Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

No Pathway Network information available for Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

Pathways in the Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction SuperPath

#	Name	Source	Genes
1	Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction	PharmGKB	ARCN1 CDH23 CIB2 COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 COPZ2 LHFPL5 LRTOMT MT-RNR1 PCDH15 TMC1 TMC2 TMIE (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDH23	Cadherin Related 23	Protein Coding	1
2	PCDH15	Protocadherin Related 15	Protein Coding	1
3	COPB2	Coat Protein Complex I Subunit Beta 2	Protein Coding	1
4	ARCN1	Archain 1 Coat Protein Complex I Subunit Delta	Protein Coding	1
5	COPZ1	Coat Protein Complex I Subunit Zeta 1	Protein Coding	1
6	COPG1	Coat Protein Complex I Subunit Gamma 1	Protein Coding	1
7	COPA	Coat Protein Complex I Subunit Alpha	Protein Coding	1
8	COPB1	Coat Protein Complex I Subunit Beta 1	Protein Coding	1
9	TMC1	Transmembrane Channel Like 1	Protein Coding	1
10	TMC2	Transmembrane Channel Like 2	Protein Coding	1
11	COPG2	Coat Protein Complex I Subunit Gamma 2	Protein Coding	1
12	COPE	Coat Protein Complex I Subunit Epsilon	Protein Coding	1
13	LHFPL5	LHFPL Tetraspan Subfamily Member 5	Protein Coding	1
14	COPZ2	Coat Protein Complex I Subunit Zeta 2	Protein Coding	1
15	CIB2	Calcium And Integrin Binding Family Member 2	Protein Coding	1
16	TMIE	Transmembrane Inner Ear	Protein Coding	1
17	MT-RNR1	Mitochondrially Encoded 12S RRNA	RNA Gene	1
18	LRTOMT	Leucine Rich Transmembrane And O-Methyltransferase Domain Containing	Protein Coding	1

Disorders associated with Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CDH23, CIB2, LHFPL5, LRTOMT, PCDH15, TMC1, TMIE	10.71
2	Deafness, autosomal recessive	Enrichment	CDH23, CIB2, LHFPL5, PCDH15, TMC1, TMIE	9.83
3	Autosomal recessive nonsyndromic deafness	Enrichment	CDH23, CIB2, LHFPL5, PCDH15, TMC1, TMIE	9.82
4	Rare genetic deafness	Enrichment	CDH23, CIB2, LRTOMT, MT-RNR1, PCDH15, TMC1	9.25
5	Ear malformation	Enrichment	CDH23, LHFPL5, PCDH15, TMC1	7.64
6	Usher syndrome, type i	Enrichment	CDH23, CIB2, PCDH15	6.05
7	Nonsyndromic hearing loss	Enrichment	CDH23, PCDH15, TMC1	4.66
8	Usher syndrome, type id	Enrichment	CDH23, PCDH15	4.60
9	Sensorineural hearing loss	Enrichment	CDH23, TMC1, TMIE	4.49
10	Usher syndrome	Enrichment	CDH23, PCDH15	3.07
11	Non-syndromic genetic deafness	Enrichment	CDH23, TMC1	2.99
12	Deafness, autosomal recessive 67	Enrichment	LHFPL5	2.88
13	Deafness, autosomal recessive 6	Enrichment	TMIE	2.88
14	Osteoporosis, childhood- or juvenile-onset, with developmental delay	Enrichment	COPB2	2.88
15	Microcephaly 19, primary, autosomal recessive	Enrichment	COPB2	2.88
16	Usher syndrome, type ij	Enrichment	CIB2	2.88
17	Short stature-micrognathia syndrome	Enrichment	ARCN1	2.88
18	Autoinflammation and autoimmunity, systemic, with immune dysregulation	Enrichment	COPA	2.88
19	Baralle-macken syndrome	Enrichment	COPB1	2.88
20	Tsh producing pituitary tumor	Enrichment	CDH23	2.88
21	Immunodeficiency 128	Enrichment	COPG1	2.88
22	Deafness, sensorineural, autosomal-mitochondrial type	Enrichment	MT-RNR1	2.58
23	Usher syndrome, type if	Enrichment	PCDH15	2.58
24	Deafness, autosomal dominant 36	Enrichment	TMC1	2.58
25	Deafness, autosomal recessive 48	Enrichment	CIB2	2.58
26	Deafness, autosomal recessive 23	Enrichment	PCDH15	2.58
27	Deafness, autosomal recessive 84a	Enrichment	CDH23	2.58
28	Deafness, autosomal recessive 7	Enrichment	TMC1	2.58
29	Combined saposin deficiency	Enrichment	CDH23	2.58
30	Combined psap deficiency	Enrichment	CDH23	2.58
31	Familial isolated pituitary adenoma	Enrichment	CDH23	2.58
32	Pituitary adenoma 5, multiple types	Enrichment	CDH23	2.28
33	Prolactinoma	Enrichment	CDH23	2.28
34	Hereditary retinal dystrophy	Enrichment	CDH23, CIB2, PCDH15	2.21
35	Fundus dystrophy	Enrichment	CDH23, CIB2, PCDH15	2.21
36	Deafness, autosomal recessive 63	Enrichment	LRTOMT	2.18
37	Deafness, nonsyndromic sensorineural, mitochondrial	Enrichment	MT-RNR1	2.10
38	Deafness, autosomal recessive 12	Enrichment	CDH23	2.10
39	Autosomal recessive intellectual developmental disorder	Enrichment	LHFPL5	2.10
40	Syndromic rod-cone dystrophy	Enrichment	CDH23	2.10
41	Meniere disease	Enrichment	CDH23	2.03
42	Usher syndrome, type iia	Enrichment	CDH23	2.03
43	Primary hyperaldosteronism	Enrichment	CDH23	1.93
44	Rare mitochondrial non-syndromic sensorineural deafness	Enrichment	MT-RNR1	1.88
45	Primary bone dysplasia	Enrichment	COPB1	1.88
46	Immune deficiency disease	Enrichment	COPB1	1.84
47	Usher syndrome type 2	Enrichment	CDH23	1.84
48	Osteochondrodysplasia	Enrichment	COPB1	1.84
49	Myoclonic epilepsy associated with ragged-red fibers	Enrichment	MT-RNR1	1.80
50	Restrictive cardiomyopathy	Enrichment	MT-RNR1	1.80
51	Cone-rod dystrophy 6	Enrichment	PCDH15	1.73
52	Cataract	Enrichment	COPB1	1.73
53	Retinitis pigmentosa	Enrichment	CDH23, PCDH15	1.50
54	Auditory neuropathy	Enrichment	MT-RNR1	1.47
55	Primary autosomal recessive microcephaly	Enrichment	COPB2	1.38
56	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-RNR1	1.32
57	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-RNR1	1.31
58	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TMC1	1.17
59	Autosomal recessive non-syndromic intellectual disability	Enrichment	LHFPL5	1.13
60	Schizophrenia	Enrichment	PCDH15	1.12
61	Leigh syndrome, nuclear	Enrichment	MT-RNR1	1.06
62	Autism	Enrichment	PCDH15	1.04
63	Leigh disease	Enrichment	MT-RNR1	1.02
64	Mitochondrial disease	Enrichment	MT-RNR1	0.96
65	Leber plus disease	Enrichment	MT-RNR1	0.92
66	Microcephaly	Enrichment	COPB1	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

Pathway Network for Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

Member Pathways for Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

Pathways in the Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction SuperPath

Associated Genes for Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

Associated Disorders for Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

Disorders associated with Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction SuperPath

STRING Interaction Network for Aminoglycoside Ototoxicity Pathway, Adverse Drug Reaction

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