Alpha-synuclein signaling

No Pathway Network information available for Alpha-synuclein signaling

Pathways in the Alpha-synuclein signaling SuperPath

#	Name	Source	Genes
1	Alpha-synuclein signaling	PubChem	BAD CAPN1 CSNK2A1 FKBP1A GRK5 HSPA4 KLK6 LCK MAOB PARK7 PLCB2 PLD1 PLD2 PPP2R5D PRKCD PRKN PRRT2 PTK2B SLC6A3 SNCA STUB1 SYK TH TOR1A UBE2L3 UCHL1 (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	1
2	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
3	KLK6	Kallikrein Related Peptidase 6	Protein Coding	1
4	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
5	PLD1	Phospholipase D1	Protein Coding	1
6	PLD2	Phospholipase D2	Protein Coding	1
7	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
8	SNCA	Synuclein Alpha	Protein Coding	1
9	PARK7	Parkinsonism Associated Deglycase	Protein Coding	1
10	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	1
11	GRK5	G Protein-Coupled Receptor Kinase 5	Protein Coding	1
12	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
13	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	1
14	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
15	PRKCD	Protein Kinase C Delta	Protein Coding	1
16	MAOB	Monoamine Oxidase B	Protein Coding	1
17	TH	Tyrosine Hydroxylase	Protein Coding	1
18	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
19	CAPN1	Calpain 1	Protein Coding	1
20	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
21	TOR1A	Torsin Family 1 Member A	Protein Coding	1
22	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
23	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	1
24	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
25	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
26	PLCB2	Phospholipase C Beta 2	Protein Coding	1

Disorders associated with Alpha-synuclein signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Early-onset parkinson's disease	Enrichment	PARK7, PRKN, SNCA, UCHL1	8.28
2	Parkinson disease, late-onset	Enrichment	PRKN, SNCA	3.02
3	Parkinson disease 1, autosomal dominant	Enrichment	SNCA	2.72
4	Dystonia 1, torsion, autosomal dominant	Enrichment	TOR1A	2.72
5	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.72
6	Parkinson disease 4, autosomal dominant	Enrichment	SNCA	2.72
7	Leprosy 2	Enrichment	PRKN	2.72
8	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.72
9	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.72
10	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	2.72
11	Parkinson disease 7, autosomal recessive early-onset	Enrichment	PARK7	2.72
12	Parkinson disease 5, autosomal dominant	Enrichment	UCHL1	2.72
13	Immunodeficiency 22	Enrichment	LCK	2.72
14	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.72
15	Arthrogryposis multiplex congenita 5	Enrichment	TOR1A	2.72
16	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	2.72
17	Colitis	Enrichment	SYK	2.72
18	Dyt1 early-onset isolated dystonia	Enrichment	TOR1A	2.72
19	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	2.72
20	Dystonia	Enrichment	TH, TOR1A	2.69
21	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	PARK7	2.42
22	Parkinson disease 12	Enrichment	PRKN	2.42
23	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.42
24	Segawa syndrome, autosomal recessive	Enrichment	TH	2.42
25	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	2.42
26	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.42
27	Spastic paraplegia 79b, autosomal recessive	Enrichment	UCHL1	2.42
28	Spinocerebellar ataxia 48	Enrichment	STUB1	2.42
29	Parkinson disease 15, autosomal recessive early-onset	Enrichment	SNCA	2.42
30	Hereditary spastic paraplegia 79a	Enrichment	UCHL1	2.42
31	Spastic paraplegia 79a, autosomal dominant, with ataxia	Enrichment	UCHL1	2.42
32	Arthritis	Enrichment	SYK	2.42
33	Prrt2-related disorder	Enrichment	PRRT2	2.42
34	Dystonia, dopa-responsive	Enrichment	TH	2.24
35	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.24
36	Torsion dystonia 1	Enrichment	TOR1A	2.24
37	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.12
38	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.12
39	Tobacco addiction	Enrichment	SLC6A3	2.12
40	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.12
41	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.12
42	Complex hereditary spastic paraplegia	Enrichment	PRKN	2.12
43	Dementia, lewy body	Enrichment	SNCA	2.02
44	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	2.02
45	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	2.02
46	Parkin type of early-onset parkinson disease	Enrichment	PRKN	2.02
47	Self-limited infantile epilepsy	Enrichment	PRRT2	2.02
48	Dystonia 11, myoclonic	Enrichment	TOR1A	1.94
49	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PARK7	1.94
50	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.94
51	Autism spectrum disorder	Enrichment	CSNK2A1, PRKN	1.74
52	Immune deficiency disease	Enrichment	SYK	1.68
53	Lung cancer susceptibility 3	Enrichment	PRKN	1.58
54	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.58
55	Parkinson's disease	Enrichment	PRKN	1.45
56	Lung cancer	Enrichment	PRKN	1.22
57	Severe combined immunodeficiency	Enrichment	LCK	1.21
58	Systemic lupus erythematosus	Enrichment	UBE2L3	1.14
59	Schizophrenia	Enrichment	PRKN	0.97
60	Autism	Enrichment	PRKN	0.89
61	Ovarian cancer	Enrichment	PRKN	0.75
62	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Alpha-synuclein signaling

Pathway Network for Alpha-synuclein signaling

Member Pathways for Alpha-synuclein signaling

Pathways in the Alpha-synuclein signaling SuperPath

Associated Genes for Alpha-synuclein signaling

Associated Disorders for Alpha-synuclein signaling

Disorders associated with Alpha-synuclein signaling SuperPath

STRING Interaction Network for Alpha-synuclein signaling

Sources for Alpha-synuclein signaling