Alternative pathway of fetal androgen synthesis

No Pathway Network information available for Alternative pathway of fetal androgen synthesis

Pathways in the Alternative pathway of fetal androgen synthesis SuperPath

#	Name	Source	Genes
1	Alternative pathway of fetal androgen synthesis	WikiPathways	AKR1C2 AKR1C4 CYB5A CYP11A1 CYP17A1 HSD17B3 HSD17B6 HSD3B2 POR SRD5A2 STAR (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HSD17B6	Hydroxysteroid 17-Beta Dehydrogenase 6	Protein Coding	1
2	CYB5A	Cytochrome B5 Type A	Protein Coding	1
3	POR	Cytochrome P450 Oxidoreductase	Protein Coding	1
4	STAR	Steroidogenic Acute Regulatory Protein	Protein Coding	1
5	SRD5A2	Steroid 5 Alpha-Reductase 2	Protein Coding	1
6	HSD17B3	Hydroxysteroid 17-Beta Dehydrogenase 3	Protein Coding	1
7	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	1
8	AKR1C2	Aldo-Keto Reductase Family 1 Member C2	Protein Coding	1
9	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	1
10	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	1
11	AKR1C4	Aldo-Keto Reductase Family 1 Member C4	Protein Coding	1

Disorders associated with Alternative pathway of fetal androgen synthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP17A1, HSD3B2, POR, STAR	10.94
2	Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency	Enrichment	CYB5A, CYP17A1	5.75
3	46,xy sex reversal 8	Enrichment	AKR1C2, AKR1C4	5.75
4	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1, CYP17A1	5.05
5	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP17A1	5.05
6	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Enrichment	CYP11A1	3.09
7	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	3.09
8	46,xy disorder of sex development due to 5-alpha-reductase 2 deficiency	Enrichment	SRD5A2	3.09
9	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	3.09
10	Non-classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	3.09
11	Classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	3.09
12	Primary ovarian insufficiency	Enrichment	CYP17A1, POR	3.00
13	Methemoglobinemia and ambiguous genitalia	Enrichment	CYB5A	2.79
14	Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	Enrichment	HSD3B2	2.79
15	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	2.79
16	Toe syndactyly, telecanthus, and anogenital and renal malformations	Enrichment	STAR	2.79
17	Xanthinuria, type i	Enrichment	SRD5A2	2.79
18	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	2.79
19	17-beta hydroxysteroid dehydrogenase iii deficiency	Enrichment	HSD17B3	2.79
20	Hypospadias 1, x-linked	Enrichment	HSD3B2	2.79
21	Cic-rearranged sarcoma	Enrichment	AKR1C2	2.79
22	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.79
23	3 beta-hydroxysteroid dehydrogenase deficiency	Enrichment	HSD3B2	2.79
24	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.79
25	Hereditary methemoglobinemia	Enrichment	CYB5A	2.79
26	Pseudovaginal perineoscrotal hypospadias	Enrichment	SRD5A2	2.39
27	Pseudohermaphroditism	Enrichment	HSD17B3	2.39
28	Familial glucocorticoid deficiency	Enrichment	STAR	2.39
29	Difference of sex development	Enrichment	HSD17B3	2.19
30	Epilepsy, myoclonic juvenile	Enrichment	HSD17B3	2.05
31	Prostate cancer	Enrichment	SRD5A2	1.63
32	Breast cancer	Enrichment	CYP17A1	1.23
33	Autism spectrum disorder	Enrichment	SRD5A2	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Alternative pathway of fetal androgen synthesis

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Member Pathways for Alternative pathway of fetal androgen synthesis

Pathways in the Alternative pathway of fetal androgen synthesis SuperPath

Associated Genes for Alternative pathway of fetal androgen synthesis

Associated Disorders for Alternative pathway of fetal androgen synthesis

Disorders associated with Alternative pathway of fetal androgen synthesis SuperPath

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