amb2 Integrin signaling

No Pathway Network information available for amb2 Integrin signaling

Pathways in the amb2 Integrin signaling SuperPath

#	Name	Source	Genes
1	amb2 Integrin signaling	PubChem	AGER APOB CCN2 HCK HMGB1 ICAM1 IL6 ITGAM ITGB2 JAM2 JAM3 LPA LRP1 MMP2 MMP9 MST1 MST1R MYH2 NFKB1 PLAT PLAU PLAUR PLG RHOA ROCK1 SELP SELPLG THY1 TLN1 TNF (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MYH2	Myosin Heavy Chain 2	Protein Coding	1
2	SELP	Selectin P	Protein Coding	1
3	THY1	Thy-1 Cell Surface Antigen	Protein Coding	1
4	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
5	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	1
6	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
7	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
8	IL6	Interleukin 6	Protein Coding	1
9	MST1	Macrophage Stimulating 1	Protein Coding	1
10	MST1R	Macrophage Stimulating 1 Receptor	Protein Coding	1
11	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
12	SELPLG	Selectin P Ligand	Protein Coding	1
13	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
14	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	1
15	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
16	PLG	Plasminogen	Protein Coding	1
17	JAM2	Junctional Adhesion Molecule 2	Protein Coding	1
18	JAM3	Junctional Adhesion Molecule 3	Protein Coding	1
19	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
20	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
21	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
22	TNF	Tumor Necrosis Factor	Protein Coding	1
23	TLN1	Talin 1	Protein Coding	1
24	RHOA	Ras Homolog Family Member A	Protein Coding	1
25	LPA	Lipoprotein(A)	Protein Coding	1
26	APOB	Apolipoprotein B	Protein Coding	1
27	LRP1	LDL Receptor Related Protein 1	Protein Coding	1
28	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
29	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
30	HMGB1	High Mobility Group Box 1	Protein Coding	1

Disorders associated with amb2 Integrin signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cerebral malaria	Enrichment	ICAM1, TNF	4.55
2	Malaria	Enrichment	ICAM1, TNF	2.93
3	Atrophoderma vermiculata	Enrichment	LRP1	2.66
4	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.66
5	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.66
6	Keratosis pilaris atrophicans	Enrichment	LRP1	2.66
7	Angioedema, hereditary, 4	Enrichment	PLG	2.66
8	Basal ganglia calcification, idiopathic, 8, autosomal recessive	Enrichment	JAM2	2.66
9	Lipoprotein quantitative trait locus	Enrichment	LPA	2.66
10	Nasopharyngeal carcinoma 3	Enrichment	MST1R	2.66
11	Hemorrhagic destruction of the brain, subependymal calcification, and cataracts	Enrichment	JAM3	2.66
12	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.66
13	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.66
14	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.66
15	Capillary leak syndrome	Enrichment	TLN1	2.66
16	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.66
17	Porencephaly-microcephaly-bilateral congenital cataract syndrome	Enrichment	JAM3	2.66
18	Systemic lupus erythematosus	Enrichment	ITGAM, TNF	2.48
19	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.35
20	Plasminogen deficiency, type i	Enrichment	PLG	2.35
21	Kyphomelic dysplasia	Enrichment	CCN2	2.35
22	Quebec platelet disorder	Enrichment	PLAU	2.35
23	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.35
24	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.35
25	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.35
26	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.35
27	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.35
28	Immunodeficiency 127	Enrichment	TNF	2.35
29	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.35
30	Hereditary angioedema	Enrichment	PLG	2.35
31	Hereditary inclusion body myopathy-joint contractures-ophthalmoplegia syndrome	Enrichment	MYH2	2.35
32	Hypobetalipoproteinemia	Enrichment	APOB	2.35
33	Metaphyseal anadysplasia	Enrichment	MMP9	2.35
34	Childhood-onset autosomal recessive myopathy with external ophthalmoplegia	Enrichment	MYH2	2.35
35	Common variable immunodeficiency 12	Enrichment	NFKB1	2.35
36	Hypercholesterolemia, familial, 2	Enrichment	APOB	2.18
37	Angioedema, hereditary, 1	Enrichment	PLG	2.18
38	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.18
39	Psoriatic arthritis	Enrichment	TNF	2.18
40	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.18
41	Migraine without aura	Enrichment	TNF	2.18
42	Kaposi sarcoma	Enrichment	IL6	2.05
43	Congenital myopathy 6 with ophthalmoplegia	Enrichment	MYH2	2.05
44	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.05
45	Alzheimer disease 2	Enrichment	PLAU	1.96
46	Hyperlipidemia, familial combined, 3	Enrichment	APOB	1.96
47	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.96
48	Cholangitis, primary sclerosing	Enrichment	MST1	1.96
49	Vascular dementia	Enrichment	TNF	1.96
50	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.96
51	Hemihyperplasia, isolated	Enrichment	RHOA	1.88
52	Type 1 diabetes mellitus	Enrichment	IL6	1.88
53	Limited scleroderma	Enrichment	CCN2	1.88
54	Common variable immunodeficiency	Enrichment	NFKB1	1.81
55	Basal ganglia calcification, idiopathic, 1	Enrichment	JAM2	1.76
56	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.76
57	Inflammatory bowel disease 1	Enrichment	IL6	1.70
58	Coronary heart disease 5	Enrichment	APOB	1.70
59	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.66
60	Asthma	Enrichment	TNF	1.62
61	Hypercholesterolemia, familial, 1	Enrichment	APOB	1.55
62	Alzheimer's disease	Enrichment	TNF	1.55
63	Familial hypercholesterolemia	Enrichment	APOB	1.49
64	Alzheimer disease, familial, 1	Enrichment	PLAU	1.43
65	Arteriovenous malformations of the brain	Enrichment	IL6	1.38
66	Cystic fibrosis	Enrichment	PLG	1.16
67	Myopathy	Enrichment	MYH2	1.07
68	Type 2 diabetes mellitus	Enrichment	IL6	1.05
69	Myeloma, multiple	Enrichment	MST1R	0.93

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

amb2 Integrin signaling

Pathway Network for amb2 Integrin signaling

Member Pathways for amb2 Integrin signaling

Pathways in the amb2 Integrin signaling SuperPath

Associated Genes for amb2 Integrin signaling

Associated Disorders for amb2 Integrin signaling

Disorders associated with amb2 Integrin signaling SuperPath

STRING Interaction Network for amb2 Integrin signaling

Sources for amb2 Integrin signaling