Dabigatran Pathway, Pharmacokinetics/Pharmacodynamics

Sources:

#	Name	Source	Genes
1	Dabigatran Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CES1 CES2 F2 UGT1A9 UGT2B15 UGT2B7 (see all 6) (see less)
2	Heroin metabolism	WikiPathways	CES1 CES2
3	Methylphenidate Pathway, Pharmacokinetics	PharmGKB	CES1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CES1	Carboxylesterase 1	Protein Coding	3
2	CES2	Carboxylesterase 2	Protein Coding	2
3	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
4	UGT2B15	UDP Glucuronosyltransferase Family 2 Member B15	Protein Coding	1
5	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	1
6	F2	Coagulation Factor II, Thrombin	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Drug metabolism, altered, ces1-related	Enrichment	CES1	4.13
2	Prothrombin deficiency, congenital	Enrichment	F2	3.35
3	Pregnancy loss, recurrent 2	Enrichment	F2	3.35
4	Prothrombin deficiency	Enrichment	F2	3.35
5	Cerebral sinovenous thrombosis	Enrichment	F2	2.88
6	Thrombophilia due to thrombin defect	Enrichment	F2	2.51
7	Crigler-najjar syndrome, type i	Enrichment	UGT1A9	2.35
8	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A9	2.35
9	Stroke, ischemic	Enrichment	F2	2.35
10	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A9	2.35
11	Crigler-najjar syndrome, type ii	Enrichment	UGT1A9	2.35
12	Gilbert syndrome	Enrichment	UGT1A9	2.31
13	Bilirubin metabolic disorder	Enrichment	UGT1A9	2.31
14	Cerebral palsy	Enrichment	F2	1.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Dabigatran Pathway, Pharmacokinetics/Pharmacodynamics