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Synthesis of substrates in N-glycan biosythesis
SuperPath
Pathway network
for
Synthesis of substrates in N-glycan biosythesis
SuperPath
14
Pathways
in the
Synthesis of substrates in N-glycan biosythesis
SuperPath
Defective DHDDS causes RP59
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Synthesis of dolichyl-phosphate-glucose
Sialic acid metabolism
Synthesis of UDP-N-acetyl-glucosamine
Synthesis of Dolichyl-phosphate
Defective MPI causes MPI-CDG
GDP-fucose biosynthesis
Synthesis of substrates in N-glycan biosythesis
Defective SRD5A3 causes SRD5A3-CDG, KHRZ
Defective PMM2 causes PMM2-CDG
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)
Synthesis of GDP-mannose
Defective DOLK causes DOLK-CDG
78
Genes
in the
Synthesis of substrates in N-glycan biosythesis
SuperPath
NUS1
DHDDS
DOLK
MPI
PMM2
SLC35C1
SRD5A3
GNE
ST3GAL6
SLC35A1
ST6GALNAC2
NEU3
NEU4
NANP
FCSK
NUDT14
ST6GALNAC3
SLC17A5
GFPT1
ST6GALNAC4
GLB1
GMDS
FUOM
ALG5
ST8SIA5
GMPPB
GMPPA
ST6GALNAC6
ST8SIA6
MVD
NEU1
NEU2
AMDHD2
ST8SIA3
PGM3
PMM1
NANS
CTSA
NAGK
ST6GALNAC1
CMAS
DOLPP1
RENBP
ST6GAL1
ST3GAL1
ST3GAL2
ST3GAL4
GNPNAT1
ST3GAL3
ST8SIA1
UAP1
GFUS
ST8SIA4
NPL
ST8SIA2
ST6GALNAC5
ST6GAL2
FPGT
ST3GAL5
GFPT2
DPM3
DPM1
DPM2
ALG3
ALG10B
DPAGT1
ALG14
ALG6
ALG11
ALG1
ALG8
ALG12
ALG9
ALG13
ALG10
ALG2
RFT1
MPDU1
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Synthesis of substrates in N-glycan biosythesis
SuperPath