Allograft rejection

No Pathway Network information available for Allograft rejection

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Allograft rejection SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Immunodeficiency due to a late component of complement deficiencyEnrichmentC5, C6, C7, C8A, C8B, C910.56
2Immunodeficiency due to a classical component pathway complement deficiencyEnrichmentC1QA, C1QB, C1QC, C2, C4A, C4B10.25
3Behcet syndromeEnrichmentC4A, FAS, HLA-B, IL10, IL12A6.83
4Systemic lupus erythematosusEnrichmentC4A, C4B, CTLA4, HLA-DRB1, IL10, TNF6.62
5C1q deficiency 1EnrichmentC1QA, C1QB, C1QC6.51
6Human immunodeficiency virus type 1EnrichmentCXCL12, HLA-C, IFNG, IL105.23
7Granulomatosis with polyangiitisEnrichmentCTLA4, HLA-DPA1, HLA-DPB15.21
8Celiac disease 1EnrichmentHLA-DQA1, HLA-DQB14.33
9Severe cutaneous adverse reactionEnrichmentHLA-A, HLA-B4.33
10Complement component 6 deficiencyEnrichmentC6, C8B4.33
11Bullous pemphigoidEnrichmentHLA-DQB1, HLA-DRB14.33
12Pediatric multiple sclerosisEnrichmentHLA-DQB1, HLA-DRB14.33
13AsthmaEnrichmentHLA-G, IL13, TNF4.31
14Takayasu arteritisEnrichmentHLA-B, IL12B3.86
15Mycosis fungoidesEnrichmentCD28, CTLA43.86
16Adult-onset myasthenia gravisEnrichmentCTLA4, HLA-DQA13.86
17Vogt-koyanagi-harada diseaseEnrichmentFAS, HLA-DRB13.86
18Saczary syndromeEnrichmentCD28, CTLA43.86
19Temporal arteritisEnrichmentHLA-B, HLA-DRB13.56
20Autoimmune lymphoproliferative syndromeEnrichmentFAS, FASLG3.56
21Idiopathic achalasiaEnrichmentHLA-DQA1, HLA-DQB13.56
22Narcolepsy 2EnrichmentHLA-DQB1, HLA-DRB13.34
23Systemic lupus erythematosus 16EnrichmentC1QA, C4A3.34
24Idiopathic aplastic anemiaEnrichmentIFNG, PRF13.34
25Il10-related early-onset inflammatory bowel diseaseEnrichmentIL10, TGFB13.16
26Narcolepsy 1EnrichmentHLA-DQB1, HLA-DRB12.90
27Lung cancerEnrichmentCASP8, FAS, FASLG2.87
28Aplastic anemiaEnrichmentIFNG, PRF12.69
29Multiple sclerosisEnrichmentHLA-DQB1, HLA-DRB12.40
30Spondyloarthropathy 1EnrichmentHLA-B2.16
31Complement component 2 deficiencyEnrichmentC22.16
32Type 1 diabetes mellitus 10EnrichmentIL2RA2.16
33Complement component 5 deficiencyEnrichmentC52.16
34Hemophagocytic lymphohistiocytosis, familial, 2EnrichmentPRF12.16
35Immunodysregulation, polyendocrinopathy, and enteropathy, x-linkedEnrichmentFOXP32.16
36Caspase 8 deficiencyEnrichmentCASP82.16
37Hypereosinophilic syndrome, idiopathicEnrichmentPDGFRA2.16
38Psoriasis 1EnrichmentHLA-C2.16
39Complement component 7 deficiencyEnrichmentC72.16
40Celiac disease 3EnrichmentCTLA42.16
41Colchicine resistanceEnrichmentABCB12.16
42Hemolytic uremic syndrome, atypical 5EnrichmentC32.16
43Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathyEnrichmentCD552.16
44Blood group, cromer systemEnrichmentCD552.16
45Complement component 8 deficiency, type iEnrichmentC8A2.16
46Macular degeneration, age-related, 15EnrichmentC92.16
47Eculizumab, poor response toEnrichmentC52.16
48Gist-plus syndromeEnrichmentPDGFRA2.16
49Immunodeficiency 69EnrichmentIFNG2.16
50Immunodeficiency with hyper-igm, type 1EnrichmentCD40LG2.16
51Encephalopathy, acute transientEnrichmentABCB12.16
52C1q deficiency 3EnrichmentC1QC2.16
53Complement component 4a deficiencyEnrichmentC4A2.16
54Graft-versus-host diseaseEnrichmentIL102.16
55Myeloid and lymphoid neoplasms associated with pdgfra rearrangementEnrichmentPDGFRA2.16
56Type 1 diabetes mellitus 12EnrichmentCTLA42.16
57Ankylosing spondylitis 1EnrichmentHLA-B2.16
58Allergic rhinitisEnrichmentIL132.16
59Pulmonary alveolar proteinosis, acquiredEnrichmentHLA-DRB12.16
60Microvascular complications of diabetes 1EnrichmentVEGFA2.16
61Inflammatory bowel disease 13EnrichmentABCB12.16
62Immunodeficiency with hyper-igm, type 3EnrichmentCD402.16
63Birdshot chorioretinopathyEnrichmentHLA-A2.16
64Blood group, chido/rodgers systemEnrichmentC4A2.16
65Immunodeficiency 31aEnrichmentSTAT12.16
66Complement component 4b deficiencyEnrichmentC4B2.16
67Immunodeficiency 29EnrichmentIL12B2.16
68Graham little-piccardi-lassueur syndromeEnrichmentHLA-DRA2.16
69Hirschsprung disease 3EnrichmentGDNF2.16
70Macular degeneration, age-related, 9EnrichmentC32.16
71Immunodeficiency 31bEnrichmentSTAT12.16
72Complement component 9 deficiencyEnrichmentC92.16
73Immunodeficiency 123 with hpv-related verrucosisEnrichmentCD282.16
74Complement component 3 deficiency, autosomal recessiveEnrichmentC32.16
75Complement component 8 deficiency, type iiEnrichmentC8B2.16
76Reactive arthritisEnrichmentHLA-B2.16
77BerylliosisEnrichmentHLA-DPB12.16
78Complement component 3 deficiencyEnrichmentC32.16
79C1q deficiency 2EnrichmentC1QB2.16
80Membranoproliferative glomerulonephritisEnrichmentC32.16
81Primary membranoproliferative glomerulonephritisEnrichmentC32.16
82Cd40 ligand deficiencyEnrichmentCD40LG2.16
83Protein-losing enteropathyEnrichmentCD552.16
84PneumothoraxEnrichmentCOL5A12.16
85Pulmonary arterial hypertension associated with connective tissue diseaseEnrichmentHLA-B2.16
86Premature agingEnrichmentVIM2.16
87Fatal post-viral neurodegenerative disorderEnrichmentPRF12.16
88Precursor t-cell acute lymphoblastic leukemiaEnrichmentTRA, TRB1.97
89Hashimoto thyroiditisEnrichmentCTLA41.86
90Camurati-engelmann disease 1EnrichmentTGFB11.86
91Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephalyEnrichmentFOXP31.86
92Immunodeficiency 41 with lymphoproliferation and autoimmunityEnrichmentIL2RA1.86
93Parkinson disease 8, autosomal dominantEnrichmentLRRK21.86
94Creutzfeldt-jakob diseaseEnrichmentHLA-DQB11.86
95Usher syndrome, type iiibEnrichmentHARS11.86
96LathosterolosisEnrichmentC51.86
97Sarcoidosis 1EnrichmentHLA-DRB11.86
98Macular degeneration, age-related, 14EnrichmentC21.86
99Charcot-marie-tooth disease, axonal, type 2wEnrichmentHARS11.86
100Immunodeficiency 31cEnrichmentSTAT11.86
101Fibromuscular dysplasia, multifocalEnrichmentCOL5A11.86
102Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB11.86
103Immunodeficiency 127EnrichmentTNF1.86
104Stevens-johnson syndromeEnrichmentHLA-B1.86
105Cataract 30EnrichmentVIM1.86
106Camurati-engelmann diseaseEnrichmentTGFB11.86
107Trypsinogen deficiencyEnrichmentTRB1.86
108Chronic eosinophilic leukemiaEnrichmentPDGFRA1.86
109Autosomal dominant charcot-marie-tooth disease type 2wEnrichmentHARS11.86
110B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalityEnrichmentPDGFRA1.86
111Severe covid-19EnrichmentHLA-A, HLA-DQB11.78
112Klippel-feil syndrome 1, autosomal dominantEnrichmentLRRK21.69
113Tuberous sclerosis 1EnrichmentIFNG1.69
114Immunodeficiency 98 with autoinflammation, x-linkedEnrichmentFASLG1.69
115Psoriatic arthritisEnrichmentTNF1.69
116Ehlers-danlos syndrome, classic type, 2EnrichmentCOL5A11.69
117Hepatitis c virusEnrichmentIFNG1.69
118Tuberous sclerosis 2EnrichmentIFNG1.69
119Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferationEnrichmentCTLA41.69
120Asparagine synthetase deficiencyEnrichmentCTLA41.69
121Migraine without auraEnrichmentTNF1.69
122Immunodeficiency 7EnrichmentTRA1.69
123Immunodeficiency, common variable, 11EnrichmentIL211.69
124Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndromeEnrichmentCTLA41.69
125Genetic atypical hemolytic-uremic syndromeEnrichmentC31.69
126Immunodeficiency, common variable, 1EnrichmentCTLA41.57
127Cerebral malariaEnrichmentTNF1.57
128Systemic-onset juvenile idiopathic arthritisEnrichmentHLA-DRB11.57
129Oculomotor apraxiaEnrichmentHARS11.57
130Vitamin d-dependent rickets, type 2aEnrichmentTRB1.47
131Hemophagocytic lymphohistiocytosis, familial, 1EnrichmentPRF11.47
132Follicular lymphomaEnrichmentHLA-DRB11.47
133Histiocytoid hemangiomaEnrichmentVIM1.47
134Vascular dementiaEnrichmentTNF1.47
135Diffuse cutaneous systemic sclerosisEnrichmentHLA-DRB11.47
136Primary hypereosinophilic syndromeEnrichmentPDGFRA1.47
137Ehlers-danlos syndrome, classic type, 1EnrichmentCOL5A11.39
138Machado-joseph diseaseEnrichmentLRRK21.39
139Type 1 diabetes mellitusEnrichmentFOXP31.39
140Renal tubular dysgenesisEnrichmentAGTR11.39
141Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.39
142Inguinal herniaEnrichmentCOL5A11.39
143Pain disorderEnrichmentCOL5A11.39
144Chronic mucocutaneous candidiasisEnrichmentSTAT11.39
145Limited sclerodermaEnrichmentHLA-DRB11.39
146Classic ehlers-danlos syndromeEnrichmentCOL5A11.39
147Atypical hemolytic uremic syndrome with complement gene abnormalityEnrichmentC31.39
148Usher syndrome, type iiiaEnrichmentHARS11.33
149Gastrointestinal stromal tumorEnrichmentPDGFRA1.33
150Common variable immunodeficiencyEnrichmentCD40LG1.33
151Oligoarticular juvenile idiopathic arthritisEnrichmentIL2RA1.33
152Rheumatoid factor-negative juvenile idiopathic arthritisEnrichmentIL2RA1.33
153B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentHLA-C1.33
154Gastroesophageal refluxEnrichmentCOL5A11.27
155Lymphoma, non-hodgkin, familialEnrichmentPRF11.27
156Orthostatic intoleranceEnrichmentCOL5A11.27
157Rheumatoid arthritisEnrichmentIL101.22
158Adult hepatocellular carcinomaEnrichmentCASP81.22
159Congenital central hypoventilation syndromeEnrichmentGDNF1.22
160Primary biliary cholangitisEnrichmentIL12A1.22
161Autosomal dominant cerebellar ataxiaEnrichmentLRRK21.22
162Hydrops fetalisEnrichmentFOXP31.22
163Cataract 30, multiple typesEnrichmentVIM1.18
164Epilepsy, idiopathic generalizedEnrichmentABCB11.14
165Early-onset parkinson's diseaseEnrichmentLRRK21.10
166Cutis laxaEnrichmentCOL5A11.10
167Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactylyEnrichmentCOL5A11.07
168Alzheimer's diseaseEnrichmentTNF1.07
169ClubfootEnrichmentCOL5A11.07
170Chromosome 1p36 deletion syndromeEnrichmentPRKCZ1.07
171CataractEnrichmentCOL5A11.04
172Cleft lip/palateEnrichmentPDGFRA1.04
173Hereditary chronic pancreatitisEnrichmentTRB1.04
174Breast cancerEnrichmentCASP8, IL21.03
175Atypical hemolytic-uremic syndromeEnrichmentC31.01
176Hypertension, essentialEnrichmentAGTR10.96
177Pancreatitis, hereditaryEnrichmentTRB0.96
178Ehlers-danlos syndromeEnrichmentCOL5A10.91
179Parkinson's diseaseEnrichmentLRRK20.91
180Centronuclear myopathyEnrichmentFOXP30.87
181Hepatocellular carcinomaEnrichmentCASP80.85
182MalariaEnrichmentTNF0.83
183Parkinson disease, late-onsetEnrichmentLRRK20.82
184Autoinflammatory diseaseEnrichmentPRF10.82
185ScoliosisEnrichmentHARS10.82
186Hirschsprung disease 1EnrichmentGDNF0.74
187Cystic fibrosisEnrichmentTGFB10.70
188Connective tissue diseaseEnrichmentCOL5A10.70
189Peripheral nervous system diseaseEnrichmentHARS10.70
190NeuropathyEnrichmentHARS10.70
191Gastric cancerEnrichmentIL1B0.59
192Familial thoracic aortic aneurysm and aortic dissectionEnrichmentCOL5A10.58
193Spastic ataxiaEnrichmentHARS10.51
194Ovarian cancerEnrichmentPDGFRA0.30
195MicrocephalyEnrichmentHARS10.24
196Inherited cancer-predisposing syndromeEnrichmentPDGFRA0.22

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