Alzheimers Disease Pathway

No Pathway Network information available for Alzheimers Disease Pathway

Pathways in the Alzheimers Disease Pathway SuperPath

#	Name	Source	Genes
1	Alzheimers Disease Pathway	QIAGEN	A2M ADAM10 ADAM17 APOE APP BACE1 BACE2 CAPN1 CDK5 CDK5R1 EGFR EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR3 FGFR4 GSK3B IGF1R INSR LIFR LRP1 MAPK1 MAPT NTRK1 NTRK2 NTRK3 PDGFRA PDGFRB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PSEN1 PSEN2 SRC (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	A2M	Alpha-2-Macroglobulin	Protein Coding	1
2	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
3	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
4	APOE	Apolipoprotein E	Protein Coding	1
5	APP	Amyloid Beta Precursor Protein	Protein Coding	1
6	BACE1	Beta-Secretase 1	Protein Coding	1
7	BACE2	Beta-Secretase 2	Protein Coding	1
8	CAPN1	Calpain 1	Protein Coding	1
9	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
10	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
11	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
12	EPOR	Erythropoietin Receptor	Protein Coding	1
13	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
14	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
15	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	1
16	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
17	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
18	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
19	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
20	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
21	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
22	INSR	Insulin Receptor	Protein Coding	1
23	LIFR	LIF Receptor Subunit Alpha	Protein Coding	1
24	LRP1	LDL Receptor Related Protein 1	Protein Coding	1
25	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
26	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
27	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
28	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
29	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	1
30	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
31	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
32	PRKCA	Protein Kinase C Alpha	Protein Coding	1
33	PRKCB	Protein Kinase C Beta	Protein Coding	1
34	PRKCD	Protein Kinase C Delta	Protein Coding	1
35	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
36	PRKCG	Protein Kinase C Gamma	Protein Coding	1
37	PRKCH	Protein Kinase C Eta	Protein Coding	1
38	PRKCI	Protein Kinase C Iota	Protein Coding	1
39	PRKD1	Protein Kinase D1	Protein Coding	1
40	PRKD3	Protein Kinase D3	Protein Coding	1
41	PRKCQ	Protein Kinase C Theta	Protein Coding	1
42	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
43	PSEN1	Presenilin 1	Protein Coding	1
44	PSEN2	Presenilin 2	Protein Coding	1
45	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1

Disorders associated with Alzheimers Disease Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer disease 4	Enrichment	APOE, PSEN1, PSEN2	7.47
2	Alzheimer's disease	Enrichment	APOE, APP, MAPT, PSEN1	7.13
3	Alzheimer disease, familial, 1	Enrichment	APOE, APP, MAPT, PSEN1	6.61
4	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	6.47
5	Early-onset autosomal dominant alzheimer disease	Enrichment	APP, PSEN1, PSEN2	5.93
6	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, FGFR3	5.63
7	Alzheimer disease 3	Enrichment	APOE, PSEN1	4.97
8	Pick disease of brain	Enrichment	MAPT, PSEN1	4.97
9	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.97
10	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.97
11	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3	4.73
12	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3	4.65
13	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.49
14	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.49
15	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17, EGFR	4.49
16	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.19
17	Glioma	Enrichment	FGFR2, NTRK3	4.19
18	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.97
19	Dementia	Enrichment	MAPT, PSEN1	3.97
20	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3	3.80
21	46,xy disorder of sex development	Enrichment	FGFR3, INSR	3.80
22	Colorectal cancer	Enrichment	ERBB2, FGFR2, FGFR3, SRC	3.72
23	Semantic dementia	Enrichment	MAPT, PSEN1	3.65
24	Pilomyxoid astrocytoma	Enrichment	FGFR1, NTRK2	3.65
25	Ovarian cancer	Enrichment	EGFR, ERBB2, NTRK1, PDGFRA	3.47
26	Progressive non-fluent aphasia	Enrichment	MAPT, PSEN1	3.42
27	Behavioral variant of frontotemporal dementia	Enrichment	MAPT, PSEN1	3.42
28	Frontotemporal dementia 1	Enrichment	MAPT, PSEN1	3.24
29	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2	3.24
30	Nk-cell enteropathy	Enrichment	ERBB4, IGF1R	3.09
31	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4, MAPT, PSEN1	3.03
32	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2	3.02
33	Hydrocephalus	Enrichment	FGFR2, PDGFRB	2.96
34	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.71
35	Erythroleukemia, familial	Enrichment	ERBB3	2.48
36	Hypochondroplasia	Enrichment	FGFR3	2.48
37	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.48
38	Paget disease, extramammary	Enrichment	ERBB2	2.48
39	Osteoglophonic dysplasia	Enrichment	FGFR1	2.48
40	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.48
41	Trigonocephaly 1	Enrichment	FGFR1	2.48
42	Atrophoderma vermiculata	Enrichment	LRP1	2.48
43	Donohue syndrome	Enrichment	INSR	2.48
44	Sea-blue histiocyte disease	Enrichment	APOE	2.48
45	Muenke syndrome	Enrichment	FGFR3	2.48
46	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.48
47	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.48
48	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.48
49	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.48
50	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.48
51	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.48
52	Apert syndrome	Enrichment	FGFR2	2.48
53	Lipoprotein glomerulopathy	Enrichment	APOE	2.48
54	Keratosis pilaris atrophicans	Enrichment	LRP1	2.48
55	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.48
56	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.48
57	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.48
58	Gist-plus syndrome	Enrichment	PDGFRA	2.48
59	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.48
60	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.48
61	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.48
62	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.48
63	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.48
64	Noonan syndrome 13	Enrichment	MAPK1	2.48
65	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.48
66	Parkinson-dementia syndrome	Enrichment	MAPT	2.48
67	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.48
68	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.48
69	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.48
70	Alzheimer disease 18	Enrichment	ADAM10	2.48
71	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.48
72	Progressive supranuclear palsy	Enrichment	MAPT	2.48
73	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.48
74	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.48
75	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.48
76	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.48
77	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.48
78	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.48
79	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.48
80	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.48
81	Acne inversa, familial, 3	Enrichment	PSEN1	2.48
82	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.48
83	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.48
84	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.48
85	Hartsfield syndrome	Enrichment	FGFR1	2.48
86	Thrombocytopenia 6	Enrichment	SRC	2.48
87	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.48
88	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.48
89	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.48
90	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.48
91	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.48
92	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.48
93	Huntington's disease-like	Enrichment	PSEN2	2.48
94	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.48
95	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.48
96	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.48
97	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.48
98	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3	2.38
99	Differentiated thyroid carcinoma	Enrichment	NTRK1, NTRK3	2.38
100	Lung cancer	Enrichment	EGFR, ERBB2	2.30
101	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.18
102	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.18
103	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	2.18
104	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.18
105	Cervical cancer	Enrichment	FGFR3	2.18
106	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.18
107	Aural atresia, congenital	Enrichment	FGFR2	2.18
108	Keratosis, seborrheic	Enrichment	FGFR3	2.18
109	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.18
110	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	2.18
111	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	2.18
112	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.18
113	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.18
114	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.18
115	Infantile myofibromatosis	Enrichment	PDGFRB	2.18
116	Split hand-foot malformation	Enrichment	FGFR2	2.18
117	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.18
118	Congenital mesoblastic nephroma	Enrichment	NTRK3	2.18
119	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.18
120	Cervix carcinoma	Enrichment	FGFR3	2.18
121	Fibrosarcoma	Enrichment	NTRK3	2.18
122	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.18
123	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.18
124	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.18
125	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.18
126	Gastric cancer	Enrichment	ERBB2, FGFR2	2.05
127	Achondroplasia	Enrichment	FGFR3	2.00
128	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.00
129	Larsen syndrome	Enrichment	FGFR3	2.00
130	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	2.00
131	Stuve-wiedemann syndrome 1	Enrichment	LIFR	2.00
132	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.00
133	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.00
134	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.00
135	Primary polycythemia	Enrichment	EPOR	2.00
136	Hamartoma	Enrichment	FGFR3	2.00
137	Testicular germ cell cancer	Enrichment	FGFR3	2.00
138	Spermatocytoma	Enrichment	FGFR3	2.00
139	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.00
140	Stüve-wiedemann syndrome	Enrichment	LIFR	2.00
141	Testicular cancer	Enrichment	FGFR3	2.00
142	Erythrocytosis, familial, 1	Enrichment	EPOR	1.88
143	Dowling-degos disease 1	Enrichment	ADAM10	1.88
144	Macular degeneration, age-related, 1	Enrichment	APOE	1.88
145	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.88
146	Barrett esophagus	Enrichment	ERBB2	1.88
147	Hereditary ataxia	Enrichment	PRKCG	1.88
148	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.88
149	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	1.88
150	Alzheimer disease 2	Enrichment	APOE	1.78
151	Insulin-like growth factor i	Enrichment	IGF1R	1.78
152	Holoprosencephaly	Enrichment	FGFR1	1.78
153	Cowden syndrome 1	Enrichment	EGFR	1.70
154	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.70
155	Split-hand/foot malformation 1	Enrichment	FGFR2	1.70
156	Holoprosencephaly 1	Enrichment	FGFR1	1.70
157	Testicular germ cell tumor	Enrichment	FGFR3	1.70
158	Lipid metabolism disorder	Enrichment	APOE	1.70
159	Nevus, epidermal	Enrichment	FGFR3	1.64
160	Myelofibrosis	Enrichment	SRC	1.64
161	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.64
162	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.64
163	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NTRK1	1.64
164	Alzheimer's disease 1	Enrichment	APP	1.64
165	Glioma susceptibility 1	Enrichment	ERBB2	1.58
166	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	1.58
167	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.53
168	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.53
169	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.49
170	Stroke, ischemic	Enrichment	PRKCH	1.49
171	Primary bone dysplasia	Enrichment	FGFR3	1.49
172	Osteochondrodysplasia	Enrichment	FGFR3	1.44
173	Specific learning disability	Enrichment	MAPK1	1.44
174	Septooptic dysplasia	Enrichment	FGFR1	1.41
175	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.41
176	Lip and oral cavity carcinoma	Enrichment	EGFR	1.41
177	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.37
178	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.34
179	Osteoporosis	Enrichment	SRC	1.34
180	Cleft lip/palate	Enrichment	PDGFRA	1.34
181	Congenital nervous system abnormality	Enrichment	FGFR3, PSEN1	1.32
182	Nervous system disease	Enrichment	FGFR3, PSEN1	1.32
183	Familial hypercholesterolemia	Enrichment	APOE	1.31
184	Microform holoprosencephaly	Enrichment	FGFR1	1.29
185	Lobar holoprosencephaly	Enrichment	FGFR1	1.29
186	Dandy-walker syndrome	Enrichment	PDGFRB	1.26
187	Heart, malformation of	Enrichment	MAPK1	1.24
188	Semilobar holoprosencephaly	Enrichment	FGFR1	1.24
189	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.24
190	Arteriovenous malformations of the brain	Enrichment	EGFR	1.21
191	Microcephaly	Enrichment	IGF1R, MAPK1	1.20
192	Endometrial cancer	Enrichment	FGFR2	1.17
193	Hepatoblastoma	Enrichment	FGFR3	1.17
194	Tooth agenesis	Enrichment	FGFR1	1.15
195	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PDGFRA	1.15
196	Kallmann syndrome	Enrichment	FGFR1	1.13
197	Parkinson disease, late-onset	Enrichment	MAPT	1.12
198	Connective tissue disease	Enrichment	FGFR3	1.00
199	Cakut	Enrichment	LIFR	0.97
200	Cerebral palsy	Enrichment	PDGFRB	0.91
201	Type 2 diabetes mellitus	Enrichment	INSR	0.88
202	West syndrome	Enrichment	NTRK2	0.87
203	Thrombocytopenia	Enrichment	SRC	0.83
204	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4	0.81
205	Hypertelorism	Enrichment	FGFR2	0.80
206	Myeloma, multiple	Enrichment	FGFR3	0.77
207	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	0.77
208	Primary ovarian insufficiency	Enrichment	NTRK1	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Alzheimers Disease Pathway

Pathway Network for Alzheimers Disease Pathway

Member Pathways for Alzheimers Disease Pathway

Pathways in the Alzheimers Disease Pathway SuperPath

Associated Genes for Alzheimers Disease Pathway

Associated Disorders for Alzheimers Disease Pathway

Disorders associated with Alzheimers Disease Pathway SuperPath

STRING Interaction Network for Alzheimers Disease Pathway

Sources for Alzheimers Disease Pathway