ALK1 signaling events

No Pathway Network information available for ALK1 signaling events

Pathways in the ALK1 signaling events SuperPath

#	Name	Source	Genes
1	ALK1 signaling events	PubChem	ACVR1 ACVR2A ACVRL1 ARRB2 BMPR2 CAV1 CSNK2B ENG FKBP1A GDF2 ID1 INHBA MAPK3 PPP1CA SMAD1 SMAD4 SMAD7 TGFB1 TGFB3 TGFBR1 TGFBR2 TLX2 (see all 22) (see less)
2	ALK1 pathway	PubChem	ACVR1 ACVRL1 FKBP1A

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACVR1	Activin A Receptor Type 1	Protein Coding	2
2	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	2
3	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	2
4	TLX2	T Cell Leukemia Homeobox 2	Protein Coding	1
5	ENG	Endoglin	Protein Coding	1
6	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	1
7	SMAD1	SMAD Family Member 1	Protein Coding	1
8	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
9	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1
10	INHBA	Inhibin Subunit Beta A	Protein Coding	1
11	ACVR2A	Activin A Receptor Type 2A	Protein Coding	1
12	GDF2	Growth Differentiation Factor 2	Protein Coding	1
13	SMAD7	SMAD Family Member 7	Protein Coding	1
14	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
15	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
16	CAV1	Caveolin 1	Protein Coding	1
17	ARRB2	Arrestin Beta 2	Protein Coding	1
18	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
19	SMAD4	SMAD Family Member 4	Protein Coding	1
20	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
21	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
22	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1

Disorders associated with ALK1 signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Heritable pulmonary arterial hypertension	Enrichment	ACVRL1, BMPR2, CAV1, ENG, GDF2	10.69
2	Hereditary hemorrhagic telangiectasia	Enrichment	ACVRL1, ENG, GDF2, SMAD4	9.66
3	Pulmonary hypertension, primary, 1	Enrichment	ACVRL1, BMPR2, ENG, GDF2	8.43
4	Loeys-dietz syndrome	Enrichment	TGFB3, TGFBR1, TGFBR2	6.51
5	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD4, TGFB3, TGFBR1, TGFBR2	6.17
6	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.60
7	Fibrodysplasia ossificans progressiva	Enrichment	ACVR1, BMPR2	5.60
8	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	5.12
9	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	ENG, SMAD4	4.60
10	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ACVRL1, ENG	4.43
11	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.95
12	Telangiectasia, hereditary hemorrhagic, type 2	Enrichment	ACVRL1	3.66
13	Telangiectasis	Enrichment	ACVRL1	3.66
14	Hemophilia a	Enrichment	ACVRL1	3.05
15	Factor viii deficiency	Enrichment	ACVRL1	3.05
16	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.79
17	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.79
18	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.79
19	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.79
20	Ovary adenocarcinoma	Enrichment	INHBA	2.79
21	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.79
22	Telangiectasia, hereditary hemorrhagic, type 5	Enrichment	GDF2	2.79
23	Colorectal cancer 3	Enrichment	SMAD7	2.79
24	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.79
25	Heritable thoracic aortic disease	Enrichment	SMAD4	2.79
26	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.79
27	Primary pulmonary hypertension	Enrichment	BMPR2	2.79
28	Pulmonary hypertension	Enrichment	BMPR2	2.79
29	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	2.79
30	Epicanthus	Enrichment	ACVR1	2.58
31	Thrombocytopenia	Enrichment	ACVRL1, SMAD4	2.57
32	Myhre syndrome	Enrichment	SMAD4	2.49
33	Camurati-engelmann disease 1	Enrichment	TGFB1	2.49
34	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	2.49
35	Pulmonary arteriovenous fistulas	Enrichment	ENG	2.49
36	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.49
37	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.49
38	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	2.49
39	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.49
40	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	2.49
41	Camurati-engelmann disease	Enrichment	TGFB1	2.49
42	Loeys-dietz syndrome 4	Enrichment	TGFB3	2.49
43	Pulmonary venoocclusive disease	Enrichment	BMPR2	2.49
44	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.49
45	Prognathism, mandibular	Enrichment	CSNK2B	2.31
46	Juvenile polyposis syndrome	Enrichment	SMAD4	2.31
47	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2	2.31
48	Enophthalmos	Enrichment	CSNK2B	2.19
49	Syndactyly	Enrichment	CSNK2B	2.19
50	Aortic aneurysm	Enrichment	TGFBR1	2.19
51	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	2.09
52	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	2.09
53	2q23.1 microduplication syndrome	Enrichment	ACVR2A	2.09
54	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	2.09
55	Familial cerebral saccular aneurysm	Enrichment	ENG	2.09
56	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	2.01
57	Limited scleroderma	Enrichment	CAV1	2.01
58	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	2.01
59	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	2.01
60	Esophageal cancer	Enrichment	TGFBR2	1.95
61	Gallbladder cancer	Enrichment	SMAD4	1.95
62	Tooth agenesis, selective, 1	Enrichment	BMPR2	1.84
63	Pectus excavatum	Enrichment	TGFBR1	1.75
64	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.71
65	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.71
66	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.65
67	Lynch syndrome	Enrichment	TGFBR2	1.62
68	Arteriovenous malformations of the brain	Enrichment	ENG	1.52
69	Ehlers-danlos syndrome	Enrichment	TGFBR2	1.52
70	Pancreatic cancer	Enrichment	SMAD4	1.40
71	Cystic fibrosis	Enrichment	TGFB1	1.30
72	Connective tissue disease	Enrichment	TGFBR2	1.30
73	Systemic lupus erythematosus	Enrichment	ENG	1.21
74	Gastric cancer	Enrichment	SMAD4	1.17
75	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	1.11
76	Colorectal cancer	Enrichment	SMAD4	0.88
77	Autism spectrum disorder	Enrichment	CSNK2B	0.79
78	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

ALK1 signaling events

Pathway Network for ALK1 signaling events

Member Pathways for ALK1 signaling events

Pathways in the ALK1 signaling events SuperPath

Associated Genes for ALK1 signaling events

Associated Disorders for ALK1 signaling events

Disorders associated with ALK1 signaling events SuperPath

STRING Interaction Network for ALK1 signaling events

Sources for ALK1 signaling events