1 |
|
Glutathione conjugation
|
47 |
4.743 |
SuperPathway |
|
Genes names |
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 2
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 4
- Glutathione Peroxidase 5
- Glutathione Peroxidase 6
- Glutathione Peroxidase 7
- Glutathione-Disulfide Reductase
- Glutathione Synthetase
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Alpha 4
- Glutathione S-Transferase Alpha 5
- Glutathione S-Transferase Kappa 1
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Mu 2
- Glutathione S-Transferase Mu 3
- Glutathione S-Transferase Mu 4
- Glutathione S-Transferase Mu 5
- Glutathione S-Transferase Omega 1
- Glutathione S-Transferase Omega 2
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
- Glutathione S-Transferase Theta 2B
- Glutathione S-Transferase Zeta 1
- Microsomal Glutathione S-Transferase 1
- Microsomal Glutathione S-Transferase 2
- Microsomal Glutathione S-Transferase 3
|
Pathways |
- glutathione biosynthesis
- Glutathione synthesis and recycling
- Glutathione conjugation
- Glutathione metabolism
- Glutathione metabolism
- glutathione-peroxide redox reactions
- glutathione redox reactions I
|
|
2 |
|
Metapathway biotransformation Phase I and II
|
296 |
2.198 |
Genes names |
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 2
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 4
- Glutathione Peroxidase 5
- Glutathione-Disulfide Reductase
- Glutathione Synthetase
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Alpha 4
- Glutathione S-Transferase Alpha 5
- Glutathione S-Transferase C-Terminal Domain Containing
- Glutathione S-Transferase Kappa 1
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Mu 2
- Glutathione S-Transferase Mu 3
- Glutathione S-Transferase Mu 4
- Glutathione S-Transferase Mu 5
- Glutathione S-Transferase Omega 1
- Glutathione S-Transferase Omega 2
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
- Glutathione S-Transferase Theta 2B
- Glutathione S-Transferase Zeta 1
- Microsomal Glutathione S-Transferase 1
- Microsomal Glutathione S-Transferase 2
- Microsomal Glutathione S-Transferase 3
|
|
3 |
|
Metabolism
|
2121 |
2.123 |
Genes names |
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 2
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 4
- Glutathione-Disulfide Reductase
- Glutathione Synthetase
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Alpha 4
- Glutathione S-Transferase Alpha 5
- Glutathione S-Transferase Kappa 1
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Mu 2
- Glutathione S-Transferase Mu 3
- Glutathione S-Transferase Mu 4
- Glutathione S-Transferase Mu 5
- Glutathione S-Transferase Omega 1
- Glutathione S-Transferase Omega 2
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
- Glutathione S-Transferase Theta 2B
- Glutathione S-Transferase Zeta 1
- Microsomal Glutathione S-Transferase 1
- Microsomal Glutathione S-Transferase 2
- Microsomal Glutathione S-Transferase 3
|
|
4 |
|
glutathione-mediated detoxification I
|
6 |
2.052 |
SuperPathway |
- glutathione-mediated detoxification I
|
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Zeta 1
|
Pathways |
- glutathione-mediated detoxification I
|
|
5 |
|
Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases
|
6 |
1.758 |
SuperPathway |
- Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases
|
Genes names |
|
Pathways |
- Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases
|
|
6 |
|
Nuclear receptors meta-pathway
|
315 |
1.702 |
Genes names |
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione-Disulfide Reductase
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Alpha 4
- Glutathione S-Transferase Alpha 5
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Mu 2
- Glutathione S-Transferase Mu 3
- Glutathione S-Transferase Mu 4
- Glutathione S-Transferase Mu 5
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
- Microsomal Glutathione S-Transferase 1
- Microsomal Glutathione S-Transferase 2
- Microsomal Glutathione S-Transferase 3
|
|
7 |
|
Cellular responses to stimuli
|
802 |
1.390 |
Genes names |
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 5
- Glutathione Peroxidase 6
- Glutathione Peroxidase 7
- Glutathione Peroxidase 8 (Putative)
- Glutathione-Disulfide Reductase
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Pi 1
|
|
8 |
|
formaldehyde oxidation II (glutathione-dependent)
|
2 |
1.357 |
SuperPathway |
- formaldehyde oxidation II (glutathione-dependent)
|
Pathways |
- formaldehyde oxidation II (glutathione-dependent)
|
|
9 |
|
Nuclear events mediated by NFE2L2
|
199 |
1.331 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 5
- Glutathione Peroxidase 6
- Glutathione Peroxidase 7
- Glutathione Peroxidase 8 (Putative)
- Glutathione-Disulfide Reductase
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Pi 1
|
|
10 |
|
Detoxification of Reactive Oxygen Species
|
37 |
1.204 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 5
- Glutathione Peroxidase 6
- Glutathione Peroxidase 7
- Glutathione Peroxidase 8 (Putative)
- Glutathione-Disulfide Reductase
- Glutathione S-Transferase Pi 1
|
|
11 |
|
One-carbon metabolism and related pathways
|
66 |
1.204 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 4
- Glutathione Peroxidase 5
- Glutathione Peroxidase 6
- Glutathione Peroxidase 7
- Glutathione-Disulfide Reductase
- Glutathione Synthetase
|
|
12 |
|
Oxidative stress response
|
32 |
0.897 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 3
- Glutathione-Disulfide Reductase
- Glutathione S-Transferase Theta 2 (Gene/Pseudogene)
- Microsomal Glutathione S-Transferase 1
|
|
13 |
|
Drug ADME
|
122 |
0.897 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
|
|
14 |
|
Naphthalene metabolism
|
24 |
0.897 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
|
|
15 |
|
2-Naphthylamine and 2-Nitronaphtalene metabolism
|
22 |
0.897 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Alpha 3
- Glutathione S-Transferase Alpha 4
- Glutathione S-Transferase Alpha 5
|
|
16 |
|
Selenium Metabolism and Selenoproteins
|
37 |
0.897 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 3
- Glutathione Peroxidase 4
- Glutathione Peroxidase 6
|
|
17 |
|
Busulfan Pathway, Pharmacodynamics
|
36 |
0.802 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Pi 1
- Microsomal Glutathione S-Transferase 2
|
|
18 |
|
HETE and HPETE biosynthesis and metabolism
|
21 |
0.802 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 4
- Microsomal Glutathione S-Transferase 2
- Microsomal Glutathione S-Transferase 3
|
|
19 |
|
Innate Immune System
|
2025 |
0.802 |
Genes names |
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Omega 1
- Glutathione S-Transferase Pi 1
- Microsomal Glutathione S-Transferase 1
|
|
20 |
|
Paracetamol ADME
|
33 |
0.695 |
Genes names |
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
|
|
21 |
|
Statin Pathway - Generalized, Pharmacokinetics
|
53 |
0.695 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Pi 1
|
|
22 |
|
Platinum Pathway, Pharmacokinetics/Pharmacodynamics
|
29 |
0.695 |
Genes names |
- Glutathione S-Transferase Mu 1
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
|
|
23 |
|
FOXA2 pathway
|
20 |
0.695 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Mu 2
|
|
24 |
|
Aflatoxin activation and detoxification
|
19 |
0.695 |
Genes names |
- Microsomal Glutathione S-Transferase 1
- Microsomal Glutathione S-Transferase 2
- Microsomal Glutathione S-Transferase 3
|
|
25 |
|
Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
|
33 |
0.695 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Mu 1
|
|
26 |
|
Fatty acid metabolism
|
179 |
0.695 |
Genes names |
- Glutathione Peroxidase 1
- Glutathione Peroxidase 2
- Glutathione Peroxidase 4
|
|
27 |
|
Gene expression (Transcription)
|
1546 |
0.567 |
Genes names |
- Glutathione Peroxidase 2
- Glutathione-Disulfide Reductase
|
|
28 |
|
Regulation of TP53 Activity
|
362 |
0.567 |
Genes names |
- Glutathione Peroxidase 2
- Glutathione-Disulfide Reductase
|
|
29 |
|
Interleukin-12 family signaling
|
57 |
0.567 |
Genes names |
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Omega 1
|
|
30 |
|
Amino acid metabolism
|
91 |
0.567 |
Genes names |
- Glutathione-Disulfide Reductase
- Glutathione Synthetase
|
|
31 |
|
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
|
15 |
0.567 |
Genes names |
- Glutathione S-Transferase Pi 1
- Glutathione S-Transferase Theta 1
|
|
32 |
|
Regulation of expression of SLITs and ROBOs
|
462 |
0.567 |
Genes names |
- Glutathione-Disulfide Reductase
- Glutathione S-Transferase Zeta 1
|
|
33 |
|
Biosynthesis of specialized proresolving mediators (SPMs)
|
19 |
0.567 |
Genes names |
- Glutathione Peroxidase 4
- Glutathione S-Transferase Mu 4
|
|
34 |
|
Cytokine Signaling in Immune system
|
732 |
0.567 |
Genes names |
- Glutathione S-Transferase Alpha 2
- Glutathione S-Transferase Omega 1
|
|
35 |
|
Metabolism of water-soluble vitamins and cofactors
|
191 |
0.567 |
Genes names |
- Glutathione S-Transferase Omega 1
- Glutathione S-Transferase Omega 2
|
|
36 |
|
TP53 Regulates Metabolic Genes
|
87 |
0.567 |
Genes names |
- Glutathione Peroxidase 2
- Glutathione-Disulfide Reductase
|
|
37 |
|
Ferroptosis
|
64 |
0.567 |
Genes names |
- Glutathione Peroxidase 4
- Glutathione Synthetase
|
|
38 |
|
Estrogen metabolism
|
23 |
0.567 |
Genes names |
- Glutathione S-Transferase Alpha 1
- Glutathione S-Transferase Mu 1
|
|
39 |
|
Exercise-induced circadian regulation
|
48 |
0.567 |
Genes names |
- Glutathione S-Transferase Mu 3
- Glutathione S-Transferase Pi 1
|
|
40 |
|
TYROBP causal network in microglia
|
60 |
0.401 |
|
41 |
|
Pyruvate metabolism
|
55 |
0.401 |
Genes names |
- Glutathione S-Transferase Zeta 1
|
|
42 |
|
Metabolic disorders of biological oxidation enzymes
|
34 |
0.401 |
|
43 |
|
Physico-chemical features and toxicity-associated pathways
|
65 |
0.401 |
|
44 |
|
p53 transcriptional gene network
|
95 |
0.401 |
|
45 |
|
Arsenic metabolism and reactive oxygen species generation
|
9 |
0.401 |
Genes names |
- Glutathione S-Transferase Omega 1
|
|
46 |
|
Amyotrophic lateral sclerosis (ALS)
|
36 |
0.401 |
|
47 |
|
NF-kappaB Signaling
|
327 |
0.401 |
|
48 |
|
Vitamin D-sensitive calcium signaling in depression
|
34 |
0.401 |
Genes names |
- Glutathione-Disulfide Reductase
|
|
49 |
|
Benzene metabolism
|
5 |
0.401 |
Genes names |
- Glutathione S-Transferase Mu 1
|
|
50 |
|
Validated transcriptional targets of deltaNp63 isoforms
|
47 |
0.401 |
|
51 |
|
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
|
23 |
0.401 |
Genes names |
- Glutathione S-Transferase Pi 1
|
|
52 |
|
Constitutive androstane receptor pathway
|
41 |
0.401 |
Genes names |
- Glutathione S-Transferase Alpha 2
|
|
53 |
|
Heme biosynthesis
|
27 |
0.401 |
Genes names |
- Glutathione S-Transferase Alpha 1
|
|
54 |
|
Peroxisomal lipid metabolism
|
167 |
0.401 |
Genes names |
- Glutathione S-Transferase Kappa 1
|
|
55 |
|
DNA Damage
|
296 |
0.401 |
Genes names |
- Glutathione S-Transferase Pi 1
|
|
56 |
|
Cytosolic sulfonation of small molecules
|
28 |
0.401 |
Genes names |
- Glutathione-Disulfide Reductase
|
|
57 |
|
Doxorubicin Pathway, Pharmacokinetics
|
28 |
0.401 |
|
58 |
|
Peptide chain elongation
|
417 |
0.401 |
Genes names |
- Glutathione-Disulfide Reductase
|
|
59 |
|
tyrosine degradation
|
11 |
0.401 |
Genes names |
- Glutathione S-Transferase Zeta 1
|
|
60 |
|
MAP Kinase Signaling
|
113 |
0.401 |
Genes names |
- Glutathione S-Transferase Pi 1
|
|
61 |
|
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
|
193 |
0.401 |
Genes names |
- Glutathione S-Transferase Zeta 1
|
|
62 |
|
purine nucleotides de novo biosynthesis
|
45 |
0.401 |
Genes names |
- Glutathione-Disulfide Reductase
|
|
63 |
|
Diseases of glycosylation
|
249 |
0.401 |
|
64 |
|
Metabolism of nucleotides
|
99 |
0.401 |
Genes names |
- Glutathione-Disulfide Reductase
|
|
65 |
|
Validated transcriptional targets of TAp63 isoforms
|
54 |
0.401 |
|
66 |
|
ascorbate recycling (cytosolic)
|
2 |
0.401 |
Genes names |
- Glutathione S-Transferase Omega 1
|
|
67 |
|
Dichloroethylene metabolism
|
8 |
0.401 |
Genes names |
- Glutathione S-Transferase Alpha 2
|
|
68 |
|
Sulfur amino acid metabolism
|
30 |
0.401 |
|
69 |
|
Neuroscience
|
341 |
0.401 |
Genes names |
- Glutathione S-Transferase Pi 1
|
|
70 |
|
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
|
2 |
0.401 |
Genes names |
- Glutathione S-Transferase Mu 4
|
|
71 |
|
Myometrial relaxation and contraction pathways
|
215 |
0.401 |
Genes names |
- Glutathione S-Transferase Omega 1
|
|
72 |
|
Direct p53 effectors
|
128 |
0.401 |
|
73 |
|
Glucose / Energy Metabolism
|
307 |
0.401 |
|
74 |
|
Arachidonate epoxygenase / epoxide hydrolase
|
7 |
0.401 |
Genes names |
- Glutathione S-Transferase Pi 1
|
|
75 |
|
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway
|
32 |
0.401 |
Genes names |
- Glutathione S-Transferase Alpha 2
|
|
76 |
|
Cyclophosphamide Pathway, Pharmacodynamics
|
18 |
0.401 |
Genes names |
- Glutathione S-Transferase Pi 1
|
|
77 |
|
Infectious disease
|
1747 |
0.401 |
|
78 |
|
C-MYB transcription factor network
|
80 |
0.401 |
Genes names |
- Glutathione S-Transferase Mu 1
|
|
79 |
|
NRF2-ARE regulation
|
23 |
0.401 |
Genes names |
- Glutathione S-Transferase Alpha 2
|
|
80 |
|
Response of EIF2AK1 (HRI) to heme deficiency
|
15 |
0.401 |
Genes names |
- ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1
|
|