a4b7 Integrin signaling
Pathways in the a4b7 Integrin signaling SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | a4b7 Integrin signaling | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | MADCAM1 | Mucosal Vascular Addressin Cell Adhesion Molecule 1 | Protein Coding | 1 |
| 2 | ITGB7 | Integrin Subunit Beta 7 | Protein Coding | 1 |
| 3 | VCAM1 | Vascular Cell Adhesion Molecule 1 | Protein Coding | 1 |
| 4 | ITGA4 | Integrin Subunit Alpha 4 | Protein Coding | 1 |
| 5 | PXN | Paxillin | Protein Coding | 1 |
| 6 | PTK2 | Protein Tyrosine Kinase 2 | Protein Coding | 1 |
| 7 | ITGB1 | Integrin Subunit Beta 1 | Protein Coding | 1 |
| 8 | RHOA | Ras Homolog Family Member A | Protein Coding | 1 |
Disorders associated with a4b7 Integrin signaling SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies | Enrichment | RHOA | 3.23 |
| 2 | Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies | Enrichment | RHOA | 3.23 |
| 3 | Retinitis pigmentosa 26 | Enrichment | ITGA4 | 2.63 |
| 4 | Hemihyperplasia, isolated | Enrichment | RHOA | 2.45 |
| 5 | Neural tube defects | Enrichment | ITGB1 | 2.12 |
| 6 | Isolated macular dystrophy | Enrichment | ITGA4 | 2.08 |
| 7 | Cone-rod dystrophy 2 | Enrichment | ITGA4 | 1.40 |
| 8 | Hereditary retinal dystrophy | Enrichment | ITGA4 | 0.80 |
| 9 | Fundus dystrophy | Enrichment | ITGA4 | 0.80 |
