Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Pathway network for the Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

Sources:

Reactome

Pathways in the Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

#	Name	Source	Genes
1	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Reactome	EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF3L EIF3M EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4H FAU PABPC1 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS4Y2 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA (see all 60) (see less)
2	Translation initiation complex formation	Reactome	EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF3L EIF3M EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H FAU PABPC1 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS4Y2 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA (see all 59) (see less)
3	Ribosomal scanning and start codon recognition	Reactome	EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF3L EIF3M EIF4A1 EIF4A2 EIF4B EIF4E EIF4G1 EIF4H EIF5 FAU RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS4Y2 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA (see all 59) (see less)
4	Formation of the ternary complex, and subsequently, the 43S complex	Reactome	EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF3L EIF3M FAU RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS4Y2 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA (see all 52) (see less)

Gene overlap in member pathways for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EIF3M	Eukaryotic Translation Initiation Factor 3 Subunit M	Protein Coding	4
2	RPS4Y2	Ribosomal Protein S4 Y-Linked 2	Protein Coding	4
3	EIF1AX	Eukaryotic Translation Initiation Factor 1A X-Linked	Protein Coding	4
4	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	4
5	EIF2S3	Eukaryotic Translation Initiation Factor 2 Subunit Gamma	Protein Coding	4
6	FAU	FAU Ubiquitin Like And Ribosomal Protein S30 Fusion	Protein Coding	4
7	EIF3K	Eukaryotic Translation Initiation Factor 3 Subunit K	Protein Coding	4
8	EIF3E	Eukaryotic Translation Initiation Factor 3 Subunit E	Protein Coding	4
9	RPSA	Ribosomal Protein SA	Protein Coding	4
10	RPS27L	Ribosomal Protein S27 Like	Protein Coding	4
11	EIF3L	Eukaryotic Translation Initiation Factor 3 Subunit L	Protein Coding	4
12	RPS2	Ribosomal Protein S2	Protein Coding	4
13	RPS3	Ribosomal Protein S3	Protein Coding	4
14	RPS3A	Ribosomal Protein S3A	Protein Coding	4
15	RPS4X	Ribosomal Protein S4 X-Linked	Protein Coding	4
16	RPS4Y1	Ribosomal Protein S4 Y-Linked 1	Protein Coding	4
17	RPS5	Ribosomal Protein S5	Protein Coding	4
18	RPS6	Ribosomal Protein S6	Protein Coding	4
19	RPS7	Ribosomal Protein S7	Protein Coding	4
20	RPS8	Ribosomal Protein S8	Protein Coding	4
21	RPS9	Ribosomal Protein S9	Protein Coding	4
22	RPS10	Ribosomal Protein S10	Protein Coding	4
23	RPS11	Ribosomal Protein S11	Protein Coding	4
24	RPS12	Ribosomal Protein S12	Protein Coding	4
25	RPS13	Ribosomal Protein S13	Protein Coding	4
26	RPS14	Ribosomal Protein S14	Protein Coding	4
27	RPS15	Ribosomal Protein S15	Protein Coding	4
28	RPS15A	Ribosomal Protein S15a	Protein Coding	4
29	RPS16	Ribosomal Protein S16	Protein Coding	4
30	RPS17	Ribosomal Protein S17	Protein Coding	4
31	RPS18	Ribosomal Protein S18	Protein Coding	4
32	RPS19	Ribosomal Protein S19	Protein Coding	4
33	RPS20	Ribosomal Protein S20	Protein Coding	4
34	RPS21	Ribosomal Protein S21	Protein Coding	4
35	RPS23	Ribosomal Protein S23	Protein Coding	4
36	RPS24	Ribosomal Protein S24	Protein Coding	4
37	RPS25	Ribosomal Protein S25	Protein Coding	4
38	RPS26	Ribosomal Protein S26	Protein Coding	4
39	RPS27	Ribosomal Protein S27	Protein Coding	4
40	RPS27A	Ribosomal Protein S27a	Protein Coding	4
41	RPS28	Ribosomal Protein S28	Protein Coding	4
42	RPS29	Ribosomal Protein S29	Protein Coding	4
43	EIF3A	Eukaryotic Translation Initiation Factor 3 Subunit A	Protein Coding	4
44	EIF3B	Eukaryotic Translation Initiation Factor 3 Subunit B	Protein Coding	4
45	EIF3C	Eukaryotic Translation Initiation Factor 3 Subunit C	Protein Coding	4
46	EIF3D	Eukaryotic Translation Initiation Factor 3 Subunit D	Protein Coding	4
47	EIF3F	Eukaryotic Translation Initiation Factor 3 Subunit F	Protein Coding	4
48	EIF3G	Eukaryotic Translation Initiation Factor 3 Subunit G	Protein Coding	4
49	EIF3H	Eukaryotic Translation Initiation Factor 3 Subunit H	Protein Coding	4
50	EIF3I	Eukaryotic Translation Initiation Factor 3 Subunit I	Protein Coding	4
51	EIF3J	Eukaryotic Translation Initiation Factor 3 Subunit J	Protein Coding	4
52	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	4
53	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	3
54	EIF4A2	Eukaryotic Translation Initiation Factor 4A2	Protein Coding	3
55	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	3
56	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	3
57	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	3
58	EIF4H	Eukaryotic Translation Initiation Factor 4H	Protein Coding	3
59	PABPC1	Poly(A) Binding Protein Cytoplasmic 1	Protein Coding	2
60	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
61	EIF5	Eukaryotic Translation Initiation Factor 5	Protein Coding	1

Disorders associated with Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Diamond-blackfan anemia	Enrichment	RPS10, RPS15A, RPS17, RPS19, RPS20, RPS24, RPS26, RPS27, RPS28, RPS29, RPS7	11.07
2	Diamond-blackfan anemia 1	Enrichment	RPS10, RPS17, RPS19, RPS20, RPS24, RPS26, RPS7	10.78
3	Diamond-blackfan anemia 15 with mandibulofacial dysostosis	Enrichment	RPS26, RPS28	4.37
4	Asplenia, isolated congenital	Enrichment	RPSA	2.42
5	Diamond-blackfan anemia 10	Enrichment	RPS26	2.42
6	Diamond-blackfan anemia 13	Enrichment	RPS29	2.42
7	Mehmo syndrome	Enrichment	EIF2S3	2.42
8	Diamond-blackfan anemia 20	Enrichment	RPS15A	2.42
9	Diamond-blackfan anemia 3	Enrichment	RPS24	2.42
10	Diamond-blackfan anemia 8	Enrichment	RPS7	2.42
11	Diamond-blackfan anemia 4	Enrichment	RPS17	2.42
12	Brachycephaly, trichomegaly, and developmental delay	Enrichment	RPS23	2.42
13	Pure red-cell aplasia	Enrichment	RPS26	2.42
14	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	2.36
15	Autism 19	Enrichment	EIF4E	2.36
16	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	Enrichment	EIF4A2	2.36
17	Chromosome 5q deletion syndrome	Enrichment	RPS14	2.12
18	Diamond-blackfan anemia 9	Enrichment	RPS10	2.12
19	Intellectual developmental disorder, autosomal recessive 67	Enrichment	EIF3F	2.12
20	Diamond-blackfan anemia 17	Enrichment	RPS27	2.12
21	Familial isolated congenital asplenia	Enrichment	RPSA	2.12
22	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	EIF3F	1.47
23	Leukemia, chronic lymphocytic	Enrichment	RPS15	1.42
24	Familial colorectal cancer type x	Enrichment	RPS20	1.38
25	Protein-deficiency anemia	Enrichment	RPS26	1.31
26	Williams-beuren syndrome	Enrichment	EIF4H	1.08
27	Parkinson disease, late-onset	Enrichment	EIF4G1	1.00
28	Differentiated thyroid carcinoma	Enrichment	EIF1AX	0.98
29	Myeloma, multiple	Enrichment	EIF1AX	0.71
30	Inherited cancer-predisposing syndrome	Enrichment	RPS20	0.40
31	Complex neurodevelopmental disorder	Enrichment	EIF4A2	0.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Pathway Network for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Pathway network for the Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

Member Pathways for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Pathways in the Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

Gene overlap in member pathways for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

Associated Genes for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Associated Disorders for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Disorders associated with Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S SuperPath

STRING Interaction Network for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Sources for Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S