1 |
|
TGFBR1 KD Mutants in Cancer
|
10 |
1.433 |
SuperPathway |
- TGFBR1 KD Mutants in Cancer
|
Pathways |
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of TGFBR2 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
|
|
2 |
|
Signaling by EGFR in Cancer
|
28 |
1.331 |
SuperPathway |
- Signaling by EGFR in Cancer
|
Pathways |
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by EGFR in Cancer
- Signaling by EGFRvIII in Cancer
|
|
3 |
|
Endometrial cancer
|
201 |
1.216 |
SuperPathway |
|
Pathways |
- Chromosomal and microsatellite instability in colorectal cancer
- Endometrial cancer
- Non-small cell lung cancer
|
|
4 |
|
SMAD2/3 MH2 Domain Mutants in Cancer
|
3 |
1.216 |
SuperPathway |
- SMAD2/3 MH2 Domain Mutants in Cancer
|
Pathways |
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
|
|
5 |
|
Loss of function of TP53 in cancer due to loss of tetramerization ability
|
1 |
1.079 |
SuperPathway |
- Loss of function of TP53 in cancer due to loss of tetramerization ability
|
Pathways |
- Loss of function of TP53 in cancer due to loss of tetramerization ability
- Loss of Function of TP53 in Cancer
|
|
6 |
|
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
|
5 |
1.079 |
SuperPathway |
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
|
Pathways |
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- FBXW7 Mutants and NOTCH1 in Cancer
|
|
7 |
|
Androgen receptor network in prostate cancer
|
105 |
1.079 |
SuperPathway |
- Androgen receptor network in prostate cancer
|
Pathways |
- Androgen receptor network in prostate cancer
- Integrated cancer pathway
|
|
8 |
|
Signaling by ALK in cancer
|
55 |
1.079 |
SuperPathway |
- Signaling by ALK in cancer
|
Pathways |
- Nuclear events stimulated by ALK signaling in cancer
- Signaling by ALK in cancer
|
|
9 |
|
Small cell lung cancer
|
96 |
0.900 |
|
10 |
|
NRP1-triggered signaling pathways in pancreatic cancer
|
53 |
0.900 |
SuperPathway |
- NRP1-triggered signaling pathways in pancreatic cancer
|
Pathways |
- NRP1-triggered signaling pathways in pancreatic cancer
|
|
11 |
|
Signaling by Overexpressed Wild-Type EGFR in Cancer
|
24 |
0.900 |
SuperPathway |
- Signaling by Overexpressed Wild-Type EGFR in Cancer
|
Pathways |
- Signaling by Overexpressed Wild-Type EGFR in Cancer
|
|
12 |
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
52 |
0.900 |
SuperPathway |
- Apoptosis-related network due to altered Notch3 in ovarian cancer
|
Pathways |
- Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
13 |
|
Metabolic reprogramming in colon cancer
|
42 |
0.900 |
SuperPathway |
- Metabolic reprogramming in colon cancer
|
Pathways |
- Metabolic reprogramming in colon cancer
|
|
14 |
|
Breast cancer pathway
|
199 |
0.900 |
|
15 |
|
Cancer immunotherapy by CTLA4 blockade
|
15 |
0.900 |
SuperPathway |
- Cancer immunotherapy by CTLA4 blockade
|
Pathways |
- Cancer immunotherapy by CTLA4 blockade
|
|
16 |
|
Cancer immunotherapy by PD-1 blockade
|
23 |
0.900 |
SuperPathway |
- Cancer immunotherapy by PD-1 blockade
|
Pathways |
- Cancer immunotherapy by PD-1 blockade
|
|
17 |
|
Constitutive Signaling by AKT1 E17K in Cancer
|
38 |
0.900 |
SuperPathway |
- Constitutive Signaling by AKT1 E17K in Cancer
|
Pathways |
- Constitutive Signaling by AKT1 E17K in Cancer
|
|
18 |
|
Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
|
3 |
0.900 |
SuperPathway |
- Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
|
Pathways |
- Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
|
|
19 |
|
miRNA regulation of p53 pathway in prostate cancer
|
32 |
0.900 |
SuperPathway |
- miRNA regulation of p53 pathway in prostate cancer
|
Pathways |
- miRNA regulation of p53 pathway in prostate cancer
|
|
20 |
|
Folate-alcohol and cancer pathway hypotheses
|
9 |
0.900 |
SuperPathway |
- Folate-alcohol and cancer pathway hypotheses
|
Pathways |
- Folate-alcohol and cancer pathway hypotheses
|
|
21 |
|
Gastric cancer network 2
|
31 |
0.900 |
|
22 |
|
Interactions of natural killer cells in pancreatic cancer
|
27 |
0.900 |
SuperPathway |
- Interactions of natural killer cells in pancreatic cancer
|
Pathways |
- Interactions of natural killer cells in pancreatic cancer
|
|
23 |
|
Glucose metabolism in triple-negative breast cancer cells
|
8 |
0.900 |
SuperPathway |
- Glucose metabolism in triple-negative breast cancer cells
|
Pathways |
- Glucose metabolism in triple-negative breast cancer cells
|
|
24 |
|
Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics
|
34 |
0.900 |
SuperPathway |
- Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics
|
Pathways |
- Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics
|
|
25 |
|
MicroRNA for targeting cancer growth and vascularization in glioblastoma
|
7 |
0.900 |
SuperPathway |
- MicroRNA for targeting cancer growth and vascularization in glioblastoma
|
Pathways |
- MicroRNA for targeting cancer growth and vascularization in glioblastoma
|
|
26 |
|
Epithelial to mesenchymal transition in colorectal cancer
|
161 |
0.900 |
SuperPathway |
- Epithelial to mesenchymal transition in colorectal cancer
|
Pathways |
- Epithelial to mesenchymal transition in colorectal cancer
|
|
27 |
|
Immune infiltration in pancreatic cancer
|
39 |
0.900 |
SuperPathway |
- Immune infiltration in pancreatic cancer
|
Pathways |
- Immune infiltration in pancreatic cancer
|
|
28 |
|
Neural crest cell migration in cancer
|
34 |
0.900 |
SuperPathway |
- Neural crest cell migration in cancer
|
Pathways |
- Neural crest cell migration in cancer
|
|
29 |
|
Signaling by FGFR3 fusions in cancer
|
1 |
0.900 |
SuperPathway |
- Signaling by FGFR3 fusions in cancer
|
Pathways |
- Signaling by FGFR3 fusions in cancer
|
|
30 |
|
Integrated breast cancer pathway
|
150 |
0.900 |
SuperPathway |
- Integrated breast cancer pathway
|
Pathways |
- Integrated breast cancer pathway
|
|
31 |
|
Bladder cancer
|
40 |
0.900 |
|
32 |
|
MAPK pathway in congenital thyroid cancer
|
11 |
0.900 |
SuperPathway |
- MAPK pathway in congenital thyroid cancer
|
Pathways |
- MAPK pathway in congenital thyroid cancer
|
|
33 |
|
Cell interactions of the pancreatic cancer microenvironment
|
28 |
0.900 |
SuperPathway |
- Cell interactions of the pancreatic cancer microenvironment
|
Pathways |
- Cell interactions of the pancreatic cancer microenvironment
|
|
34 |
|
Retinoblastoma gene in cancer
|
86 |
0.900 |
SuperPathway |
- Retinoblastoma gene in cancer
|
Pathways |
- Retinoblastoma gene in cancer
|
|
35 |
|
T cell modulation in pancreatic cancer
|
45 |
0.900 |
SuperPathway |
- T cell modulation in pancreatic cancer
|
Pathways |
- T cell modulation in pancreatic cancer
|
|
36 |
|
Senescence and autophagy in cancer
|
105 |
0.900 |
SuperPathway |
- Senescence and autophagy in cancer
|
Pathways |
- Senescence and autophagy in cancer
|
|
37 |
|
Gastric cancer network 1
|
29 |
0.900 |
|
38 |
|
Metabolic reprogramming in pancreatic cancer
|
42 |
0.900 |
SuperPathway |
- Metabolic reprogramming in pancreatic cancer
|
Pathways |
- Metabolic reprogramming in pancreatic cancer
|
|
39 |
|
Deregulation of Rab and Rab effector genes in bladder cancer
|
16 |
0.900 |
SuperPathway |
- Deregulation of Rab and Rab effector genes in bladder cancer
|
Pathways |
- Deregulation of Rab and Rab effector genes in bladder cancer
|
|
40 |
|
Colorectal Cancer Metastasis
|
165 |
0.900 |
SuperPathway |
- Colorectal Cancer Metastasis
|
Pathways |
- Colorectal Cancer Metastasis
|
|
41 |
|
TGF-beta receptor signaling activates SMADs
|
46 |
0.863 |
Pathways |
- Loss of Function of SMAD2/3 in Cancer
- Loss of Function of TGFBR1 in Cancer
- TGFBR1 LBD Mutants in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
|
|
42 |
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
74 |
0.748 |
Pathways |
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
|
|
43 |
|
EML4 and NUDC in mitotic spindle formation
|
248 |
0.620 |
Genes names |
- Suppressor Of Cancer Cell Invasion
|
|
44 |
|
ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
|
18 |
0.620 |
Genes names |
- Urothelial Cancer Associated 1
|
|
45 |
|
Signaling by Rho GTPases
|
722 |
0.620 |
Genes names |
- Suppressor Of Cancer Cell Invasion
|
|
46 |
|
RhoA signaling pathway
|
36 |
0.620 |
Genes names |
- Suppressor Of Cancer Cell Invasion
|
|
47 |
|
pyrimidine deoxyribonucleotides biosynthesis from CTP
|
16 |
0.620 |
Genes names |
- Nucleoside-Triphosphatase, Cancer-Related
|
|
48 |
|
Cytoskeletal Signaling
|
308 |
0.620 |
Genes names |
- Suppressor Of Cancer Cell Invasion
|
|
49 |
|
Pyrimidine metabolism
|
85 |
0.620 |
Genes names |
- Nucleoside-Triphosphatase, Cancer-Related
|
|
50 |
|
Signal Transduction
|
2590 |
0.620 |
Genes names |
- Suppressor Of Cancer Cell Invasion
|
|
51 |
|
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
|
88 |
0.611 |
Pathways |
- Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
|
|
52 |
|
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
|
135 |
0.611 |
Pathways |
- Constitutive Signaling by Aberrant PI3K in Cancer
- PI3K/AKT Signaling in Cancer
|
|
53 |
|
TP53 Regulates Transcription of Cell Cycle Genes
|
48 |
0.432 |
Pathways |
- Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
|
|
54 |
|
NOTCH2 Activation and Transmission of Signal to the Nucleus
|
50 |
0.432 |
Pathways |
- Signaling by NOTCH1 HD Domain Mutants in Cancer
|
|
55 |
|
Transport of inorganic cations/anions and amino acids/oligopeptides
|
728 |
0.432 |
Pathways |
- Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
|
|
56 |
|
CTNNB1 S33 mutants aren't phosphorylated
|
58 |
0.432 |
Pathways |
- Signaling by WNT in cancer
|
|
57 |
|
Transcriptional Regulation by MECP2
|
62 |
0.432 |
Pathways |
- PTEN Loss of Function in Cancer
|
|
58 |
|
ERK Signaling
|
1185 |
0.432 |
Pathways |
- Molecular Mechanisms of Cancer
|
|
59 |
|
Doxorubicin Pathway, Pharmacokinetics
|
28 |
0.432 |
Pathways |
- Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
|
|
60 |
|
serine and glycine biosynthesis
|
18 |
0.432 |
Pathways |
- Amino acid metabolism in triple-negative breast cancer cells
|
|
61 |
|
Prolactin Signaling
|
432 |
0.432 |
Pathways |
- TCA cycle nutrient use and invasiveness of ovarian cancer
|
|
62 |
|
GPCR Pathway
|
712 |
0.432 |
Pathways |
- Breast Cancer Regulation by Stathmin1
|
|
63 |
|
MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement
|
21 |
0.432 |
Pathways |
- MFAP5-mediated ovarian cancer cell motility and invasiveness
|
|
64 |
|
PPAR signaling pathway
|
69 |
0.432 |
|
65 |
|
ncRNAs involved in Wnt signaling in hepatocellular carcinoma
|
220 |
0.432 |
Pathways |
- lncRNA in canonical Wnt signaling and colorectal cancer
|
|
66 |
|
Signaling by ERBB2 KD Mutants
|
29 |
0.432 |
Pathways |
- Signaling by ERBB2 in Cancer
|
|