ADORA2B mediated anti-inflammatory cytokines production

Pathway network for the ADORA2B mediated anti-inflammatory cytokines production SuperPath

Sources:

Reactome
QIAGEN
WikiPathways
GeneGo (Thomson Reuters)
PharmGKB

Pathways in the ADORA2B mediated anti-inflammatory cytokines production SuperPath

#	Name	Source	Genes
1	ADORA2B mediated anti-inflammatory cytokines production	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2B CREB1 GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IL6 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX (see all 43) (see less)
2	Parasitic Infection Pathways	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2B AHCYL1 APP ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK C3 C3AR1 CALM1 CALM2 CALM3 CASP1 CD163 CD247 CD3G CDC42 CREB1 CRK CTSG CYBA CYFIP1 CYFIP2 CYSLTR1 CYSLTR2 DOCK1 DPEP1 DPEP2 DVL1 DVL2 DVL3 ELMO1 ELMO2 ENTPD1 ENTPD5 FCGR1A FCGR2A FCGR3A FGR FURIN FYN FZD7 GGT1 GGT5 GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GSDMD HCK HMOX1 HSP90AB1 IL10 IL18 IL1A IL1B IL6 ITPR1 ITPR2 ITPR3 JUN LYN MAPK1 MAPK14 MAPK3 MAPK8 MEFV MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NFKB1 NFKB2 NLRP3 NOX1 NOXA1 NOXO1 NT5E P2RX4 P2RX7 PLCG1 PLCG2 PLK2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX PSTPIP1 PTK2 PYCARD RAC1 RELA RHBDF2 SRC SUGT1 SYK TXN TXNIP VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 WNT5A YES1 (see all 163) (see less)
3	Leishmania infection	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2B AHCYL1 APP ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK C3 C3AR1 CALM1 CALM2 CALM3 CASP1 CD163 CD247 CD3G CDC42 CREB1 CRK CTSG CYBA CYFIP1 CYFIP2 CYSLTR1 CYSLTR2 DOCK1 DPEP1 DPEP2 DVL1 DVL2 DVL3 ELMO1 ELMO2 ENTPD1 ENTPD5 FCGR1A FCGR2A FCGR3A FGR FURIN FYN FZD7 GGT1 GGT5 GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GSDMD HCK HMOX1 HSP90AB1 IL10 IL18 IL1A IL1B IL6 ITPR1 ITPR2 ITPR3 JUN LYN MAPK1 MAPK14 MAPK3 MAPK8 MEFV MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NFKB1 NFKB2 NLRP3 NOX1 NOXA1 NOXO1 NT5E P2RX4 P2RX7 PLCG1 PLCG2 PLK2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX PSTPIP1 PTK2 PYCARD RAC1 RELA RHBDF2 SRC SUGT1 SYK TXN TXNIP VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 WNT5A YES1 (see all 163) (see less)
4	Hedgehog Signaling in Mammals	QIAGEN	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 BMP1 BMP10 BMP15 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8B CREBBP DHH GLI1 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IHH PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTCH1 PTCH2 SMO STK36 SUFU TUBA3C TUBA4A TUBA8 TUBB1 TUBB2A TUBB2B TUBB3 TUBB6 TUBB7P TUBD1 TUBE1 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B (see all 102) (see less)
5	Relaxin Pathway	QIAGEN	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKT1 ATF4 BRAF CREB1 CREB3 CREB3L4 ELK1 FOS GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GUCY1A1 GUCY1A2 GUCY1B1 GUCY2D GUCY2EP GUCY2F JUN MAP2K1 MAPK1 MAPK3 MMP9 NFKB1 NFKBIA NFKBIB NFKBIE NOS2 NOS3 NPR1 NPR2 PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCZ RAP1A RAP1B RLN1 RLN2 RLN3 RXFP1 RXFP2 VEGFA (see all 94) (see less)
6	G protein signaling pathways	WikiPathways	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARHGEF1 CALM1 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAQ GNAS GNAZ GNB1 GNB2 GNB3 GNB5 GNG10 GNG11 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HRAS ITPR1 KCNJ3 KRAS NRAS PDE1A PDE1B PDE1C PDE4A PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PLCB3 PPP3CA PPP3CC PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RHOA RRAS SLC9A1 (see all 91) (see less)
7	Signal transduction cAMP signaling	GeneGo (Thomson Reuters)	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GSK3A GSK3B KDELR1 KDELR2 KDELR3 LIPE PHKA1 PHKA2 PHKG1 PHKG2 PLN PPP3CA PPP3CB PPP3CC PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 RAP1A RAP2A RAPGEF3 RAPGEF4 RYR1 (see all 79) (see less)
8	Anti-inflammatory response favouring Leishmania parasite infection	Reactome	ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2B AHCYL1 CALM1 CALM2 CALM3 CD163 CD247 CD3G CREB1 CYSLTR1 CYSLTR2 DPEP1 DPEP2 FCGR1A FCGR2A FCGR3A FGR FURIN FYN GGT1 GGT5 GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HCK IL10 IL6 ITPR1 ITPR2 ITPR3 LYN MAPK14 MYH9 PLCG1 PLCG2 PLK2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX RHBDF2 SRC SYK YES1 (see all 78) (see less)
9	Leishmania parasite growth and survival	Reactome	ADAM17 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2B AHCYL1 CALM1 CALM2 CALM3 CD163 CD247 CD3G CREB1 CYSLTR1 CYSLTR2 DPEP1 DPEP2 FCGR1A FCGR2A FCGR3A FGR FURIN FYN GGT1 GGT5 GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HCK IL10 IL6 ITPR1 ITPR2 ITPR3 LYN MAPK14 MYH9 PLCG1 PLCG2 PLK2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX RHBDF2 SRC SYK YES1 (see all 78) (see less)
10	Alpha-Adrenergic Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 ADRA1A ADRA2A ARAF BRAF CALM1 CALM2 CALM3 CAMK1 CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 GNAI1 GNAI2 GNAI3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GYS1 GYS2 HRAS ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MRAS NRAS PHKA1 PHKA2 PHKB PHKG1 PHKG2 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAF1 RRAS RRAS2 SLC8A1 SLC8A2 SLC8A3 (see all 77) (see less)
11	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation	GeneGo (Thomson Reuters)	ABL1 ACTB ACTG1 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADD1 ADD2 AKAP13 ARHGEF7 CALM1 CALM2 CALM3 CDC42 CFL1 CFL2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITGA4 ITGB1 ITPR1 ITPR2 ITPR3 LASP1 LIMK1 MYL1 MYL3 MYL4 MYL6 MYL6B MYLK MYLK2 MYLK3 PAK1 PLCB3 PPP1CB PPP1R12A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PXN RAC1 RHOA ROCK1 ROCK2 SPTAN1 SPTBN1 VASP YWHAB (see all 75) (see less)
12	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics	PharmGKB	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB2 ARRB1 ARRB2 CACNA1B CACNA1C CACNA1D CACNA1S CAVIN3 ELF2 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB1L GNB2 GNB3 GNB4 GNG2 GNG3 GNG4 GNG5 GNG7 GRK2 GRK3 ITPR1 MAPK1 NHERF1 NHERF2 PDE4A PDE4B PDE4C PDE4D PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RGS1 SLC9A1 SLC9A2 SLC9A3 SLC9A3P1 SLC9A4 SLC9A5 SLC9A6 SRC (see all 66) (see less)
13	G alpha (z) signalling events	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA2A ADRA2B ADRA2C GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH RGS16 RGS17 RGS19 RGS20 RGS4 RGSL1 (see all 47) (see less)
14	GPER1 signaling	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 FN1 GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPER1 ITGA5 ITGB1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B SHC1 SRC (see all 45) (see less)
15	FCGR3A-mediated IL10 synthesis	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AHCYL1 CALM1 CALM2 CALM3 CD247 CD3G CREB1 FCGR1A FCGR2A FCGR3A FGR FYN HCK IL10 ITPR1 ITPR2 ITPR3 LYN PLCG1 PLCG2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX SRC SYK YES1 (see all 40) (see less)
16	Glucagon signaling in metabolic regulation	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GCG GCGR GNAS GNB1 GNB2 GNB3 GNB4 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B (see all 33) (see less)
17	FCGR activation	Reactome	CD247 CD3G FCGR1A FCGR2A FCGR3A FGR FYN HCK LYN SRC SYK YES1 (see all 12) (see less)
18	CD163 mediating an anti-inflammatory response	Reactome	ADAM17 CD163 FURIN IL10 IL6 MAPK14 MYH9 PLK2 RHBDF2 (see all 9) (see less)
19	LTC4-CYSLTR mediated IL4 production	Reactome	CYSLTR1 CYSLTR2 DPEP1 DPEP2 GGT1 GGT5 (see all 6) (see less)
20	Androgen receptor signaling pathway	WikiPathways	RLN1

Gene overlap in member pathways for ADORA2B mediated anti-inflammatory cytokines production SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADCY1	Adenylate Cyclase 1	Protein Coding	16
2	ADCY2	Adenylate Cyclase 2	Protein Coding	16
3	ADCY3	Adenylate Cyclase 3	Protein Coding	16
4	ADCY5	Adenylate Cyclase 5	Protein Coding	15
5	ADCY6	Adenylate Cyclase 6	Protein Coding	15
6	ADCY7	Adenylate Cyclase 7	Protein Coding	15
7	ADCY8	Adenylate Cyclase 8	Protein Coding	15
8	ADCY9	Adenylate Cyclase 9	Protein Coding	15
9	ADCY4	Adenylate Cyclase 4	Protein Coding	15
10	GNB1	G Protein Subunit Beta 1	Protein Coding	15
11	GNB2	G Protein Subunit Beta 2	Protein Coding	15
12	GNB3	G Protein Subunit Beta 3	Protein Coding	15
13	GNG3	G Protein Subunit Gamma 3	Protein Coding	15
14	GNG4	G Protein Subunit Gamma 4	Protein Coding	15
15	GNG5	G Protein Subunit Gamma 5	Protein Coding	15
16	GNG7	G Protein Subunit Gamma 7	Protein Coding	15
17	GNAS	GNAS Complex Locus	Protein Coding	14
18	GNG10	G Protein Subunit Gamma 10	Protein Coding	14
19	GNG11	G Protein Subunit Gamma 11	Protein Coding	14
20	GNG13	G Protein Subunit Gamma 13	Protein Coding	14
21	GNG2	G Protein Subunit Gamma 2	Protein Coding	14
22	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	14
23	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	14
24	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	14
25	GNG12	G Protein Subunit Gamma 12	Protein Coding	14
26	GNB4	G Protein Subunit Beta 4	Protein Coding	14
27	GNG8	G Protein Subunit Gamma 8	Protein Coding	14
28	GNB5	G Protein Subunit Beta 5	Protein Coding	13
29	GNAI1	G Protein Subunit Alpha I1	Protein Coding	13
30	GNAI2	G Protein Subunit Alpha I2	Protein Coding	13
31	GNAI3	G Protein Subunit Alpha I3	Protein Coding	13
32	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	13
33	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	13
34	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	13
35	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	13
36	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	13
37	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	13
38	GNAZ	G Protein Subunit Alpha Z	Protein Coding	11
39	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	9
40	CALM1	Calmodulin 1	Protein Coding	9
41	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	8
42	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	8
43	CALM2	Calmodulin 2	Protein Coding	8
44	CALM3	Calmodulin 3	Protein Coding	8
45	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	7
46	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	7
47	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	7
48	IL6	Interleukin 6	Protein Coding	6
49	PRKX	Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit	Protein Coding	6
50	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	6
51	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	6
52	FCGR3A	Fc Gamma Receptor IIIa	Protein Coding	6
53	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
54	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
55	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
56	IL10	Interleukin 10	Protein Coding	6
57	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
58	PLCG1	Phospholipase C Gamma 1	Protein Coding	6
59	PLCG2	Phospholipase C Gamma 2	Protein Coding	6
60	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	6
61	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	6
62	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	6
63	CD247	CD247 Molecule	Protein Coding	6
64	ADORA2B	Adenosine A2b Receptor	Protein Coding	5
65	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	5
66	PLK2	Polo Like Kinase 2	Protein Coding	5
67	CYSLTR1	Cysteinyl Leukotriene Receptor 1	Protein Coding	5
68	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	5
69	DPEP1	Dipeptidase 1	Protein Coding	5
70	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	5
71	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	5
72	MYH9	Myosin Heavy Chain 9	Protein Coding	5
73	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	5
74	CYSLTR2	Cysteinyl Leukotriene Receptor 2	Protein Coding	5
75	DPEP2	Dipeptidase 2	Protein Coding	5
76	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	5
77	RHBDF2	Rhomboid 5 Homolog 2	Protein Coding	5
78	CD163	CD163 Molecule	Protein Coding	5
79	PRKCZ	Protein Kinase C Zeta	Protein Coding	5
80	PRKCH	Protein Kinase C Eta	Protein Coding	5
81	PRKCG	Protein Kinase C Gamma	Protein Coding	5
82	PRKCE	Protein Kinase C Epsilon	Protein Coding	5
83	PRKCD	Protein Kinase C Delta	Protein Coding	5
84	PRKCB	Protein Kinase C Beta	Protein Coding	5
85	PRKCA	Protein Kinase C Alpha	Protein Coding	5
86	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
87	GNAO1	G Protein Subunit Alpha O1	Protein Coding	4
88	PRKCQ	Protein Kinase C Theta	Protein Coding	4
89	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	3
90	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
91	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
92	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
93	RAC1	Rac Family Small GTPase 1	Protein Coding	3
94	ACTB	Actin Beta	Protein Coding	3
95	ACTG1	Actin Gamma 1	Protein Coding	3
96	WNT5A	Wnt Family Member 5A	Protein Coding	3
97	CDC42	Cell Division Cycle 42	Protein Coding	3
98	GNA11	G Protein Subunit Alpha 11	Protein Coding	3
99	GNA12	G Protein Subunit Alpha 12	Protein Coding	3
100	GNA13	G Protein Subunit Alpha 13	Protein Coding	3
101	GNA14	G Protein Subunit Alpha 14	Protein Coding	3
102	GNA15	G Protein Subunit Alpha 15	Protein Coding	3
103	GNAL	G Protein Subunit Alpha L	Protein Coding	3
104	PLCB3	Phospholipase C Beta 3	Protein Coding	3
105	PRKD1	Protein Kinase D1	Protein Coding	3
106	PRKCI	Protein Kinase C Iota	Protein Coding	3
107	PRKD3	Protein Kinase D3	Protein Coding	3
108	ABI1	Abl Interactor 1	Protein Coding	2
109	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	2
110	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	2
111	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	2
112	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	2
113	ACTR3	Actin Related Protein 3	Protein Coding	2
114	ACTR2	Actin Related Protein 2	Protein Coding	2
115	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	2
116	ABI2	Abl Interactor 2	Protein Coding	2
117	WASF2	WASP Family Member 2	Protein Coding	2
118	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
119	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	2
120	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	2
121	TXNIP	Thioredoxin Interacting Protein	Protein Coding	2
122	NCKAP1	NCK Associated Protein 1	Protein Coding	2
123	WASF3	WASP Family Member 3	Protein Coding	2
124	NOXA1	NADPH Oxidase Activator 1	Protein Coding	2
125	SUGT1	SGT1 Assembly Cochaperone Of MIS12 Kinetochore Complex	Protein Coding	2
126	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	2
127	NOXO1	NADPH Oxidase Organizer 1	Protein Coding	2
128	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
129	WIPF2	WAS/WASL Interacting Protein Family Member 2	Protein Coding	2
130	CTSG	Cathepsin G	Protein Coding	2
131	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	2
132	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	2
133	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	2
134	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	2
135	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	2
136	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	2
137	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	2
138	NOX1	NADPH Oxidase 1	Protein Coding	2
139	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
140	PYCARD	PYD And CARD Domain Containing	Protein Coding	2
141	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	2
142	HMOX1	Heme Oxygenase 1	Protein Coding	2
143	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
144	APP	Amyloid Beta Precursor Protein	Protein Coding	2
145	IL1A	Interleukin 1 Alpha	Protein Coding	2
146	IL1B	Interleukin 1 Beta	Protein Coding	2
147	IL18	Interleukin 18	Protein Coding	2
148	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	2
149	MYH2	Myosin Heavy Chain 2	Protein Coding	2
150	MYO1C	Myosin IC	Protein Coding	2
151	MYO5A	Myosin VA	Protein Coding	2
152	MYO9B	Myosin IXB	Protein Coding	2
153	MYO10	Myosin X	Protein Coding	2
154	NCK1	NCK Adaptor Protein 1	Protein Coding	2
155	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
156	NT5E	5''-Nucleotidase Ecto	Protein Coding	2
157	P2RX4	Purinergic Receptor P2X 4	Protein Coding	2
158	P2RX7	Purinergic Receptor P2X 7	Protein Coding	2
159	NCKIPSD	NCK Interacting Protein With SH3 Domain	Protein Coding	2
160	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	2
161	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
162	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
163	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
164	ELMO2	Engulfment And Cell Motility 2	Protein Coding	2
165	WIPF3	WAS/WASL Interacting Protein Family Member 3	Protein Coding	2
166	BTK	Bruton Tyrosine Kinase	Protein Coding	2
167	C3	Complement C3	Protein Coding	2
168	C3AR1	Complement C3a Receptor 1	Protein Coding	2
169	TXN	Thioredoxin	Protein Coding	2
170	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
171	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
172	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	2
173	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	2
174	GSDMD	Gasdermin D	Protein Coding	2
175	FZD7	Frizzled Class Receptor 7	Protein Coding	2
176	CASP1	Caspase 1	Protein Coding	2
177	WASF1	WASP Family Member 1	Protein Coding	2
178	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
179	PSTPIP1	Proline-Serine-Threonine Phosphatase Interacting Protein 1	Protein Coding	2
180	ENTPD1	Ectonucleoside Triphosphate Diphosphohydrolase 1	Protein Coding	2
181	ENTPD5	Ectonucleoside Triphosphate Diphosphohydrolase 5 (Inactive)	Protein Coding	2
182	ELMO1	Engulfment And Cell Motility 1	Protein Coding	2
183	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	2
184	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	2
185	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
186	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
187	PDE1A	Phosphodiesterase 1A	Protein Coding	2
188	PDE1B	Phosphodiesterase 1B	Protein Coding	2
189	PDE1C	Phosphodiesterase 1C	Protein Coding	2
190	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
191	RLN1	Relaxin 1	Protein Coding	2
192	PDE4C	Phosphodiesterase 4C	Protein Coding	2
193	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	2
194	RRAS	RAS Related	Protein Coding	2
195	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
196	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
197	PDE4D	Phosphodiesterase 4D	Protein Coding	2
198	PDE4B	Phosphodiesterase 4B	Protein Coding	2
199	PDE4A	Phosphodiesterase 4A	Protein Coding	2
200	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
201	RHOA	Ras Homolog Family Member A	Protein Coding	2
202	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
203	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
204	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	2
205	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	2
206	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	2
207	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	2
208	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	2
209	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	2
210	PHKA1	Phosphorylase Kinase Regulatory Subunit Alpha 1	Protein Coding	2
211	PHKA2	Phosphorylase Kinase Regulatory Subunit Alpha 2	Protein Coding	2
212	PHKG1	Phosphorylase Kinase Catalytic Subunit Gamma 1	Protein Coding	2
213	PHKG2	Phosphorylase Kinase Catalytic Subunit Gamma 2	Protein Coding	2
214	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	2
215	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
216	BMP1	Bone Morphogenetic Protein 1	Protein Coding	1
217	BMP10	Bone Morphogenetic Protein 10	Protein Coding	1
218	BMP15	Bone Morphogenetic Protein 15	Protein Coding	1
219	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
220	BMP3	Bone Morphogenetic Protein 3	Protein Coding	1
221	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
222	BMP5	Bone Morphogenetic Protein 5	Protein Coding	1
223	BMP6	Bone Morphogenetic Protein 6	Protein Coding	1
224	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
225	BMP8B	Bone Morphogenetic Protein 8b	Protein Coding	1
226	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
227	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	1
228	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
229	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	1
230	TUBB6	Tubulin Beta 6 Class V	Protein Coding	1
231	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	1
232	PTCH1	Patched 1	Protein Coding	1
233	PTCH2	Patched 2	Protein Coding	1
234	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
235	STK36	Serine/Threonine Kinase 36	Protein Coding	1
236	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	1
237	TUBA4A	Tubulin Alpha 4a	Protein Coding	1
238	TUBA3C	Tubulin Alpha 3c	Protein Coding	1
239	TUBA8	Tubulin Alpha 8	Protein Coding	1
240	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	1
241	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	1
242	TUBB3	Tubulin Beta 3 Class III	Protein Coding	1
243	TUBB7P	Tubulin Beta 7 Pseudogene	Pseudogene	1
244	TUBD1	Tubulin Delta 1	Protein Coding	1
245	TUBE1	Tubulin Epsilon 1	Protein Coding	1
246	TUBG1	Tubulin Gamma 1	Protein Coding	1
247	TUBG2	Tubulin Gamma 2	Protein Coding	1
248	TUBGCP2	Tubulin Gamma Complex Component 2	Protein Coding	1
249	TUBGCP3	Tubulin Gamma Complex Component 3	Protein Coding	1
250	TUBGCP5	Tubulin Gamma Complex Component 5	Protein Coding	1
251	TUBGCP6	Tubulin Gamma Complex Component 6	Protein Coding	1
252	WNT1	Wnt Family Member 1	Protein Coding	1
253	WNT10A	Wnt Family Member 10A	Protein Coding	1
254	WNT10B	Wnt Family Member 10B	Protein Coding	1
255	WNT11	Wnt Family Member 11	Protein Coding	1
256	WNT9A	Wnt Family Member 9A	Protein Coding	1
257	WNT9B	Wnt Family Member 9B	Protein Coding	1
258	WNT16	Wnt Family Member 16	Protein Coding	1
259	WNT2	Wnt Family Member 2	Protein Coding	1
260	WNT2B	Wnt Family Member 2B	Protein Coding	1
261	WNT3	Wnt Family Member 3	Protein Coding	1
262	WNT3A	Wnt Family Member 3A	Protein Coding	1
263	WNT4	Wnt Family Member 4	Protein Coding	1
264	WNT5B	Wnt Family Member 5B	Protein Coding	1
265	WNT6	Wnt Family Member 6	Protein Coding	1
266	WNT7A	Wnt Family Member 7A	Protein Coding	1
267	WNT7B	Wnt Family Member 7B	Protein Coding	1
268	WNT8A	Wnt Family Member 8A	Protein Coding	1
269	WNT8B	Wnt Family Member 8B	Protein Coding	1
270	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
271	ATF4	Activating Transcription Factor 4	Protein Coding	1
272	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
273	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
274	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
275	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
276	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
277	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
278	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
279	GUCY2D	Guanylate Cyclase 2D, Retinal	Protein Coding	1
280	GUCY2EP	Guanylate Cyclase 2E, Pseudogene	Pseudogene	1
281	GUCY2F	Guanylate Cyclase 2F, Retinal	Protein Coding	1
282	RXFP1	Relaxin Family Peptide Receptor 1	Protein Coding	1
283	RXFP2	Relaxin Family Peptide Receptor 2	Protein Coding	1
284	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
285	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
286	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
287	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
288	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
289	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
290	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	1
291	NPR2	Natriuretic Peptide Receptor 2	Protein Coding	1
292	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
293	PDE2A	Phosphodiesterase 2A	Protein Coding	1
294	PDE3A	Phosphodiesterase 3A	Protein Coding	1
295	PDE3B	Phosphodiesterase 3B	Protein Coding	1
296	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
297	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
298	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
299	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
300	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
301	RLN2	Relaxin 2	Protein Coding	1
302	RLN3	Relaxin 3	Protein Coding	1
303	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
304	PDE8A	Phosphodiesterase 8A	Protein Coding	1
305	PDE7A	Phosphodiesterase 7A	Protein Coding	1
306	PDE7B	Phosphodiesterase 7B	Protein Coding	1
307	AKAP12	A-Kinase Anchoring Protein 12	Protein Coding	1
308	AKAP5	A-Kinase Anchoring Protein 5	Protein Coding	1
309	AKAP6	A-Kinase Anchoring Protein 6	Protein Coding	1
310	AKAP7	A-Kinase Anchoring Protein 7	Protein Coding	1
311	PDE8B	Phosphodiesterase 8B	Protein Coding	1
312	AKAP1	A-Kinase Anchoring Protein 1	Protein Coding	1
313	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
314	AKAP11	A-Kinase Anchoring Protein 11	Protein Coding	1
315	AKAP9	A-Kinase Anchoring Protein 9	Protein Coding	1
316	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
317	AKAP4	A-Kinase Anchoring Protein 4	Protein Coding	1
318	AKAP10	A-Kinase Anchoring Protein 10	Protein Coding	1
319	AKAP3	A-Kinase Anchoring Protein 3	Protein Coding	1
320	AKAP8	A-Kinase Anchoring Protein 8	Protein Coding	1
321	KCNJ3	Potassium Inwardly Rectifying Channel Subfamily J Member 3	Protein Coding	1
322	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
323	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
324	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	1
325	PLN	Phospholamban	Protein Coding	1
326	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
327	RAP2A	RAP2A, Member Of RAS Oncogene Family	Protein Coding	1
328	RYR1	Ryanodine Receptor 1	Protein Coding	1
329	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	1
330	KDELR1	KDEL Endoplasmic Reticulum Protein Retention Receptor 1	Protein Coding	1
331	KDELR2	KDEL Endoplasmic Reticulum Protein Retention Receptor 2	Protein Coding	1
332	KDELR3	KDEL Endoplasmic Reticulum Protein Retention Receptor 3	Protein Coding	1
333	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	1
334	PRKD2	Protein Kinase D2	Protein Coding	1
335	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	1
336	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
337	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
338	CAMK1G	Calcium/Calmodulin Dependent Protein Kinase IG	Protein Coding	1
339	GYS1	Glycogen Synthase 1	Protein Coding	1
340	GYS2	Glycogen Synthase 2	Protein Coding	1
341	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
342	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
343	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
344	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
345	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
346	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
347	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
348	PHKB	Phosphorylase Kinase Regulatory Subunit Beta	Protein Coding	1
349	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
350	RRAS2	RAS Related 2	Protein Coding	1
351	SLC8A1	Solute Carrier Family 8 Member A1	Protein Coding	1
352	SLC8A2	Solute Carrier Family 8 Member A2	Protein Coding	1
353	SLC8A3	Solute Carrier Family 8 Member A3	Protein Coding	1
354	ADD1	Adducin 1	Protein Coding	1
355	ADD2	Adducin 2	Protein Coding	1
356	CFL1	Cofilin 1	Protein Coding	1
357	CFL2	Cofilin 2	Protein Coding	1
358	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
359	LASP1	LIM And SH3 Protein 1	Protein Coding	1
360	LIMK1	LIM Domain Kinase 1	Protein Coding	1
361	MYL1	Myosin Light Chain 1	Protein Coding	1
362	MYL3	Myosin Light Chain 3	Protein Coding	1
363	MYL4	Myosin Light Chain 4	Protein Coding	1
364	MYL6	Myosin Light Chain 6	Protein Coding	1
365	MYLK	Myosin Light Chain Kinase	Protein Coding	1
366	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
367	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
368	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
369	PXN	Paxillin	Protein Coding	1
370	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
371	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	1
372	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	1
373	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
374	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
375	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
376	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
377	MYLK2	Myosin Light Chain Kinase 2	Protein Coding	1
378	MYLK3	Myosin Light Chain Kinase 3	Protein Coding	1
379	MYL6B	Myosin Light Chain 6B	Protein Coding	1
380	RGS1	Regulator Of G Protein Signaling 1	Protein Coding	1
381	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	1
382	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	1
383	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
384	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
385	SLC9A2	Solute Carrier Family 9 Member A2	Protein Coding	1
386	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	1
387	SLC9A3P1	Solute Carrier Family 9 Member 3 Pseudogene 1	Pseudogene	1
388	SLC9A5	Solute Carrier Family 9 Member A5	Protein Coding	1
389	SLC9A6	Solute Carrier Family 9 Member A6	Protein Coding	1
390	ARRB2	Arrestin Beta 2	Protein Coding	1
391	NHERF2	NHERF Family PDZ Scaffold Protein 2	Protein Coding	1
392	ARRB1	Arrestin Beta 1	Protein Coding	1
393	GNB1L	G Protein Subunit Beta 1 Like	Protein Coding	1
394	PLCB1	Phospholipase C Beta 1	Protein Coding	1
395	ELF2	E74 Like ETS Transcription Factor 2	Protein Coding	1
396	PLCB2	Phospholipase C Beta 2	Protein Coding	1
397	PLCB4	Phospholipase C Beta 4	Protein Coding	1
398	ADRB2	Adrenoceptor Beta 2	Protein Coding	1
399	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
400	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
401	NHERF1	NHERF Family PDZ Scaffold Protein 1	Protein Coding	1
402	CAVIN3	Caveolae Associated Protein 3	Protein Coding	1
403	SLC9A4	Solute Carrier Family 9 Member A4	Protein Coding	1
404	RGS19	Regulator Of G Protein Signaling 19	Protein Coding	1
405	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	1
406	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	1
407	RGS17	Regulator Of G Protein Signaling 17	Protein Coding	1
408	RGSL1	Regulator Of G Protein Signaling Like 1	Protein Coding	1
409	RGS4	Regulator Of G Protein Signaling 4	Protein Coding	1
410	RGS16	Regulator Of G Protein Signaling 16	Protein Coding	1
411	RGS20	Regulator Of G Protein Signaling 20	Protein Coding	1
412	FN1	Fibronectin 1	Protein Coding	1
413	GPER1	G Protein-Coupled Estrogen Receptor 1	Protein Coding	1
414	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
415	SHC1	SHC Adaptor Protein 1	Protein Coding	1
416	GCG	Glucagon	Protein Coding	1
417	GCGR	Glucagon Receptor	Protein Coding	1

Disorders associated with ADORA2B mediated anti-inflammatory cytokines production SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cutaneous leishmaniasis	Direct
2	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2	16.00
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2	10.85
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.66
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.01
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.01
7	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	8.63
8	Phosphorylase kinase deficiency	Enrichment	PHKA1, PHKA2, PHKB, PHKG2	8.32
9	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	7.18
10	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.75
11	Anastomosing haemangioma	Enrichment	GNA11, GNA14, GNAQ	6.53
12	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.15
13	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	5.24
14	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.22
15	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	5.22
16	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	5.22
17	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	5.22
18	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	5.22
19	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3, WNT5A	5.17
20	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3, WNT5A	5.17
21	Basal cell nevus syndrome 1	Enrichment	PTCH1, PTCH2, SUFU	5.09
22	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.05
23	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3, WNT5A	4.78
24	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	4.69
25	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.67
26	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.52
27	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.50
28	Glycogen storage disease due to liver phosphorylase kinase deficiency	Enrichment	PHKA2, PHKG2	4.50
29	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3, WNT5A	4.48
30	Ellis-van creveld syndrome	Enrichment	GLI1, PRKACA, PRKACB	4.47
31	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.43
32	Acrodysostosis	Enrichment	PDE4D, PRKAR1A	4.35
33	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.35
34	Glycogen storage disease ixd	Enrichment	PHKA1, PHKG1	4.02
35	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.02
36	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.86
37	Medulloblastoma	Enrichment	PTCH1, PTCH2, SUFU	3.85
38	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3R1	3.85
39	Wiskott-aldrich syndrome	Enrichment	WAS, WIPF1	3.84
40	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1, NCKAP1L	3.84
41	Immunodeficiency 72	Enrichment	NCKAP1, NCKAP1L	3.84
42	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	3.78
43	Tubulinopathy-associated dysgyria	Enrichment	TUBB2B, TUBB3	3.78
44	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.72
45	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.72
46	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GNB1, PPP3CA	3.70
47	Achromatopsia 4	Enrichment	GNAI3, GNAT2	3.55
48	Tubulinopathy	Enrichment	TUBB2A, TUBB2B	3.48
49	Severe combined immunodeficiency	Enrichment	CD247, CD3G	3.43
50	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.36
51	Lissencephaly	Enrichment	TUBB2B, TUBB3, TUBG1	3.30
52	Ventricular septal defect 1	Enrichment	BMP2, BMP7	3.26
53	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.18
54	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.18
55	Gallbladder cancer	Enrichment	BRAF, KRAS	3.18
56	Melanoma, uveal	Enrichment	GNA11, GNAQ	3.18
57	Basal cell carcinoma 1	Enrichment	PTCH1, PTCH2	3.08
58	Congenital fibrosis of the extraocular muscles	Enrichment	TUBB2B, TUBB3	3.08
59	Immunodeficiency 20	Enrichment	FCGR3A	3.05
60	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	3.05
61	Immunodeficiency 25	Enrichment	CD247	3.05
62	Thrombocytopenia 6	Enrichment	SRC	3.05
63	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	3.05
64	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	3.05
65	Colitis	Enrichment	SYK	3.05
66	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.95
67	Choreatic disease	Enrichment	GNAO1, PDE2A	2.89
68	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.86
69	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3	2.85
70	Behcet syndrome	Enrichment	IL10, MEFV, PSTPIP1	2.84
71	Hemochromatosis, type 1	Enrichment	BMP2, BMP6	2.82
72	Primary hyperaldosteronism	Enrichment	BRAF, GNAS	2.78
73	Glycogen storage disease	Enrichment	GYS1, GYS2	2.77
74	Immunodeficiency 17	Enrichment	CD3G	2.75
75	Arthritis	Enrichment	SYK	2.75
76	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	2.69
77	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	2.62
78	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.61
79	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.61
80	Carney complex, type 1	Enrichment	PRKAR1A	2.61
81	Osseous heteroplasia, progressive	Enrichment	GNAS	2.61
82	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.61
83	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.61
84	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.61
85	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.61
86	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.61
87	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.61
88	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.61
89	Myxoma, intracardiac	Enrichment	PRKAR1A	2.61
90	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.61
91	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.61
92	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.61
93	Disorders of gnas inactivation	Enrichment	GNAS	2.61
94	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.61
95	Mahvash disease	Enrichment	GCGR	2.61
96	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.61
97	Sick sinus syndrome 4	Enrichment	GNB2	2.61
98	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.61
99	Monostotic fibrous dysplasia	Enrichment	GNAS	2.61
100	Mazabraud syndrome	Enrichment	GNAS	2.61
101	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247	2.58
102	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.56
103	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.54
104	Ventricular tachycardia, familial	Enrichment	GNAI2	2.48
105	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.48
106	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.48
107	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.46
108	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.46
109	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.46
110	Meningioma	Enrichment	SMO, SUFU	2.45
111	Hypertension, essential	Enrichment	ADD1, GNB3	2.41
112	Cone-rod dystrophy 6	Enrichment	GNAT2, GUCY2D	2.39
113	Sudden infant death syndrome	Enrichment	CALM2, PLN	2.37
114	Microcephaly	Enrichment	ABL1, ACTB, ACTG1, GNB1	2.32
115	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.31
116	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.31
117	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.31
118	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.31
119	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.31
120	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.31
121	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.31
122	Usher syndrome, type iv	Enrichment	PRKAR1A	2.31
123	Pseudohypoparathyroidism	Enrichment	GNAS	2.31
124	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.31
125	Fibrolamellar carcinoma	Enrichment	PRKACA	2.31
126	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.31
127	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.31
128	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.31
129	Cerebral visual impairment	Enrichment	GNB1	2.31
130	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	2.31
131	Intellectual developmental disorder, x-linked, syndromic, christianson type	Enrichment	SLC9A6	2.31
132	Nephrolithiasis/osteoporosis, hypophosphatemic, 2	Enrichment	NHERF1	2.31
133	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.31
134	Noonan syndrome 13	Enrichment	MAPK1	2.31
135	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.31
136	Congenital myopathy 18	Enrichment	CACNA1S	2.31
137	Neurodegenerative disorder, x-linked, female-restricted, with parkinsonism and cognitive impairment	Enrichment	SLC9A6	2.31
138	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.31
139	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.31
140	Brugada syndrome 3	Enrichment	CACNA1C	2.31
141	Malignant hyperthermia 5	Enrichment	CACNA1S	2.31
142	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.31
143	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	2.31
144	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.31
145	Atypical timothy syndrome	Enrichment	CACNA1C	2.31
146	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.31
147	Timothy syndrome type 2	Enrichment	CACNA1C	2.31
148	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	2.31
149	Timothy syndrome type 1	Enrichment	CACNA1C	2.31
150	Cacna1c-related disorders	Enrichment	CACNA1C	2.31
151	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.29
152	Polydactyly, postaxial, type a1	Enrichment	GLI1, PTCH1	2.26
153	Osteogenesis imperfecta, type iii	Enrichment	BMP1, WNT1	2.26
154	Rare genetic intellectual disability	Enrichment	CREBBP, GNAO1	2.26
155	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.26
156	Baraitser-winter syndrome 1	Enrichment	ACTB	2.26
157	Cardiomyopathy, familial hypertrophic, 8	Enrichment	MYL3	2.26
158	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.26
159	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.26
160	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.26
161	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.26
162	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.26
163	Atrial fibrillation, familial, 18	Enrichment	MYL4	2.26
164	Nemaline myopathy 7	Enrichment	CFL2	2.26
165	Becker nevus syndrome	Enrichment	ACTB	2.26
166	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.26
167	Long qt syndrome 16	Enrichment	CALM3	2.26
168	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.26
169	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.26
170	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.26
171	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.26
172	Congenital myopathy 14	Enrichment	MYL1	2.26
173	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.26
174	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.26
175	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.26
176	Long qt syndrome 15	Enrichment	CALM2	2.26
177	Baraitser-winter syndrome	Enrichment	ACTB	2.26
178	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.26
179	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.26
180	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.26
181	Nocarh syndrome	Enrichment	CDC42	2.26
182	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.26
183	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.26
184	Oculoectodermal syndrome	Enrichment	KRAS	2.25
185	Pallister-killian syndrome	Enrichment	ARAF	2.25
186	Noonan syndrome 5	Enrichment	RAF1	2.25
187	Melorheostosis, isolated	Enrichment	MAP2K1	2.25
188	Noonan syndrome 7	Enrichment	BRAF	2.25
189	Leopard syndrome 3	Enrichment	BRAF	2.25
190	Glycogen storage disease ixc	Enrichment	PHKG2	2.25
191	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.25
192	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.25
193	Melanosis, neurocutaneous	Enrichment	NRAS	2.25
194	Noonan syndrome 6	Enrichment	NRAS	2.25
195	Noonan syndrome 11	Enrichment	MRAS	2.25
196	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.25
197	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.25
198	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.25
199	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.25
200	Lymphangioma	Enrichment	BRAF	2.25
201	Phace association	Enrichment	BRAF	2.25
202	Melorheostosis	Enrichment	MAP2K1	2.25
203	Leopard syndrome 2	Enrichment	RAF1	2.25
204	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.25
205	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.25
206	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.25
207	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.25
208	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.25
209	Trigonitis	Enrichment	RAF1	2.25
210	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.25
211	Congenital pulmonary airway malformation	Enrichment	KRAS	2.25
212	Syringocystadenoma papilliferum	Enrichment	BRAF	2.25
213	Ganglioglioma	Enrichment	BRAF	2.25
214	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.25
215	Phace syndrome	Enrichment	BRAF	2.25
216	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.25
217	Classic hairy cell leukemia	Enrichment	BRAF	2.25
218	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.25
219	Neurocutaneous melanocytosis	Enrichment	NRAS	2.25
220	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.23
221	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.23
222	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.23
223	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.23
224	Congenital myopathy with myasthenic-like onset	Enrichment	RYR1	2.23
225	Gnao1-related disorder	Enrichment	GNAO1	2.23
226	Calf-predominant weakness-gastrocnemius medialis atrophy-distal myopathy	Enrichment	RYR1	2.23
227	Benign samaritan congenital myopathy	Enrichment	RYR1	2.23
228	Myelofibrosis	Enrichment	SRC	2.21
229	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	2.21
230	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	2.21
231	Microform holoprosencephaly	Enrichment	PTCH1, SUFU	2.20
232	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	2.18
233	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.18
234	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.18
235	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.18
236	Hypopituitarism	Enrichment	GNAI2	2.18
237	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.18
238	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.17
239	Striatal degeneration, autosomal dominant 1	Enrichment	PDE8B	2.17
240	Sturge-weber syndrome	Enrichment	GNAQ	2.17
241	Immunodeficiency 62	Enrichment	ARHGEF1	2.17
242	Long qt syndrome 11	Enrichment	AKAP9	2.17
243	Dystonia 25	Enrichment	GNAL	2.17
244	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.17
245	Pigmented nodular adrenocortical disease, primary, 3	Enrichment	PDE8B	2.17
246	Deafness, autosomal dominant 74	Enrichment	PDE1C	2.17
247	Spermatogenic failure 82	Enrichment	AKAP3	2.17
248	Striatal degeneration, autosomal dominant	Enrichment	PDE8B	2.17
249	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.17
250	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.17
251	Proteus syndrome	Enrichment	AKT1	2.16
252	Hypertension and brachydactyly syndrome	Enrichment	PDE3A	2.16
253	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.16
254	Short syndrome	Enrichment	PIK3R1	2.16
255	Night blindness, congenital stationary, type1i	Enrichment	GUCY2D	2.16
256	Intellectual developmental disorder with paroxysmal dyskinesia or seizures	Enrichment	PDE2A	2.16
257	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.16
258	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	2.16
259	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.16
260	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.16
261	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.16
262	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	2.16
263	Cowden syndrome 6	Enrichment	AKT1	2.16
264	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.16
265	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.16
266	Mccune-albright syndrome	Enrichment	GNAS	2.14
267	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.14
268	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	2.14
269	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.12
270	46,xy sex reversal 7	Enrichment	DHH	2.12
271	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.12
272	Curry-jones syndrome	Enrichment	SMO	2.12
273	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.12
274	Schilbach-rott syndrome	Enrichment	PTCH1	2.12
275	Polydactyly, preaxial i	Enrichment	GLI1	2.12
276	Split-hand/foot malformation 6	Enrichment	WNT10B	2.12
277	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.12
278	Tooth agenesis, selective, 8	Enrichment	WNT10B	2.12
279	Polydactyly, postaxial, type a8	Enrichment	GLI1	2.12
280	Joubert syndrome 32	Enrichment	SUFU	2.12
281	Ovarian dysgenesis 2	Enrichment	BMP15	2.12
282	Diarrhea 9	Enrichment	WNT2B	2.12
283	Microphthalmia, syndromic 6	Enrichment	BMP4	2.12
284	Orofacial cleft 11	Enrichment	BMP4	2.12
285	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.12
286	Acrocapitofemoral dysplasia	Enrichment	IHH	2.12
287	Santos syndrome	Enrichment	WNT7A	2.12
288	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.12
289	Iron overload	Enrichment	BMP6	2.12
290	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.12
291	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.12
292	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.12
293	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.12
294	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.12
295	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.12
296	Ciliary dyskinesia, primary, 46	Enrichment	STK36	2.12
297	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.12
298	Immature teratoma of ovary	Enrichment	BMP15	2.12
299	Congenital myopathy 26	Enrichment	TUBA4A	2.12
300	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.12
301	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.12
302	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.12
303	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.12
304	Turner syndrome	Enrichment	PTCH1	2.12
305	Menke-hennekam syndrome	Enrichment	CREBBP	2.12
306	Monosomy 9q22.3	Enrichment	PTCH1	2.12
307	Immune deficiency disease	Enrichment	SYK	2.01
308	Chorea, benign hereditary	Enrichment	ADCY5	2.01
309	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	2.01
310	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.01
311	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	2.01
312	Carney complex variant	Enrichment	PRKAR1A	2.01
313	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	2.01
314	Familial sick sinus syndrome	Enrichment	GNB2	2.01
315	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.01
316	Timothy syndrome	Enrichment	CACNA1C	2.01
317	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	2.01
318	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	ELF2	2.01
319	Diarrhea 8, secretory sodium, congenital	Enrichment	SLC9A3	2.01
320	Long qt syndrome 8	Enrichment	CACNA1C	2.01
321	Hypophosphatemia	Enrichment	NHERF1	2.01
322	Ocular melanoma	Enrichment	PLCB4	2.01
323	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.01
324	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	2.01
325	Dominant hypophosphatemia with nephrolithiasis or osteoporosis	Enrichment	NHERF1	2.01
326	Macs syndrome	Enrichment	PTCH1, WNT7B	2.01
327	Long qt syndrome	Enrichment	CACNA1C, CACNA1S	2.00
328	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.00
329	Congenital stationary night blindness	Enrichment	GNAT1, GNB3	1.96
330	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	1.96
331	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.96
332	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.96
333	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.96
334	Long qt syndrome 14	Enrichment	CALM1	1.96
335	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.96
336	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.96
337	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.96
338	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.96
339	Immune system disease	Enrichment	CDC42	1.96
340	Costello syndrome	Enrichment	HRAS	1.95
341	Glycogen storage disease 0, liver	Enrichment	GYS2	1.95
342	Glycogen storage disease ixa1	Enrichment	PHKA2	1.95
343	Pulmonic stenosis	Enrichment	BRAF	1.95
344	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.95
345	Noonan syndrome 12	Enrichment	RRAS2	1.95
346	Glycogen storage disease 0, muscle	Enrichment	GYS1	1.95
347	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	1.95
348	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	1.95
349	Glycogen storage disease viii	Enrichment	PHKA2	1.95
350	Tafro syndrome	Enrichment	MAP2K2	1.95
351	Wooly hair nevus	Enrichment	HRAS	1.95
352	Malignant hyperthermia 1	Enrichment	RYR1	1.94
353	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.94
354	Cardiomyopathy, dilated, 1p	Enrichment	PLN	1.94
355	Cardiomyopathy, familial hypertrophic, 18	Enrichment	PLN	1.94
356	Osteogenesis imperfecta, type xxi	Enrichment	KDELR2	1.94
357	King-denborough syndrome	Enrichment	RYR1	1.94
358	Exercise-induced malignant hyperthermia	Enrichment	RYR1	1.94
359	Bladder cancer	Enrichment	HRAS, KRAS	1.93
360	Microphthalmia	Enrichment	PTCH1, WNT7B	1.93
361	Tooth agenesis	Enrichment	WNT10A, WNT10B	1.93
362	Cone dystrophy	Enrichment	GNAT2, GUCY2D	1.93
363	Tylosis with esophageal cancer	Enrichment	RHBDF2	1.92
364	Calcification of joints and arteries	Enrichment	NT5E	1.92
365	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	1.92
366	Ramon syndrome	Enrichment	ELMO2	1.92
367	Thrombocytopenia 1	Enrichment	WAS	1.92
368	Cinca syndrome	Enrichment	NLRP3	1.92
369	Deafness, autosomal dominant 17	Enrichment	MYH9	1.92
370	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	1.92
371	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne	Enrichment	PSTPIP1	1.92
372	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	1.92
373	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	1.92
374	Glutathionuria	Enrichment	GGT1	1.92
375	Griscelli syndrome, type 1	Enrichment	MYO5A	1.92
376	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	1.92
377	Elejalde neuroectodermal melanolysosomal syndrome	Enrichment	MYO5A	1.92
378	Muckle-wells syndrome	Enrichment	NLRP3	1.92
379	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	1.92
380	Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia	Enrichment	PSTPIP1	1.92
381	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	1.92
382	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	1.92
383	Vascular malformation, primary intraosseous	Enrichment	ELMO2	1.92
384	Graft-versus-host disease	Enrichment	IL10	1.92
385	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.92
386	Cerebral amyloid angiopathy, app-related	Enrichment	APP	1.92
387	Celiac disease 4	Enrichment	MYO9B	1.92
388	Macular degeneration, age-related, 9	Enrichment	C3	1.92
389	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	1.92
390	Heme oxygenase 1 deficiency	Enrichment	HMOX1	1.92
391	Was-related disorders	Enrichment	WAS	1.92
392	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	1.92
393	Primary intraosseous venous malformation	Enrichment	ELMO2	1.92
394	Complement component 3 deficiency	Enrichment	C3	1.92
395	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	1.92
396	Membranoproliferative glomerulonephritis	Enrichment	C3	1.92
397	Primary membranoproliferative glomerulonephritis	Enrichment	C3	1.92
398	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	1.92
399	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	1.92
400	Temporomandibular joint anomaly	Enrichment	DOCK1	1.92
401	Osteoporosis	Enrichment	SRC	1.91
402	Brittle bone disorder	Enrichment	BMP1, WNT1	1.89
403	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.88
404	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.87
405	Angioma, tufted	Enrichment	GNA14	1.87
406	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.87
407	Isolated micronodular adrenocortical disease	Enrichment	PDE8B	1.87
408	Hereditary ataxia	Enrichment	PRKCG	1.86
409	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.86
410	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	1.86
411	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.86
412	Epiphyseal chondrodysplasia, miura type	Enrichment	NPR2	1.86
413	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.86
414	Acromesomelic dysplasia 1	Enrichment	NPR2	1.86
415	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.86
416	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.86
417	Metaphyseal anadysplasia	Enrichment	MMP9	1.86
418	Common variable immunodeficiency 12	Enrichment	NFKB1	1.86
419	Lung cancer	Enrichment	BRAF, KRAS	1.85
420	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.84
421	Gillespie syndrome	Enrichment	ITPR1	1.84
422	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SLC9A3	1.84
423	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1C	1.84
424	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.84
425	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.82
426	Pallister-hall-like syndrome	Enrichment	SMO	1.82
427	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.82
428	Microcephaly and chorioretinopathy, autosomal recessive, 1	Enrichment	TUBGCP6	1.82
429	Thumb deformity	Enrichment	CREBBP	1.82
430	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.82
431	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.82
432	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.82
433	46,xy gonadal dysgenesis with minifascicular neuropathy	Enrichment	DHH	1.82
434	Tetraamelia syndrome 1	Enrichment	WNT3	1.82
435	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.82
436	Osteogenesis imperfecta, type xiii	Enrichment	BMP1	1.82
437	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.82
438	Cortical dysplasia, complex, with other brain malformations 4	Enrichment	TUBG1	1.82
439	Cortical dysplasia, complex, with other brain malformations 15	Enrichment	TUBGCP2	1.82
440	Microcephaly and chorioretinopathy 1	Enrichment	TUBGCP6	1.82
441	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.82
442	Congenital fibrosarcoma	Enrichment	SUFU	1.82
443	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.82
444	Craniosynostosis 7	Enrichment	BMP2	1.82
445	Basal cell nevus syndrome 2	Enrichment	SUFU	1.82
446	Postaxial polydactyly type b	Enrichment	GLI1	1.82
447	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.82
448	Commissural facial cleft	Enrichment	PTCH2	1.82
449	Breast cancer	Enrichment	AKT1, GNG3, JUN	1.82
450	Cerebral palsy	Enrichment	CACNA1C, GNB1	1.81
451	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.78
452	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	1.78
453	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	1.78
454	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.78
455	Dystonia	Enrichment	CAMK2B, GNB1	1.78
456	Brachydactyly	Enrichment	GNAS	1.77
457	Ataxia-telangiectasia	Enrichment	BRAF	1.77
458	Glycogen storage disease ixb	Enrichment	PHKB	1.77
459	Tethered spinal cord syndrome	Enrichment	BRAF	1.77
460	Spermatocytoma	Enrichment	HRAS	1.77
461	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	1.76
462	Lynch syndrome 5	Enrichment	RYR1	1.76
463	Bronchopulmonary dysplasia	Enrichment	RYR1	1.76
464	Intrinsic cardiomyopathy	Enrichment	PLN	1.76
465	Melanoma of soft tissue	Enrichment	CREB1	1.76
466	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.71
467	Hypothyroidism	Enrichment	GNB1	1.71
468	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	1.71
469	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.71
470	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.71
471	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.71
472	Malignant hyperthermia	Enrichment	CACNA1S	1.71
473	Thrombocytopenia	Enrichment	MYH9, SRC, WAS	1.70
474	Hirschsprung disease 1	Enrichment	IHH, SMO	1.70
475	Malaria	Enrichment	FCGR2A	1.70
476	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	1.69
477	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	1.69
478	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.69
479	Epilepsy, familial focal, with variable foci 2	Enrichment	NPR2	1.69
480	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.69
481	Immunodeficiency 14	Enrichment	PIK3R1	1.69
482	Polr3-related leukodystrophy	Enrichment	GUCY2D	1.69
483	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.67
484	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.66
485	Retinitis pigmentosa 26	Enrichment	ITGA4	1.66
486	Aminoacylase 1 deficiency	Enrichment	ACTB	1.66
487	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.66
488	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	1.66
489	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.66
490	Brachydactyly, type a1	Enrichment	IHH	1.65
491	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.65
492	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.65
493	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.65
494	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.65
495	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.65
496	Holoprosencephaly 7	Enrichment	PTCH1	1.65
497	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.65
498	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.65
499	Desmoplastic/nodular medulloblastoma	Enrichment	SUFU	1.65
500	Tetraamelia syndrome	Enrichment	WNT3	1.65
501	High bone mass osteogenesis imperfecta	Enrichment	BMP1	1.65
502	Colorectal cancer	Enrichment	AKT1, BRAF, PIK3R1	1.65
503	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.65
504	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.65
505	Aland island eye disease	Enrichment	PHKA2	1.65
506	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.65
507	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.65
508	Craniopharyngioma	Enrichment	BRAF	1.65
509	Pilocytic astrocytoma	Enrichment	KRAS	1.65
510	Newborn respiratory distress syndrome	Enrichment	BRAF	1.65
511	Epidermolytic nevus	Enrichment	HRAS	1.65
512	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	RYR1	1.64
513	Myopathy, centronuclear, 2	Enrichment	RYR1	1.64
514	Sacral defect with anterior meningocele	Enrichment	RYR1	1.64
515	Intellectual developmental disorder, autosomal dominant 26	Enrichment	RYR1	1.64
516	Congenital myopathy 1a	Enrichment	RYR1	1.64
517	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.62
518	Familial mediterranean fever, autosomal dominant	Enrichment	MEFV	1.62
519	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.62
520	Cataract 35	Enrichment	MYH9	1.62
521	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.62
522	Griscelli syndrome, type 3	Enrichment	MYO5A	1.62
523	Coenzyme q10 deficiency, primary, 6	Enrichment	ENTPD5	1.62
524	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3	1.62
525	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.62
526	Familial mediterranean fever	Enrichment	MEFV	1.62
527	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	1.62
528	Agammaglobulinemia, x-linked	Enrichment	BTK	1.62
529	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.62
530	Rela fusion-positive ependymoma	Enrichment	RELA	1.62
531	Spastic paraplegia 64, autosomal recessive	Enrichment	ENTPD1	1.62
532	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	1.62
533	Pericardial effusion	Enrichment	NLRP3	1.62
534	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	1.62
535	Hereditary inclusion body myopathy-joint contractures-ophthalmoplegia syndrome	Enrichment	MYH2	1.62
536	Pseudosarcomatous fibromatosis	Enrichment	MYH9	1.62
537	Intermittent hydrarthrosis	Enrichment	MEFV	1.62
538	Immunodeficiency 133	Enrichment	ARPC5	1.62
539	Childhood-onset autosomal recessive myopathy with external ophthalmoplegia	Enrichment	MYH2	1.62
540	Congenital nervous system abnormality	Enrichment	CAMK2B, GNAO1, GNB5	1.62
541	Nervous system disease	Enrichment	CAMK2B, GNAO1, GNB5	1.62
542	Heart conduction disease	Enrichment	CACNA1C	1.62
543	Sleep disorder	Enrichment	SLC9A6	1.62
544	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, MYH9, MYO1C	1.61
545	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.58
546	Myelodysplastic syndrome	Enrichment	GNB1	1.58
547	Visceral myopathy 1	Enrichment	MYLK	1.56
548	Pervasive developmental disorder	Enrichment	SPTBN1	1.56
549	Coloboma of choroid and retina	Enrichment	ACTG1	1.56
550	Rare pervasive developmental disorder	Enrichment	SPTBN1	1.56
551	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.56
552	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.56
553	Short stature with nonspecific skeletal abnormalities 1	Enrichment	NPR2	1.56
554	Congenital generalized lipodystrophy	Enrichment	FOS	1.56
555	Cystic fibrosis	Enrichment	FCGR2A	1.55
556	Congenital myopathy 1b, autosomal recessive	Enrichment	RYR1	1.54
557	Cardiac arrest	Enrichment	PLN	1.54
558	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	1.54
559	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.54
560	Brachydactyly, type a2	Enrichment	BMP2	1.53
561	Polydactyly, preaxial ii	Enrichment	PTCH1	1.53
562	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.53
563	Microtia-anotia	Enrichment	BMP5	1.53
564	Ectodermal dysplasia	Enrichment	WNT10A	1.53
565	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	TUBGCP6	1.53
566	Oculomotor apraxia	Enrichment	SUFU	1.53
567	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.51
568	Hemihyperplasia, isolated	Enrichment	RHOA	1.49
569	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.49
570	Typical nemaline myopathy	Enrichment	CFL2	1.49
571	Autoinflammatory disease	Enrichment	MEFV, NLRP3	1.48
572	Wilms tumor 5	Enrichment	BRAF	1.47
573	Breast adenocarcinoma	Enrichment	KRAS	1.47
574	Lung squamous cell carcinoma	Enrichment	KRAS	1.47
575	Systemic lupus erythematosus	Enrichment	FCGR2A	1.47
576	Stroke, ischemic	Enrichment	PRKCH	1.47
577	Alzheimer disease 2	Enrichment	NOS3	1.47
578	Choroidal dystrophy, central areolar, 1	Enrichment	GUCY2D	1.47
579	3-methylglutaconic aciduria, type iii	Enrichment	GUCY2D	1.47
580	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PDE2A	1.47
581	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.47
582	Pre-eclampsia	Enrichment	NOS3	1.47
583	Histiocytoid hemangioma	Enrichment	FOS	1.47
584	Myopathy, centronuclear, 1	Enrichment	RYR1	1.46
585	Spastic ataxia	Enrichment	ITPR1, SPTAN1	1.46
586	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	1.45
587	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.45
588	Neutrophilic dermatosis, acute febrile	Enrichment	MEFV	1.45
589	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	1.45
590	Agammaglobulinemia 1	Enrichment	BTK	1.45
591	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	1.45
592	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	1.45
593	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.45
594	Atrioventricular septal defect	Enrichment	BMP5	1.43
595	Chromosome 15q11.2 deletion syndrome	Enrichment	TUBG1	1.43
596	Congenital heart defects, multiple types, 4	Enrichment	BMP7	1.43
597	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.43
598	Focal epilepsy	Enrichment	SPTAN1	1.42
599	Moyamoya angiopathy	Enrichment	ABL1	1.42
600	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.42
601	Megacolon	Enrichment	SLC8A1	1.41
602	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.40
603	Myeloma, multiple	Enrichment	BRAF, KRAS	1.40
604	Cleft palate, isolated	Enrichment	GNB1	1.39
605	Moyamoya disease 1	Enrichment	GUCY1A1	1.39
606	Neural tube defects	Enrichment	ITGB1	1.37
607	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.37
608	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.37
609	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.37
610	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.36
611	Atrial septal defect 1	Enrichment	BMP2	1.35
612	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.35
613	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.35
614	Anterior segment dysgenesis 5	Enrichment	BMP4	1.35
615	Renal dysplasia, cystic	Enrichment	WNT9B	1.35
616	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.35
617	Renal hypoplasia	Enrichment	WNT9B	1.35
618	Diarrhea	Enrichment	WNT2B	1.35
619	Hypertrichosis	Enrichment	CREBBP	1.35
620	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.35
621	Multiple pterygium syndrome, lethal type	Enrichment	RYR1	1.34
622	Congenital muscular dystrophy	Enrichment	RYR1	1.34
623	Kaposi sarcoma	Enrichment	IL6	1.33
624	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.33
625	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.33
626	Congenital myopathy 6 with ophthalmoplegia	Enrichment	MYH2	1.33
627	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.33
628	Paroxysmal dystonia	Enrichment	PDE2A	1.32
629	Overgrowth syndrome	Enrichment	PIK3R1	1.32
630	Nephrolithiasis	Enrichment	NHERF1	1.32
631	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	ADD1	1.31
632	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.31
633	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.30
634	Ventricular septal defect	Enrichment	BRAF	1.30
635	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	PLN	1.29
636	Hydrops fetalis	Enrichment	RYR1	1.29
637	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBB2B	1.29
638	Congenital hydrocephalus	Enrichment	PTCH1	1.29
639	Specific learning disability	Enrichment	MAPK1	1.28
640	Spermatogenic failure 5	Enrichment	AKAP3	1.28
641	Cat eye syndrome	Enrichment	ACTG1	1.27
642	Isolated tracheo-esophageal fistula	Enrichment	ADD1	1.27
643	Leber congenital amaurosis 1	Enrichment	GUCY2D	1.27
644	Melanoma	Enrichment	BRAF	1.26
645	Cardiac conduction defect	Enrichment	CACNA1C	1.25
646	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	1.23
647	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.23
648	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1	1.23
649	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.23
650	Deafness, autosomal recessive 63	Enrichment	MYH9	1.23
651	Cryptorchidism, unilateral or bilateral	Enrichment	RXFP2	1.22
652	Cowden syndrome	Enrichment	AKT1	1.22
653	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.21
654	Movement disease	Enrichment	GNAO1	1.21
655	Strabismus	Enrichment	GNB1	1.20
656	Congenital long qt syndrome	Enrichment	ITPR3	1.19
657	Bilateral perisylvian polymicrogyria	Enrichment	TUBB2B	1.18
658	Renal agenesis, bilateral	Enrichment	WNT9B	1.18
659	Multiple sclerosis	Enrichment	ITPR1	1.18
660	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.17
661	Achromatopsia	Enrichment	GNAT2	1.17
662	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.17
663	Type 1 diabetes mellitus	Enrichment	IL6	1.16
664	Hemangioma, capillary infantile	Enrichment	MYH9	1.16
665	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.16
666	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	1.16
667	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.15
668	Anterior segment dysgenesis	Enrichment	ITPR1	1.15
669	Protein-deficiency anemia	Enrichment	NRAS	1.15
670	Peters-plus syndrome	Enrichment	BMP4	1.14
671	Stickler syndrome	Enrichment	BMP4	1.14
672	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	RYR1	1.14
673	Clubfoot	Enrichment	RYR1	1.14
674	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.13
675	Heart disease	Enrichment	ABL1	1.13
676	Isolated macular dystrophy	Enrichment	ITGA4	1.13
677	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.12
678	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A, PTCH1, SUFU	1.11
679	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	PLN	1.10
680	Meningioma, familial	Enrichment	SUFU	1.10
681	46,xy complete gonadal dysgenesis	Enrichment	DHH	1.10
682	Alzheimer's disease 1	Enrichment	APP	1.09
683	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.09
684	Wilms tumor 1	Enrichment	BRAF	1.09
685	Lynch syndrome	Enrichment	KRAS	1.09
686	Congenital myopathy 4a, autosomal dominant	Enrichment	RYR1	1.08
687	Heart, malformation of	Enrichment	MAPK1	1.08
688	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	1.06
689	Congenital hypothyroidism	Enrichment	TUBB1	1.06
690	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.06
691	46 xx gonadal dysgenesis	Enrichment	BMP15	1.06
692	Rhabdomyosarcoma	Enrichment	HRAS	1.06
693	Congenital myopathy	Enrichment	CACNA1S	1.05
694	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	RYR1	1.05
695	Dandy-walker syndrome	Enrichment	PPP1CB	1.05
696	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.03
697	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.03
698	Chronic kidney disease	Enrichment	WNT9B	1.03
699	Neuromuscular disease	Enrichment	SPTAN1	1.02
700	Centronuclear myopathy	Enrichment	CACNA1S	1.01
701	Beckwith-wiedemann syndrome	Enrichment	RYR1	1.00
702	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.00
703	Esophageal atresia/tracheoesophageal fistula	Enrichment	ADD1	1.00
704	Cleft lip/palate	Enrichment	BMP4	1.00
705	Diffuse large b-cell lymphoma	Enrichment	BRAF	0.99
706	Rheumatoid arthritis	Enrichment	IL10	0.99
707	Chronic granulomatous disease	Enrichment	CYBA	0.99
708	Williams-beuren syndrome	Enrichment	LIMK1	0.98
709	Gliosarcoma	Enrichment	NFKBIA	0.98
710	Corpus callosum, agenesis of	Enrichment	CREBBP	0.97
711	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.97
712	Septopreoptic holoprosencephaly	Enrichment	PTCH1	0.97
713	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.97
714	Midline interhemispheric variant of holoprosencephaly	Enrichment	PTCH1	0.97
715	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	0.96
716	Scoliosis	Enrichment	SLC9A6	0.96
717	Alzheimer disease, familial, 1	Enrichment	NOS3	0.95
718	Giant cell glioblastoma	Enrichment	NFKBIA	0.95
719	Primary ciliary dyskinesia	Enrichment	PRKAR1B, STK36	0.95
720	Ovarian cancer	Enrichment	KRAS, RRAS2	0.95
721	Lobar holoprosencephaly	Enrichment	PTCH1	0.94
722	Leukemia, chronic lymphocytic	Enrichment	P2RX7	0.94
723	Jeune thoracic dystrophy	Enrichment	GRK2	0.94
724	Brugada syndrome	Enrichment	CACNA1C	0.92
725	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	0.92
726	Alobar holoprosencephaly	Enrichment	PTCH1	0.92
727	Complex neurodevelopmental disorder	Enrichment	CACNA1C, GNB2	0.91
728	Combined immunodeficiency	Enrichment	ARPC1B	0.90
729	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	0.90
730	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	0.90
731	Familial atrial fibrillation	Enrichment	MYL4	0.90
732	Semilobar holoprosencephaly	Enrichment	PTCH1	0.90
733	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	0.90
734	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.89
735	Craniosynostosis	Enrichment	NPR2	0.89
736	Pancreatic cancer	Enrichment	KRAS	0.88
737	Nephrotic syndrome	Enrichment	FN1	0.88
738	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.87
739	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.86
740	Myocardial infarction	Enrichment	GUCY1A1	0.85
741	Non-syndromic male infertility due to sperm motility disorder	Enrichment	AKAP4	0.84
742	Alzheimer's disease	Enrichment	APP	0.84
743	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.83
744	Atypical hemolytic-uremic syndrome	Enrichment	C3	0.78
745	Neuronal ceroid lipofuscinosis	Enrichment	MEFV	0.78
746	Kidney disease	Enrichment	MEFV	0.78
747	Familial hypertrophic cardiomyopathy	Enrichment	MYL3	0.78
748	Cakut	Enrichment	ACTG1	0.76
749	Hypertension	Enrichment	MYH9	0.75
750	Left ventricular noncompaction	Enrichment	RAF1	0.74
751	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	0.74
752	Non-syndromic genetic deafness	Enrichment	ACTG1	0.74
753	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.74
754	Centralopathic epilepsy	Enrichment	PLCB1	0.72
755	West syndrome	Enrichment	PLCB1	0.71
756	Fetal akinesia deformation sequence 1	Enrichment	RYR1	0.71
757	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.71
758	Human immunodeficiency virus type 1	Enrichment	IL10	0.71
759	Isolated joubert syndrome	Enrichment	SUFU	0.69
760	Hereditary spastic paraplegia	Enrichment	SPTAN1	0.68
761	Nonsyndromic hearing loss	Enrichment	ACTG1	0.68
762	Myopathy	Enrichment	RYR1	0.68
763	Hypertrophic cardiomyopathy	Enrichment	MYL3	0.67
764	Eye disease	Enrichment	GNAT2	0.67
765	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.66
766	Gastric cancer	Enrichment	KRAS	0.66
767	Distal arthrogryposis	Enrichment	RYR1	0.66
768	Hereditary breast carcinoma	Enrichment	KRAS	0.65
769	Multisystem inflammatory syndrome in children	Enrichment	CD163	0.63
770	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1B	0.62
771	Rare genetic deafness	Enrichment	ACTG1, MYH9	0.61
772	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.58
773	Optic atrophy plus syndrome	Enrichment	GUCY2D	0.58
774	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.57
775	Cone-rod dystrophy 2	Enrichment	ITGA4	0.50
776	Hereditary retinal dystrophy	Enrichment	GNAT1, GNAT2, GUCY2D	0.49
777	Fundus dystrophy	Enrichment	GNAT1, GNAT2, GUCY2D	0.49
778	Autism	Enrichment	CAMK2G	0.47
779	Primary ovarian insufficiency	Enrichment	NOS3	0.47
780	Type 2 diabetes mellitus	Enrichment	IL6	0.40
781	Retinitis pigmentosa	Enrichment	GNAT1, GUCY2D	0.36
782	Leber plus disease	Enrichment	GUCY2D	0.31
783	Deafness, autosomal recessive	Enrichment	MYH9	0.27
784	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ADORA2B mediated anti-inflammatory cytokines production

Pathway Network for ADORA2B mediated anti-inflammatory cytokines production

Pathway network for the ADORA2B mediated anti-inflammatory cytokines production SuperPath

Member Pathways for ADORA2B mediated anti-inflammatory cytokines production

Pathways in the ADORA2B mediated anti-inflammatory cytokines production SuperPath

Gene overlap in member pathways for ADORA2B mediated anti-inflammatory cytokines production SuperPath

Associated Genes for ADORA2B mediated anti-inflammatory cytokines production

Associated Disorders for ADORA2B mediated anti-inflammatory cytokines production

Disorders associated with ADORA2B mediated anti-inflammatory cytokines production SuperPath

STRING Interaction Network for ADORA2B mediated anti-inflammatory cytokines production

Sources for ADORA2B mediated anti-inflammatory cytokines production