.37
253	Retinopathy of prematurity	Enrichment	FZD4	1.37
254	Aortic aneurysm	Enrichment	SMAD3	1.37
255	Corneal dystrophy	Enrichment	GRHL2	1.37
256	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Enrichment	TRIM71	1.37
257	Persistent mullerian duct syndrome	Enrichment	AMH	1.37
258	Silver-russell syndrome due to a point mutation	Enrichment	HMGA2	1.37
259	Middle aortic syndrome	Enrichment	GATA6	1.37
260	Isolated congenitally uncorrected transposition of the great arteries	Enrichment	ZIC3	1.37
261	Complex neurodevelopmental disorder	Enrichment	BCORL1, HTT, JARID2, PPP2CA	1.34
262	Cakut	Enrichment	FOXC1, GATA3	1.28
263	Kbg syndrome	Enrichment	TBX1	1.28
264	Exudative vitreoretinopathy 1	Enrichment	FZD4	1.28
265	Von hippel-lindau syndrome	Enrichment	CCND1	1.28
266	Norrie disease	Enrichment	FZD4	1.28
267	Ventricular septal defect 1	Enrichment	BMP7	1.28
268	Cholangitis, primary sclerosing	Enrichment	TCF4	1.28
269	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.28
270	Congenital ptosis	Enrichment	ZFHX4	1.28
271	Myeloproliferative neoplasm	Enrichment	JAK2	1.28
272	Juvenile glaucoma	Enrichment	FOXC1	1.28
273	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.28
274	2q23.1 microduplication syndrome	Enrichment	ACVR2A	1.28
275	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.28
276	Kabuki syndrome 1	Enrichment	KDM6A	1.20
277	Corneal dystrophy, posterior polymorphous, 1	Enrichment	GRHL2	1.20
278	Facioscapulohumeral muscular dystrophy 1	Enrichment	DNMT3B	1.20
279	Split-hand/foot malformation 1	Enrichment	LEF1	1.20
280	Wilms tumor 5	Enrichment	TRIM28	1.20
281	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B	1.20
282	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.20
283	Silver-russell syndrome 1	Enrichment	HMGA2	1.13
284	Myelofibrosis	Enrichment	JAK2	1.13
285	Coats disease	Enrichment	FZD4	1.13
286	Semantic dementia	Enrichment	C9orf72	1.13
287	Essential thrombocythemia	Enrichment	JAK2	1.13
288	Gallbladder cancer	Enrichment	SMAD4	1.13
289	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.13
290	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.13
291	Congenital hydrocephalus	Enrichment	TRIM71	1.13
292	Exudative vitreoretinopathy	Enrichment	FZD4	1.08
293	Combined pituitary hormone deficiency	Enrichment	FOXA2	1.08
294	Charge syndrome	Enrichment	KDM6A	1.03
295	Ellis-van creveld syndrome	Enrichment	PRKACA	1.03
296	Polydactyly	Enrichment	SMAD6	1.03
297	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.03
298	Adult hepatocellular carcinoma	Enrichment	AXIN1	1.03
299	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.03
300	Progressive non-fluent aphasia	Enrichment	C9orf72	1.03
301	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.03
302	Behavioral variant of frontotemporal dementia	Enrichment	C9orf72	1.03
303	Leukemia, chronic lymphocytic	Enrichment	CCND1	0.99
304	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	C9orf72	0.99
305	Stickler syndrome	Enrichment	BMP4	0.99
306	Hypertelorism	Enrichment	ELP4, PAX6	0.96
307	Meningioma, familial	Enrichment	SCHIP1	0.95
308	Nanophthalmos	Enrichment	SOX2	0.95
309	Familial colorectal cancer type x	Enrichment	BMPR1A	0.95
310	Digeorge syndrome	Enrichment	TBX1	0.91
311	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	0.91
312	Aortic valve disease 1	Enrichment	SMAD6	0.88
313	Diaphragmatic hernia, congenital	Enrichment	GATA6	0.88
314	Acute promyelocytic leukemia	Enrichment	PRKAR1A	0.88
315	Primary ovarian insufficiency	Enrichment	JAK2, ZNF462	0.87
316	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.85
317	Cleft lip/palate	Enrichment	BMP4	0.85
318	Renal cell carcinoma, nonpapillary	Enrichment	SETD2	0.82
319	Wilms tumor 1	Enrichment	TRIM28	0.82
320	Corpus callosum, agenesis of	Enrichment	SETD2	0.82
321	Isolated corpus callosum agenesis	Enrichment	SETD2	0.82
322	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	SETD2	0.82
323	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	AHDC1	0.80
324	Wolff-parkinson-white syndrome	Enrichment	NODAL	0.80
325	Hydrocephalus, congenital, 1	Enrichment	SETD2	0.80
326	Gliosarcoma	Enrichment	FGFR1	0.80
327	Dandy-walker syndrome	Enrichment	SETD2	0.77
328	Polycystic liver disease	Enrichment	HNF4A	0.77
329	Giant cell glioblastoma	Enrichment	FGFR1	0.77
330	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	0.77
331	Patent foramen ovale	Enrichment	GATA6	0.75
332	Congenital myopathy	Enrichment	ASCC3	0.73
333	Ehlers-danlos syndrome	Enrichment	SMAD3	0.73
334	Maturity-onset diabetes of the young	Enrichment	HNF4A	0.71
335	Lissencephaly	Enrichment	MACF1	0.69
336	Hepatoblastoma	Enrichment	EXT2	0.69
337	Hepatocellular carcinoma	Enrichment	AXIN1	0.67
338	Scoliosis	Enrichment	TBX6	0.64
339	Pancreatic cancer	Enrichment	SMAD4	0.62
340	Hydrops fetalis, nonimmune	Enrichment	FOXC2	0.61
341	Bladder cancer	Enrichment	KDM6A	0.57
342	Hirschsprung disease 1	Enrichment	AXIN2	0.57
343	Differentiated thyroid carcinoma	Enrichment	CCDC6	0.57
344	Visceral heterotaxy 5	Enrichment	NODAL	0.54
345	Non-immune hydrops fetalis	Enrichment	FOXC2	0.54
346	Lung cancer	Enrichment	NFE2L2	0.53
347	Connective tissue disease	Enrichment	SMAD3	0.53
348	Usher syndrome	Enrichment	CEP250	0.52
349	Nephronophthisis	Enrichment	PIAS1	0.52
350	Leukemia, acute myeloid	Enrichment	JAK2	0.45
351	Type 2 diabetes mellitus	Enrichment	HNF4A	0.43
352	Gastric cancer	Enrichment	SMAD4	0.43
353	Hereditary breast carcinoma	Enrichment	ZNF462	0.42
354	Microcephaly	Enrichment	TCF4, ZIC2	0.41
355	Thrombocytopenia	Enrichment	SMAD4	0.39
356	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GRHL2	0.36
357	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	0.34
358	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	C9orf72	0.33
359	Autism	Enrichment	JARID2	0.26
360	Breast cancer	Enrichment	ZNF462	0.25
361	Dilated cardiomyopathy	Enrichment	GATA6	0.23
362	Mitochondrial disease	Enrichment	C1QBP	0.21
363	Congenital nervous system abnormality	Enrichment	ZIC2	0.16
364	Nervous system disease	Enrichment	ZIC2	0.16
365	Hereditary retinal dystrophy	Enrichment	CEP250, FZD4	0.08
366	Fundus dystrophy	Enrichment	CEP250, FZD4	0.08

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mesodermal commitment pathway

Pathway Network for Mesodermal commitment pathway

Member Pathways for Mesodermal commitment pathway

Pathways in the Mesodermal commitment pathway SuperPath

Associated Genes for Mesodermal commitment pathway

Associated Disorders for Mesodermal commitment pathway

Disorders associated with Mesodermal commitment pathway SuperPath

STRING Interaction Network for Mesodermal commitment pathway

Sources for Mesodermal commitment pathway