Alpha4 beta1 integrin signaling events

No Pathway Network information available for Alpha4 beta1 integrin signaling events

Pathways in the Alpha4 beta1 integrin signaling events SuperPath

#	Name	Source	Genes
1	Alpha4 beta1 integrin signaling events	PubChem	ABI1 ADAM28 ARF6 BCAR1 CD14 CD81 CDC42 CRK DOCK1 FN1 GIT1 IGSF8 ITGA4 ITGB1 JAM2 JAML MDK MYH2 PRKACA PRKACB PRKAR1A PRKAR1B PTK2 PTK2B PTPRA PXN RAC1 SPP1 SRC THBS1 THBS2 TLN1 VCAM1 YWHAZ (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADAM28	ADAM Metallopeptidase Domain 28	Protein Coding	1
2	MYH2	Myosin Heavy Chain 2	Protein Coding	1
3	IGSF8	Immunoglobulin Superfamily Member 8	Protein Coding	1
4	THBS2	Thrombospondin 2	Protein Coding	1
5	ABI1	Abl Interactor 1	Protein Coding	1
6	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
7	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
8	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
9	CD14	CD14 Molecule	Protein Coding	1
10	CD81	CD81 Molecule	Protein Coding	1
11	MDK	Midkine	Protein Coding	1
12	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
13	JAML	Junction Adhesion Molecule Like	Protein Coding	1
14	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
15	JAM2	Junctional Adhesion Molecule 2	Protein Coding	1
16	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
17	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
18	THBS1	Thrombospondin 1	Protein Coding	1
19	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
20	FN1	Fibronectin 1	Protein Coding	1
21	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
22	PXN	Paxillin	Protein Coding	1
23	GIT1	GIT ArfGAP 1	Protein Coding	1
24	CDC42	Cell Division Cycle 42	Protein Coding	1
25	PTPRA	Protein Tyrosine Phosphatase Receptor Type A	Protein Coding	1
26	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
27	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
28	TLN1	Talin 1	Protein Coding	1
29	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
30	RAC1	Rac Family Small GTPase 1	Protein Coding	1
31	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
32	ARF6	ARF GTPase 6	Protein Coding	1
33	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
34	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1

Disorders associated with Alpha4 beta1 integrin signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, YWHAZ	4.44
2	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.66
3	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.60
4	Carney complex, type 1	Enrichment	PRKAR1A	2.60
5	Immunodeficiency, common variable, 6	Enrichment	CD81	2.60
6	Basal ganglia calcification, idiopathic, 8, autosomal recessive	Enrichment	JAM2	2.60
7	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.60
8	Myxoma, intracardiac	Enrichment	PRKAR1A	2.60
9	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.60
10	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.60
11	Thrombocytopenia 6	Enrichment	SRC	2.60
12	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.60
13	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.60
14	Capillary leak syndrome	Enrichment	TLN1	2.60
15	Nocarh syndrome	Enrichment	CDC42	2.60
16	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.60
17	Temporomandibular joint anomaly	Enrichment	DOCK1	2.60
18	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.30
19	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.30
20	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.30
21	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.30
22	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.30
23	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.30
24	Dystonia 30	Enrichment	PTPRA	2.30
25	Usher syndrome, type iv	Enrichment	PRKAR1A	2.30
26	Acrodysostosis	Enrichment	PRKAR1A	2.30
27	Fibrolamellar carcinoma	Enrichment	PRKACA	2.30
28	Hereditary inclusion body myopathy-joint contractures-ophthalmoplegia syndrome	Enrichment	MYH2	2.30
29	Immune system disease	Enrichment	CDC42	2.30
30	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.30
31	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.30
32	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD81	2.30
33	Childhood-onset autosomal recessive myopathy with external ophthalmoplegia	Enrichment	MYH2	2.30
34	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.12
35	Ehlers-danlos syndrome, classic-like, 3	Enrichment	THBS2	2.12
36	Carney complex variant	Enrichment	PRKAR1A	2.00
37	Retinitis pigmentosa 26	Enrichment	ITGA4	2.00
38	Congenital myopathy 6 with ophthalmoplegia	Enrichment	MYH2	2.00
39	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	2.00
40	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.00
41	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.83
42	Myelofibrosis	Enrichment	SRC	1.76
43	Intervertebral disc disease	Enrichment	THBS2	1.76
44	Basal ganglia calcification, idiopathic, 1	Enrichment	JAM2	1.70
45	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.65
46	Neural tube defects	Enrichment	ITGB1	1.49
47	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.49
48	Osteoporosis	Enrichment	SRC	1.46
49	Isolated macular dystrophy	Enrichment	ITGA4	1.46
50	Ehlers-danlos syndrome	Enrichment	THBS2	1.33
51	Systemic lupus erythematosus	Enrichment	SPP1	1.03
52	Myopathy	Enrichment	MYH2	1.02
53	Nephrotic syndrome	Enrichment	FN1	0.99
54	Thrombocytopenia	Enrichment	SRC	0.94
55	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.93
56	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.89
57	Primary ovarian insufficiency	Enrichment	THBS1	0.86
58	Cone-rod dystrophy 2	Enrichment	ITGA4	0.80
59	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.76
60	Colorectal cancer	Enrichment	SRC	0.71
61	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.55
62	Hereditary retinal dystrophy	Enrichment	ITGA4	0.28
63	Fundus dystrophy	Enrichment	ITGA4	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Alpha4 beta1 integrin signaling events

Pathway Network for Alpha4 beta1 integrin signaling events

Member Pathways for Alpha4 beta1 integrin signaling events

Pathways in the Alpha4 beta1 integrin signaling events SuperPath

Associated Genes for Alpha4 beta1 integrin signaling events

Associated Disorders for Alpha4 beta1 integrin signaling events

Disorders associated with Alpha4 beta1 integrin signaling events SuperPath

STRING Interaction Network for Alpha4 beta1 integrin signaling events

Sources for Alpha4 beta1 integrin signaling events