AMP-activated protein kinase signaling

Pathway network for the AMP-activated protein kinase signaling SuperPath

Sources:

WikiPathways
Sino Biological

Pathways in the AMP-activated protein kinase signaling SuperPath

#	Name	Source	Genes
1	AMP-activated protein kinase signaling	WikiPathways	ACACA ACACB ADIPOQ ADIPOR1 ADIPOR2 ADRA1A ADRA1B AKT1 AKT2 CAB39 CAMKK1 CAMKK2 CCNA1 CCNA2 CCNB1 CDKN1A CPT1A CPT1B CPT1C CRTC2 EEF2 EEF2K EIF4EBP1 ELAVL1 FASN GYS1 GYS2 HMGCR HNF4A INS-IGF2 INSR LEP LEPR LIPE LOC105372522 MTOR PFKFB3 PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PPARGC1B PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 RPS6KB1 RPS6KB2 RPTOR SLC2A4 SLC2A4RG SREBF1 STK11 STRADA STRADB TP53 TSC1 TSC2 (see all 67) (see less)
2	AMPK Signaling Pathway	Sino Biological	ADIPOQ AKT1 AKT1S1 AKT2 AKT3 AKTIP ATIC CAB39L CAMKK1 CCNA1 CCNA2 CCNB1 CDKN1A CPT1A CPT1B CREB1 CREB3 CREB3L1 CREB3L2 CREB3L4 CRTC2 EEF2 EEF2K EIF4EBP1 ELF4 FAS GSK3B HDAC4 HNF4A HRAS INS INSR LEP MAPK1 MAPT MTOR PFKFB3 PIK3CA PIK3CB PIK3R1 PIK3R2 PNPLA2 PPARGC1A PPP1R12A PPP2CA PPP2CB PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKAG1 PRKAG2 PRKAG3 PTK2 RAF1 RHEB RHEBL1 RPS6 RPS6KA1 RPS6KB1 RPS6KB2 RPTOR SESN1 SESN2 SIRT1 STK11 TP53 (see all 68) (see less)
3	Leptin and adiponectin	WikiPathways	ACACA ADIPOQ ADIPOR1 ADIPOR2 CPT1A LEP LEPR PRKAA1 PRKAB1 PRKAG1 (see all 10) (see less)

Gene overlap in member pathways for AMP-activated protein kinase signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	3
2	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	3
3	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	3
4	LEP	Leptin	Protein Coding	3
5	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	3
6	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	3
7	CCNB1	Cyclin B1	Protein Coding	2
8	CCNA1	Cyclin A1	Protein Coding	2
9	CCNA2	Cyclin A2	Protein Coding	2
10	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	2
11	ADIPOR2	Adiponectin Receptor 2	Protein Coding	2
12	TP53	Tumor Protein P53	Protein Coding	2
13	STK11	Serine/Threonine Kinase 11	Protein Coding	2
14	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	2
15	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	2
16	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	2
17	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	2
18	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	2
19	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
20	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
21	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
22	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
23	PFKFB3	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3	Protein Coding	2
24	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	2
25	ADIPOR1	Adiponectin Receptor 1	Protein Coding	2
26	LEPR	Leptin Receptor	Protein Coding	2
27	INSR	Insulin Receptor	Protein Coding	2
28	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	2
29	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	2
30	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
31	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
32	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
33	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	2
34	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	2
35	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	2
36	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
37	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	2
38	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	2
39	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	2
40	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
41	STRADA	STE20 Related Adaptor Alpha	Protein Coding	1
42	TSC2	TSC Complex Subunit 2	Protein Coding	1
43	TSC1	TSC Complex Subunit 1	Protein Coding	1
44	INS-IGF2	INS-IGF2 Readthrough	Protein Coding	1
45	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
46	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
47	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
48	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
49	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
50	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
51	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	1
52	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	1
53	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
54	GYS2	Glycogen Synthase 2	Protein Coding	1
55	GYS1	Glycogen Synthase 1	Protein Coding	1
56	FASN	Fatty Acid Synthase	Protein Coding	1
57	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	1
58	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	1
59	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	1
60	PPARGC1B	PPARG Coactivator 1 Beta	Protein Coding	1
61	CPT1C	Carnitine Palmitoyltransferase 1C	Protein Coding	1
62	CAMKK2	Calcium/Calmodulin Dependent Protein Kinase Kinase 2	Protein Coding	1
63	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
64	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
65	SLC2A4RG	SLC2A4 Regulator	Protein Coding	1
66	STRADB	STE20 Related Adaptor Beta	Protein Coding	1
67	CAB39	Calcium Binding Protein 39	Protein Coding	1
68	AKT1S1	AKT1 Substrate 1	Protein Coding	1
69	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
70	AKTIP	AKT Interacting Protein	Protein Coding	1
71	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	1
72	CAB39L	Calcium Binding Protein 39 Like	Protein Coding	1
73	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
74	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
75	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
76	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	1
77	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
78	ELF4	E74 Like ETS Transcription Factor 4	Protein Coding	1
79	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
80	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
81	HDAC4	Histone Deacetylase 4	Protein Coding	1
82	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
83	INS	Insulin	Protein Coding	1
84	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
85	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
86	PNPLA2	Patatin Like Domain 2, Triacylglycerol Lipase	Protein Coding	1
87	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
88	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
89	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
90	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
91	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
92	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
93	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
94	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
95	RHEBL1	RHEB Like 1	Protein Coding	1
96	RPS6	Ribosomal Protein S6	Protein Coding	1
97	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
98	SESN1	Sestrin 1	Protein Coding	1
99	SESN2	Sestrin 2	Protein Coding	1
100	SIRT1	Sirtuin 1	Protein Coding	1

Disorders associated with AMP-activated protein kinase signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, RHEB	8.54
2	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TP53, TSC1, TSC2	7.17
3	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA, STK11, TP53	6.56
4	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	6.34
5	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	6.34
6	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.32
7	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA, TP53	5.64
8	Leptin deficiency or dysfunction	Enrichment	LEP, LEPR	5.53
9	Bladder cancer	Enrichment	CDKN1A, PIK3CA, TP53, TSC1	4.93
10	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.62
11	Type 2 diabetes mellitus	Enrichment	AKT2, HNF4A, INSR, SLC2A4	4.28
12	Colorectal cancer	Enrichment	AKT1, INS-IGF2, PIK3CA, PIK3R1, TP53	4.17
13	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.14
14	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.14
15	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.14
16	Hamartoma	Enrichment	TSC1, TSC2	4.14
17	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.14
18	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	4.13
19	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.84
20	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.83
21	Gallbladder cancer	Enrichment	PIK3CA, TP53	3.30
22	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.30
23	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.29
24	Noonan syndrome 3	Enrichment	HRAS, RAF1	3.29
25	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.17
26	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	3.13
27	Leptin receptor deficiency	Enrichment	LEPR	3.13
28	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.07
29	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.06
30	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.98
31	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.96
32	Gastric cancer	Enrichment	PIK3CA, STK11, TP53	2.91
33	Glycogen storage disease	Enrichment	GYS1, GYS2	2.89
34	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, TP53	2.88
35	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	2.88
36	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.83
37	Meningioma	Enrichment	AKT1, PIK3CA	2.81
38	Ovarian cancer	Enrichment	AKT1, PIK3CA, TP53, TSC2	2.81
39	Adiponectin deficiency	Enrichment	ADIPOQ	2.66
40	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, RAF1	2.60
41	Myeloma, multiple	Enrichment	HDAC4, PIK3R2, TP53	2.56
42	Rhabdomyosarcoma	Enrichment	HRAS, TP53	2.55
43	Inherited cancer-predisposing syndrome	Enrichment	STK11, TP53, TSC1, TSC2	2.39
44	Maturity-onset diabetes of the young	Enrichment	HNF4A, INS	2.35
45	Macrodactyly	Enrichment	PIK3CA	2.31
46	Proteus syndrome	Enrichment	AKT1	2.31
47	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.31
48	Donohue syndrome	Enrichment	INSR	2.31
49	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.31
50	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.31
51	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.31
52	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.31
53	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.31
54	Cowden syndrome 5	Enrichment	PIK3CA	2.31
55	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.31
56	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.31
57	Short syndrome	Enrichment	PIK3R1	2.31
58	Bone marrow failure syndrome 5	Enrichment	TP53	2.31
59	Papilloma of choroid plexus	Enrichment	TP53	2.31
60	Basal cell carcinoma 7	Enrichment	TP53	2.31
61	Anaplastic thyroid carcinoma	Enrichment	TP53	2.31
62	Ifap syndrome 2	Enrichment	SREBF1	2.31
63	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.31
64	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.31
65	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.31
66	Spinocerebellar ataxia 26	Enrichment	EEF2	2.31
67	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.31
68	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.31
69	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.31
70	Cowden syndrome 6	Enrichment	AKT1	2.31
71	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.31
72	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.31
73	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.31
74	Ductal carcinoma in situ	Enrichment	TP53	2.31
75	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.31
76	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.31
77	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.31
78	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.31
79	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.31
80	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.31
81	Hypospadias	Enrichment	PIK3CA	2.31
82	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.31
83	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.31
84	Choroid plexus cancer	Enrichment	TP53	2.31
85	Rare venous malformation	Enrichment	PIK3CA	2.31
86	Diaphragmatic eventration	Enrichment	PIK3CA	2.31
87	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.31
88	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.31
89	Rare combined vascular malformation	Enrichment	PIK3CA	2.31
90	Cavernous lymphangioma	Enrichment	PIK3CA	2.31
91	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.31
92	Intestinal polyposis syndrome	Enrichment	STK11	2.31
93	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.31
94	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.31
95	Macrodactyly of toe	Enrichment	PIK3CA	2.31
96	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.31
97	Autoinflammatory syndrome, familial, x-linked, behcet-like 2	Enrichment	ELF4	2.30
98	Aica-ribosiduria due to atic deficiency	Enrichment	ATIC	2.30
99	Noonan syndrome 5	Enrichment	RAF1	2.30
100	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.30
101	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	2.30
102	Noonan syndrome 13	Enrichment	MAPK1	2.30
103	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.30
104	Parkinson-dementia syndrome	Enrichment	MAPT	2.30
105	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.30
106	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.30
107	Progressive supranuclear palsy	Enrichment	MAPT	2.30
108	Leopard syndrome 2	Enrichment	RAF1	2.30
109	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.30
110	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.30
111	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.30
112	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.30
113	Trigonitis	Enrichment	RAF1	2.30
114	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.30
115	Capillary hemangioma	Enrichment	AKT3	2.30
116	Primary triglyceride deposit cardiomyovasculopathy	Enrichment	PNPLA2	2.30
117	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.30
118	Hepatocellular carcinoma	Enrichment	PIK3CA, TP53	2.28
119	Noonan syndrome 1	Enrichment	HRAS, RAF1	2.23
120	Breast cancer	Enrichment	AKT1, PIK3CA, TP53	2.22
121	Pancreatic cancer	Enrichment	STK11, TP53	2.17
122	Rasopathy	Enrichment	HRAS, RAF1	2.13
123	Prostate cancer	Enrichment	PIK3CA, TP53	2.05
124	Peutz-jeghers syndrome	Enrichment	STK11	2.01
125	Maturity-onset diabetes of the young, type 1	Enrichment	HNF4A	2.01
126	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.01
127	Glycogen storage disease 0, liver	Enrichment	GYS2	2.01
128	Cervical cancer	Enrichment	TP53	2.01
129	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.01
130	Keratosis, seborrheic	Enrichment	PIK3CA	2.01
131	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.01
132	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.01
133	Silver-russell syndrome 3	Enrichment	INS-IGF2	2.01
134	Maturity-onset diabetes of the young, type 10	Enrichment	INS-IGF2	2.01
135	Noonan syndrome 8	Enrichment	PIK3CA	2.01
136	Lymphoma, hodgkin, classic	Enrichment	TP53	2.01
137	Hyperproinsulinemia	Enrichment	INS-IGF2	2.01
138	Spastic paraplegia 73, autosomal dominant	Enrichment	CPT1C	2.01
139	Cebalid syndrome	Enrichment	MTOR	2.01
140	Polyhydramnios, megalencephaly, and symptomatic epilepsy	Enrichment	STRADA	2.01
141	Glycogen storage disease 0, muscle	Enrichment	GYS1	2.01
142	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.01
143	Congenital fibrosarcoma	Enrichment	TP53	2.01
144	Li-fraumeni syndrome 1	Enrichment	TP53	2.01
145	Sarcoma	Enrichment	TP53	2.01
146	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS-IGF2	2.01
147	Cervix carcinoma	Enrichment	TP53	2.01
148	Immune system disease	Enrichment	PIK3CD	2.01
149	Hodgkin's lymphoma	Enrichment	TP53	2.01
150	Smith-kingsmore syndrome	Enrichment	MTOR	2.01
151	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	2.01
152	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	2.01
153	Hyperinsulinism	Enrichment	HNF4A	2.01
154	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF4A	2.01
155	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.01
156	Costello syndrome	Enrichment	HRAS	2.00
157	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	ELF4	2.00
158	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.00
159	Neutral lipid storage disease with myopathy	Enrichment	PNPLA2	2.00
160	Pick disease of brain	Enrichment	MAPT	2.00
161	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.00
162	Senior-loken syndrome 7	Enrichment	AKT3	2.00
163	Fibrolamellar carcinoma	Enrichment	PRKACA	2.00
164	Bardet-biedl syndrome 16	Enrichment	AKT3	2.00
165	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.00
166	Wooly hair nevus	Enrichment	HRAS	2.00
167	Lung cancer	Enrichment	FAS, PIK3CA	1.95
168	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2, RAF1	1.93
169	Type 1 diabetes mellitus 2	Enrichment	INS-IGF2	1.83
170	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.83
171	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	1.83
172	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.83
173	Osteogenic sarcoma	Enrichment	TP53	1.83
174	Nasopharyngeal carcinoma	Enrichment	TP53	1.83
175	Tuberous sclerosis 2	Enrichment	TSC2	1.83
176	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	1.83
177	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.83
178	Testicular germ cell cancer	Enrichment	STK11	1.83
179	Anaplastic astrocytoma	Enrichment	TP53	1.83
180	Xanthinuria, type ii	Enrichment	TSC2	1.83
181	Squamous cell carcinoma	Enrichment	TP53	1.83
182	Adenocarcinoma	Enrichment	TP53	1.83
183	Bone osteosarcoma	Enrichment	TP53	1.83
184	Testicular cancer	Enrichment	STK11	1.83
185	Keratoacanthoma	Enrichment	PIK3CA	1.83
186	Apc-associated polyposis conditions	Enrichment	STK11	1.83
187	Glomerulopathy with fibronectin deposits 2	Enrichment	ATIC	1.82
188	Large congenital melanocytic nevus	Enrichment	HRAS	1.82
189	Spermatocytoma	Enrichment	HRAS	1.82
190	Melanoma of soft tissue	Enrichment	CREB1	1.82
191	Vogt-koyanagi-harada disease	Enrichment	FAS	1.82
192	Small cell cancer of the lung	Enrichment	TP53	1.71
193	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.71
194	Maturity-onset diabetes of the young, type 3	Enrichment	HNF4A	1.71
195	Neonatal diabetes mellitus	Enrichment	INS-IGF2	1.71
196	Lung sarcomatoid carcinoma	Enrichment	TP53	1.71
197	Cerebrovascular disease	Enrichment	PIK3CA	1.71
198	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.71
199	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.71
200	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.70
201	Autoimmune lymphoproliferative syndrome	Enrichment	FAS	1.70
202	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.70
203	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.70
204	Epidermolytic nevus	Enrichment	HRAS	1.70
205	Capillary malformations, congenital	Enrichment	PIK3CA	1.61
206	Rhabdomyosarcoma 2	Enrichment	TP53	1.61
207	Familial adenomatous polyposis 1	Enrichment	STK11	1.61
208	Lymphoma	Enrichment	TP53	1.61
209	Acute megakaryocytic leukemia	Enrichment	TP53	1.61
210	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.61
211	Dementia	Enrichment	MAPT	1.61
212	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.53
213	Li-fraumeni syndrome	Enrichment	TP53	1.53
214	Cowden syndrome 1	Enrichment	PIK3CA	1.53
215	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.53
216	Testicular germ cell tumor	Enrichment	STK11	1.53
217	Keratoconus	Enrichment	TSC1	1.53
218	Adrenocortical carcinoma	Enrichment	TP53	1.53
219	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.53
220	46,xy disorder of sex development	Enrichment	INSR	1.53
221	Type 1 diabetes mellitus	Enrichment	INS	1.53
222	Esophageal cancer	Enrichment	TP53	1.47
223	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.47
224	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.47
225	Silver-russell syndrome 1	Enrichment	INS-IGF2	1.47
226	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.47
227	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.47
228	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.47
229	Polycystic kidney disease 1	Enrichment	TSC2	1.47
230	Essential thrombocythemia	Enrichment	TP53	1.47
231	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.47
232	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT, PPARGC1A	1.47
233	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.46
234	Semantic dementia	Enrichment	MAPT	1.46
235	Pilomyxoid astrocytoma	Enrichment	RAF1	1.46
236	Megacolon	Enrichment	AKT3	1.46
237	Follicular thyroid carcinoma	Enrichment	HRAS	1.46
238	Body mass index quantitative trait locus 11	Enrichment	LEPR	1.44
239	Glioma susceptibility 1	Enrichment	TP53	1.41
240	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.41
241	Permanent neonatal diabetes mellitus	Enrichment	INS-IGF2	1.41
242	Ellis-van creveld syndrome	Enrichment	PRKACB	1.36
243	Primary hyperaldosteronism	Enrichment	TP53	1.36
244	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.36
245	Progressive non-fluent aphasia	Enrichment	MAPT	1.35
246	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.35
247	Leukemia, chronic lymphocytic	Enrichment	TP53	1.32
248	Melanoma	Enrichment	STK11	1.32
249	Familial colorectal cancer	Enrichment	TP53	1.32
250	Polymicrogyria	Enrichment	AKT3	1.31
251	Myelodysplastic syndrome	Enrichment	TP53	1.28
252	Diabetes mellitus	Enrichment	INS-IGF2	1.28
253	Frontotemporal dementia 1	Enrichment	MAPT	1.27
254	Specific learning disability	Enrichment	MAPK1	1.27
255	Nk-cell enteropathy	Enrichment	PIK3CB	1.21
256	Alzheimer's disease	Enrichment	MAPT	1.20
257	Lung cancer susceptibility 3	Enrichment	TP53	1.17
258	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.14
259	Wilms tumor 1	Enrichment	INS-IGF2	1.14
260	Lynch syndrome	Enrichment	PIK3CA	1.14
261	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.14
262	Kidney disease	Enrichment	TSC1	1.14
263	Rare genetic intellectual disability	Enrichment	MTOR	1.14
264	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	1.14
265	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.12
266	Gliosarcoma	Enrichment	TP53	1.12
267	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.09
268	Polycystic liver disease	Enrichment	HNF4A	1.09
269	Giant cell glioblastoma	Enrichment	TP53	1.09
270	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	1.09
271	Alzheimer disease, familial, 1	Enrichment	MAPT	1.09
272	Beckwith-wiedemann syndrome	Enrichment	INS-IGF2	1.07
273	Heart, malformation of	Enrichment	MAPK1	1.06
274	Diffuse large b-cell lymphoma	Enrichment	TP53	1.05
275	Behcet syndrome	Enrichment	FAS	1.04
276	Endometrial cancer	Enrichment	PIK3CA	1.01
277	Hepatoblastoma	Enrichment	TP53	1.01
278	Diamond-blackfan anemia 1	Enrichment	TP53	0.97
279	Brittle bone disorder	Enrichment	CREB3L1	0.96
280	Parkinson disease, late-onset	Enrichment	MAPT	0.94
281	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.94
282	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.91
283	Hirschsprung disease 1	Enrichment	SREBF1	0.87
284	Differentiated thyroid carcinoma	Enrichment	HRAS	0.87
285	Non-immune hydrops fetalis	Enrichment	HRAS	0.84
286	Left ventricular noncompaction	Enrichment	RAF1	0.79
287	Diamond-blackfan anemia	Enrichment	TP53	0.79
288	Leukemia, acute myeloid	Enrichment	TP53	0.74
289	Benign epilepsy with centrotemporal spikes	Enrichment	STRADA	0.74
290	Centralopathic epilepsy	Enrichment	STRADA	0.72
291	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.72
292	Nephrotic syndrome	Enrichment	ATIC	0.71
293	West syndrome	Enrichment	TSC2	0.71
294	Hypertelorism	Enrichment	PIK3CA	0.64
295	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.63
296	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.62
297	Dilated cardiomyopathy	Enrichment	RAF1	0.48
298	Congenital nervous system abnormality	Enrichment	TSC2	0.39
299	Nervous system disease	Enrichment	TSC2	0.39
300	Autism spectrum disorder	Enrichment	TSC2	0.38
301	Microcephaly	Enrichment	MAPK1	0.33
302	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.33

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

AMP-activated protein kinase signaling

Pathway Network for AMP-activated protein kinase signaling

Pathway network for the AMP-activated protein kinase signaling SuperPath

Member Pathways for AMP-activated protein kinase signaling

Pathways in the AMP-activated protein kinase signaling SuperPath

Gene overlap in member pathways for AMP-activated protein kinase signaling SuperPath

Associated Genes for AMP-activated protein kinase signaling

Associated Disorders for AMP-activated protein kinase signaling

Disorders associated with AMP-activated protein kinase signaling SuperPath

STRING Interaction Network for AMP-activated protein kinase signaling

Sources for AMP-activated protein kinase signaling