4-aminobutanoate degradation I

Sources:

#	Name	Source	Genes
1	4-aminobutanoate degradation I	PubChem	ABAT ALDH5A1
2	GABA metabolism (aka GHB)	WikiPathways	ABAT ADHFE1 AKR7A2 ALDH5A1 DPEP1 GAD1 GAD2 GLS GLS2 MAOB PON3 (see all 11) (see less)
3	GABA shunt	PubChem	ABAT ALDH5A1 GAD1 GAD2 GLUD1 GLUD2 (see all 6) (see less)
4	glutamine degradation/glutamate biosynthesis	PubChem	GLS GLS2
5	4-aminobutyrate degradation	PubChem	ABAT ALDH5A1
6	L-glutamate biosynthesis II	PubChem	GLUD1 GLUD2
7	Degradation of GABA	Reactome	ABAT ALDH5A1
8	L-glutamate degradation X	PubChem	GLUD1 GLUD2
9	glutamate biosynthesis/degradation	PubChem	GLUD1 GLUD2
10	β-alanine degradation	PubChem	ABAT

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABAT	4-Aminobutyrate Aminotransferase	Protein Coding	6
2	ALDH5A1	Aldehyde Dehydrogenase 5 Family Member A1	Protein Coding	5
3	GLUD2	Glutamate Dehydrogenase 2	Protein Coding	4
4	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	4
5	GAD1	Glutamate Decarboxylase 1	Protein Coding	2
6	GAD2	Glutamate Decarboxylase 2	Protein Coding	2
7	GLS	Glutaminase	Protein Coding	2
8	GLS2	Glutaminase 2	Protein Coding	2
9	AKR7A2	Aldo-Keto Reductase Family 7 Member A2	Protein Coding	1
10	MAOB	Monoamine Oxidase B	Protein Coding	1
11	ADHFE1	Alcohol Dehydrogenase Iron Containing 1	Protein Coding	1
12	DPEP1	Dipeptidase 1	Protein Coding	1
13	PON3	Paraoxonase 3	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gaba aminotransferase deficiency	Enrichment	ABAT	4.13
2	Gaba-transaminase deficiency	Enrichment	ABAT	4.13
3	Casgid syndrome	Enrichment	GLS	3.83
4	Developmental and epileptic encephalopathy 71	Enrichment	GLS	3.83
5	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	3.83
6	Hyperinsulinemic hypoglycemia, familial, 6	Enrichment	GLUD1	3.83
7	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	3.53
8	Succinic semialdehyde dehydrogenase deficiency	Enrichment	ALDH5A1	3.35
9	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	3.35
10	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GLUD1	3.05
11	Nonsyndromic genetic hyperinsulinism	Enrichment	GLUD1	3.05
12	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	2.75
13	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	2.75
14	Esophageal atresia/tracheoesophageal fistula	Enrichment	GLS	2.55
15	Fetal akinesia deformation sequence 1	Enrichment	ALDH5A1	2.26
16	Distal arthrogryposis	Enrichment	ALDH5A1	2.21
17	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLUD2	2.08
18	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PON3	1.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for 4-aminobutanoate degradation I