AHR Pathway

No Pathway Network information available for AHR Pathway

Pathways in the AHR Pathway SuperPath

#	Name	Source	Genes
1	AHR Pathway	QIAGEN	AHR AHRR AIP ARNT EP300 ESR1 GTF2B HSP90AA1 NCOA1 NCOA2 NCOA3 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 POLR2A POLR2B POLR2C RB1 RELA SMARCA4 SP1 SUMO1 TBP (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AHR	Aryl Hydrocarbon Receptor	Protein Coding	1
2	AHRR	Aryl Hydrocarbon Receptor Repressor	Protein Coding	1
3	AIP	AHR Interacting HSP90 Co-Chaperone	Protein Coding	1
4	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
5	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
6	ESR1	Estrogen Receptor 1	Protein Coding	1
7	GTF2B	General Transcription Factor IIB	Protein Coding	1
8	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
9	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
10	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
11	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	1
12	NCOA7	Nuclear Receptor Coactivator 7	Protein Coding	1
13	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
14	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	1
15	NR2F1	Nuclear Receptor Subfamily 2 Group F Member 1	Protein Coding	1
16	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
17	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
18	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
19	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
20	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
21	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
22	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
23	SP1	Sp1 Transcription Factor	Protein Coding	1
24	TBP	TATA-Box Binding Protein	Protein Coding	1
25	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	1

Disorders associated with AHR Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited cancer-predisposing syndrome	Enrichment	AIP, RB1, SMARCA4	2.75
2	Retinitis pigmentosa 85	Enrichment	AHR	2.73
3	Orofacial cleft 10	Enrichment	SUMO1	2.73
4	Foveal hypoplasia 3	Enrichment	AHR	2.73
5	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.73
6	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.73
7	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.73
8	Trilateral retinoblastoma	Enrichment	RB1	2.73
9	Lung oat cell carcinoma	Enrichment	RB1	2.73
10	Spinocerebellar ataxia 17	Enrichment	TBP	2.43
11	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	2.43
12	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.43
13	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.43
14	Menke-hennekam syndrome 2	Enrichment	EP300	2.43
15	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	2.43
16	Rela fusion-positive ependymoma	Enrichment	RELA	2.43
17	Bosch-boonstra-schaaf optic atrophy syndrome	Enrichment	NR2F1	2.43
18	Otosclerosis 12	Enrichment	SMARCA4	2.43
19	Coffin-siris syndrome 4	Enrichment	SMARCA4	2.43
20	Acromegaly	Enrichment	AIP	2.43
21	Familial retinoblastoma	Enrichment	RB1	2.43
22	Null pituitary adenoma	Enrichment	AIP	2.43
23	Familial isolated pituitary adenoma	Enrichment	AIP	2.43
24	Silent pituitary adenoma	Enrichment	AIP	2.43
25	Gigantism	Enrichment	AIP	2.43
26	Retinoblastoma	Enrichment	RB1	2.26
27	Osteogenic sarcoma	Enrichment	RB1	2.26
28	Estrogen resistance	Enrichment	ESR1	2.26
29	Pituitary adenoma 1, multiple types	Enrichment	AIP	2.26
30	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.26
31	Hypotrichosis 8	Enrichment	RB1	2.26
32	Squamous cell carcinoma	Enrichment	RB1	2.26
33	Migraine without aura	Enrichment	ESR1	2.26
34	Bone osteosarcoma	Enrichment	RB1	2.26
35	Growth hormone secreting pituitary adenoma	Enrichment	AIP	2.26
36	Aip familial isolated pituitary adenomas	Enrichment	AIP	2.26
37	Small cell cancer of the lung	Enrichment	RB1	2.13
38	Lynch syndrome 4	Enrichment	RB1	2.13
39	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	2.13
40	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.13
41	Prolactinoma	Enrichment	AIP	2.13
42	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.04
43	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.96
44	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.96
45	Neuroblastoma	Enrichment	SMARCA4	1.83
46	Charge syndrome	Enrichment	EP300	1.78
47	Ventricular septal defect	Enrichment	SMARCA4	1.78
48	Migraine with or without aura 1	Enrichment	ESR1	1.70
49	Atrial heart septal defect	Enrichment	SMARCA4	1.70
50	Interatrial communication	Enrichment	SMARCA4	1.70
51	Lip and oral cavity carcinoma	Enrichment	RB1	1.66
52	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.63
53	Lung cancer susceptibility 3	Enrichment	RB1	1.59
54	Coffin-siris syndrome 1	Enrichment	SMARCA4	1.56
55	Polydactyly, postaxial, type a1	Enrichment	EP300	1.56
56	Familial hypercholesterolemia	Enrichment	SMARCA4	1.56
57	Rare genetic intellectual disability	Enrichment	EP300	1.56
58	Cleft palate, isolated	Enrichment	SMARCA4	1.51
59	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	1.46
60	Parkinson's disease	Enrichment	TBP	1.46
61	Myocardial infarction	Enrichment	ESR1	1.40
62	Tooth agenesis	Enrichment	SUMO1	1.40
63	Parkinson disease, late-onset	Enrichment	TBP	1.36
64	Bladder cancer	Enrichment	RB1	1.28
65	Cakut	Enrichment	NRIP1	1.22
66	Cerebral palsy	Enrichment	SMARCA4	1.16
67	Optic atrophy plus syndrome	Enrichment	NR2F1	1.11
68	Hereditary breast carcinoma	Enrichment	ESR1	1.11
69	Myeloma, multiple	Enrichment	NCOR2	1.01
70	Breast cancer	Enrichment	ESR1	0.89
71	Colorectal cancer	Enrichment	EP300	0.83
72	Ovarian cancer	Enrichment	RB1	0.77
73	Autism spectrum disorder	Enrichment	NR2F1	0.74
74	Microcephaly	Enrichment	EP300	0.69
75	Retinitis pigmentosa	Enrichment	AHR	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for AHR Pathway

Member Pathways for AHR Pathway

Pathways in the AHR Pathway SuperPath

Associated Genes for AHR Pathway

Associated Disorders for AHR Pathway

Disorders associated with AHR Pathway SuperPath

STRING Interaction Network for AHR Pathway

Sources for AHR Pathway