activated TAK1 mediates p38 MAPK activation

No Pathway Network information available for activated TAK1 mediates p38 MAPK activation

Pathways in the activated TAK1 mediates p38 MAPK activation SuperPath

#	Name	Source	Genes
1	activated TAK1 mediates p38 MAPK activation	Reactome	IKBKG IRAK1 IRAK2 MAP2K3 MAP2K6 MAP3K7 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 NOD1 NOD2 RIPK2 RPS27A TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 23) (see less)
2	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Reactome	IKBKG IRAK1 IRAK2 MAP2K4 MAP2K7 MAP3K7 MAPK10 MAPK8 MAPK9 NOD1 NOD2 RIPK2 RPS27A TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	2
2	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
3	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
4	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	2
5	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
6	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	2
7	RPS27A	Ribosomal Protein S27a	Protein Coding	2
8	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	2
9	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
10	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
11	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
12	UBB	Ubiquitin B	Protein Coding	2
13	UBC	Ubiquitin C	Protein Coding	2
14	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
15	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	2
16	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
17	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
18	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
19	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
20	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
21	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
22	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
23	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
24	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
25	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
26	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
27	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
28	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1

Disorders associated with activated TAK1 mediates p38 MAPK activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Malaria	Enrichment	IKBKG, MAPKAPK3	3.17
2	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.79
3	Incontinentia pigmenti	Enrichment	IKBKG	2.79
4	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.79
5	Blau syndrome	Enrichment	NOD2	2.79
6	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.79
7	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.79
8	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.79
9	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.77
10	Immunodeficiency 33	Enrichment	IKBKG	2.49
11	Yao syndrome	Enrichment	NOD2	2.49
12	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.49
13	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.49
14	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.49
15	Crohn's disease	Enrichment	NOD2	2.49
16	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.49
17	Submucosal cleft palate	Enrichment	UBB	2.49
18	Cleft hard palate	Enrichment	UBB	2.49
19	Pelvic organ prolapse	Enrichment	TAB2	2.31
20	Uvula, bifid	Enrichment	UBB	2.31
21	Cleft soft palate	Enrichment	UBB	2.31
22	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.31
23	Bacteremia 2	Enrichment	MAPKAPK3	2.29
24	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.19
25	Tuberculosis	Enrichment	MAPKAPK3	2.17
26	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.09
27	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.09
28	Lennox-gastaut syndrome	Enrichment	MAPK10	1.89
29	Inflammatory bowel disease 1	Enrichment	NOD2	1.84
30	Coronary heart disease 5	Enrichment	IKBKG	1.84
31	Migraine with or without aura 1	Enrichment	TAB2	1.75
32	Aortic valve disease 1	Enrichment	TAB2	1.68
33	Patent foramen ovale	Enrichment	TAB2	1.54
34	Behcet syndrome	Enrichment	NOD2	1.52
35	Autoinflammatory disease	Enrichment	NOD2	1.42
36	Systemic lupus erythematosus	Enrichment	IRAK1	1.21
37	Dilated cardiomyopathy	Enrichment	TAB2	0.91

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

activated TAK1 mediates p38 MAPK activation

Pathway Network for activated TAK1 mediates p38 MAPK activation

Member Pathways for activated TAK1 mediates p38 MAPK activation

Pathways in the activated TAK1 mediates p38 MAPK activation SuperPath

Associated Genes for activated TAK1 mediates p38 MAPK activation

Associated Disorders for activated TAK1 mediates p38 MAPK activation

Disorders associated with activated TAK1 mediates p38 MAPK activation SuperPath

STRING Interaction Network for activated TAK1 mediates p38 MAPK activation

Sources for activated TAK1 mediates p38 MAPK activation