Acute myeloid leukemia

No Pathway Network information available for Acute myeloid leukemia

Pathways in the Acute myeloid leukemia SuperPath

#	Name	Source	Genes
1	Acute myeloid leukemia	WikiPathways	AKT1 AKT2 AKT3 BAD BCL2A1 BRAF CCNA1 CCNA2 CCND1 CD14 CEBPA CEBPE CHUK CSF1R CSF2 DUSP6 EIF4EBP1 FCGR1A FLT3 GRB2 HRAS IKBKB IKBKG IL3 ITGAM JUP KIT KRAS LEF1 LOC100506403 MAP2K1 MAP2K2 MAPK1 MAPK3 MPO MTOR MYC NFKB1 NRAS PER2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIM1 PIM2 PML PPARD RAF1 RARA RELA RPS6KB1 RPS6KB2 RUNX1T1 SOS1 SOS2 SPI1 STAT3 STAT5A STAT5B TCF7 TCF7L1 TCF7L2 ZBTB16 (see all 66) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD14	CD14 Molecule	Protein Coding	1
2	CCNA1	Cyclin A1	Protein Coding	1
3	CCNA2	Cyclin A2	Protein Coding	1
4	PER2	Period Circadian Regulator 2	Protein Coding	1
5	RUNX1T1	RUNX1 Partner Transcriptional Co-Repressor 1	Protein Coding	1
6	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
7	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
8	ZBTB16	Zinc Finger And BTB Domain Containing 16	Protein Coding	1
9	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
10	TCF7	Transcription Factor 7	Protein Coding	1
11	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
12	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
13	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
14	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
15	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
16	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
17	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
18	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
19	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
20	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
21	BCL2A1	BCL2 Related Protein A1	Protein Coding	1
22	CCND1	Cyclin D1	Protein Coding	1
23	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
24	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
25	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
26	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
27	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
28	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
29	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
30	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
31	PML	PML Nuclear Body Scaffold	Protein Coding	1
32	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
33	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
34	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
35	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
36	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
37	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
38	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
39	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
40	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
41	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
42	MPO	Myeloperoxidase	Protein Coding	1
43	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
44	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
45	JUP	Junction Plakoglobin	Protein Coding	1
46	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
47	IL3	Interleukin 3	Protein Coding	1
48	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
49	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
50	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
51	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
52	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	1
53	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
54	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
55	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
56	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
57	CSF2	Colony Stimulating Factor 2	Protein Coding	1
58	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
59	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
60	PIM2	Pim-2 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
61	CEBPE	CCAAT Enhancer Binding Protein Epsilon	Protein Coding	1
62	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
63	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
64	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
65	LOC100506403	Uncharacterized LOC100506403	RNA Gene	1
66	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1

Disorders associated with Acute myeloid leukemia SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	11.25
2	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	10.79
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.69
4	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	10.61
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.26
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.26
7	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA, FLT3, KIT, RUNX1T1	8.59
8	Acute promyelocytic leukemia	Enrichment	PML, RARA, STAT3, STAT5B, ZBTB16	8.53
9	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.75
10	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	7.75
11	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	7.45
12	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.96
13	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, KIT, PIK3CA	6.61
14	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.36
15	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.36
16	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA	5.96
17	Leukemia, acute myeloid	Enrichment	CEBPA, FLT3, KIT, KRAS, NRAS	5.87
18	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	5.66
19	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	5.42
20	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	5.42
21	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	5.42
22	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	5.42
23	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	5.42
24	Colorectal cancer	Enrichment	AKT1, BRAF, CCND1, NRAS, PIK3CA, PIK3R1	5.41
25	Myeloma, multiple	Enrichment	BRAF, CCND1, FLT3, KRAS, PIK3R2	5.13
26	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.04
27	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	4.96
28	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.89
29	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1, SPI1	4.89
30	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.63
31	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.63
32	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.16
33	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.16
34	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.16
35	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.16
36	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.86
37	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.86
38	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.86
39	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	3.86
40	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3, MYC, ZBTB16	3.74
41	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	3.64
42	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.46
43	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	3.44
44	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.32
45	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.32
46	Lung cancer	Enrichment	BRAF, KRAS, PIK3CA	3.31
47	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.09
48	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	2.90
49	Ovarian cancer	Enrichment	AKT1, KIT, KRAS, PIK3CA	2.83
50	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.83
51	Meningioma	Enrichment	AKT1, PIK3CA	2.83
52	Alzheimer's disease	Enrichment	CSF1R, MPO	2.76
53	Nk-cell enteropathy	Enrichment	PIK3CB, RUNX1T1	2.76
54	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.69
55	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.63
56	Alzheimer disease, familial, 1	Enrichment	CSF1R, MPO	2.52
57	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.42
58	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	2.42
59	Macrodactyly	Enrichment	PIK3CA	2.31
60	Proteus syndrome	Enrichment	AKT1	2.31
61	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.31
62	Oculoectodermal syndrome	Enrichment	KRAS	2.31
63	Incontinentia pigmenti	Enrichment	IKBKG	2.31
64	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.31
65	Immunodeficiency 108 with autoinflammation	Enrichment	CEBPE	2.31
66	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.31
67	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.31
68	Noonan syndrome 5	Enrichment	RAF1	2.31
69	Noonan syndrome 4	Enrichment	SOS1	2.31
70	Mastocytosis, cutaneous	Enrichment	KIT	2.31
71	Advanced sleep phase syndrome, familial, 1	Enrichment	PER2	2.31
72	Melorheostosis, isolated	Enrichment	MAP2K1	2.31
73	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.31
74	Noonan syndrome 7	Enrichment	BRAF	2.31
75	Leopard syndrome 3	Enrichment	BRAF	2.31
76	Skeletal defects, genital hypoplasia, and impaired intellectual development	Enrichment	ZBTB16	2.31
77	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.31
78	Cowden syndrome 5	Enrichment	PIK3CA	2.31
79	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.31
80	Melanosis, neurocutaneous	Enrichment	NRAS	2.31
81	Noonan syndrome 9	Enrichment	SOS2	2.31
82	Noonan syndrome 6	Enrichment	NRAS	2.31
83	Fetal encasement syndrome	Enrichment	CHUK	2.31
84	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.31
85	Naxos disease	Enrichment	JUP	2.31
86	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.31
87	Immunodeficiency 15b	Enrichment	IKBKB	2.31
88	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.31
89	Noonan syndrome 13	Enrichment	MAPK1	2.31
90	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.31
91	Immunodeficiency 15a	Enrichment	IKBKB	2.31
92	Short syndrome	Enrichment	PIK3R1	2.31
93	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.31
94	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.31
95	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.31
96	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.31
97	Lymphangioma	Enrichment	BRAF	2.31
98	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.31
99	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.31
100	Phace association	Enrichment	BRAF	2.31
101	Melorheostosis	Enrichment	MAP2K1	2.31
102	Leopard syndrome 2	Enrichment	RAF1	2.31
103	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.31
104	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.31
105	Cowden syndrome 6	Enrichment	AKT1	2.31
106	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.31
107	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.31
108	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.31
109	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.31
110	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.31
111	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.31
112	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.31
113	Chronic mast cell leukemia	Enrichment	KIT	2.31
114	Trigonitis	Enrichment	RAF1	2.31
115	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.31
116	Csf1r-related disorder	Enrichment	CSF1R	2.31
117	Hypospadias	Enrichment	PIK3CA	2.31
118	Capillary hemangioma	Enrichment	AKT3	2.31
119	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.31
120	Agammaglobulinemia	Enrichment	SPI1	2.31
121	Isolated bone marrow mastocytosis	Enrichment	KIT	2.31
122	Congenital pulmonary airway malformation	Enrichment	KRAS	2.31
123	Smoldering systemic mastocytosis	Enrichment	KIT	2.31
124	Cebpe-associated autoinflammation-immunodeficiency-neutrophil dysfunction syndrome	Enrichment	CEBPE	2.31
125	Rare venous malformation	Enrichment	PIK3CA	2.31
126	Diaphragmatic eventration	Enrichment	PIK3CA	2.31
127	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.31
128	Mastocytosis	Enrichment	KIT	2.31
129	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.31
130	Syringocystadenoma papilliferum	Enrichment	BRAF	2.31
131	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.31
132	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.31
133	Rare combined vascular malformation	Enrichment	PIK3CA	2.31
134	Ganglioglioma	Enrichment	BRAF	2.31
135	Cavernous lymphangioma	Enrichment	PIK3CA	2.31
136	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.31
137	Cutaneous mastocytoma	Enrichment	KIT	2.31
138	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.31
139	Phace syndrome	Enrichment	BRAF	2.31
140	Typical urticaria pigmentosa	Enrichment	KIT	2.31
141	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.31
142	Classic hairy cell leukemia	Enrichment	BRAF	2.31
143	Nodular urticaria pigmentosa	Enrichment	KIT	2.31
144	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.31
145	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.31
146	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.31
147	Acute mast cell leukemia	Enrichment	KIT	2.31
148	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.31
149	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.31
150	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.31
151	Macrodactyly of toe	Enrichment	PIK3CA	2.31
152	Neurocutaneous melanocytosis	Enrichment	NRAS	2.31
153	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.31
154	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.31
155	Testis seminoma	Enrichment	KIT	2.31
156	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA	2.24
157	Dilated cardiomyopathy	Enrichment	BRAF, JUP, RAF1	2.16
158	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.01
159	Burkitt lymphoma	Enrichment	MYC	2.01
160	Fibromatosis, gingival, 1	Enrichment	SOS1	2.01
161	Costello syndrome	Enrichment	HRAS	2.01
162	Specific granule deficiency 1	Enrichment	CEBPE	2.01
163	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.01
164	Immunodeficiency 33	Enrichment	IKBKG	2.01
165	Piebald trait	Enrichment	KIT	2.01
166	Keratosis, seborrheic	Enrichment	PIK3CA	2.01
167	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.01
168	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.01
169	Noonan syndrome 8	Enrichment	PIK3CA	2.01
170	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.01
171	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.01
172	Cebalid syndrome	Enrichment	MTOR	2.01
173	Rela fusion-positive ependymoma	Enrichment	RELA	2.01
174	Senior-loken syndrome 7	Enrichment	AKT3	2.01
175	Split hand-foot malformation	Enrichment	LEF1	2.01
176	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.01
177	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.01
178	Immune system disease	Enrichment	PIK3CD	2.01
179	Bardet-biedl syndrome 16	Enrichment	AKT3	2.01
180	Smith-kingsmore syndrome	Enrichment	MTOR	2.01
181	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.01
182	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.01
183	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.01
184	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.01
185	Common variable immunodeficiency 12	Enrichment	NFKB1	2.01
186	Tafro syndrome	Enrichment	MAP2K2	2.01
187	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.01
188	Specific granule deficiency	Enrichment	CEBPE	2.01
189	Wooly hair nevus	Enrichment	HRAS	2.01
190	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.00
191	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.84
192	Ataxia-telangiectasia	Enrichment	BRAF	1.84
193	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.84
194	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.84
195	Nuchal bleb, familial	Enrichment	SOS1	1.84
196	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.84
197	Tethered spinal cord syndrome	Enrichment	BRAF	1.84
198	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.84
199	Hyper ige syndrome	Enrichment	STAT3	1.84
200	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.84
201	Testicular germ cell cancer	Enrichment	KIT	1.84
202	Spermatocytoma	Enrichment	HRAS	1.84
203	Advanced sleep phase syndrome	Enrichment	PER2	1.84
204	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.84
205	Keratoacanthoma	Enrichment	PIK3CA	1.84
206	Type 2 diabetes mellitus	Enrichment	AKT2, TCF7L2	1.75
207	Gastric cancer	Enrichment	KRAS, PIK3CA	1.73
208	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.71
209	Myeloperoxidase deficiency	Enrichment	MPO	1.71
210	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.71
211	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.71
212	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.71
213	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.71
214	Mantle cell lymphoma	Enrichment	CCND1	1.71
215	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.71
216	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.71
217	Cerebrovascular disease	Enrichment	PIK3CA	1.71
218	Craniopharyngioma	Enrichment	BRAF	1.71
219	Pilocytic astrocytoma	Enrichment	KRAS	1.71
220	Newborn respiratory distress syndrome	Enrichment	BRAF	1.71
221	Epidermolytic nevus	Enrichment	HRAS	1.71
222	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.71
223	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.71
224	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.71
225	Gingival fibromatosis	Enrichment	SOS1	1.71
226	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.71
227	Capillary malformations, congenital	Enrichment	PIK3CA	1.62
228	Von hippel-lindau syndrome	Enrichment	CCND1	1.62
229	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.62
230	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.62
231	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.54
232	Cowden syndrome 1	Enrichment	PIK3CA	1.54
233	Split-hand/foot malformation 1	Enrichment	LEF1	1.54
234	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.54
235	Testicular germ cell tumor	Enrichment	KIT	1.54
236	Wilms tumor 5	Enrichment	BRAF	1.54
237	Gastrointestinal stromal tumor	Enrichment	KIT	1.47
238	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.47
239	Alzheimer's disease 1	Enrichment	MPO	1.47
240	Megacolon	Enrichment	AKT3	1.47
241	Common variable immunodeficiency	Enrichment	NFKB1	1.47
242	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.47
243	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.42
244	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.42
245	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.37
246	Coronary heart disease 5	Enrichment	IKBKG	1.37
247	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.37
248	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.37
249	Primary hyperaldosteronism	Enrichment	BRAF	1.37
250	Ventricular septal defect	Enrichment	BRAF	1.37
251	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.32
252	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.32
253	Polymicrogyria	Enrichment	AKT3	1.32
254	Melanoma	Enrichment	BRAF	1.32
255	Frontotemporal dementia 1	Enrichment	CSF1R	1.28
256	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.28
257	Specific learning disability	Enrichment	MAPK1	1.28
258	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.25
259	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.25
260	Aortic valve disease 1	Enrichment	SOS1	1.21
261	Protein-deficiency anemia	Enrichment	NRAS	1.21
262	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.18
263	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.18
264	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.15
265	Wilms tumor 1	Enrichment	BRAF	1.15
266	Rare genetic intellectual disability	Enrichment	MTOR	1.15
267	Wolff-parkinson-white syndrome	Enrichment	JUP	1.12
268	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.12
269	Rhabdomyosarcoma	Enrichment	HRAS	1.12
270	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.10
271	Dandy-walker syndrome	Enrichment	BRAF	1.10
272	Heart, malformation of	Enrichment	MAPK1	1.08
273	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	1.08
274	Endometrial cancer	Enrichment	PIK3CA	1.01
275	Hepatocellular carcinoma	Enrichment	PIK3CA	0.99
276	Malaria	Enrichment	IKBKG	0.97
277	Kallmann syndrome	Enrichment	DUSP6	0.97
278	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.96
279	Pancreatic cancer	Enrichment	KRAS	0.94
280	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.92
281	Prostate cancer	Enrichment	PIK3CA	0.88
282	Inherited cancer-predisposing syndrome	Enrichment	CEBPA, KIT	0.87
283	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.83
284	Severe combined immunodeficiency	Enrichment	IKBKB	0.83
285	Left ventricular noncompaction	Enrichment	RAF1	0.80
286	Systemic lupus erythematosus	Enrichment	ITGAM	0.76
287	Hypertelorism	Enrichment	PIK3CA	0.65
288	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.64
289	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.63
290	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.61
291	Autism	Enrichment	TCF7L2	0.53
292	Autism spectrum disorder	Enrichment	MAP2K1	0.38
293	Microcephaly	Enrichment	MAPK1	0.34
294	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Acute myeloid leukemia

Pathway Network for Acute myeloid leukemia

Member Pathways for Acute myeloid leukemia

Pathways in the Acute myeloid leukemia SuperPath

Associated Genes for Acute myeloid leukemia

Associated Disorders for Acute myeloid leukemia

Disorders associated with Acute myeloid leukemia SuperPath

STRING Interaction Network for Acute myeloid leukemia

Sources for Acute myeloid leukemia