Activation of RAC1

No Pathway Network information available for Activation of RAC1

Pathways in the Activation of RAC1 SuperPath

#	Name	Source	Genes
1	Activation of RAC1	Reactome	BUB1B-PAK6 NCK1 NCK2 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 RAC1 ROBO1 SLIT2 SOS1 SOS2 (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
2	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	1
3	NCK1	NCK Adaptor Protein 1	Protein Coding	1
4	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
5	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
6	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
7	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
8	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
9	RAC1	Rac Family Small GTPase 1	Protein Coding	1
10	ROBO1	Roundabout Guidance Receptor 1	Protein Coding	1
11	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
12	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
13	NCK2	NCK Adaptor Protein 2	Protein Coding	1
14	SLIT2	Slit Guidance Ligand 2	Protein Coding	1

Disorders associated with Activation of RAC1 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6, PAK6	5.01
2	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6, PAK6	4.56
3	Noonan syndrome 1	Enrichment	SOS1, SOS2	3.61
4	Rasopathy	Enrichment	SOS1, SOS2	3.50
5	Cakut	Enrichment	ROBO1, SLIT2	3.26
6	Nystagmus 8, congenital, autosomal recessive	Enrichment	ROBO1	2.99
7	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.99
8	Noonan syndrome 4	Enrichment	SOS1	2.99
9	Noonan syndrome 9	Enrichment	SOS2	2.99
10	Knobloch syndrome 2	Enrichment	PAK2	2.99
11	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.99
12	Autosomal recessive congenital nystagmus	Enrichment	ROBO1	2.99
13	Pituitary hormone deficiency, combined or isolated, 8	Enrichment	ROBO1	2.99
14	Neurooculorenal syndrome	Enrichment	ROBO1	2.99
15	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.99
16	Congenital nystagmus	Enrichment	ROBO1	2.99
17	Fibromatosis, gingival, 1	Enrichment	SOS1	2.69
18	Pulmonic stenosis	Enrichment	SOS1	2.69
19	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.69
20	Nuchal bleb, familial	Enrichment	SOS1	2.51
21	Knobloch syndrome	Enrichment	PAK2	2.38
22	Gingival fibromatosis	Enrichment	SOS1	2.38
23	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.38
24	Knobloch syndrome 1	Enrichment	PAK2	2.29
25	Noonan syndrome 3	Enrichment	SOS1	2.14
26	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.03
27	Renal agenesis, bilateral	Enrichment	ROBO1	2.03
28	Aortic valve disease 1	Enrichment	SOS1	1.87
29	Pituitary stalk interruption syndrome	Enrichment	ROBO1	1.84
30	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.84
31	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.81
32	Tetralogy of fallot	Enrichment	ROBO1	1.58
33	Microcephaly	Enrichment	PAK3	0.92
34	Complex neurodevelopmental disorder	Enrichment	PAK3	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Activation of RAC1

Pathway Network for Activation of RAC1

Member Pathways for Activation of RAC1

Pathways in the Activation of RAC1 SuperPath

Associated Genes for Activation of RAC1

Associated Disorders for Activation of RAC1

Disorders associated with Activation of RAC1 SuperPath

STRING Interaction Network for Activation of RAC1

Sources for Activation of RAC1