Activation of NLRP3 inflammasome by SARS-CoV-2

No Pathway Network information available for Activation of NLRP3 inflammasome by SARS-CoV-2

#	Name	Source	Genes
1	Activation of NLRP3 inflammasome by SARS-CoV-2	WikiPathways	CASP1 IL1B NFKB1 NLRP3 PYCARD RELA TRAF3 (see all 7) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CASP1	Caspase 1	Protein Coding	1
2	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
3	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
4	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
5	IL1B	Interleukin 1 Beta	Protein Coding	1
6	PYCARD	PYD And CARD Domain Containing	Protein Coding	1
7	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cinca syndrome	Enrichment	NLRP3	3.29
2	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	3.29
3	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	3.29
4	Muckle-wells syndrome	Enrichment	NLRP3	3.29
5	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	3.29
6	Immunodeficiency 132a	Enrichment	TRAF3	3.29
7	Immunodeficiency 132b	Enrichment	TRAF3	3.29
8	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	3.29
9	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	3.29
10	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.99
11	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.99
12	Rela fusion-positive ependymoma	Enrichment	RELA	2.99
13	Pericardial effusion	Enrichment	NLRP3	2.99
14	Common variable immunodeficiency 12	Enrichment	NFKB1	2.99
15	Herpes simplex virus encephalitis	Enrichment	TRAF3	2.59
16	Common variable immunodeficiency	Enrichment	NFKB1	2.44
17	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.29
18	Arteriovenous malformations of the brain	Enrichment	NLRP3	2.01
19	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.95
20	Autoinflammatory disease	Enrichment	NLRP3	1.91
21	Gastric cancer	Enrichment	IL1B	1.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Activation of NLRP3 inflammasome by SARS-CoV-2