Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Pathway network for the Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

Sources:

PharmGKB
WikiPathways
Reactome

Pathways in the Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	PharmGKB	ACE ACE2 AGT AGTR1 AGTR2 ATP6AP2 BDKRB1 BDKRB2 CMA1 CTSG CYP11B2 KNG1 MAPK1 MAPK3 MAS1 MME NOS3 NR3C2 REN TGFB1 (see all 20) (see less)
2	RAS and bradykinin pathways in COVID-19	WikiPathways	ACE ACE2 AGT AGTR1 AGTR2 BDKRB1 BDKRB2 CPN1 CYP24A1 CYP3A4 F12 KLK1 KLKB1 KNG1 MAPK1 NFKB1 NOS1 NOS3 PRKG1 REN RHOA ROCK1 SERPINE1 SERPING1 TNF VDR (see all 26) (see less)
3	ACE Inhibitor Pathway, Pharmacodynamics	PharmGKB	ACE ACE2 AGT AGTR1 AGTR2 ATP6AP2 BDKRB1 BDKRB2 CMA1 CTSG CYP11B2 KNG1 MAPK1 MAPK3 MAS1 MME NOS3 NR3C2 REN TGFB1 (see all 20) (see less)
4	ACE inhibitor pathway	WikiPathways	ACE ACE2 AGT AGTR1 AGTR2 ATP6AP2 BDKRB1 BDKRB2 CMA1 CTSG CYP11B2 KNG1 MAS1 NOS3 NR3C2 REN TGFB1 (see all 17) (see less)
5	Renin-angiotensin-aldosterone system (RAAS)	WikiPathways	ACE AGT AGTR1 AGTR2 CMA1 CTSG REN (see all 7) (see less)
6	Non-classical role of vitamin D	WikiPathways	ACE2 AGT AGTR1 AGTR2 REN
7	Kinin-Kallikrein pathway	WikiPathways	CPN1 F12 KLKB1 KNG1 SERPING1
8	Defective SERPING1 causes hereditary angioedema	Reactome	F12 KLKB1 SERPING1
9	Conversion of angiotensinogen to angiotensin II	WikiPathways	ACE CMA1 CTSG
10	Downregulation of ACE2 by SARS-CoV-2 spike protein	WikiPathways	ACE2 AGTR1 AGTR2

Gene overlap in member pathways for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	7
2	AGTR2	Angiotensin II Receptor Type 2	Protein Coding	7
3	REN	Renin	Protein Coding	6
4	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6
5	AGT	Angiotensinogen	Protein Coding	6
6	ACE	Angiotensin I Converting Enzyme	Protein Coding	6
7	KNG1	Kininogen 1	Protein Coding	5
8	CTSG	Cathepsin G	Protein Coding	5
9	CMA1	Chymase 1	Protein Coding	5
10	BDKRB1	Bradykinin Receptor B1	Protein Coding	4
11	BDKRB2	Bradykinin Receptor B2	Protein Coding	4
12	NOS3	Nitric Oxide Synthase 3	Protein Coding	4
13	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	3
14	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	3
15	ATP6AP2	ATPase H+ Transporting Accessory Protein 2	Protein Coding	3
16	MAS1	MAS1 Proto-Oncogene, G Protein-Coupled Receptor	Protein Coding	3
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
18	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	3
19	SERPING1	Serpin Family G Member 1	Protein Coding	3
20	KLKB1	Kallikrein B1	Protein Coding	3
21	F12	Coagulation Factor XII	Protein Coding	3
22	MME	Membrane Metalloendopeptidase	Protein Coding	2
23	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
24	CPN1	Carboxypeptidase N Subunit 1	Protein Coding	2
25	VDR	Vitamin D Receptor	Protein Coding	1
26	TNF	Tumor Necrosis Factor	Protein Coding	1
27	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
28	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
29	SERPINE1	Serpin Family E Member 1	Protein Coding	1
30	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
31	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
32	RHOA	Ras Homolog Family Member A	Protein Coding	1
33	KLK1	Kallikrein 1	Protein Coding	1
34	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	1
35	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1

Disorders associated with Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	C1 inhibitor deficiency	Direct
2	Hereditary angioedema	Direct
3	Renal tubular dysgenesis	Enrichment	ACE, AGT, AGTR1, REN	10.67
4	Angioedema	Enrichment	F12, SERPING1	6.96
5	Angioedema, hereditary, 1	Enrichment	F12, SERPING1	6.49
6	Hypertension, essential	Enrichment	AGT, AGTR1, NOS3	5.96
7	Stroke, ischemic	Enrichment	ACE, NOS3	4.18
8	Microvascular complications of diabetes 3	Enrichment	ACE	3.66
9	Complement component 4, partial deficiency of	Enrichment	SERPING1	3.43
10	High molecular weight kininogen deficiency	Enrichment	KNG1	3.43
11	Carboxypeptidase n deficiency	Enrichment	CPN1	3.43
12	Angioedema, hereditary, 3	Enrichment	F12	3.43
13	Prekallikrein deficiency	Enrichment	KLKB1	3.43
14	Angioedema, hereditary, 6	Enrichment	KNG1	3.43
15	Urticaria	Enrichment	F12	3.43
16	Hereditary angioedema with c1inh deficiency	Enrichment	SERPING1	3.43
17	F12-associated cold autoinflammatory syndrome	Enrichment	F12	3.43
18	Inherited prekallikrein deficiency	Enrichment	KLKB1	3.43
19	Tubulointerstitial kidney disease, autosomal dominant 4	Enrichment	REN	3.13
20	Factor xii deficiency	Enrichment	F12	3.13
21	Congenital disorder of glycosylation, type iir	Enrichment	ATP6AP2	2.90
22	Parkinsonism with spasticity, x-linked	Enrichment	ATP6AP2	2.90
23	Intellectual developmental disorder, x-linked, syndromic, hedera type	Enrichment	ATP6AP2	2.90
24	Hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy	Enrichment	NR3C2	2.90
25	Pseudohyperaldosteronism type 2	Enrichment	NR3C2	2.90
26	Syndromic x-linked intellectual disability hedera type	Enrichment	ATP6AP2	2.90
27	Hemorrhage, intracerebral	Enrichment	ACE	2.88
28	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	KNG1	2.83
29	Spinocerebellar ataxia 43	Enrichment	MME	2.83
30	Noonan syndrome 13	Enrichment	MAPK1	2.83
31	Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization	Enrichment	MME	2.83
32	Charcot-marie-tooth disease type 2t	Enrichment	MME	2.83
33	Mme-related autosomal dominant charcot marie tooth disease type 2	Enrichment	MME	2.83
34	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.72
35	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.72
36	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.72
37	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.72
38	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.72
39	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.72
40	Rickets	Enrichment	VDR	2.72
41	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.72
42	Camurati-engelmann disease 1	Enrichment	TGFB1	2.60
43	Corticosterone methyloxidase type i deficiency	Enrichment	CYP11B2	2.60
44	Corticosterone methyloxidase type ii deficiency	Enrichment	CYP11B2	2.60
45	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	NR3C2	2.60
46	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.60
47	Camurati-engelmann disease	Enrichment	TGFB1	2.60
48	Familial hypoaldosteronism	Enrichment	CYP11B2	2.60
49	Pseudohypoaldosteronism	Enrichment	NR3C2	2.60
50	Early-onset familial hypoaldosteronism	Enrichment	CYP11B2	2.60
51	Charcot-marie-tooth disease, axonal, type 2t	Enrichment	MME	2.53
52	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	2.42
53	Kallikrein, decreased urinary activity of	Enrichment	KLK1	2.42
54	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.42
55	Immunodeficiency 127	Enrichment	TNF	2.42
56	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1	2.42
57	Common variable immunodeficiency 12	Enrichment	NFKB1	2.42
58	Bilirubin metabolic disorder	Enrichment	F12	2.39
59	Myocardial infarction	Enrichment	ACE	2.31
60	Psoriatic arthritis	Enrichment	TNF	2.24
61	Migraine without aura	Enrichment	TNF	2.24
62	Hypertension	Enrichment	F12	2.23
63	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.23
64	Alzheimer disease 2	Enrichment	NOS3	2.20
65	Pre-eclampsia	Enrichment	NOS3	2.20
66	Hyperaldosteronism, familial, type i	Enrichment	CYP11B2	2.13
67	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	2.13
68	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	2.13
69	Cakut	Enrichment	ACE	2.12
70	Idiopathic achalasia	Enrichment	NOS1	2.12
71	Cerebral malaria	Enrichment	TNF	2.12
72	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	2.12
73	Hepatoblastoma	Enrichment	REN	2.11
74	Non-syndromic x-linked intellectual disability	Enrichment	AGTR2	2.10
75	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	2.02
76	Vascular dementia	Enrichment	TNF	2.02
77	Hemihyperplasia, isolated	Enrichment	RHOA	1.94
78	Common variable immunodeficiency	Enrichment	NFKB1	1.87
79	Specific learning disability	Enrichment	MAPK1	1.79
80	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.72
81	Asthma	Enrichment	TNF	1.68
82	Alzheimer disease, familial, 1	Enrichment	NOS3	1.68
83	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.61
84	Alzheimer's disease	Enrichment	TNF	1.61
85	Heart, malformation of	Enrichment	MAPK1	1.58
86	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MME	1.56
87	Cystic fibrosis	Enrichment	TGFB1	1.40
88	Hepatocellular carcinoma	Enrichment	VDR	1.38
89	Malaria	Enrichment	TNF	1.36
90	Peripheral nervous system disease	Enrichment	MME	1.34
91	Neuropathy	Enrichment	MME	1.34
92	Primary ovarian insufficiency	Enrichment	NOS3	1.15
93	Systemic lupus erythematosus	Enrichment	TNF	1.14
94	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	1.09
95	Autism spectrum disorder	Enrichment	NR3C2	0.89
96	Microcephaly	Enrichment	MAPK1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Pathway Network for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Pathway network for the Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

Member Pathways for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Pathways in the Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

Gene overlap in member pathways for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

Associated Genes for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Associated Disorders for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Disorders associated with Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

Sources for Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics