a6b1 and a6b4 Integrin signaling

No Pathway Network information available for a6b1 and a6b4 Integrin signaling

Pathways in the a6b1 and a6b4 Integrin signaling SuperPath

#	Name	Source	Genes
1	a6b1 and a6b4 Integrin signaling	PubChem	AKT1 CASP3 CASP7 CD9 CDH1 COL17A1 EGF EGFR ERBB2 ERBB3 GRB2 HRAS IL1A ITGA6 ITGB1 ITGB4 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 MET MST1 MST1R PIK3CA PIK3R1 PMP22 PRKCA RAC1 RPS6KB1 SFN SHC1 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
2	PMP22	Peripheral Myelin Protein 22	Protein Coding	1
3	IL1A	Interleukin 1 Alpha	Protein Coding	1
4	MST1	Macrophage Stimulating 1	Protein Coding	1
5	MST1R	Macrophage Stimulating 1 Receptor	Protein Coding	1
6	EGF	Epidermal Growth Factor	Protein Coding	1
7	CASP7	Caspase 7	Protein Coding	1
8	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
9	CD9	CD9 Molecule	Protein Coding	1
10	LAMA4	Laminin Subunit Alpha 4	Protein Coding	1
11	LAMB2	Laminin Subunit Beta 2	Protein Coding	1
12	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
13	LAMA2	Laminin Subunit Alpha 2	Protein Coding	1
14	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	1
15	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
16	LAMC2	Laminin Subunit Gamma 2	Protein Coding	1
17	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
18	LAMB3	Laminin Subunit Beta 3	Protein Coding	1
19	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
20	CDH1	Cadherin 1	Protein Coding	1
21	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
22	LAMA1	Laminin Subunit Alpha 1	Protein Coding	1
23	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
24	PRKCA	Protein Kinase C Alpha	Protein Coding	1
25	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
26	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
27	RAC1	Rac Family Small GTPase 1	Protein Coding	1
28	SFN	Stratifin	Protein Coding	1
29	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
30	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
31	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
32	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
33	SHC1	SHC Adaptor Protein 1	Protein Coding	1
34	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
35	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
36	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
37	CASP3	Caspase 3	Protein Coding	1

Disorders associated with a6b1 and a6b4 Integrin signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	COL17A1, ITGB4, LAMA3, LAMB3, LAMC2	10.63
2	Junctional epidermolysis bullosa non-herlitz type	Enrichment	COL17A1, ITGB4, LAMA3, LAMB3, LAMC2	10.63
3	Junctional epidermolysis bullosa	Enrichment	COL17A1, ITGA6, ITGB4, LAMA3, LAMB3, LAMC2	10.62
4	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, HRAS, PIK3CA	7.89
5	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, PIK3CA	7.82
6	Colorectal cancer	Enrichment	AKT1, CDH1, ERBB2, MET, PIK3CA, PIK3R1	6.94
7	Ovarian cancer	Enrichment	AKT1, CDH1, EGFR, ERBB2, MET, PIK3CA	6.55
8	Skin disease	Enrichment	COL17A1, ITGB4, LAMB3, LAMC2	6.48
9	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3, LAMB3, LAMC2	6.43
10	Lung cancer	Enrichment	EGFR, ERBB2, MET, PIK3CA	5.80
11	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	5.39
12	Multiple sclerosis	Enrichment	ITGB4, LAMA5, LAMB1	5.18
13	Amelogenesis imperfecta, type ia	Enrichment	COL17A1, LAMB3	5.14
14	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	COL17A1, ITGB4	5.14
15	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.66
16	Breast cancer	Enrichment	AKT1, CDH1, PIK3CA, SHC1	4.30
17	Epidermolysis bullosa	Enrichment	ITGA6, LAMB3	4.14
18	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.97
19	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	3.97
20	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.97
21	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	3.97
22	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.82
23	Gastric cancer	Enrichment	CDH1, ERBB2, PIK3CA	3.67
24	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, PIK3CA	3.64
25	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.59
26	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.59
27	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.59
28	Amelogenesis imperfecta, type ie	Enrichment	COL17A1, LAMB3	3.49
29	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.49
30	Meningioma	Enrichment	AKT1, PIK3CA	3.33
31	Amelogenesis imperfecta	Enrichment	COL17A1, LAMB3	3.26
32	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2	3.19
33	Endometrial cancer	Enrichment	CDH1, PIK3CA	2.83
34	Hepatocellular carcinoma	Enrichment	MET, PIK3CA	2.79
35	Charcot-marie-tooth disease and deafness	Enrichment	PMP22	2.56
36	Erythroleukemia, familial	Enrichment	ERBB3	2.56
37	Macrodactyly	Enrichment	PIK3CA	2.56
38	Proteus syndrome	Enrichment	AKT1	2.56
39	Paget disease, extramammary	Enrichment	ERBB2	2.56
40	Guillain-barre syndrome, familial	Enrichment	PMP22	2.56
41	Hypomagnesemia 4, renal	Enrichment	EGF	2.56
42	Neuropathy, hereditary, with liability to pressure palsies	Enrichment	PMP22	2.56
43	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.56
44	Cardiomyopathy, dilated, 1jj	Enrichment	LAMA4	2.56
45	Cowden syndrome 5	Enrichment	PIK3CA	2.56
46	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.56
47	Lissencephaly 5	Enrichment	LAMB1	2.56
48	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.56
49	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.56
50	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.56
51	Short syndrome	Enrichment	PIK3R1	2.56
52	Osteofibrous dysplasia	Enrichment	MET	2.56
53	Deafness, autosomal recessive 97	Enrichment	MET	2.56
54	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.56
55	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.56
56	Autism 9	Enrichment	MET	2.56
57	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.56
58	Cowden syndrome 6	Enrichment	AKT1	2.56
59	Nasopharyngeal carcinoma 3	Enrichment	MST1R	2.56
60	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.56
61	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.56
62	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.56
63	Arthrogryposis, distal, type 11	Enrichment	MET	2.56
64	Late-onset junctional epidermolysis bullosa	Enrichment	COL17A1	2.56
65	Hypospadias	Enrichment	PIK3CA	2.56
66	Breast lobular carcinoma	Enrichment	CDH1	2.56
67	Rare venous malformation	Enrichment	PIK3CA	2.56
68	Diaphragmatic eventration	Enrichment	PIK3CA	2.56
69	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.56
70	Rare combined vascular malformation	Enrichment	PIK3CA	2.56
71	Cavernous lymphangioma	Enrichment	PIK3CA	2.56
72	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.56
73	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.56
74	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.56
75	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.56
76	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.56
77	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.56
78	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.56
79	Macrodactyly of toe	Enrichment	PIK3CA	2.56
80	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.56
81	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	2.56
82	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3	2.55
83	Prostate cancer	Enrichment	CDH1, PIK3CA	2.55
84	Charcot-marie-tooth disease, demyelinating, type 1a	Enrichment	PMP22	2.26
85	Amelogenesis imperfecta, type ib	Enrichment	COL17A1	2.26
86	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.26
87	Costello syndrome	Enrichment	HRAS	2.26
88	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	2.26
89	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.26
90	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	2.26
91	Keratosis, seborrheic	Enrichment	PIK3CA	2.26
92	Lissencephaly 1	Enrichment	LAMB1	2.26
93	Epithelial recurrent erosion dystrophy	Enrichment	COL17A1	2.26
94	Roussy-levy hereditary areflexic dystasia	Enrichment	PMP22	2.26
95	Noonan syndrome 8	Enrichment	PIK3CA	2.26
96	Pierson syndrome	Enrichment	LAMB2	2.26
97	Epidermolysis bullosa, junctional 3b, severe	Enrichment	LAMC2	2.26
98	Epidermolysis bullosa, junctional 3a, intermediate	Enrichment	LAMC2	2.26
99	Epidermolysis bullosa, junctional 4, intermediate	Enrichment	COL17A1	2.26
100	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.26
101	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	2.26
102	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.26
103	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	2.26
104	Childhood hepatocellular carcinoma	Enrichment	MET	2.26
105	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.26
106	Charcot-marie-tooth disease type 1a	Enrichment	PMP22	2.26
107	Papillary renal cell carcinoma	Enrichment	MET	2.26
108	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	2.26
109	Wooly hair nevus	Enrichment	HRAS	2.26
110	Inherited cancer-predisposing syndrome	Enrichment	CDH1, EGFR, MET	2.26
111	Charcot-marie-tooth disease	Enrichment	LAMA2, PMP22	2.26
112	Nephrotic syndrome	Enrichment	LAMA5, LAMB2	2.22
113	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.09
114	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	2.09
115	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.09
116	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.09
117	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	2.09
118	Large congenital melanocytic nevus	Enrichment	HRAS	2.09
119	Poretti-boltshauser syndrome	Enrichment	LAMA1	2.09
120	Immunodeficiency 14	Enrichment	PIK3R1	2.09
121	Charcot-marie-tooth disease type 1	Enrichment	PMP22	2.09
122	Spermatocytoma	Enrichment	HRAS	2.09
123	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.09
124	Renal cell carcinoma	Enrichment	MET	2.09
125	Keratoacanthoma	Enrichment	PIK3CA	2.09
126	Lama2-related muscular dystrophy	Enrichment	LAMA2	2.09
127	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.96
128	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.96
129	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.96
130	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.96
131	Barrett esophagus	Enrichment	ERBB2	1.96
132	Cerebrovascular disease	Enrichment	PIK3CA	1.96
133	Corneal dystrophy	Enrichment	COL17A1	1.96
134	Epidermolytic nevus	Enrichment	HRAS	1.96
135	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.96
136	Hypertrophic neuropathy of dejerine-sottas	Enrichment	PMP22	1.87
137	Capillary malformations, congenital	Enrichment	PIK3CA	1.87
138	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.87
139	Cholangitis, primary sclerosing	Enrichment	MST1	1.87
140	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	1.87
141	Aplasia cutis congenita	Enrichment	ITGB4	1.87
142	Hemimegalencephaly	Enrichment	PIK3CA	1.87
143	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.79
144	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.79
145	Cleft lip with or without cleft palate	Enrichment	CDH1	1.79
146	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.72
147	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.72
148	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.72
149	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.72
150	Noonan syndrome 3	Enrichment	HRAS	1.72
151	Gallbladder cancer	Enrichment	PIK3CA	1.72
152	Follicular thyroid carcinoma	Enrichment	HRAS	1.72
153	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.72
154	Overgrowth syndrome	Enrichment	PIK3R1	1.72
155	Arthrogryposis, distal, type 1a	Enrichment	MET	1.67
156	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.67
157	Glioma susceptibility 1	Enrichment	ERBB2	1.67
158	Congenital muscular dystrophy	Enrichment	LAMA2	1.67
159	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.61
160	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.57
161	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	1.53
162	Neural tube defects	Enrichment	ITGB1	1.46
163	Cleft lip/palate	Enrichment	CDH1	1.43
164	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.40
165	Lynch syndrome	Enrichment	PIK3CA	1.40
166	Kidney disease	Enrichment	LAMB2	1.40
167	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.40
168	Creatine phosphokinase, elevated serum	Enrichment	LAMA2	1.37
169	Isolated elevated serum creatine phosphokinase levels	Enrichment	LAMA2	1.37
170	Rhabdomyosarcoma	Enrichment	HRAS	1.37
171	Gliosarcoma	Enrichment	EGFR	1.37
172	Giant cell glioblastoma	Enrichment	EGFR	1.34
173	Arteriovenous malformations of the brain	Enrichment	EGFR	1.30
174	Noonan syndrome 1	Enrichment	HRAS	1.22
175	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.16
176	Rasopathy	Enrichment	HRAS	1.16
177	Differentiated thyroid carcinoma	Enrichment	HRAS	1.12
178	Non-immune hydrops fetalis	Enrichment	HRAS	1.09
179	Peripheral nervous system disease	Enrichment	PMP22	1.08
180	Neuropathy	Enrichment	PMP22	1.08
181	Genetic steroid-resistant nephrotic syndrome	Enrichment	LAMA5	1.05
182	Hypertelorism	Enrichment	PIK3CA	0.88
183	Familial isolated dilated cardiomyopathy	Enrichment	LAMA4	0.87
184	Myeloma, multiple	Enrichment	MST1R	0.85
185	Dilated cardiomyopathy	Enrichment	LAMA2	0.71
186	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.66
187	Hereditary retinal dystrophy	Enrichment	LAMA1	0.26
188	Fundus dystrophy	Enrichment	LAMA1	0.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

a6b1 and a6b4 Integrin signaling

Pathway Network for a6b1 and a6b4 Integrin signaling

Member Pathways for a6b1 and a6b4 Integrin signaling

Pathways in the a6b1 and a6b4 Integrin signaling SuperPath

Associated Genes for a6b1 and a6b4 Integrin signaling

Associated Disorders for a6b1 and a6b4 Integrin signaling

Disorders associated with a6b1 and a6b4 Integrin signaling SuperPath

STRING Interaction Network for a6b1 and a6b4 Integrin signaling

Sources for a6b1 and a6b4 Integrin signaling