Acyl chain remodelling of PE

Pathway network for the Acyl chain remodelling of PE SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Acyl chain remodelling of PE SuperPath

#	Name	Source	Genes
1	Acyl chain remodelling of PE	Reactome	ABHD4 LPCAT3 LPCAT4 MBOAT1 MBOAT2 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLA2R1 PLAAT1 PLAAT2 PLAAT3 PLAAT4 PLAAT5 PLBD1 PNPLA8 (see all 29) (see less)
2	Acyl chain remodelling of PC	Reactome	LPCAT1 LPCAT2 LPCAT3 LPCAT4 MBOAT2 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLA2R1 PLAAT3 PLB1 PLBD1 PNPLA8 TMEM86B (see all 27) (see less)
3	Acyl chain remodelling of PS	Reactome	LPCAT3 LPCAT4 MBOAT1 OSBPL10 OSBPL5 OSBPL8 PLA1A PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4B PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2R1 PLAAT3 (see all 22) (see less)
4	Lipid metabolism in senescent cells	WikiPathways	ALOX5 CDKN1A HRAS PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2D PLA2G3 PLA2G4A PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLA2G7 PTGS2 SLCO2A1 TP53 (see all 20) (see less)

Gene overlap in member pathways for Acyl chain remodelling of PE SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLA2G4E	Phospholipase A2 Group IVE	Protein Coding	4
2	PLA2G4F	Phospholipase A2 Group IVF	Protein Coding	4
3	PLA2G2D	Phospholipase A2 Group IID	Protein Coding	4
4	PLA2G4D	Phospholipase A2 Group IVD	Protein Coding	4
5	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	4
6	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	4
7	PLA2G5	Phospholipase A2 Group V	Protein Coding	4
8	PLA2G12A	Phospholipase A2 Group XIIA	Protein Coding	4
9	PLA2G10	Phospholipase A2 Group X	Protein Coding	4
10	PLA2G4B	Phospholipase A2 Group IVB	Protein Coding	3
11	LPCAT3	Lysophosphatidylcholine Acyltransferase 3	Protein Coding	3
12	PLAAT3	Phospholipase A And Acyltransferase 3	Protein Coding	3
13	PLA2R1	Phospholipase A2 Receptor 1	Protein Coding	3
14	LPCAT4	Lysophosphatidylcholine Acyltransferase 4	Protein Coding	3
15	PLA2G2E	Phospholipase A2 Group IIE	Protein Coding	3
16	PLA2G3	Phospholipase A2 Group III	Protein Coding	3
17	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	3
18	PLA2G2F	Phospholipase A2 Group IIF	Protein Coding	3
19	PLA2G6	Phospholipase A2 Group VI	Protein Coding	3
20	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	3
21	MBOAT2	Membrane Bound Glycerophospholipid O-Acyltransferase 2	Protein Coding	2
22	MBOAT1	Membrane Bound Glycerophospholipid O-Acyltransferase 1	Protein Coding	2
23	PNPLA8	Patatin Like Domain 8, Phospholipase A2	Protein Coding	2
24	PLBD1	Phospholipase B Domain Containing 1	Protein Coding	2
25	PLAAT5	Phospholipase A And Acyltransferase 5	Protein Coding	1
26	PLAAT2	Phospholipase A And Acyltransferase 2	Protein Coding	1
27	PLAAT1	Phospholipase A And Acyltransferase 1	Protein Coding	1
28	PLAAT4	Phospholipase A And Acyltransferase 4	Protein Coding	1
29	ABHD4	Abhydrolase Domain Containing 4, N-Acyl Phospholipase B	Protein Coding	1
30	PLB1	Phospholipase B1	Protein Coding	1
31	TMEM86B	Transmembrane Protein 86B	Protein Coding	1
32	LPCAT2	Lysophosphatidylcholine Acyltransferase 2	Protein Coding	1
33	LPCAT1	Lysophosphatidylcholine Acyltransferase 1	Protein Coding	1
34	OSBPL5	Oxysterol Binding Protein Like 5	Protein Coding	1
35	OSBPL8	Oxysterol Binding Protein Like 8	Protein Coding	1
36	OSBPL10	Oxysterol Binding Protein Like 10	Protein Coding	1
37	PLA1A	Phospholipase A1 Member A	Protein Coding	1
38	PLA2G12B	Phospholipase A2 Group XIIB	Protein Coding	1
39	PLA2G7	Phospholipase A2 Group VII	Protein Coding	1
40	TP53	Tumor Protein P53	Protein Coding	1
41	SLCO2A1	Solute Carrier Organic Anion Transporter Family Member 2A1	Protein Coding	1
42	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
43	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
44	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	1
45	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1

Disorders associated with Acyl chain remodelling of PE SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	CDKN1A, HRAS, TP53	5.01
2	Lip and oral cavity carcinoma	Enrichment	HRAS, TP53	3.87
3	Rhabdomyosarcoma	Enrichment	HRAS, TP53	3.61
4	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	2.83
5	Hypertrophic osteoarthropathy, primary, autosomal dominant	Enrichment	SLCO2A1	2.83
6	Fleck retina, familial benign	Enrichment	PLA2G5	2.83
7	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	2.83
8	Bone marrow failure syndrome 5	Enrichment	TP53	2.83
9	Papilloma of choroid plexus	Enrichment	TP53	2.83
10	Basal cell carcinoma 7	Enrichment	TP53	2.83
11	Anaplastic thyroid carcinoma	Enrichment	TP53	2.83
12	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	2.83
13	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	2.83
14	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.83
15	Ductal carcinoma in situ	Enrichment	TP53	2.83
16	Platelet-activating factor acetylhydrolase deficiency	Enrichment	PLA2G7	2.83
17	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.83
18	Chronic enteropathy associated with slco2a1 gene	Enrichment	SLCO2A1	2.83
19	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.83
20	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.83
21	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.83
22	Choroid plexus cancer	Enrichment	TP53	2.83
23	Atherosclerosis	Enrichment	ALOX5	2.83
24	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.83
25	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.83
26	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.83
27	Familial benign flecked retina	Enrichment	PLA2G5	2.83
28	Lipodystrophy, familial partial, type 9	Enrichment	PLAAT3	2.79
29	Mitochondrial myopathy with lactic acidosis	Enrichment	PNPLA8	2.70
30	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.53
31	Costello syndrome	Enrichment	HRAS	2.53
32	Cervical cancer	Enrichment	TP53	2.53
33	Lymphoma, hodgkin, classic	Enrichment	TP53	2.53
34	Phoar2-enteropathy syndrome	Enrichment	SLCO2A1	2.53
35	Congenital fibrosarcoma	Enrichment	TP53	2.53
36	Li-fraumeni syndrome 1	Enrichment	TP53	2.53
37	Sarcoma	Enrichment	TP53	2.53
38	Primary hypertrophic osteoarthropathy	Enrichment	SLCO2A1	2.53
39	Cervix carcinoma	Enrichment	TP53	2.53
40	Hodgkin's lymphoma	Enrichment	TP53	2.53
41	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.53
42	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	2.53
43	Wooly hair nevus	Enrichment	HRAS	2.53
44	Bardet-biedl syndrome 10	Enrichment	OSBPL8	2.49
45	Late-onset retinal degeneration	Enrichment	PLA2G5	2.35
46	Osteogenic sarcoma	Enrichment	TP53	2.35
47	Nasopharyngeal carcinoma	Enrichment	TP53	2.35
48	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1	Enrichment	SLCO2A1	2.35
49	Large congenital melanocytic nevus	Enrichment	HRAS	2.35
50	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.35
51	Anaplastic astrocytoma	Enrichment	TP53	2.35
52	Squamous cell carcinoma	Enrichment	TP53	2.35
53	Adenocarcinoma	Enrichment	TP53	2.35
54	Bone osteosarcoma	Enrichment	TP53	2.35
55	Spermatocytoma	Enrichment	HRAS	2.35
56	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.23
57	Small cell cancer of the lung	Enrichment	TP53	2.23
58	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.23
59	Lung sarcomatoid carcinoma	Enrichment	TP53	2.23
60	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.23
61	Epidermolytic nevus	Enrichment	HRAS	2.23
62	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	LPCAT2	2.22
63	Rhabdomyosarcoma 2	Enrichment	TP53	2.13
64	Lymphoma	Enrichment	TP53	2.13
65	Acute megakaryocytic leukemia	Enrichment	TP53	2.13
66	Li-fraumeni syndrome	Enrichment	TP53	2.05
67	Adrenocortical carcinoma	Enrichment	TP53	2.05
68	Breast adenocarcinoma	Enrichment	TP53	2.05
69	Esophageal cancer	Enrichment	TP53	1.99
70	Nevus, epidermal	Enrichment	HRAS	1.99
71	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.99
72	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.99
73	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.99
74	Noonan syndrome 3	Enrichment	HRAS	1.99
75	Essential thrombocythemia	Enrichment	TP53	1.99
76	Gallbladder cancer	Enrichment	TP53	1.99
77	Follicular thyroid carcinoma	Enrichment	HRAS	1.99
78	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.99
79	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.93
80	Glioma susceptibility 1	Enrichment	TP53	1.93
81	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.93
82	Arteriovenous malformation	Enrichment	HRAS	1.88
83	Adult hepatocellular carcinoma	Enrichment	TP53	1.88
84	Primary hyperaldosteronism	Enrichment	TP53	1.88
85	Leukemia, chronic lymphocytic	Enrichment	TP53	1.83
86	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.83
87	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	1.83
88	Familial colorectal cancer	Enrichment	TP53	1.83
89	Asthma	Enrichment	ALOX5	1.79
90	Myelodysplastic syndrome	Enrichment	TP53	1.79
91	Lung non-small cell carcinoma	Enrichment	HRAS	1.79
92	Lung cancer susceptibility 3	Enrichment	TP53	1.69
93	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.66
94	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	1.63
95	Gliosarcoma	Enrichment	TP53	1.63
96	Giant cell glioblastoma	Enrichment	TP53	1.61
97	Diffuse large b-cell lymphoma	Enrichment	TP53	1.56
98	Hepatoblastoma	Enrichment	TP53	1.52
99	Hepatocellular carcinoma	Enrichment	TP53	1.50
100	Diamond-blackfan anemia 1	Enrichment	TP53	1.48
101	Noonan syndrome 1	Enrichment	HRAS	1.48
102	Pancreatic cancer	Enrichment	TP53	1.44
103	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.42
104	Rasopathy	Enrichment	HRAS	1.42
105	Prostate cancer	Enrichment	TP53	1.38
106	Differentiated thyroid carcinoma	Enrichment	HRAS	1.38
107	Non-immune hydrops fetalis	Enrichment	HRAS	1.35
108	Diamond-blackfan anemia	Enrichment	TP53	1.29
109	Leukemia, acute myeloid	Enrichment	TP53	1.24
110	Gastric cancer	Enrichment	TP53	1.21
111	Hereditary breast carcinoma	Enrichment	TP53	1.20
112	Bardet-biedl syndrome	Enrichment	OSBPL8	1.18
113	Spastic ataxia	Enrichment	PLA2G6	1.12
114	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.11
115	Myeloma, multiple	Enrichment	TP53	1.10
116	Breast cancer	Enrichment	TP53	0.98
117	Colorectal cancer	Enrichment	TP53	0.92
118	Ovarian cancer	Enrichment	TP53	0.86
119	Congenital nervous system abnormality	Enrichment	PLA2G6	0.84
120	Nervous system disease	Enrichment	PLA2G6	0.84
121	Microcephaly	Enrichment	PLA2G6	0.78
122	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.75
123	Hereditary retinal dystrophy	Enrichment	OSBPL8	0.42
124	Fundus dystrophy	Enrichment	OSBPL8	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Acyl chain remodelling of PE

Pathway Network for Acyl chain remodelling of PE

Pathway network for the Acyl chain remodelling of PE SuperPath

Member Pathways for Acyl chain remodelling of PE

Pathways in the Acyl chain remodelling of PE SuperPath

Gene overlap in member pathways for Acyl chain remodelling of PE SuperPath

Associated Genes for Acyl chain remodelling of PE

Associated Disorders for Acyl chain remodelling of PE

Disorders associated with Acyl chain remodelling of PE SuperPath

STRING Interaction Network for Acyl chain remodelling of PE

Sources for Acyl chain remodelling of PE