3-phosphoinositide biosynthesis

No Pathway Network information available for 3-phosphoinositide biosynthesis

Pathways in the 3-phosphoinositide biosynthesis SuperPath

#	Name	Source	Genes
1	3-phosphoinositide biosynthesis	PubChem	CDIPT FIG4 PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP5K1A PIP5K1B PIP5K1C SACM1L (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PI4K2B	Phosphatidylinositol 4-Kinase Type 2 Beta	Protein Coding	1
2	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
3	PI4K2A	Phosphatidylinositol 4-Kinase Type 2 Alpha	Protein Coding	1
4	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	1
5	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
6	PI4KA	Phosphatidylinositol 4-Kinase Alpha	Protein Coding	1
7	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
8	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
9	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	1
10	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
11	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
12	FIG4	FIG4 Phosphoinositide 5-Phosphatase	Protein Coding	1
13	PIKFYVE	Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing	Protein Coding	1
14	PI4KB	Phosphatidylinositol 4-Kinase Beta	Protein Coding	1
15	SACM1L	SAC1 Like Phosphatidylinositide Phosphatase	Protein Coding	1
16	CDIPT	CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase	Protein Coding	1
17	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
18	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
19	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
20	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
21	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
22	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
23	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
24	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
25	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with 3-phosphoinositide biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.01
2	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	5.01
3	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	5.01
4	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.71
5	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.84
6	Macrodactyly	Enrichment	PIK3CA	2.73
7	Corneal dystrophy, fleck	Enrichment	PIKFYVE	2.73
8	Polymicrogyria, bilateral temporooccipital	Enrichment	FIG4	2.73
9	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.73
10	Cowden syndrome 5	Enrichment	PIK3CA	2.73
11	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.73
12	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.73
13	Short syndrome	Enrichment	PIK3R1	2.73
14	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.73
15	Amyotrophic lateral sclerosis 11	Enrichment	FIG4	2.73
16	Charcot-marie-tooth disease, demyelinating, type 4j	Enrichment	FIG4	2.73
17	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.73
18	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.73
19	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.73
20	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.73
21	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.73
22	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.73
23	Spastic paraplegia 84, autosomal recessive	Enrichment	PI4KA	2.73
24	Charcot-marie-tooth disease type 4j	Enrichment	FIG4	2.73
25	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.73
26	Deafness, autosomal dominant 87	Enrichment	PI4KB	2.73
27	Hypospadias	Enrichment	PIK3CA	2.73
28	Rare venous malformation	Enrichment	PIK3CA	2.73
29	Diaphragmatic eventration	Enrichment	PIK3CA	2.73
30	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.73
31	Rare combined vascular malformation	Enrichment	PIK3CA	2.73
32	Gastrointestinal defects and immunodeficiency syndrome 2	Enrichment	PI4KA	2.73
33	Cavernous lymphangioma	Enrichment	PIK3CA	2.73
34	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.73
35	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.73
36	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.73
37	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.73
38	Macrodactyly of toe	Enrichment	PIK3CA	2.73
39	Pi4ka-related disorder	Enrichment	PI4KA	2.73
40	Yunis-varon syndrome	Enrichment	FIG4	2.43
41	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.43
42	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.43
43	Keratosis, seborrheic	Enrichment	PIK3CA	2.43
44	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.43
45	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PI4KA	2.43
46	Noonan syndrome 8	Enrichment	PIK3CA	2.43
47	Spermatogenic failure 17	Enrichment	PIK3C2G	2.43
48	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.43
49	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.43
50	Immune system disease	Enrichment	PIK3CD	2.43
51	Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities	Enrichment	PI4K2A	2.43
52	Combined immunodeficiency-multiple intestinal atresia	Enrichment	PI4KA	2.43
53	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.26
54	Heparin cofactor ii deficiency	Enrichment	PI4KA	2.26
55	Keratoacanthoma	Enrichment	PIK3CA	2.26
56	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.13
57	Cerebrovascular disease	Enrichment	PIK3CA	2.13
58	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.13
59	Capillary malformations, congenital	Enrichment	PIK3CA	2.04
60	Pseudovaginal perineoscrotal hypospadias	Enrichment	FIG4	2.04
61	Hemimegalencephaly	Enrichment	PIK3CA	2.04
62	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.96
63	Cowden syndrome 1	Enrichment	PIK3CA	1.96
64	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.96
65	Breast adenocarcinoma	Enrichment	PIK3CA	1.96
66	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.96
67	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.96
68	Nevus, epidermal	Enrichment	PIK3CA	1.89
69	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.89
70	Gallbladder cancer	Enrichment	PIK3CA	1.89
71	Overgrowth syndrome	Enrichment	PIK3R1	1.89
72	Arteriovenous malformation	Enrichment	PIK3CA	1.78
73	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.78
74	Bilateral perisylvian polymicrogyria	Enrichment	PI4KA	1.78
75	Cowden syndrome	Enrichment	PIK3CA	1.78
76	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.74
77	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.70
78	Meningioma	Enrichment	PIK3CA	1.66
79	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.66
80	Nk-cell enteropathy	Enrichment	PIK3CB	1.63
81	Lynch syndrome	Enrichment	PIK3CA	1.56
82	Charcot-marie-tooth disease type 4	Enrichment	FIG4	1.49
83	Endometrial cancer	Enrichment	PIK3CA	1.42
84	Hepatocellular carcinoma	Enrichment	PIK3CA	1.40
85	Bladder cancer	Enrichment	PIK3CA	1.28
86	Prostate cancer	Enrichment	PIK3CA	1.28
87	Lung cancer	Enrichment	PIK3CA	1.24
88	Charcot-marie-tooth disease	Enrichment	FIG4	1.14
89	Gastric cancer	Enrichment	PIK3CA	1.12
90	Hereditary breast carcinoma	Enrichment	PIK3CA	1.11
91	Hypertelorism	Enrichment	PIK3CA	1.04
92	Myeloma, multiple	Enrichment	PIK3R2	1.01
93	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	FIG4	0.99
94	Breast cancer	Enrichment	PIK3CA	0.89
95	Ovarian cancer	Enrichment	PIK3CA	0.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

3-phosphoinositide biosynthesis

Pathway Network for 3-phosphoinositide biosynthesis

Member Pathways for 3-phosphoinositide biosynthesis

Pathways in the 3-phosphoinositide biosynthesis SuperPath

Associated Genes for 3-phosphoinositide biosynthesis

Associated Disorders for 3-phosphoinositide biosynthesis

Disorders associated with 3-phosphoinositide biosynthesis SuperPath

STRING Interaction Network for 3-phosphoinositide biosynthesis

Sources for 3-phosphoinositide biosynthesis