Activation of the pre-replicative complex

Pathway network for the Activation of the pre-replicative complex SuperPath

Sources:

Reactome
QIAGEN
GeneGo (Thomson Reuters)
WikiPathways
PubChem

Pathways in the Activation of the pre-replicative complex SuperPath

#	Name	Source	Genes
1	Activation of the pre-replicative complex	Reactome	CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 GMNN MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 POLE POLE2 POLE3 POLE4 PRIM1 PRIM2 RPA1 RPA2 RPA3 RPA4 (see all 33) (see less)
2	Cell Cycle Control of Chromosomal Replication	QIAGEN	CDC45 CDC6 CDC7 CDK10 CDK19 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDT1 CHEK2 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLB POLD1 POLD2 POLD4 POLE POLE2 POLE4 POLG POLH POLK POLQ POLR1A TENT4A (see all 43) (see less)
3	Cell cycle Start of DNA replication in early S phase	GeneGo (Thomson Reuters)	CBX5 CCNE1 CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 DBF4B E2F1 GMNN H1-0 H1-1 H1-10 H1-2 H1-3 H1-4 H1-5 H1-6 H1-8 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POLA1 POLA2 PPP2CA PPP2CB PRIM1 PRIM2 RPA1 RPA2 RPA3 TFDP1 (see all 43) (see less)
4	DNA replication	WikiPathways	CDC45 CDC6 CDC7 CDK2 CDT1 DBF4 GMNN MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPA4 UBA52 UBC (see all 42) (see less)
5	Activation of ATR in response to replication stress	Reactome	ATR ATRIP CDC25A CDC25C CDC45 CDC6 CDC7 CDK2 CHEK1 CLSPN DBF4 HUS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RAD1 RAD17 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 (see all 37) (see less)
6	ATR signaling pathway	PubChem	ATR ATRIP BRCA2 CCNA2 CDC25A CDC25C CDC6 CDK2 CEP164 CHEK1 CLSPN FANCD2 HUS1 MCM2 MCM7 MDM2 NBN PLK1 PPP2CA PPP2R1A PPP2R2B RAD1 RAD17 RAD51 RAD9A RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 SMARCAL1 TIMELESS TIPIN TOPBP1 YWHAB YWHAZ (see all 37) (see less)
7	DNA strand elongation	Reactome	CDC45 DNA2 FEN1 GINS1 GINS2 GINS3 GINS4 LIG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 (see all 32) (see less)
8	Lagging Strand Synthesis	Reactome	DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 (see all 20) (see less)
9	Processive synthesis on the lagging strand	Reactome	DNA2 FEN1 LIG1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RPA1 RPA2 RPA3 (see all 15) (see less)
10	Removal of the Flap Intermediate	Reactome	DNA2 FEN1 PCNA POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 PRIM1 PRIM2 RPA1 RPA2 RPA3 (see all 14) (see less)
11	Unwinding of DNA	Reactome	CDC45 GINS1 GINS2 GINS3 GINS4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 (see all 12) (see less)
12	CDC6 association with the ORC:origin complex	Reactome	CDC6 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 (see all 8) (see less)
13	DNA replication initiation	Reactome	POLA1 POLA2 POLE POLE2 POLE3 POLE4 PRIM1 PRIM2 (see all 8) (see less)

Gene overlap in member pathways for Activation of the pre-replicative complex SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	9
2	RPA1	Replication Protein A1	Protein Coding	9
3	RPA2	Replication Protein A2	Protein Coding	9
4	POLA2	DNA Polymerase Alpha 2, Accessory Subunit	Protein Coding	8
5	MCM2	Minichromosome Maintenance Complex Component 2	Protein Coding	8
6	MCM7	Minichromosome Maintenance Complex Component 7	Protein Coding	8
7	PRIM1	DNA Primase Subunit 1	Protein Coding	8
8	PRIM2	DNA Primase Subunit 2	Protein Coding	8
9	RPA3	Replication Protein A3	Protein Coding	8
10	MCM3	Minichromosome Maintenance Complex Component 3	Protein Coding	7
11	MCM4	Minichromosome Maintenance Complex Component 4	Protein Coding	7
12	MCM5	Minichromosome Maintenance Complex Component 5	Protein Coding	7
13	MCM6	Minichromosome Maintenance Complex Component 6	Protein Coding	7
14	CDC45	Cell Division Cycle 45	Protein Coding	7
15	CDC6	Cell Division Cycle 6	Protein Coding	7
16	CDK2	Cyclin Dependent Kinase 2	Protein Coding	6
17	ORC6	Origin Recognition Complex Subunit 6	Protein Coding	6
18	ORC3	Origin Recognition Complex Subunit 3	Protein Coding	6
19	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	6
20	ORC2	Origin Recognition Complex Subunit 2	Protein Coding	6
21	ORC4	Origin Recognition Complex Subunit 4	Protein Coding	6
22	ORC5	Origin Recognition Complex Subunit 5	Protein Coding	6
23	MCM8	Minichromosome Maintenance 8 Homologous Recombination Repair Factor	Protein Coding	6
24	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	6
25	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	6
26	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	6
27	MCM10	Minichromosome Maintenance 10 Replication Initiation Factor	Protein Coding	5
28	CDC7	Cell Division Cycle 7	Protein Coding	5
29	RFC4	Replication Factor C Subunit 4	Protein Coding	5
30	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	5
31	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	5
32	RFC5	Replication Factor C Subunit 5	Protein Coding	5
33	RFC3	Replication Factor C Subunit 3	Protein Coding	5
34	RFC2	Replication Factor C Subunit 2	Protein Coding	5
35	DBF4	DBF4-CDC7 Kinase Regulatory Subunit	Protein Coding	4
36	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	4
37	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	4
38	CDT1	Chromatin Licensing And DNA Replication Factor 1	Protein Coding	4
39	DNA2	DNA Replication Helicase/Nuclease 2	Protein Coding	4
40	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	4
41	GMNN	Geminin DNA Replication Inhibitor	Protein Coding	3
42	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	3
43	RFC1	Replication Factor C Subunit 1	Protein Coding	3
44	LIG1	DNA Ligase 1	Protein Coding	3
45	RPA4	Replication Protein A4	Protein Coding	2
46	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	2
47	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
48	CHEK1	Checkpoint Kinase 1	Protein Coding	2
49	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	2
50	ATR	ATR Checkpoint Kinase	Protein Coding	2
51	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	2
52	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	2
53	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	2
54	CLSPN	Claspin	Protein Coding	2
55	ATRIP	ATR Interacting Protein	Protein Coding	2
56	CDC25A	Cell Division Cycle 25A	Protein Coding	2
57	CDC25C	Cell Division Cycle 25C	Protein Coding	2
58	GINS2	GINS Complex Subunit 2	Protein Coding	2
59	GINS3	GINS Complex Subunit 3	Protein Coding	2
60	GINS4	GINS Complex Subunit 4	Protein Coding	2
61	GINS1	GINS Complex Subunit 1	Protein Coding	2
62	CDK10	Cyclin Dependent Kinase 10	Protein Coding	1
63	CDK19	Cyclin Dependent Kinase 19	Protein Coding	1
64	CDK3	Cyclin Dependent Kinase 3	Protein Coding	1
65	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
66	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
67	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
68	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
69	CDK8	Cyclin Dependent Kinase 8	Protein Coding	1
70	CDK9	Cyclin Dependent Kinase 9	Protein Coding	1
71	CHEK2	Checkpoint Kinase 2	Protein Coding	1
72	POLB	DNA Polymerase Beta	Protein Coding	1
73	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	1
74	POLH	DNA Polymerase Eta	Protein Coding	1
75	POLK	DNA Polymerase Kappa	Protein Coding	1
76	POLQ	DNA Polymerase Theta	Protein Coding	1
77	POLR1A	RNA Polymerase I Subunit A	Protein Coding	1
78	TENT4A	Terminal Nucleotidyltransferase 4A	Protein Coding	1
79	CCNE1	Cyclin E1	Protein Coding	1
80	E2F1	E2F Transcription Factor 1	Protein Coding	1
81	H1-0	H1.0 Linker Histone	Protein Coding	1
82	H1-2	H1.2 Linker Histone, Cluster Member	Protein Coding	1
83	H1-3	H1.3 Linker Histone, Cluster Member	Protein Coding	1
84	H1-4	H1.4 Linker Histone, Cluster Member	Protein Coding	1
85	H1-5	H1.5 Linker Histone, Cluster Member	Protein Coding	1
86	H1-6	H1.6 Linker Histone, Cluster Member	Protein Coding	1
87	H1-1	H1.1 Linker Histone, Cluster Member	Protein Coding	1
88	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
89	TFDP1	Transcription Factor Dp-1	Protein Coding	1
90	H1-10	H1.10 Linker Histone	Protein Coding	1
91	CBX5	Chromobox 5	Protein Coding	1
92	DBF4B	DBF4B-CDC7 Kinase Regulatory Subunit	Protein Coding	1
93	H1-8	H1.8 Linker Histone	Protein Coding	1
94	UBC	Ubiquitin C	Protein Coding	1
95	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
96	RAD9B	RAD9 Checkpoint Clamp Component B	Protein Coding	1
97	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	1
98	SMARCAL1	SNF2 Related Chromatin Remodeling Annealing Helicase 1	Protein Coding	1
99	CCNA2	Cyclin A2	Protein Coding	1
100	FANCD2	FA Complementation Group D2	Protein Coding	1
101	TIPIN	TIMELESS Interacting Protein	Protein Coding	1
102	TIMELESS	Timeless Circadian Regulator	Protein Coding	1
103	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	1
104	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
105	RAD51	RAD51 Recombinase	Protein Coding	1
106	NBN	Nibrin	Protein Coding	1
107	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
108	CEP164	Centrosomal Protein 164	Protein Coding	1
109	PLK1	Polo Like Kinase 1	Protein Coding	1
110	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
111	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
112	MDM2	MDM2 Proto-Oncogene	Protein Coding	1

Disorders associated with Activation of the pre-replicative complex SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meier-gorlin syndrome 1	Enrichment	CDC45, CDC6, CDT1, MCM7, ORC1, ORC4, ORC6	16.00
2	Familial colorectal cancer type x	Enrichment	CHEK2, POLD1, POLE	5.32
3	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	4.55
4	Seckel syndrome	Enrichment	DNA2, PRIM1	4.05
5	Fanconi anemia, complementation group a	Enrichment	BRCA2, FANCD2, RAD51	3.94
6	Hereditary breast carcinoma	Enrichment	BRCA2, NBN, RAD51	3.64
7	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA2, NBN, RAD51	3.35
8	Breast-ovarian cancer, familial 1	Enrichment	BRCA2, NBN	3.26
9	Meier-gorlin syndrome 3	Enrichment	ORC6	3.23
10	Meier-gorlin syndrome 2	Enrichment	ORC4	3.23
11	Premature ovarian failure 10	Enrichment	MCM8	3.23
12	Meier-gorlin syndrome 5	Enrichment	CDC6	3.23
13	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	3.23
14	Van esch-o'driscoll syndrome	Enrichment	POLA1	3.23
15	Colorectal cancer 12	Enrichment	POLE	3.23
16	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	3.23
17	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CHEK2, POLD1, POLE	3.10
18	Lactose intolerance, adult type	Enrichment	MCM6	3.05
19	Anisometropia	Enrichment	MCM7	3.05
20	Immunodeficiency 54	Enrichment	MCM4	3.05
21	Deafness, autosomal dominant 70	Enrichment	MCM2	3.05
22	Meier-gorlin syndrome 8	Enrichment	MCM5	3.05
23	Meier-gorlin syndrome 7	Enrichment	CDC45	3.05
24	Colorectal cancer 10	Enrichment	POLD1	2.99
25	Seckel syndrome 8	Enrichment	DNA2	2.99
26	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.99
27	Immunodeficiency 120	Enrichment	POLD1	2.99
28	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6	Enrichment	DNA2	2.99
29	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.99
30	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.99
31	Rothmund-thomson syndrome, type 4	Enrichment	DNA2	2.99
32	Immunodeficiency 122	Enrichment	POLD3	2.99
33	Breast cancer	Enrichment	BRCA2, NBN, RAD51	2.96
34	Immunodeficiency 96	Enrichment	LIG1	2.96
35	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	2.93
36	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	2.93
37	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	2.93
38	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	2.93
39	Diffuse large b-cell lymphoma	Enrichment	BRCA2, NBN	2.92
40	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.83
41	Partington syndrome	Enrichment	POLA1	2.75
42	Immunodeficiency 55	Enrichment	GINS1	2.75
43	Rothmund-thomson syndrome, type 2	Enrichment	DNA2	2.69
44	Pancreatic cancer	Enrichment	BRCA2, NBN	2.68
45	Immunodeficiency 80 with or without congenital cardiomyopathy	Enrichment	MCM10	2.61
46	Meier-gorlin syndrome 4	Enrichment	CDT1	2.61
47	Meier-gorlin syndrome 6	Enrichment	GMNN	2.61
48	Ovarian cancer	Enrichment	BRCA2, FANCD2, NBN	2.59
49	Colorectal cancer	Enrichment	CHEK2, POLD1, POLE	2.58
50	Seckel syndrome 1	Enrichment	ATR	2.56
51	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.56
52	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.56
53	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.56
54	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	2.56
55	Glioma susceptibility 3	Enrichment	BRCA2	2.56
56	Mirror movements 2	Enrichment	RAD51	2.56
57	Schimke immunoosseous dysplasia	Enrichment	SMARCAL1	2.56
58	Accelerated tumor formation	Enrichment	MDM2	2.56
59	Fanconi anemia, complementation group r	Enrichment	RAD51	2.56
60	Lessel-kubisch syndrome	Enrichment	MDM2	2.56
61	Pancreatic cancer 2	Enrichment	BRCA2	2.56
62	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.56
63	Advanced sleep phase syndrome, familial, 4	Enrichment	TIMELESS	2.56
64	Nephronophthisis 15	Enrichment	CEP164	2.56
65	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.56
66	Prostate cancer	Enrichment	BRCA2, NBN	2.55
67	2q23.1 microduplication syndrome	Enrichment	ORC4	2.53
68	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	2.53
69	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.50
70	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.50
71	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.50
72	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	2.50
73	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.50
74	Leiomyosarcoma	Enrichment	CHEK2	2.50
75	Childhood myocerebrohepatopathy spectrum	Enrichment	POLG	2.50
76	Spinocerebellar ataxia with epilepsy	Enrichment	POLG	2.50
77	Recessive mitochondrial ataxia syndrome	Enrichment	POLG	2.50
78	Rahman syndrome	Enrichment	H1-4	2.50
79	Astigmatism	Enrichment	MCM7	2.45
80	Enophthalmos	Enrichment	MCM7	2.45
81	Farsightedness	Enrichment	MCM7	2.35
82	Childhood apraxia of speech	Enrichment	RFC3	2.35
83	Microcephaly	Enrichment	MCM7, NBN, SMARCAL1	2.35
84	Primary autosomal recessive microcephaly	Enrichment	CDK6, MCM7	2.34
85	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	2.26
86	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.26
87	Inflammatory breast carcinoma	Enrichment	BRCA2	2.26
88	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.26
89	Bilateral breast cancer	Enrichment	BRCA2	2.26
90	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	2.26
91	Gastric cancer	Enrichment	BRCA2, NBN	2.22
92	Ebstein anomaly	Enrichment	CDK8	2.20
93	Fanconi anemia, complementation group i	Enrichment	POLG	2.20
94	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	POLK	2.20
95	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.20
96	Developmental and epileptic encephalopathy 87	Enrichment	CDK19	2.20
97	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1	Enrichment	POLG	2.20
98	Al kaissi syndrome	Enrichment	CDK10	2.20
99	Li-fraumeni syndrome 1	Enrichment	CHEK2	2.20
100	Sarcoma	Enrichment	CHEK2	2.20
101	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	2.20
102	Polg-related disorders	Enrichment	POLG	2.20
103	Autosomal recessive progressive external ophthalmoplegia	Enrichment	POLG	2.20
104	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	2.20
105	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP	2.09
106	Chilblain lupus 1	Enrichment	ATRIP	2.09
107	Chilblain lupus	Enrichment	ATRIP	2.09
108	Nijmegen breakage syndrome	Enrichment	NBN	2.09
109	Tumor predisposition syndrome 1	Enrichment	BRCA2	2.09
110	Dedifferentiated liposarcoma	Enrichment	MDM2	2.09
111	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	2.09
112	Well-differentiated liposarcoma	Enrichment	MDM2	2.09
113	Isolated growth hormone deficiency, type ia	Enrichment	DNA2	2.08
114	Burn-mckeown syndrome	Enrichment	POLR1A	2.02
115	Osteogenic sarcoma	Enrichment	CHEK2	2.02
116	Bone osteosarcoma	Enrichment	CHEK2	2.02
117	Idiopathic camptocormia	Enrichment	POLG	2.02
118	Aicardi-goutieres syndrome 1	Enrichment	ATRIP	1.96
119	Thrombotic microangiopathy	Enrichment	ATRIP	1.96
120	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.96
121	Mirror movements 1	Enrichment	RAD51	1.96
122	Chordoma	Enrichment	BRCA2	1.96
123	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.96
124	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA2	1.96
125	Cholangiocarcinoma	Enrichment	BRCA2	1.96
126	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.96
127	Combined immunodeficiency	Enrichment	POLD1	1.95
128	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.95
129	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.95
130	Azoospermia	Enrichment	MCM8	1.93
131	Generalized epilepsy	Enrichment	POLG	1.90
132	Hemoglobin c disease	Enrichment	CHEK2	1.90
133	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP	1.87
134	Vascular dementia	Enrichment	ATRIP	1.87
135	Fanconi anemia, complementation group d2	Enrichment	FANCD2	1.87
136	Von hippel-lindau syndrome	Enrichment	FANCD2	1.87
137	Atrioventricular septal defect	Enrichment	SMARCAL1	1.87
138	Breast-ovarian cancer, familial 2	Enrichment	BRCA2	1.87
139	Primary ovarian insufficiency	Enrichment	CHEK2, POLG	1.82
140	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	Enrichment	POLG	1.80
141	Li-fraumeni syndrome	Enrichment	MDM2	1.79
142	Kabuki syndrome 1	Enrichment	BRCA2	1.79
143	Machado-joseph disease	Enrichment	POLG	1.72
144	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	POLG	1.72
145	Wilms tumor 5	Enrichment	CHEK2	1.72
146	Mitochondrial dna depletion syndrome 1	Enrichment	POLG	1.72
147	Mitochondrial dna depletion syndrome	Enrichment	POLG	1.72
148	Microphthalmia	Enrichment	MCM7	1.71
149	Mitochondrial dna depletion syndrome 4a	Enrichment	POLG	1.66
150	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	1.61
151	Polydactyly	Enrichment	BRCA2	1.61
152	Mitochondrial dna depletion syndrome 4b	Enrichment	POLG	1.60
153	Aicardi-goutieres syndrome	Enrichment	ATRIP	1.57
154	Aplastic anemia	Enrichment	NBN	1.57
155	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	1.57
156	Parkinson's disease	Enrichment	RFC1	1.56
157	Colonic benign neoplasm	Enrichment	CHEK2	1.55
158	Autosomal dominant cerebellar ataxia	Enrichment	POLG	1.55
159	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	POLG	1.55
160	Williams-beuren syndrome	Enrichment	RFC2	1.54
161	Leukemia, acute lymphoblastic	Enrichment	NBN	1.53
162	Uterine corpus cancer	Enrichment	BRCA2	1.53
163	Lynch syndrome 1	Enrichment	CHEK2	1.50
164	Melanoma	Enrichment	CHEK2	1.50
165	Xeroderma pigmentosum, variant type	Enrichment	POLH	1.46
166	Parkinson disease, late-onset	Enrichment	RFC1	1.46
167	Neural tube defects	Enrichment	RAD9B	1.46
168	Senior-loken syndrome 1	Enrichment	CEP164	1.46
169	Premature menopause	Enrichment	NBN	1.46
170	Medulloblastoma	Enrichment	BRCA2	1.43
171	Wilms tumor 1	Enrichment	BRCA2	1.40
172	Atypical hemolytic-uremic syndrome	Enrichment	SMARCAL1	1.40
173	Diaphragmatic hernia, congenital	Enrichment	CDK8	1.39
174	Nk-cell enteropathy	Enrichment	CHEK2	1.39
175	Rhabdomyosarcoma	Enrichment	BRCA2	1.37
176	Isolated congenital microcephaly	Enrichment	SMARCAL1	1.37
177	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MCM2	1.35
178	Polycystic liver disease	Enrichment	CDC25A	1.34
179	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.34
180	Lynch syndrome	Enrichment	CHEK2	1.33
181	Hydrocephalus, congenital, 1	Enrichment	CDK8	1.30
182	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	1.30
183	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.28
184	Focal segmental glomerulosclerosis	Enrichment	SMARCAL1	1.27
185	Heart, malformation of	Enrichment	CDK8	1.26
186	Endometrial cancer	Enrichment	BRCA2	1.25
187	Lissencephaly	Enrichment	NBN	1.25
188	Hepatoblastoma	Enrichment	BRCA2	1.25
189	Hepatocellular carcinoma	Enrichment	NBN	1.23
190	Bladder cancer	Enrichment	BRCA2	1.12
191	Auditory neuropathy	Enrichment	H1-4	1.10
192	Lung cancer	Enrichment	CHEK2	1.01
193	Systemic lupus erythematosus	Enrichment	ATRIP	0.99
194	Cerebral palsy	Enrichment	BRCA2	0.99
195	Leukemia, acute myeloid	Enrichment	FANCD2	0.98
196	Nephrotic syndrome	Enrichment	SMARCAL1	0.95
197	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	POLG	0.94
198	Hereditary spastic paraplegia	Enrichment	POLG	0.90
199	Hypertrophic cardiomyopathy	Enrichment	POLG	0.89
200	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.89
201	Myeloma, multiple	Enrichment	BRCA2	0.85
202	Body mass index quantitative trait locus 11	Enrichment	POLG	0.83
203	Undetermined early-onset epileptic encephalopathy	Enrichment	CDK19	0.79
204	Hereditary retinal dystrophy	Enrichment	ATRIP, CEP164	0.73
205	Fundus dystrophy	Enrichment	ATRIP, CEP164	0.73
206	Leigh syndrome, nuclear	Enrichment	POLG	0.71
207	Mitochondrial disease	Enrichment	POLG	0.62
208	Congenital nervous system abnormality	Enrichment	POLG	0.54
209	Nervous system disease	Enrichment	POLG	0.54
210	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Activation of the pre-replicative complex

Pathway Network for Activation of the pre-replicative complex

Pathway network for the Activation of the pre-replicative complex SuperPath

Member Pathways for Activation of the pre-replicative complex

Pathways in the Activation of the pre-replicative complex SuperPath

Gene overlap in member pathways for Activation of the pre-replicative complex SuperPath

Associated Genes for Activation of the pre-replicative complex

Associated Disorders for Activation of the pre-replicative complex

Disorders associated with Activation of the pre-replicative complex SuperPath

STRING Interaction Network for Activation of the pre-replicative complex

Sources for Activation of the pre-replicative complex