(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)

Sources:

#	Name	Source	Genes
1	(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)	PubChem	ELOVL2 ELOVL5 FADS2
2	alpha-linolenic acid (ALA) metabolism	Reactome	ABCD1 ACAA1 ACOT8 ACOX1 ACSL1 ELOVL1 ELOVL2 ELOVL3 ELOVL5 FADS1 FADS2 HSD17B4 SCP2 (see all 13) (see less)
3	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	Reactome	ABCD1 ACAA1 ACOT8 ACOX1 ACSL1 ELOVL1 ELOVL2 ELOVL3 ELOVL5 FADS1 FADS2 HSD17B4 SCP2 (see all 13) (see less)
4	Linoleic acid (LA) metabolism	Reactome	ABCD1 ACSL1 ELOVL1 ELOVL2 ELOVL3 ELOVL5 FADS1 FADS2 (see all 8) (see less)
5	Linoleic acid metabolism affected by SARS-CoV-2	WikiPathways	ACE2 ACOT2 ELOVL2 ELOVL5 FADS1 FADS2 (see all 6) (see less)
6	docosahexaenoate biosynthesis III (6-desaturase, mammals)	PubChem	ACOX1 EHHADH ELOVL2 ELOVL5 FADS2
7	(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)	PubChem	ACOX1 EHHADH ELOVL2 ELOVL5 FADS2
8	icosapentaenoate biosynthesis II (6-desaturase, mammals)	PubChem	ACSL1 ELOVL5 FADS1 FADS2
9	icosapentaenoate biosynthesis III (8-desaturase, mammals)	PubChem	ACSL1 ELOVL5 FADS1 FADS2
10	docosahexaenoate biosynthesis IV (4-desaturase, mammals)	PubChem	ELOVL2 ELOVL5 FADS2
11	docosahexaenoate biosynthesis III (mammals)	PubChem	ELOVL2 ELOVL5 FADS2
12	arachidonate biosynthesis V (8-detaturase, mammals)	PubChem	FADS1 FADS2
13	Defective ABCD1 causes ALD	Reactome	ABCD1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FADS2	Fatty Acid Desaturase 2	Protein Coding	12
2	ELOVL5	ELOVL Fatty Acid Elongase 5	Protein Coding	11
3	ELOVL2	ELOVL Fatty Acid Elongase 2	Protein Coding	9
4	FADS1	Fatty Acid Desaturase 1	Protein Coding	7
5	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	5
6	ABCD1	ATP Binding Cassette Subfamily D Member 1	Protein Coding	4
7	ACOX1	Acyl-CoA Oxidase 1	Protein Coding	4
8	ELOVL1	ELOVL Fatty Acid Elongase 1	Protein Coding	3
9	ELOVL3	ELOVL Fatty Acid Elongase 3	Protein Coding	3
10	ACOT8	Acyl-CoA Thioesterase 8	Protein Coding	2
11	ACAA1	Acetyl-CoA Acyltransferase 1	Protein Coding	2
12	HSD17B4	Hydroxysteroid 17-Beta Dehydrogenase 4	Protein Coding	2
13	SCP2	Sterol Carrier Protein 2	Protein Coding	2
14	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	2
15	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
16	ACOT2	Acyl-CoA Thioesterase 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adrenoleukodystrophy	Direct
2	Spinocerebellar ataxia 38	Enrichment	ELOVL5	3.66
3	Fanconi renotubular syndrome 3	Enrichment	EHHADH	3.43
4	Peroxisomal acyl-coa oxidase deficiency	Enrichment	ACOX1	3.43
5	Mitchell syndrome	Enrichment	ACOX1	3.43
6	Hypoadrenocorticism, familial	Enrichment	ABCD1	3.23
7	Encephalitis	Enrichment	ABCD1	3.23
8	X-linked cerebral adrenoleukodystrophy	Enrichment	ABCD1	3.23
9	Adrenomyeloneuropathy	Enrichment	ABCD1	3.23
10	Chronic primary adrenal insufficiency	Enrichment	ABCD1	3.23
11	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	3.02
12	D-bifunctional protein deficiency	Enrichment	EHHADH	2.96
13	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	ABCD1	2.93
14	Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facial features	Enrichment	ELOVL1	2.93
15	Cadds	Enrichment	ABCD1	2.93
16	Primary fanconi renotubular syndrome	Enrichment	EHHADH	2.83
17	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	ABCD1	2.75
18	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	ABCD1	2.75
19	Congenital nervous system abnormality	Enrichment	ABCD1, HSD17B4	2.35
20	Nervous system disease	Enrichment	ABCD1, HSD17B4	2.35
21	Myocarditis	Enrichment	ABCD1	2.33
22	Perrault syndrome	Enrichment	HSD17B4	2.12
23	Perrault syndrome 2	Enrichment	HSD17B4	2.07
24	Perrault syndrome 1	Enrichment	HSD17B4	1.82
25	Hirschsprung disease 1	Enrichment	ABCD1	1.77
26	Rare genetic deafness	Enrichment	HSD17B4	1.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)