Activation of NF-KappaB by PKR

Pathway network for the Activation of NF-KappaB by PKR SuperPath

Sources:

QIAGEN
WikiPathways

Pathways in the Activation of NF-KappaB by PKR SuperPath

#	Name	Source	Genes
1	Activation of NF-KappaB by PKR	QIAGEN	CHUK CREBBP EIF2AK2 EIF2S1 EP300 IFNG IFNGR1 IKBKB IKBKE IKBKG NFKB1 NFKBIA NFKBIB NFKBIE PRKRA REL RELA (see all 17) (see less)
2	Cellular Transformation by HTLV1	QIAGEN	CHUK CREB1 CREBBP DNAJA3 FOS HSPA1A HSPA1B HSPA4 HSPA8 IFNG IFNGR1 IFNGR2 IKBKB IKBKE IKBKG JAK2 JUN KAT2B LTA MAPK10 MAPK8 MAPK9 NFKB1 NFKBIA NFKBIB NFKBIE RELA SLC2A1 SRF TAX1BP3 TNF TNFRSF1A TNFRSF1B VAC14 (see all 34) (see less)
3	STING pathway in Kawasaki-like disease and COVID-19	WikiPathways	CGAS CHUK F3 FCGR2A GSDMD IFNB1 IKBKB IKBKE IKBKG IL1B IRF3 ITPR1 NFKB1 NFKBIA NFKBIE NLRP3 NLRX1 REL RELA STING1 TBK1 (see all 21) (see less)
4	Canonical NF-kB pathway	WikiPathways	CHUK IKBKB IKBKG NFKB1 NFKBIA NFKBIE REL (see all 7) (see less)

Gene overlap in member pathways for Activation of NF-KappaB by PKR SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
2	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
3	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	4
4	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	4
5	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	4
6	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	4
7	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
8	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3
9	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
10	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
11	IFNG	Interferon Gamma	Protein Coding	2
12	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	2
13	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
14	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
15	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
16	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
17	PRKRA	Protein Activator Of Interferon Induced Protein Kinase EIF2AK2	Protein Coding	1
18	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
19	DNAJA3	DnaJ Heat Shock Protein Family (Hsp40) Member A3	Protein Coding	1
20	VAC14	VAC14 Component Of PIKFYVE Complex	Protein Coding	1
21	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
22	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
23	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
24	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	1
25	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
26	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
27	JAK2	Janus Kinase 2	Protein Coding	1
28	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
29	LTA	Lymphotoxin Alpha	Protein Coding	1
30	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
31	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
32	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
33	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
34	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
35	SRF	Serum Response Factor	Protein Coding	1
36	TAX1BP3	Tax1 Binding Protein 3	Protein Coding	1
37	TNF	Tumor Necrosis Factor	Protein Coding	1
38	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
39	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
40	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
41	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
42	IL1B	Interleukin 1 Beta	Protein Coding	1
43	IFNB1	Interferon Beta 1	Protein Coding	1
44	STING1	Stimulator Of Interferon Response CGAMP Interactor 1	Protein Coding	1
45	TBK1	TANK Binding Kinase 1	Protein Coding	1
46	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	1
47	F3	Coagulation Factor III, Tissue Factor	Protein Coding	1
48	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
49	CGAS	Cyclic GMP-AMP Synthase	Protein Coding	1
50	GSDMD	Gasdermin D	Protein Coding	1
51	NLRX1	NLR Family Member X1	Protein Coding	1

Disorders associated with Activation of NF-KappaB by PKR SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	6.64
2	Psoriatic arthritis	Enrichment	LTA, TNF	4.74
3	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.66
4	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.66
5	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.81
6	Incontinentia pigmenti	Enrichment	IKBKG	3.29
7	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	3.29
8	Fetal encasement syndrome	Enrichment	CHUK	3.29
9	Immunodeficiency 15b	Enrichment	IKBKB	3.29
10	Immunodeficiency 15a	Enrichment	IKBKB	3.29
11	Immunodeficiency 92	Enrichment	REL	3.29
12	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	3.29
13	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.29
14	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.29
15	Multisystem inflammatory syndrome in children	Enrichment	IFNB1, IRF3	3.29
16	Malaria	Enrichment	FCGR2A, IKBKG	3.25
17	Behcet syndrome	Enrichment	IFNGR1, TNFRSF1A	2.99
18	Immunodeficiency 33	Enrichment	IKBKG	2.99
19	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.99
20	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.99
21	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.99
22	Common variable immunodeficiency 12	Enrichment	NFKB1	2.99
23	Helicobacter pylori infection	Enrichment	IFNGR1	2.90
24	Immunodeficiency 27a	Enrichment	IFNGR1	2.90
25	Immunodeficiency 69	Enrichment	IFNG	2.90
26	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.90
27	Immunodeficiency 27b	Enrichment	IFNGR1	2.90
28	Dystonia 33	Enrichment	EIF2AK2	2.90
29	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.90
30	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.90
31	Menke-hennekam syndrome	Enrichment	CREBBP	2.90
32	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.81
33	Cinca syndrome	Enrichment	NLRP3	2.81
34	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.81
35	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.81
36	Sting-associated vasculopathy, infantile-onset	Enrichment	STING1	2.81
37	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.81
38	Muckle-wells syndrome	Enrichment	NLRP3	2.81
39	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.81
40	Sting-associated vasculopathy with onset in infancy	Enrichment	STING1	2.81
41	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.81
42	Corticobasal syndrome	Enrichment	TBK1	2.81
43	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.81
44	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.81
45	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.81
46	Thumb deformity	Enrichment	CREBBP	2.60
47	Dystonia 16	Enrichment	PRKRA	2.60
48	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.60
49	Menke-hennekam syndrome 2	Enrichment	EP300	2.60
50	Rela fusion-positive ependymoma	Enrichment	RELA	2.60
51	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.60
52	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.60
53	Leprosy 4	Enrichment	LTA	2.60
54	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.60
55	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.60
56	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.60
57	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.60
58	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.60
59	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.60
60	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.60
61	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.59
62	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.51
63	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.51
64	Pericardial effusion	Enrichment	NLRP3	2.51
65	Common variable immunodeficiency	Enrichment	NFKB1	2.44
66	Tuberous sclerosis 1	Enrichment	IFNG	2.43
67	Hepatitis c virus	Enrichment	IFNG	2.43
68	Tuberous sclerosis 2	Enrichment	IFNG	2.43
69	Tethered spinal cord syndrome	Enrichment	CREBBP	2.43
70	Torsion dystonia 1	Enrichment	EIF2AK2	2.43
71	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.43
72	Coronary heart disease 5	Enrichment	IKBKG	2.33
73	Gillespie syndrome	Enrichment	ITPR1	2.33
74	Familial chilblain lupus	Enrichment	STING1	2.33
75	Hepatitis b	Enrichment	IFNGR1	2.30
76	Yunis-varon syndrome	Enrichment	VAC14	2.30
77	Dystonia 9	Enrichment	SLC2A1	2.30
78	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.30
79	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.30
80	Thrombocythemia 3	Enrichment	JAK2	2.30
81	Immunodeficiency 127	Enrichment	TNF	2.30
82	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.30
83	Striatonigral degeneration, childhood-onset	Enrichment	VAC14	2.30
84	Polycythemia	Enrichment	JAK2	2.30
85	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.30
86	Hypereosinophilic syndrome	Enrichment	JAK2	2.30
87	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.29
88	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.21
89	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.20
90	Idiopathic aplastic anemia	Enrichment	IFNG	2.20
91	Hypertrichosis	Enrichment	CREBBP	2.13
92	Polycythemia vera	Enrichment	JAK2	2.12
93	Mycosis fungoides	Enrichment	TNFRSF1B	2.12
94	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.12
95	Immunodeficiency 28	Enrichment	IFNGR2	2.12
96	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.12
97	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.12
98	Migraine without aura	Enrichment	TNF	2.12
99	Melanoma of soft tissue	Enrichment	CREB1	2.12
100	Saczary syndrome	Enrichment	TNFRSF1B	2.12
101	Herpes simplex virus encephalitis	Enrichment	TBK1	2.11
102	Gliosarcoma	Enrichment	NFKBIA	2.08
103	Giant cell glioblastoma	Enrichment	NFKBIA	2.06
104	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	2.03
105	Erythrocytosis, familial, 1	Enrichment	JAK2	2.00
106	Budd-chiari syndrome	Enrichment	JAK2	2.00
107	Congenital generalized lipodystrophy	Enrichment	FOS	2.00
108	Cerebral malaria	Enrichment	TNF	2.00
109	Motor neuron disease	Enrichment	TBK1	1.97
110	Charge syndrome	Enrichment	EP300	1.95
111	Aplastic anemia	Enrichment	IFNG	1.90
112	Myeloproliferative neoplasm	Enrichment	JAK2	1.90
113	Histiocytoid hemangioma	Enrichment	FOS	1.90
114	Vascular dementia	Enrichment	TNF	1.90
115	Progressive non-fluent aphasia	Enrichment	TBK1	1.86
116	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.81
117	Severe combined immunodeficiency	Enrichment	IKBKB	1.77
118	Heart disease	Enrichment	CREBBP	1.76
119	Myelofibrosis	Enrichment	JAK2	1.76
120	Essential thrombocythemia	Enrichment	JAK2	1.76
121	Paroxysmal dystonia	Enrichment	SLC2A1	1.76
122	Polydactyly, postaxial, type a1	Enrichment	EP300	1.73
123	Corpus callosum, agenesis of	Enrichment	CREBBP	1.73
124	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.73
125	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.73
126	Lennox-gastaut syndrome	Enrichment	MAPK10	1.70
127	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.70
128	Multiple sclerosis	Enrichment	ITPR1	1.67
129	Human immunodeficiency virus type 1	Enrichment	IFNG	1.65
130	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.65
131	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.65
132	Anterior segment dysgenesis	Enrichment	ITPR1	1.64
133	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.63
134	Asthma	Enrichment	TNF	1.56
135	Arteriovenous malformations of the brain	Enrichment	NLRP3	1.54
136	Scoliosis	Enrichment	CREBBP	1.53
137	Alzheimer's disease	Enrichment	TNF	1.49
138	Autoinflammatory disease	Enrichment	NLRP3	1.44
139	Cystic fibrosis	Enrichment	FCGR2A	1.31
140	Myocardial infarction	Enrichment	LTA	1.27
141	Systemic lupus erythematosus	Enrichment	FCGR2A	1.23
142	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.22
143	Gastric cancer	Enrichment	IL1B	1.19
144	Strabismus	Enrichment	SLC2A1	1.18
145	Myeloma, multiple	Enrichment	CREBBP	1.17
146	Spastic ataxia	Enrichment	ITPR1	1.10
147	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	1.06
148	Autism	Enrichment	CREBBP	1.06
149	Leukemia, acute myeloid	Enrichment	JAK2	1.02
150	Epilepsy	Enrichment	SLC2A1	1.02
151	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	1.01
152	Centralopathic epilepsy	Enrichment	SLC2A1	0.99
153	Colorectal cancer	Enrichment	EP300	0.98
154	West syndrome	Enrichment	SLC2A1	0.98
155	Congenital nervous system abnormality	Enrichment	CREBBP	0.90
156	Nervous system disease	Enrichment	CREBBP	0.90
157	Primary ovarian insufficiency	Enrichment	JAK2	0.86
158	Microcephaly	Enrichment	EP300	0.84
159	Breast cancer	Enrichment	JUN	0.76

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Activation of NF-KappaB by PKR

Pathway Network for Activation of NF-KappaB by PKR

Pathway network for the Activation of NF-KappaB by PKR SuperPath

Member Pathways for Activation of NF-KappaB by PKR

Pathways in the Activation of NF-KappaB by PKR SuperPath

Gene overlap in member pathways for Activation of NF-KappaB by PKR SuperPath

Associated Genes for Activation of NF-KappaB by PKR

Associated Disorders for Activation of NF-KappaB by PKR

Disorders associated with Activation of NF-KappaB by PKR SuperPath

STRING Interaction Network for Activation of NF-KappaB by PKR

Sources for Activation of NF-KappaB by PKR