Activation of NMDA receptors and postsynaptic events

Pathway network for the Activation of NMDA receptors and postsynaptic events SuperPath

Sources:

Reactome

Pathways in the Activation of NMDA receptors and postsynaptic events SuperPath

#	Name	Source	Genes
1	Activation of NMDA receptors and postsynaptic events	Reactome	ACTN2 ADCY1 ADCY8 APBA1 ARHGEF7 CALM1 CALM2 CALM3 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CASK CREB1 DLG1 DLG2 DLG3 DLG4 ERBB4 GIT1 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B HRAS KIF17 KPNA2 KRAS LIN7A LIN7B LIN7C MAPK1 MAPK3 NBEA NEFL NRAS NRG1 NRGN PDPK1 PPM1E PPM1F PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX RAC1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 SRC TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 94) (see less)
2	Post NMDA receptor activation events	Reactome	ACTN2 ADCY1 ADCY8 ARHGEF7 CALM1 CALM2 CALM3 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 DLG1 DLG2 DLG3 DLG4 ERBB4 GIT1 GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS KPNA2 KRAS MAPK1 MAPK3 NEFL NRAS NRG1 NRGN PDPK1 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX RAC1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 SRC TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 81) (see less)
3	Assembly and cell surface presentation of NMDA receptors	Reactome	ACTN2 APBA1 CAMK2A CAMK2B CAMK2D CAMK2G CASK DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B KIF17 LIN7A LIN7B LIN7C NBEA NEFL TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 43) (see less)
4	Activation of RAC1 downstream of NMDARs	Reactome	ARHGEF7 CALM1 CALM2 CALM3 CAMK1 CAMKK1 CAMKK2 GIT1 RAC1 (see all 9) (see less)

Gene overlap in member pathways for Activation of NMDA receptors and postsynaptic events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TUBA1B	Tubulin Alpha 1b	Protein Coding	3
2	TUBB3	Tubulin Beta 3 Class III	Protein Coding	3
3	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	3
4	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	3
5	CAMKK2	Calcium/Calmodulin Dependent Protein Kinase Kinase 2	Protein Coding	3
6	TUBA3E	Tubulin Alpha 3e	Protein Coding	3
7	TUBA3D	Tubulin Alpha 3d	Protein Coding	3
8	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	3
9	DLG2	Discs Large MAGUK Scaffold Protein 2	Protein Coding	3
10	DLG3	Discs Large MAGUK Scaffold Protein 3	Protein Coding	3
11	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	3
12	TUBB8B	Tubulin Beta 8B	Protein Coding	3
13	GIT1	GIT ArfGAP 1	Protein Coding	3
14	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	3
15	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	3
16	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	3
17	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	3
18	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	3
19	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	3
20	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	3
21	NEFL	Neurofilament Light Chain	Protein Coding	3
22	TUBA8	Tubulin Alpha 8	Protein Coding	3
23	RAC1	Rac Family Small GTPase 1	Protein Coding	3
24	TUBA4A	Tubulin Alpha 4a	Protein Coding	3
25	TUBA3C	Tubulin Alpha 3c	Protein Coding	3
26	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	3
27	TUBA1A	Tubulin Alpha 1a	Protein Coding	3
28	TUBAL3	Tubulin Alpha Like 3	Protein Coding	3
29	TUBA4B	Tubulin Alpha 4b	Protein Coding	3
30	CALM1	Calmodulin 1	Protein Coding	3
31	CALM2	Calmodulin 2	Protein Coding	3
32	CALM3	Calmodulin 3	Protein Coding	3
33	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	3
34	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	3
35	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	3
36	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	3
37	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	3
38	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	3
39	TUBB6	Tubulin Beta 6 Class V	Protein Coding	3
40	TUBA1C	Tubulin Alpha 1c	Protein Coding	3
41	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	3
42	ACTN2	Actinin Alpha 2	Protein Coding	3
43	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	3
44	ADCY1	Adenylate Cyclase 1	Protein Coding	2
45	ADCY8	Adenylate Cyclase 8	Protein Coding	2
46	GRIN3A	Glutamate Ionotropic Receptor NMDA Type Subunit 3A	Protein Coding	2
47	GRIN3B	Glutamate Ionotropic Receptor NMDA Type Subunit 3B	Protein Coding	2
48	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
49	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	2
50	NBEA	Neurobeachin	Protein Coding	2
51	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	2
52	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	2
53	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	2
54	NRG1	Neuregulin 1	Protein Coding	2
55	APBA1	Amyloid Beta Precursor Protein Binding Family A Member 1	Protein Coding	2
56	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
57	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	2
58	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
59	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
60	NRGN	Neurogranin	Protein Coding	2
61	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	2
62	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
63	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	2
64	LIN7C	Lin-7 Cell Polarity Scaffold C	Protein Coding	2
65	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	2
66	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	2
67	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	2
68	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	2
69	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
70	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
71	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
72	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	2
73	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	2
74	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	2
75	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	2
76	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	2
77	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
78	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
79	PRKX	Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit	Protein Coding	2
80	KIF17	Kinesin Family Member 17	Protein Coding	2
81	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	2
82	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	2
83	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
84	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	2
85	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	2
86	LIN7B	Lin-7 Cell Polarity Scaffold B	Protein Coding	2
87	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
88	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	2
89	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	2
90	LIN7A	Lin-7 Cell Polarity Scaffold A	Protein Coding	2
91	PPM1E	Protein Phosphatase, Mg2+/Mn2+ Dependent 1E	Protein Coding	1
92	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
93	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
94	PPM1F	Protein Phosphatase, Mg2+/Mn2+ Dependent 1F	Protein Coding	1

Disorders associated with Activation of NMDA receptors and postsynaptic events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.95
2	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	7.53
3	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, ERBB4, GRIA1, GRIN1, GRIN2B, NBEA	7.32
4	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	6.93
5	Lissencephaly	Enrichment	TUBA1A, TUBA3E, TUBB2B, TUBB3	6.30
6	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	6.23
7	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	6.09
8	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.09
9	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.15
10	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	4.49
11	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.45
12	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	4.05
13	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.98
14	Long qt syndrome	Enrichment	CALM1, CALM2	3.74
15	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.69
16	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.68
17	West syndrome	Enrichment	GRIA3, GRIN1, GRIN2B, TUBA1A	3.62
18	Cerebral palsy	Enrichment	GRIN2B, TUBA1A, TUBB4A	3.60
19	Epilepsy	Enrichment	GRIN2A, GRIN2B, NBEA	3.57
20	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	3.48
21	Congenital nervous system abnormality	Enrichment	CAMK2B, CASK, TUBA1A, TUBB4A	3.46
22	Nervous system disease	Enrichment	CAMK2B, CASK, TUBA1A, TUBB4A	3.46
23	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.46
24	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	3.36
25	Rasopathy	Enrichment	HRAS, KRAS, NRAS	3.32
26	Microcephaly	Enrichment	CAMK2B, CASK, GRIN2B, TUBB4A	3.22
27	Long qt syndrome 16	Enrichment	CALM3	3.18
28	Long qt syndrome 15	Enrichment	CALM2	3.18
29	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.18
30	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.17
31	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.14
32	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.14
33	Noonan syndrome 3	Enrichment	HRAS, KRAS	3.14
34	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.14
35	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.02
36	Isolated congenital microcephaly	Enrichment	CASK, TUBA3E	2.94
37	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.91
38	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.88
39	Long qt syndrome 14	Enrichment	CALM1	2.88
40	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.88
41	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK, GRIN1	2.84
42	Dystonia	Enrichment	CAMK2B, CASK, GRIA3	2.75
43	Specific learning disability	Enrichment	MAPK1, RPS6KA3	2.73
44	Non-syndromic x-linked intellectual disability	Enrichment	CASK, DLG3, RPS6KA3	2.71
45	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.65
46	Auditory neuropathy	Enrichment	NEFL, TUBB4A	2.52
47	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.50
48	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.50
49	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.50
50	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.50
51	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.50
52	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.50
53	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.50
54	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.50
55	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.50
56	Congenital myopathy 8	Enrichment	ACTN2	2.50
57	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.50
58	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.50
59	Neurodevelopmental disorder with or without early-onset generalized epilepsy	Enrichment	NBEA	2.50
60	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.50
61	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.50
62	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.50
63	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.50
64	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.50
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.50
66	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.50
67	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.50
68	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.50
69	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.50
70	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.50
71	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.50
72	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.50
73	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.50
74	Congenital myopathy 26	Enrichment	TUBA4A	2.50
75	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.50
76	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.50
77	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.50
78	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.50
79	Landau-kleffner syndrome	Enrichment	GRIN2A	2.50
80	Cask-related intellectual disability	Enrichment	CASK	2.50
81	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.50
82	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.50
83	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.50
84	Grin2a-related disorders	Enrichment	GRIN2A	2.50
85	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.40
86	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.28
87	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.22
88	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.22
89	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.22
90	Oculoectodermal syndrome	Enrichment	KRAS	2.22
91	Carney complex, type 1	Enrichment	PRKAR1A	2.22
92	Melanosis, neurocutaneous	Enrichment	NRAS	2.22
93	Noonan syndrome 6	Enrichment	NRAS	2.22
94	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.22
95	Noonan syndrome 13	Enrichment	MAPK1	2.22
96	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.22
97	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.22
98	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.22
99	Myxoma, intracardiac	Enrichment	PRKAR1A	2.22
100	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.22
101	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.22
102	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.22
103	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.22
104	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.22
105	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.22
106	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.22
107	Thrombocytopenia 6	Enrichment	SRC	2.22
108	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.22
109	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.22
110	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.22
111	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.22
112	Congenital pulmonary airway malformation	Enrichment	KRAS	2.22
113	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.22
114	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.22
115	Neurocutaneous melanocytosis	Enrichment	NRAS	2.22
116	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.20
117	Fg syndrome 4	Enrichment	CASK	2.20
118	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.20
119	Intellectual developmental disorder, x-linked 90	Enrichment	DLG3	2.20
120	Cerebellar, ocular, craniofacial, and genital syndrome	Enrichment	NBEA	2.20
121	Keratoconus 9	Enrichment	TUBA3D	2.20
122	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.20
123	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.20
124	Lissencephaly 3	Enrichment	TUBA1A	2.20
125	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.20
126	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.20
127	Syndromic x-linked intellectual disability	Enrichment	CASK	2.20
128	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.20
129	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.20
130	Torsion dystonia 4	Enrichment	TUBB4A	2.20
131	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.20
132	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.20
133	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.20
134	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.16
135	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.16
136	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.16
137	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	2.13
138	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	2.09
139	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	2.02
140	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	2.02
141	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.02
142	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	2.02
143	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	2.02
144	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	2.02
145	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	2.02
146	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.02
147	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.02
148	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.02
149	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	2.02
150	Cerebellar disease	Enrichment	CASK	2.02
151	Dlg4-related synaptopathy	Enrichment	DLG4	2.02
152	Sudden infant death syndrome	Enrichment	CALM2	1.95
153	Costello syndrome	Enrichment	HRAS	1.92
154	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.92
155	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.92
156	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.92
157	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.92
158	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.92
159	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.92
160	Usher syndrome, type iv	Enrichment	PRKAR1A	1.92
161	Acrodysostosis	Enrichment	PRKAR1A	1.92
162	Fibrolamellar carcinoma	Enrichment	PRKACA	1.92
163	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.92
164	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.92
165	Wooly hair nevus	Enrichment	HRAS	1.92
166	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	1.90
167	Astigmatism	Enrichment	GRIN2B	1.90
168	Bladder cancer	Enrichment	HRAS, KRAS	1.89
169	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.83
170	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	1.80
171	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	1.80
172	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.80
173	Sleep disorder	Enrichment	GRIN2B	1.80
174	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2, PRKAG2	1.78
175	Langerhans cell histiocytosis	Enrichment	NRAS	1.75
176	Spermatocytoma	Enrichment	HRAS	1.75
177	Melanoma of soft tissue	Enrichment	CREB1	1.75
178	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.72
179	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.72
180	Autism	Enrichment	CAMK2G, NBEA	1.66
181	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.63
182	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.63
183	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.63
184	Carney complex variant	Enrichment	PRKAR1A	1.63
185	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.63
186	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.63
187	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.63
188	Pilocytic astrocytoma	Enrichment	KRAS	1.63
189	Epidermolytic nevus	Enrichment	HRAS	1.63
190	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.62
191	Cryptorchidism	Enrichment	TUBA1A	1.60
192	Hypertrophic cardiomyopathy	Enrichment	ACTN2, PRKAG2	1.57
193	Mulibrey nanism	Enrichment	PPM1E	1.56
194	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.55
195	Thrombocytopenia	Enrichment	SRC, TUBB1	1.48
196	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.45
197	Breast adenocarcinoma	Enrichment	KRAS	1.45
198	Lung squamous cell carcinoma	Enrichment	KRAS	1.45
199	Congenital hypothyroidism	Enrichment	TUBB1	1.43
200	Autism spectrum disorder	Enrichment	GRIA1, GRIN2B, NBEA	1.40
201	Myelofibrosis	Enrichment	SRC	1.39
202	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.39
203	Gallbladder cancer	Enrichment	KRAS	1.39
204	Pilomyxoid astrocytoma	Enrichment	KRAS	1.39
205	Cleft lip/palate	Enrichment	DLG1	1.36
206	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.33
207	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.33
208	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.33
209	Gastroesophageal reflux	Enrichment	RPS6KA3	1.33
210	Orthostatic intolerance	Enrichment	RPS6KA3	1.33
211	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	1.33
212	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.30
213	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	1.30
214	Arteriovenous malformation	Enrichment	HRAS	1.28
215	Ventricular septal defect	Enrichment	RPS6KA3	1.28
216	Dandy-walker syndrome	Enrichment	TUBA1A	1.28
217	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIA4, GRIN2B	1.26
218	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.24
219	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	NEFL	1.23
220	Craniosynostosis	Enrichment	GRIN2B	1.21
221	Lip and oral cavity carcinoma	Enrichment	HRAS	1.16
222	Scoliosis	Enrichment	GRIN2B	1.13
223	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.13
224	Protein-deficiency anemia	Enrichment	NRAS	1.13
225	Nk-cell enteropathy	Enrichment	ERBB4	1.13
226	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.12
227	Osteoporosis	Enrichment	SRC	1.09
228	Lung cancer susceptibility 3	Enrichment	KRAS	1.09
229	Lynch syndrome	Enrichment	KRAS	1.07
230	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.04
231	Rhabdomyosarcoma	Enrichment	HRAS	1.04
232	Colorectal cancer	Enrichment	NRAS, SRC	1.02
233	Peripheral nervous system disease	Enrichment	NEFL	1.01
234	Neuropathy	Enrichment	NEFL	1.01
235	Heart, malformation of	Enrichment	MAPK1	0.99
236	Left ventricular noncompaction	Enrichment	ACTN2	0.98
237	Arteriovenous malformations of the brain	Enrichment	KRAS	0.97
238	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.95
239	Charcot-marie-tooth disease	Enrichment	NEFL	0.91
240	Optic atrophy plus syndrome	Enrichment	TUBB6	0.88
241	Pancreatic cancer	Enrichment	KRAS	0.86
242	Sensorineural hearing loss	Enrichment	NEFL	0.85
243	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.84
244	Spastic ataxia	Enrichment	TUBB3	0.81
245	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2	0.81
246	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	0.79
247	Schizophrenia	Enrichment	DLG2	0.77
248	Lung cancer	Enrichment	KRAS	0.76
249	Developmental and epileptic encephalopathy	Enrichment	GRIA3	0.65
250	Dilated cardiomyopathy	Enrichment	ACTN2	0.65
251	Gastric cancer	Enrichment	KRAS	0.64
252	Hereditary breast carcinoma	Enrichment	KRAS	0.63
253	Leber plus disease	Enrichment	TUBB4B	0.58
254	Hypertelorism	Enrichment	RPS6KA3	0.57
255	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.55
256	Myeloma, multiple	Enrichment	KRAS	0.54
257	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	0.53
258	Body mass index quantitative trait locus 11	Enrichment	GRIA4	0.53
259	Breast cancer	Enrichment	KRAS	0.44
260	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.44
261	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.38
262	Ovarian cancer	Enrichment	KRAS	0.34
263	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Activation of NMDA receptors and postsynaptic events

Pathway Network for Activation of NMDA receptors and postsynaptic events

Pathway network for the Activation of NMDA receptors and postsynaptic events SuperPath

Member Pathways for Activation of NMDA receptors and postsynaptic events

Pathways in the Activation of NMDA receptors and postsynaptic events SuperPath

Gene overlap in member pathways for Activation of NMDA receptors and postsynaptic events SuperPath

Associated Genes for Activation of NMDA receptors and postsynaptic events

Associated Disorders for Activation of NMDA receptors and postsynaptic events

Disorders associated with Activation of NMDA receptors and postsynaptic events SuperPath

STRING Interaction Network for Activation of NMDA receptors and postsynaptic events

Sources for Activation of NMDA receptors and postsynaptic events