A-beta Uptake and Degradation

No Pathway Network information available for A-beta Uptake and Degradation

Pathways in the A-beta Uptake and Degradation SuperPath

#	Name	Source	Genes
1	A-beta Uptake and Degradation	R&D Systems	A2M ACE ACE2 AGER APOE APP APPL1 C3AR1 CCL2 CCR2 CD14 CD36 CD40 CD40LG CD47 CX3CL1 CX3CR1 ECE1 ECE2 FPR2 IDE LDLR LRP1 LY96 MARCO MME MMEL1 MMP2 MMP9 MSR1 PTPRC TLR4 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MARCO	Macrophage Receptor With Collagenous Structure	Protein Coding	1
2	APP	Amyloid Beta Precursor Protein	Protein Coding	1
3	LRP1	LDL Receptor Related Protein 1	Protein Coding	1
4	APOE	Apolipoprotein E	Protein Coding	1
5	LDLR	Low Density Lipoprotein Receptor	Protein Coding	1
6	ACE	Angiotensin I Converting Enzyme	Protein Coding	1
7	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
8	IDE	Insulin Degrading Enzyme	Protein Coding	1
9	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
10	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
11	MME	Membrane Metalloendopeptidase	Protein Coding	1
12	MMEL1	Membrane Metalloendopeptidase Like 1	Protein Coding	1
13	ECE1	Endothelin Converting Enzyme 1	Protein Coding	1
14	ECE2	Endothelin Converting Enzyme 2	Protein Coding	1
15	FPR2	Formyl Peptide Receptor 2	Protein Coding	1
16	CD47	CD47 Molecule	Protein Coding	1
17	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
18	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
19	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	1
20	MSR1	Macrophage Scavenger Receptor 1	Protein Coding	1
21	TLR4	Toll Like Receptor 4	Protein Coding	1
22	LY96	Lymphocyte Antigen 96	Protein Coding	1
23	CD14	CD14 Molecule	Protein Coding	1
24	C3AR1	Complement C3a Receptor 1	Protein Coding	1
25	CD40	CD40 Molecule	Protein Coding	1
26	CD40LG	CD40 Ligand	Protein Coding	1
27	A2M	Alpha-2-Macroglobulin	Protein Coding	1
28	APPL1	Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1	Protein Coding	1
29	CX3CL1	C-X3-C Motif Chemokine Ligand 1	Protein Coding	1
30	CX3CR1	C-X3-C Motif Chemokine Receptor 1	Protein Coding	1
31	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
32	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	1

Disorders associated with A-beta Uptake and Degradation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperlipoproteinemia, type iii	Enrichment	APOE, LDLR	5.27
2	Human immunodeficiency virus type 1	Enrichment	CCL2, CCR2, CX3CR1	5.02
3	Lipid metabolism disorder	Enrichment	APOE, LDLR	4.09
4	Alzheimer's disease	Enrichment	APOE, APP	3.38
5	Familial hypercholesterolemia	Enrichment	APOE, LDLR	3.26
6	Alzheimer disease, familial, 1	Enrichment	APOE, APP	3.14
7	Atrophoderma vermiculata	Enrichment	LRP1	2.63
8	Sea-blue histiocyte disease	Enrichment	APOE	2.63
9	Coronary heart disease 7	Enrichment	CD36	2.63
10	Lipoprotein glomerulopathy	Enrichment	APOE	2.63
11	Polycystic lung disease	Enrichment	CCR2	2.63
12	Keratosis pilaris atrophicans	Enrichment	LRP1	2.63
13	Spinocerebellar ataxia 43	Enrichment	MME	2.63
14	Microvascular complications of diabetes 3	Enrichment	ACE	2.63
15	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.63
16	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.63
17	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.63
18	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.63
19	Hirschsprung disease, cardiac defects, and autonomic dysfunction	Enrichment	ECE1	2.63
20	Macular degeneration, age-related, 10	Enrichment	TLR4	2.63
21	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.63
22	Macular degeneration, age-related, 12	Enrichment	CX3CR1	2.63
23	Maturity-onset diabetes of the young, type 14	Enrichment	APPL1	2.63
24	Cd45 deficiency	Enrichment	PTPRC	2.63
25	Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization	Enrichment	MME	2.63
26	Charcot-marie-tooth disease type 2t	Enrichment	MME	2.63
27	Mme-related autosomal dominant charcot marie tooth disease type 2	Enrichment	MME	2.63
28	Cd40 ligand deficiency	Enrichment	CD40LG	2.63
29	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.33
30	Alzheimer disease 3	Enrichment	APOE	2.33
31	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.33
32	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.33
33	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.33
34	Charcot-marie-tooth disease, axonal, type 2t	Enrichment	MME	2.33
35	Metaphyseal anadysplasia	Enrichment	MMP9	2.33
36	Hypercholesterolemia, familial, 2	Enrichment	LDLR	2.15
37	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.15
38	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.15
39	Alzheimer disease 4	Enrichment	APOE	2.15
40	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.15
41	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.15
42	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.15
43	Macular degeneration, age-related, 1	Enrichment	APOE	2.03
44	Barrett esophagus	Enrichment	MSR1	2.03
45	Blood platelet disease	Enrichment	CD36	2.03
46	Cerebral malaria	Enrichment	CD36	2.03
47	Alzheimer disease 2	Enrichment	APOE	1.93
48	Hyperlipidemia, familial combined, 3	Enrichment	LDLR	1.93
49	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1	1.93
50	Cowden syndrome 1	Enrichment	LDLR	1.85
51	Renal tubular dysgenesis	Enrichment	ACE	1.85
52	Hemorrhage, intracerebral	Enrichment	ACE	1.85
53	Alzheimer's disease 1	Enrichment	APP	1.79
54	Common variable immunodeficiency	Enrichment	CD40LG	1.79
55	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.79
56	Homozygous familial hypercholesterolemia	Enrichment	LDLR	1.73
57	Coronary heart disease 5	Enrichment	LDLR	1.68
58	Primary biliary cholangitis	Enrichment	MMEL1	1.68
59	Stroke, ischemic	Enrichment	ACE	1.63
60	Hypercholesterolemia, familial, 1	Enrichment	LDLR	1.52
61	Hypertension, essential	Enrichment	ECE1	1.40
62	Behcet syndrome	Enrichment	TLR4	1.36
63	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MME	1.36
64	Maturity-onset diabetes of the young	Enrichment	APPL1	1.34
65	Myocardial infarction	Enrichment	ACE	1.30
66	Malaria	Enrichment	CD36	1.28
67	Hirschsprung disease 1	Enrichment	ECE1	1.18
68	Prostate cancer	Enrichment	MSR1	1.18
69	Peripheral nervous system disease	Enrichment	MME	1.14
70	Neuropathy	Enrichment	MME	1.14
71	Severe combined immunodeficiency	Enrichment	PTPRC	1.12
72	Cakut	Enrichment	ACE	1.11
73	Ovarian cancer	Enrichment	MSR1	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

A-beta Uptake and Degradation

Pathway Network for A-beta Uptake and Degradation

Member Pathways for A-beta Uptake and Degradation

Pathways in the A-beta Uptake and Degradation SuperPath

Associated Genes for A-beta Uptake and Degradation

Associated Disorders for A-beta Uptake and Degradation

Disorders associated with A-beta Uptake and Degradation SuperPath

STRING Interaction Network for A-beta Uptake and Degradation

Sources for A-beta Uptake and Degradation