Agrin Interactions at Neuromuscular Junction

No Pathway Network information available for Agrin Interactions at Neuromuscular Junction

Pathways in the Agrin Interactions at Neuromuscular Junction SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Agrin Interactions at Neuromuscular Junction SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Noonan syndrome 1EnrichmentHRAS, KRAS, MRAS, NRAS, RRAS, RRAS29.41
2Lung non-small cell carcinomaEnrichmentEGFR, ERBB2, HRAS, KRAS, NRAS9.33
3RasopathyEnrichmentHRAS, KRAS, MRAS, NRAS, RRAS27.21
4Bladder cancerEnrichmentEGFR, ERBB2, ERBB3, HRAS, KRAS6.96
5Postsynaptic congenital myasthenic syndromesEnrichmentAGRN, CHRNA1, MUSK, RAPSN6.90
6Lung cancer susceptibility 3EnrichmentACTA2, EGFR, ERBB2, KRAS6.60
7Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS, KRAS, NRAS6.58
8Nevus, epidermalEnrichmentHRAS, KRAS, NRAS5.64
9Non-immune hydrops fetalisEnrichmentACTA1, CHRNA1, HRAS, KRAS5.12
10Lung cancerEnrichmentACTA2, EGFR, ERBB2, KRAS5.07
11Juvenile myelomonocytic leukemiaEnrichmentKRAS, NRAS, RRAS4.85
12Ras-associated autoimmune leukoproliferative disorderEnrichmentKRAS, NRAS4.78
13Baraitser-winter cerebrofrontofacial syndromeEnrichmentACTB, ACTG14.78
14Congenital myasthenic syndromeEnrichmentAGRN, CHRNA1, RAPSN4.63
15Noonan syndrome and noonan-related syndromeEnrichmentHRAS, KRAS, NRAS4.53
16Large congenital melanocytic nevusEnrichmentHRAS, NRAS4.30
17Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentKRAS, NRAS4.00
18Hydrops fetalis, nonimmuneEnrichmentACTA1, CHRNA1, HRAS3.79
19Hirschsprung disease 1EnrichmentERBB2, ERBB3, NRG33.65
20Differentiated thyroid carcinomaEnrichmentHRAS, KRAS, NRAS3.65
21Lung squamous cell carcinomaEnrichmentEGFR, KRAS3.60
22Thyroid cancer, nonmedullary, 2EnrichmentHRAS, NRAS3.46
23Leukemia, chronic myeloidEnrichmentKRAS, NRAS3.46
24Noonan syndrome 3EnrichmentHRAS, KRAS3.46
25Follicular thyroid carcinomaEnrichmentHRAS, NRAS3.46
26Melanocytic nevus syndrome, congenitalEnrichmentHRAS, NRAS3.34
27Multiple pterygium syndrome, lethal typeEnrichmentCHRNA1, RAPSN3.34
28Fetal akinesia deformation sequence 1EnrichmentACTA1, MUSK, RAPSN3.33
29Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiencyEnrichmentMUSK, RAPSN3.13
30Ovarian cancerEnrichmentEGFR, ERBB2, KRAS, RRAS23.10
31Lip and oral cavity carcinomaEnrichmentEGFR, HRAS2.97
32MicrocephalyEnrichmentACTB, ACTG1, MAPK1, PAK32.78
33Creatine phosphokinase, elevated serumEnrichmentDAG1, LAMA22.71
34Isolated elevated serum creatine phosphokinase levelsEnrichmentDAG1, LAMA22.71
35Arteriovenous malformations of the brainEnrichmentEGFR, KRAS2.56
36Congenital myopathyEnrichmentACTA1, CHRNA12.56
37Centronuclear myopathyEnrichmentACTA1, CHRNA12.48
38Erythroleukemia, familialEnrichmentERBB32.38
39Paget disease, extramammaryEnrichmentERBB22.38
40Baraitser-winter syndrome 1EnrichmentACTB2.38
41Oculoectodermal syndromeEnrichmentKRAS2.38
42Intellectual developmental disorder, x-linked 30EnrichmentPAK32.38
43Systemic lupus erythematosus 6EnrichmentITGAM2.38
44Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosisEnrichmentRAC22.38
45Congenital myopathy 2a, typical, autosomal dominantEnrichmentACTA12.38
46Myasthenic syndrome, congenital, 11, associated with acetylcholine receptor deficiencyEnrichmentRAPSN2.38
47Muscular dystrophy-dystroglycanopathy , type a, 9EnrichmentDAG12.38
48Melanosis, neurocutaneousEnrichmentNRAS2.38
49Myopathy, scapulohumeroperonealEnrichmentACTA12.38
50Lethal congenital contracture syndrome 2EnrichmentERBB32.38
51Noonan syndrome 6EnrichmentNRAS2.38
52Fetal akinesia deformation sequence 2EnrichmentRAPSN2.38
53Noonan syndrome 11EnrichmentMRAS2.38
54Megacystis-microcolon-intestinal hypoperistalsis syndrome 5EnrichmentACTG22.38
55Visceral neuropathy, familial, 2, autosomal recessiveEnrichmentERBB22.38
56Noonan syndrome 13EnrichmentMAPK12.38
57Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiencyEnrichmentMUSK2.38
58Knobloch syndrome 2EnrichmentPAK22.38
59Neurodevelopmental disorder with structural brain anomalies and dysmorphic faciesEnrichmentRAC32.38
60Intellectual developmental disorder with macrocephaly, seizures, and speech delayEnrichmentPAK12.38
61Congenital smooth muscle hamartoma, with or without hemihypertrophyEnrichmentACTB2.38
62Intellectual developmental disorder, x-linked 46EnrichmentARHGEF62.38
63Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemiaEnrichmentRAC22.38
64Cardiofaciocutaneous syndrome 2EnrichmentKRAS2.38
65Becker nevus syndromeEnrichmentACTB2.38
66Dystonia-deafness syndrome 1EnrichmentACTB2.38
67Visceral neuropathy, familial, 3, autosomal dominantEnrichmentACTG22.38
68Congenital myopathy 2b, severe infantile, autosomal recessiveEnrichmentACTA12.38
69Amyotrophic lateral sclerosis 19EnrichmentERBB42.38
70Autosomal dominant familial visceral neuropathyEnrichmentACTG22.38
71Muscular dystrophy-dystroglycanopathy , type c, 9EnrichmentDAG12.38
72Thrombocytopenia 6EnrichmentSRC2.38
73Takenouchi-kosaki syndromeEnrichmentCDC422.38
74Congenital myopathy 2c, severe infantile, autosomal dominantEnrichmentACTA12.38
75Thrombocytopenia 8, with dysmorphic features and developmental delayEnrichmentACTB2.38
76Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopeniaEnrichmentRAC22.38
77Baraitser-winter syndromeEnrichmentACTB2.38
78Congenital pulmonary airway malformationEnrichmentKRAS2.38
79Immune dysregulation, neurodevelopmental defects, and colitisEnrichmentITGAV2.38
80Zebra body myopathyEnrichmentACTA12.38
81Infantile lad-like disease due to rac2 deficiencyEnrichmentRAC22.38
82Congenital smooth muscle hamartomaEnrichmentACTB2.38
83Reticular dysgenesis-like severe combined immunodeficiencyEnrichmentRAC22.38
84Nocarh syndromeEnrichmentCDC422.38
85Developmental malformations-deafness-dystonia syndromeEnrichmentACTB2.38
86Muscle-eye-brain disease with bilateral multicystic leucodystrophyEnrichmentDAG12.38
87Phakomatosis pigmentokeratoticaEnrichmentHRAS2.38
88Actin-accumulation myopathyEnrichmentACTA12.38
89Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndromEnrichmentRAC12.38
90Myopathic intestinal pseudoobstructionEnrichmentACTG22.38
91Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndromeEnrichmentRAC22.38
92Serous carcinoma of the corpus uteriEnrichmentERBB22.38
93Neurocutaneous melanocytosisEnrichmentNRAS2.38
94Actg2 visceral myopathyEnrichmentACTG22.38
95Laminin subunit alpha 2-related muscular dystrophyEnrichmentLAMA22.38
96Colorectal cancerEnrichmentERBB2, NRAS, SRC2.26
97Costello syndromeEnrichmentHRAS2.08
98Visceral neuropathy, familial, 1, autosomal recessiveEnrichmentERBB32.08
99Aortic aneurysm, familial thoracic 2EnrichmentACTA22.08
100Deafness, autosomal dominant 20EnrichmentACTG12.08
101Smooth muscle dysfunction syndromeEnrichmentACTA22.08
102Encephalocraniocutaneous lipomatosisEnrichmentKRAS2.08
103Aortic aneurysm, familial thoracic 6EnrichmentACTA22.08
104Baraitser-winter syndrome 2EnrichmentACTG12.08
105Moyamoya disease 5EnrichmentACTA22.08
106Intellectual developmental disorder, autosomal dominant 48EnrichmentRAC12.08
107Noonan syndrome 12EnrichmentRRAS22.08
108Immune system diseaseEnrichmentCDC422.08
109Intestinal obstructionEnrichmentACTG22.08
110Wooly hair nevusEnrichmentHRAS2.08
111Leukemia, acute myeloidEnrichmentKRAS, NRAS1.93
112MyopathyEnrichmentACTA1, RAPSN1.93
113Muscular dystrophy, duchenne typeEnrichmentUTRN1.91
114Langerhans cell histiocytosisEnrichmentNRAS1.91
115Muscular dystrophy, congenital merosin-deficient, 1aEnrichmentLAMA21.91
116Neonatal nephrocutaneous inflammatory syndromeEnrichmentEGFR1.91
117Bronchopulmonary dysplasiaEnrichmentMUSK1.91
118SpermatocytomaEnrichmentHRAS1.91
119Neonatal inflammatory skin and bowel diseaseEnrichmentEGFR1.91
120Lama2-related muscular dystrophyEnrichmentLAMA21.91
121Distal arthrogryposisEnrichmentACTA1, RAPSN1.89
122Gastric cancerEnrichmentERBB2, KRAS1.87
123Cardiofaciocutaneous syndrome 1EnrichmentKRAS1.78
124Diffuse gastric and lobular breast cancer syndromeEnrichmentKRAS1.78
125Nemaline myopathy 2EnrichmentACTA11.78
126Robinow syndrome, autosomal dominant 1EnrichmentDVL11.78
127Megacystis-microcolon-intestinal hypoperistalsis syndrome 1EnrichmentACTG21.78
128Autoimmune lymphoproliferative syndromeEnrichmentACTA21.78
129Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.78
130Myasthenic syndrome, congenital, 1b, fast-channelEnrichmentCHRNA11.78
131Barrett esophagusEnrichmentERBB21.78
132Aminoacylase 1 deficiencyEnrichmentACTB1.78
133Cardiofaciocutaneous syndromeEnrichmentKRAS1.78
134Lung sarcomatoid carcinomaEnrichmentKRAS1.78
135Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemiaEnrichmentCDC421.78
136Pilocytic astrocytomaEnrichmentKRAS1.78
137Epidermolytic nevusEnrichmentHRAS1.78
138Autosomal dominant robinow syndromeEnrichmentDVL11.78
139Knobloch syndromeEnrichmentPAK21.78
140Intermediate nemaline myopathyEnrichmentACTA11.78
141Pseudomyogenic hemangioendotheliomaEnrichmentACTB1.78
142Visceral myopathy 1EnrichmentACTG21.69
143Congenital myopathy 3 with rigid spineEnrichmentACTA11.69
144Robinow syndrome, autosomal recessive 1EnrichmentDVL11.69
145Knobloch syndrome 1EnrichmentPAK21.69
146Mosaic variegated aneuploidy syndrome 1EnrichmentPAK61.69
147Myasthenic syndrome, congenital, 8EnrichmentAGRN1.69
148Robinow syndrome, autosomal dominant 2EnrichmentDVL11.69
149Muscular dystrophy, limb-girdle, autosomal recessive 23EnrichmentLAMA21.69
150Coloboma of choroid and retinaEnrichmentACTG11.69
151Severe congenital nemaline myopathyEnrichmentACTA11.69
152Cowden syndrome 1EnrichmentEGFR1.61
153Moyamoya disease 1EnrichmentACTA21.61
154Autosomal recessive robinow syndromeEnrichmentDVL11.61
155Intestinal pseudo-obstructionEnrichmentACTG21.61
156Breast adenocarcinomaEnrichmentKRAS1.61
157Typical nemaline myopathyEnrichmentACTA11.61
158MyelofibrosisEnrichmentSRC1.54
159Squamous cell carcinoma, head and neckEnrichmentEGFR1.54
160Myasthenic syndrome, congenital, 1a, slow-channelEnrichmentCHRNA11.54
161Capillary malformation-arteriovenous malformation 1EnrichmentKRAS1.54
162Gallbladder cancerEnrichmentKRAS1.54
163Pilomyxoid astrocytomaEnrichmentKRAS1.54
164Childhood-onset nemaline myopathyEnrichmentACTA11.54
165Glioma susceptibility 1EnrichmentERBB21.49
166Lennox-gastaut syndromeEnrichmentMAPK101.49
167Congenital muscular dystrophyEnrichmentLAMA21.49
168Mosaic variegated aneuploidy syndromeEnrichmentPAK61.49
169Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentRAC11.44
170Arteriovenous malformationEnrichmentHRAS1.44
171Hydrops fetalisEnrichmentRAPSN1.44
172Breast cancerEnrichmentJUN, KRAS1.42
173Cat eye syndromeEnrichmentACTG11.39
174Myopathy, x-linked, with excessive autophagyEnrichmentHRAS1.39
175Nemaline myopathyEnrichmentACTA11.39
176Dilated cardiomyopathyEnrichmentACTA1, LAMA21.37
177Specific learning disabilityEnrichmentMAPK11.35
178Presynaptic congenital myasthenic syndromesEnrichmentAGRN1.35
179Neural tube defectsEnrichmentITGB11.28
180Protein-deficiency anemiaEnrichmentNRAS1.28
181Nk-cell enteropathyEnrichmentERBB41.28
182OsteoporosisEnrichmentSRC1.25
183Walker-warburg syndromeEnrichmentDAG11.25
184Congenital myopathy 4a, autosomal dominantEnrichmentACTA11.22
185Lynch syndromeEnrichmentKRAS1.22
186RhabdomyosarcomaEnrichmentHRAS1.19
187GliosarcomaEnrichmentEGFR1.19
188Giant cell glioblastomaEnrichmentEGFR1.17
189Heart, malformation ofEnrichmentMAPK11.14
190Neuromuscular diseaseEnrichmentACTA11.14
191LissencephalyEnrichmentACTG11.08
192Complex neurodevelopmental disorderEnrichmentPAK3, RAC31.03
193Pancreatic cancerEnrichmentKRAS1.01
194Severe covid-19EnrichmentITGAV0.95
195Connective tissue diseaseEnrichmentACTA20.91
196CakutEnrichmentACTG10.88
197Non-syndromic x-linked intellectual disabilityEnrichmentARHGEF60.86
198Non-syndromic genetic deafnessEnrichmentACTG10.86
199Systemic lupus erythematosusEnrichmentITGAM0.83
200Charcot-marie-tooth diseaseEnrichmentLAMA20.81
201Nonsyndromic hearing lossEnrichmentACTG10.80
202Familial thoracic aortic aneurysm and aortic dissectionEnrichmentACTA20.78
203Hereditary breast carcinomaEnrichmentKRAS0.78
204ThrombocytopeniaEnrichmentSRC0.74
205Autosomal dominant non-syndromic intellectual disabilityEnrichmentERBB40.73
206Rare autosomal dominant non-syndromic sensorineural deafness type dfnaEnrichmentACTG10.71
207Hereditary breast ovarian cancer syndromeEnrichmentKRAS0.69
208Myeloma, multipleEnrichmentKRAS0.68
209Frontotemporal dementia and/or amyotrophic lateral sclerosis 7EnrichmentERBB40.67
210AutismEnrichmentCHRNA10.59
211Rare genetic deafnessEnrichmentACTG10.55
212Inherited cancer-predisposing syndromeEnrichmentEGFR0.37

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