Aflatoxin activation and detoxification
Pathway network for the Aflatoxin activation and detoxification SuperPath
Sources:
- Reactome
- PharmGKB
- WikiPathways
- PubChem
Pathways in the Aflatoxin activation and detoxification SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Aflatoxin activation and detoxification | Reactome | |
| 2 | Aflatoxin b Pathway, Pharmacokinetics | PharmGKB | |
| 3 | Perampanel Pathway, Pharmacokinetics | PharmGKB | |
| 4 | Lidocaine metabolism | WikiPathways | |
| 5 | Defective ACY1 causes encephalopathy | Reactome | |
| 6 | crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | CYP1A2 | Cytochrome P450 Family 1 Subfamily A Member 2 | Protein Coding | 4 |
| 2 | CYP3A4 | Cytochrome P450 Family 3 Subfamily A Member 4 | Protein Coding | 4 |
| 3 | CYP3A5 | Cytochrome P450 Family 3 Subfamily A Member 5 | Protein Coding | 3 |
| 4 | CYP2A13 | Cytochrome P450 Family 2 Subfamily A Member 13 | Protein Coding | 2 |
| 5 | AKR7L | Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene) | Protein Coding | 2 |
| 6 | ACY1 | Aminoacylase 1 | Protein Coding | 2 |
| 7 | GGT6 | Gamma-Glutamyltransferase 6 | Protein Coding | 1 |
| 8 | DPEP1 | Dipeptidase 1 | Protein Coding | 1 |
| 9 | AKR7A3 | Aldo-Keto Reductase Family 7 Member A3 | Protein Coding | 1 |
| 10 | GGT1 | Gamma-Glutamyltransferase 1 | Protein Coding | 1 |
| 11 | GGT7 | Gamma-Glutamyltransferase 7 | Protein Coding | 1 |
| 12 | GGT5 | Gamma-Glutamyltransferase 5 | Protein Coding | 1 |
| 13 | MGST1 | Microsomal Glutathione S-Transferase 1 | Protein Coding | 1 |
| 14 | MGST2 | Microsomal Glutathione S-Transferase 2 | Protein Coding | 1 |
| 15 | MGST3 | Microsomal Glutathione S-Transferase 3 | Protein Coding | 1 |
| 16 | DPEP2 | Dipeptidase 2 | Protein Coding | 1 |
| 17 | AKR7A2 | Aldo-Keto Reductase Family 7 Member A2 | Protein Coding | 1 |
| 18 | ACY3 | Aminoacylase 3 | Protein Coding | 1 |
Disorders associated with Aflatoxin activation and detoxification SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Toxic encephalopathy | Direct | ||
| 2 | Pulmonary disease, chronic obstructive | Enrichment | MGST1, MGST3 | 3.89 |
| 3 | Vitamin d-dependent rickets, type 3 | Enrichment | CYP3A4 | 3.83 |
| 4 | Glutathionuria | Enrichment | GGT1 | 2.88 |
| 5 | Hypertension, essential | Enrichment | CYP3A5 | 2.43 |
| 6 | Aminoacylase 1 deficiency | Enrichment | ACY1 | 2.28 |
