A-beta Plaque Formation and APP Metabolism

No Pathway Network information available for A-beta Plaque Formation and APP Metabolism

Pathways in the A-beta Plaque Formation and APP Metabolism SuperPath

#	Name	Source	Genes
1	A-beta Plaque Formation and APP Metabolism	R&D Systems	ACE ACE2 ADAM10 ADAM17 ADAM9 APH1A APP APPL1 BACE1 CST3 CTSB CTSD IDE MME MMEL1 MMP2 MMP9 NCSTN PLAT PLG PSEN1 PSEN2 PSENEN (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APP	Amyloid Beta Precursor Protein	Protein Coding	1
2	ACE	Angiotensin I Converting Enzyme	Protein Coding	1
3	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
4	IDE	Insulin Degrading Enzyme	Protein Coding	1
5	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
6	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
7	MME	Membrane Metalloendopeptidase	Protein Coding	1
8	MMEL1	Membrane Metalloendopeptidase Like 1	Protein Coding	1
9	PLG	Plasminogen	Protein Coding	1
10	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	1
11	CST3	Cystatin C	Protein Coding	1
12	CTSB	Cathepsin B	Protein Coding	1
13	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
14	ADAM9	ADAM Metallopeptidase Domain 9	Protein Coding	1
15	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
16	APPL1	Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1	Protein Coding	1
17	PSEN1	Presenilin 1	Protein Coding	1
18	PSEN2	Presenilin 2	Protein Coding	1
19	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
20	NCSTN	Nicastrin	Protein Coding	1
21	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
22	BACE1	Beta-Secretase 1	Protein Coding	1
23	CTSD	Cathepsin D	Protein Coding	1

Disorders associated with A-beta Plaque Formation and APP Metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Early-onset autosomal dominant alzheimer disease	Enrichment	APP, PSEN1, PSEN2	6.83
2	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP, CST3	5.56
3	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	5.08
4	Alzheimer's disease	Enrichment	APP, PSEN1	3.67
5	Alzheimer disease, familial, 1	Enrichment	APP, PSEN1	3.43
6	Keratolytic winter erythema	Enrichment	CTSB	2.77
7	Macular degeneration, age-related, 11	Enrichment	CST3	2.77
8	Cone-rod dystrophy 9	Enrichment	ADAM9	2.77
9	Acne inversa, familial, 1	Enrichment	NCSTN	2.77
10	Spinocerebellar ataxia 43	Enrichment	MME	2.77
11	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	2.77
12	Microvascular complications of diabetes 3	Enrichment	ACE	2.77
13	Angioedema, hereditary, 4	Enrichment	PLG	2.77
14	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.77
15	Alzheimer disease 18	Enrichment	ADAM10	2.77
16	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.77
17	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.77
18	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.77
19	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.77
20	Acne inversa, familial, 3	Enrichment	PSEN1	2.77
21	Maturity-onset diabetes of the young, type 14	Enrichment	APPL1	2.77
22	Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization	Enrichment	MME	2.77
23	Leukodystrophy, adult-onset, autosomal dominant, without amyloid angiopathy	Enrichment	CST3	2.77
24	Charcot-marie-tooth disease type 2t	Enrichment	MME	2.77
25	Mme-related autosomal dominant charcot marie tooth disease type 2	Enrichment	MME	2.77
26	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.77
27	Pash syndrome	Enrichment	NCSTN	2.77
28	Huntington's disease-like	Enrichment	PSEN2	2.77
29	Plasminogen deficiency, type i	Enrichment	PLG	2.47
30	Alzheimer disease 3	Enrichment	PSEN1	2.47
31	Pick disease of brain	Enrichment	PSEN1	2.47
32	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.47
33	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.47
34	Hereditary angioedema	Enrichment	PLG	2.47
35	Charcot-marie-tooth disease, axonal, type 2t	Enrichment	MME	2.47
36	Metaphyseal anadysplasia	Enrichment	MMP9	2.47
37	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	2.44
38	Angioedema, hereditary, 1	Enrichment	PLG	2.29
39	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.29
40	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.29
41	Dowling-degos disease 1	Enrichment	ADAM10	2.17
42	Dowling-degos disease	Enrichment	PSENEN	2.17
43	Dementia	Enrichment	PSEN1	2.07
44	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.99
45	Renal tubular dysgenesis	Enrichment	ACE	1.99
46	Hemorrhage, intracerebral	Enrichment	ACE	1.99
47	Semantic dementia	Enrichment	PSEN1	1.93
48	Alzheimer's disease 1	Enrichment	APP	1.93
49	Progressive non-fluent aphasia	Enrichment	PSEN1	1.82
50	Primary biliary cholangitis	Enrichment	MMEL1	1.82
51	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.82
52	Stroke, ischemic	Enrichment	ACE	1.77
53	Frontotemporal dementia 1	Enrichment	PSEN1	1.73
54	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	1.60
55	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MME	1.50
56	Maturity-onset diabetes of the young	Enrichment	APPL1	1.48
57	Myocardial infarction	Enrichment	ACE	1.44
58	Skin disease	Enrichment	NCSTN	1.44
59	Cystic fibrosis	Enrichment	PLG	1.28
60	Peripheral nervous system disease	Enrichment	MME	1.28
61	Neuropathy	Enrichment	MME	1.28
62	Cakut	Enrichment	ACE	1.25
63	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	1.03
64	Cone-rod dystrophy 2	Enrichment	ADAM9	0.96
65	Congenital nervous system abnormality	Enrichment	PSEN1	0.78
66	Nervous system disease	Enrichment	PSEN1	0.78
67	Retinitis pigmentosa	Enrichment	ADAM9	0.52
68	Hereditary retinal dystrophy	Enrichment	ADAM9	0.41
69	Fundus dystrophy	Enrichment	ADAM9	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

A-beta Plaque Formation and APP Metabolism

Pathway Network for A-beta Plaque Formation and APP Metabolism

Member Pathways for A-beta Plaque Formation and APP Metabolism

Pathways in the A-beta Plaque Formation and APP Metabolism SuperPath

Associated Genes for A-beta Plaque Formation and APP Metabolism

Associated Disorders for A-beta Plaque Formation and APP Metabolism

Disorders associated with A-beta Plaque Formation and APP Metabolism SuperPath

STRING Interaction Network for A-beta Plaque Formation and APP Metabolism

Sources for A-beta Plaque Formation and APP Metabolism