AMPK Enzyme Complex Pathway

No Pathway Network information available for AMPK Enzyme Complex Pathway

Pathways in the AMPK Enzyme Complex Pathway SuperPath

#	Name	Source	Genes
1	AMPK Enzyme Complex Pathway	QIAGEN	ACACA ACACB ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C AK1 AK2 AK5 AK7 AKT1 AKT2 AKT3 ARID1A CAB39 CFTR CHRNA1 CHRNB1 CKM COX10 COX11 COX15 COX17 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX7A1 COX7A2 COX7B COX7B2 COX7C COX8A COX8C CPT1A CPT1B CPT1C CPT2 CRAT EIF4EBP1 FASN GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GYS1 GYS2 HELLS HLTF HMGCR INS INSR IRS1 IRS2 KAT2B LEP LIPE MAP2K3 MAPK14 MLYCD MTOR NOS2 NOS3 PDPK1 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PPAT PPM1A PPM1B PPM1G PPM1L PPP2CA PPP2CB PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B RPS6KB1 RPTOR SLC2A1 SLC2A4 SMARCA1 SMARCA2 SMARCA4 SMARCA5 SMARCAD1 SMARCAL1 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SRC STK11 STRADA TFR2 TFRC TSC1 TSC2 (see all 153) (see less)
2	Chromatin Remodeling	QIAGEN	HELLS HLTF SMARCA1 SMARCA2 SMARCA4 SMARCA5 SMARCAD1 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HELLS	Helicase, Lymphoid Specific	Protein Coding	2
2	SMARCA1	SNF2 Related Chromatin Remodeling ATPase 1	Protein Coding	2
3	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	2
4	HLTF	Helicase Like Transcription Factor	Protein Coding	2
5	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	2
6	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	2
7	SMARCAD1	SNF2 Related Chromatin Remodeling ATPase With DExD Box 1	Protein Coding	2
8	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	2
9	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	2
10	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	2
11	SMARCD1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D1	Protein Coding	2
12	SMARCD2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D2	Protein Coding	2
13	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	2
14	SMARCE1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit E1	Protein Coding	2
15	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	1
16	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	1
17	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	1
18	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	1
19	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	1
20	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
21	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	1
22	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	1
23	AK1	Adenylate Kinase 1	Protein Coding	1
24	AK2	Adenylate Kinase 2	Protein Coding	1
25	AK5	Adenylate Kinase 5	Protein Coding	1
26	AK7	Adenylate Kinase 7	Protein Coding	1
27	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
28	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
29	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
30	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	1
31	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
32	CHRNA1	Cholinergic Receptor Nicotinic Alpha 1 Subunit	Protein Coding	1
33	CHRNB1	Cholinergic Receptor Nicotinic Beta 1 Subunit	Protein Coding	1
34	CKM	Creatine Kinase, M-Type	Protein Coding	1
35	COX10	Cytochrome C Oxidase Assembly Factor Heme A:Farnesyltransferase COX10	Protein Coding	1
36	COX11	Cytochrome C Oxidase Copper Chaperone COX11	Protein Coding	1
37	COX15	Cytochrome C Oxidase Assembly Factor COX15	Protein Coding	1
38	COX17	Cytochrome C Oxidase Copper Chaperone COX17	Protein Coding	1
39	COX4I1	Cytochrome C Oxidase Subunit 4I1	Protein Coding	1
40	COX4I2	Cytochrome C Oxidase Subunit 4I2	Protein Coding	1
41	COX5A	Cytochrome C Oxidase Subunit 5A	Protein Coding	1
42	COX5B	Cytochrome C Oxidase Subunit 5B	Protein Coding	1
43	COX6A1	Cytochrome C Oxidase Subunit 6A1	Protein Coding	1
44	COX6A2	Cytochrome C Oxidase Subunit 6A2	Protein Coding	1
45	COX6B1	Cytochrome C Oxidase Subunit 6B1	Protein Coding	1
46	COX6C	Cytochrome C Oxidase Subunit 6C	Protein Coding	1
47	COX7A1	Cytochrome C Oxidase Subunit 7A1	Protein Coding	1
48	COX7A2	Cytochrome C Oxidase Subunit 7A2	Protein Coding	1
49	COX7B	Cytochrome C Oxidase Subunit 7B	Protein Coding	1
50	COX7B2	Cytochrome C Oxidase Subunit 7B2	Protein Coding	1
51	COX7C	Cytochrome C Oxidase Subunit 7C	Protein Coding	1
52	COX8A	Cytochrome C Oxidase Subunit 8A	Protein Coding	1
53	COX8C	Cytochrome C Oxidase Subunit 8C	Protein Coding	1
54	COX6B2	Cytochrome C Oxidase Subunit 6B2	Protein Coding	1
55	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	1
56	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	1
57	CPT1C	Carnitine Palmitoyltransferase 1C	Protein Coding	1
58	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	1
59	CRAT	Carnitine O-Acetyltransferase	Protein Coding	1
60	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
61	FASN	Fatty Acid Synthase	Protein Coding	1
62	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
63	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
64	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
65	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
66	GNA14	G Protein Subunit Alpha 14	Protein Coding	1
67	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
68	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
69	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
70	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
71	GNAL	G Protein Subunit Alpha L	Protein Coding	1
72	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
73	GNAS	GNAS Complex Locus	Protein Coding	1
74	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
75	GNB1	G Protein Subunit Beta 1	Protein Coding	1
76	GNB2	G Protein Subunit Beta 2	Protein Coding	1
77	GNB3	G Protein Subunit Beta 3	Protein Coding	1
78	GNB4	G Protein Subunit Beta 4	Protein Coding	1
79	GNB5	G Protein Subunit Beta 5	Protein Coding	1
80	GNG10	G Protein Subunit Gamma 10	Protein Coding	1
81	GNG11	G Protein Subunit Gamma 11	Protein Coding	1
82	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
83	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
84	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
85	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
86	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
87	GNG5	G Protein Subunit Gamma 5	Protein Coding	1
88	GNG7	G Protein Subunit Gamma 7	Protein Coding	1
89	GNG8	G Protein Subunit Gamma 8	Protein Coding	1
90	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
91	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	1
92	GYS1	Glycogen Synthase 1	Protein Coding	1
93	GYS2	Glycogen Synthase 2	Protein Coding	1
94	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
95	INS	Insulin	Protein Coding	1
96	INSR	Insulin Receptor	Protein Coding	1
97	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
98	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
99	LEP	Leptin	Protein Coding	1
100	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	1
101	STRADA	STE20 Related Adaptor Alpha	Protein Coding	1
102	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
103	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
104	MLYCD	Malonyl-CoA Decarboxylase	Protein Coding	1
105	CAB39	Calcium Binding Protein 39	Protein Coding	1
106	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
107	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
108	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
109	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
110	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
111	PFKFB1	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1	Protein Coding	1
112	PFKFB2	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2	Protein Coding	1
113	PFKFB3	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3	Protein Coding	1
114	PFKFB4	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4	Protein Coding	1
115	PFKL	Phosphofructokinase, Liver Type	Protein Coding	1
116	PFKM	Phosphofructokinase, Muscle	Protein Coding	1
117	PFKP	Phosphofructokinase, Platelet	Protein Coding	1
118	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
119	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
120	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
121	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
122	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	1
123	PPM1A	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A	Protein Coding	1
124	PPM1B	Protein Phosphatase, Mg2+/Mn2+ Dependent 1B	Protein Coding	1
125	PPM1G	Protein Phosphatase, Mg2+/Mn2+ Dependent 1G	Protein Coding	1
126	PPM1L	Protein Phosphatase, Mg2+/Mn2+ Dependent 1L	Protein Coding	1
127	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
128	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
129	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
130	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
131	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
132	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
133	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
134	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
135	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
136	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
137	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
138	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
139	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
140	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
141	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
142	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
143	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
144	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
145	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
146	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
147	SMARCAL1	SNF2 Related Chromatin Remodeling Annealing Helicase 1	Protein Coding	1
148	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
149	STK11	Serine/Threonine Kinase 11	Protein Coding	1
150	TFR2	Transferrin Receptor 2	Protein Coding	1
151	TFRC	Transferrin Receptor	Protein Coding	1
152	TSC1	TSC Complex Subunit 1	Protein Coding	1
153	TSC2	TSC Complex Subunit 2	Protein Coding	1

Disorders associated with AMPK Enzyme Complex Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coffin-siris syndrome 1	Enrichment	SMARCA4, SMARCB1, SMARCC2, SMARCD1, SMARCE1	10.74
2	Cox deficiency, benign infantile mitochondrial myopathy	Enrichment	COX10, COX4I1, COX5A, COX6A2, COX6B1, COX8A	8.28
3	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	6.00
4	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	5.25
5	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	5.25
6	Meningioma, familial	Enrichment	SMARCB1, SMARCE1	4.27
7	Meningioma	Enrichment	SMARCB1, SMARCE1	4.19
8	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	COX10, COX4I1, COX6B1, COX8A	4.01
9	Type 2 diabetes mellitus	Enrichment	AKT2, INSR, IRS1, IRS2, SLC2A4	3.98
10	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	3.90
11	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	3.90
12	Glycogen storage disease	Enrichment	GYS1, GYS2, PFKM	3.66
13	Inherited cancer-predisposing syndrome	Enrichment	SMARCA4, SMARCB1, SMARCE1	3.52
14	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.42
15	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3R1	3.42
16	Hamartoma	Enrichment	TSC1, TSC2	3.42
17	Anastomosing haemangioma	Enrichment	GNA11, GNA14	3.42
18	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.13
19	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.13
20	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.13
21	Basan syndrome	Enrichment	SMARCAD1	2.99
22	Adermatoglyphia	Enrichment	SMARCAD1	2.99
23	Huriez syndrome	Enrichment	SMARCAD1	2.99
24	Coffin-siris syndrome 5	Enrichment	SMARCE1	2.99
25	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Enrichment	HELLS	2.99
26	Coffin-siris syndrome 11	Enrichment	SMARCD1	2.99
27	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	2.99
28	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	2.99
29	Neurilemmoma	Enrichment	SMARCB1	2.99
30	Coffin-siris syndrome 3	Enrichment	SMARCB1	2.99
31	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.99
32	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.99
33	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	2.99
34	Keratoderma with scleroatrophy of the extremities	Enrichment	SMARCAD1	2.99
35	Facial cleft	Enrichment	SMARCE1	2.99
36	Autosomal recessive severe congenital neutropenia	Enrichment	SMARCD2	2.99
37	Hemimegalencephaly	Enrichment	AKT3, MTOR	2.91
38	Alopecia, androgenetic, 1	Enrichment	SMARCD1	2.69
39	Specific granule deficiency 1	Enrichment	SMARCD2	2.69
40	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	2.69
41	Schwannomatosis 1	Enrichment	SMARCB1	2.69
42	Specific granule deficiency 2	Enrichment	SMARCD2	2.69
43	Coffin-siris syndrome 8	Enrichment	SMARCC2	2.69
44	Otosclerosis 12	Enrichment	SMARCA4	2.69
45	Coffin-siris syndrome 4	Enrichment	SMARCA4	2.69
46	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	2.69
47	Specific granule deficiency	Enrichment	SMARCD2	2.69
48	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	CHRNA1, CHRNB1	2.59
49	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	2.59
50	Microcephaly	Enrichment	ARID1A, GNAO1, GNB1, SLC2A1, SMARCA5, SMARCAL1	2.57
51	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1	2.51
52	Schwannomatosis	Enrichment	SMARCB1	2.51
53	Nicolaides-baraitser syndrome	Enrichment	SMARCA2	2.38
54	Blepharophimosis	Enrichment	SMARCA2	2.38
55	Smarca2-related nicolaides-baraitser syndrome	Enrichment	SMARCA2	2.38
56	Full schwannomatosis	Enrichment	SMARCB1	2.38
57	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.36
58	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	2.36
59	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	HELLS	2.21
60	Congenital hydrocephalus	Enrichment	SMARCC1	2.14
61	Postsynaptic congenital myasthenic syndromes	Enrichment	CHRNA1, CHRNB1	2.11
62	Ewing sarcoma	Enrichment	SMARCA5	2.08
63	Neuroblastoma	Enrichment	SMARCA4	2.08
64	Ventricular septal defect	Enrichment	SMARCA4	2.03
65	Proteus syndrome	Enrichment	AKT1	1.95
66	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	1.95
67	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	1.95
68	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.95
69	Donohue syndrome	Enrichment	INSR	1.95
70	Linear skin defects with multiple congenital anomalies 2	Enrichment	COX7B	1.95
71	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	1.95
72	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	1.95
73	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	1.95
74	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	1.95
75	Carney complex, type 1	Enrichment	PRKAR1A	1.95
76	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	1.95
77	Carnitine acetyltransferase deficiency	Enrichment	CRAT	1.95
78	Osseous heteroplasia, progressive	Enrichment	GNAS	1.95
79	Myasthenic syndrome, congenital, 2a, slow-channel	Enrichment	CHRNB1	1.95
80	Schimke immunoosseous dysplasia	Enrichment	SMARCAL1	1.95
81	Myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency	Enrichment	CHRNB1	1.95
82	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	1.95
83	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.95
84	Ventricular tachycardia, familial	Enrichment	GNAI2	1.95
85	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	1.95
86	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.95
87	Mitochondrial complex iv deficiency, nuclear type 18	Enrichment	COX6A2	1.95
88	Pituitary adenoma 3, multiple types	Enrichment	GNAS	1.95
89	Short syndrome	Enrichment	PIK3R1	1.95
90	Mitochondrial complex iv deficiency, nuclear type 23	Enrichment	COX11	1.95
91	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	1.95
92	Spermatogenic failure 27	Enrichment	AK7	1.95
93	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.95
94	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	1.95
95	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	1.95
96	Myxoma, intracardiac	Enrichment	PRKAR1A	1.95
97	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	1.95
98	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	1.95
99	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.95
100	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.95
101	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	1.95
102	Dystonia 25	Enrichment	GNAL	1.95
103	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.95
104	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	1.95
105	Cowden syndrome 6	Enrichment	AKT1	1.95
106	Immunodeficiency 46	Enrichment	TFRC	1.95
107	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.95
108	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.95
109	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.95
110	Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis	Enrichment	COX4I2	1.95
111	Disorders of gnas inactivation	Enrichment	GNAS	1.95
112	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	1.95
113	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.95
114	Thrombocytopenia 6	Enrichment	SRC	1.95
115	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.95
116	Mitochondrial complex iv deficiency, nuclear type 7	Enrichment	COX6B1	1.95
117	Mitochondrial complex iv deficiency, nuclear type 20	Enrichment	COX5A	1.95
118	Neurodegeneration with brain iron accumulation 8	Enrichment	CRAT	1.95
119	Sick sinus syndrome 4	Enrichment	GNB2	1.95
120	Mitochondrial complex iv deficiency, nuclear type 16	Enrichment	COX4I1	1.95
121	Mitochondrial complex iv deficiency, nuclear type 15	Enrichment	COX8A	1.95
122	Charcot-marie-tooth disease, recessive intermediate d	Enrichment	COX6A1	1.95
123	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	1.95
124	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	1.95
125	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	1.95
126	Capillary hemangioma	Enrichment	AKT3	1.95
127	Pancreatic insufficiency-anemia-hyperostosis syndrome	Enrichment	COX4I2	1.95
128	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	1.95
129	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	1.95
130	Epilepsy with myoclonic absences	Enrichment	SLC2A1	1.95
131	Monostotic fibrous dysplasia	Enrichment	GNAS	1.95
132	Gnao1-related disorder	Enrichment	GNAO1	1.95
133	Phakomatosis cesiomarmorata	Enrichment	GNA11	1.95
134	Intestinal polyposis syndrome	Enrichment	STK11	1.95
135	Kaposiform hemangioendothelioma	Enrichment	GNA14	1.95
136	Mazabraud syndrome	Enrichment	GNAS	1.95
137	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	1.95
138	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.95
139	Atrial heart septal defect	Enrichment	SMARCA4	1.95
140	Interatrial communication	Enrichment	SMARCA4	1.95
141	Rare genetic intellectual disability	Enrichment	GNAO1, MTOR	1.92
142	West syndrome	Enrichment	GNAO1, SLC2A1, TSC2	1.88
143	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.87
144	Nk-cell enteropathy	Enrichment	SMARCB1	1.87
145	Pituitary stalk interruption syndrome	Enrichment	SMARCA2	1.84
146	Familial hypercholesterolemia	Enrichment	SMARCA4	1.81
147	Hypertension, essential	Enrichment	GNB3, NOS3	1.81
148	Cleft palate, isolated	Enrichment	GNB1, SMARCA4	1.81
149	Colorectal cancer	Enrichment	AKT1, ARID1A, PIK3R1, SRC	1.77
150	Peutz-jeghers syndrome	Enrichment	STK11	1.65
151	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.65
152	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.65
153	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.65
154	Glycogen storage disease 0, liver	Enrichment	GYS2	1.65
155	Glycogen storage disease vii	Enrichment	PFKM	1.65
156	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.65
157	Immunoerythromyeloid hypoplasia	Enrichment	AK2	1.65
158	Reticular dysgenesis	Enrichment	AK2	1.65
159	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	1.65
160	Dystonia 9	Enrichment	SLC2A1	1.65
161	Carnitine palmitoyltransferase ii deficiency, infantile	Enrichment	CPT2	1.65
162	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.65
163	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.65
164	Carnitine palmitoyltransferase ii deficiency, lethal neonatal	Enrichment	CPT2	1.65
165	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.65
166	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	1.65
167	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.65
168	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	1.65
169	Mitochondrial complex iv deficiency, nuclear type 6	Enrichment	COX15	1.65
170	Angioma, tufted	Enrichment	GNA14	1.65
171	Maturity-onset diabetes of the young, type 10	Enrichment	INS	1.65
172	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.65
173	Carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced	Enrichment	CPT2	1.65
174	Encephalopathy, acute, infection-induced 4	Enrichment	CPT2	1.65
175	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.65
176	Hyperproinsulinemia	Enrichment	INS	1.65
177	Spastic paraplegia 73, autosomal dominant	Enrichment	CPT1C	1.65
178	Cebalid syndrome	Enrichment	MTOR	1.65
179	Usher syndrome, type iv	Enrichment	PRKAR1A	1.65
180	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	1.65
181	Polyhydramnios, megalencephaly, and symptomatic epilepsy	Enrichment	STRADA	1.65
182	Glycogen storage disease 0, muscle	Enrichment	GYS1	1.65
183	Senior-loken syndrome 7	Enrichment	AKT3	1.65
184	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.65
185	Acrodysostosis	Enrichment	PRKAR1A	1.65
186	Pseudohypoparathyroidism	Enrichment	GNAS	1.65
187	Fibrolamellar carcinoma	Enrichment	PRKACA	1.65
188	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	1.65
189	Anemia, congenital, nonspherocytic hemolytic, 3	Enrichment	AK1	1.65
190	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.65
191	Bardet-biedl syndrome 16	Enrichment	AKT3	1.65
192	Hypopituitarism	Enrichment	GNAI2	1.65
193	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.65
194	Smith-kingsmore syndrome	Enrichment	MTOR	1.65
195	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	1.65
196	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.65
197	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.65
198	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.65
199	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	1.65
200	Acute necrotizing encephalopathy of childhood	Enrichment	CPT2	1.65
201	Cerebral visual impairment	Enrichment	GNB1	1.65
202	Phakomatosis cesioflammea	Enrichment	GNA11	1.65
203	Congenital nervous system abnormality	Enrichment	CPT2, GNAO1, GNB5, TSC2	1.50
204	Nervous system disease	Enrichment	CPT2, GNAO1, GNB5, TSC2	1.50
205	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1, SLC2A1	1.49
206	Mccune-albright syndrome	Enrichment	GNAS	1.48
207	Type 1 diabetes mellitus 2	Enrichment	INS	1.48
208	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.48
209	Linear skin defects with multiple congenital anomalies 1	Enrichment	COX7B	1.48
210	Hemochromatosis, type 3	Enrichment	TFR2	1.48
211	Nuchal bleb, familial	Enrichment	CFTR	1.48
212	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.48
213	Tuberous sclerosis 2	Enrichment	TSC2	1.48
214	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	1.48
215	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.48
216	Coffin-siris syndrome 2	Enrichment	ARID1A	1.48
217	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.48
218	Testicular germ cell cancer	Enrichment	STK11	1.48
219	Xanthinuria, type ii	Enrichment	TSC2	1.48
220	Immunodeficiency 14	Enrichment	PIK3R1	1.48
221	Periventricular leukomalacia	Enrichment	ARID1A	1.48
222	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.48
223	Testicular cancer	Enrichment	STK11	1.48
224	Apc-associated polyposis conditions	Enrichment	STK11	1.48
225	Hydrops fetalis, nonimmune	Enrichment	ARID1A, CHRNA1	1.46
226	Non-syndromic x-linked intellectual disability	Enrichment	SMARCA1	1.44
227	Strabismus	Enrichment	GNB1, SLC2A1	1.43
228	Cerebral palsy	Enrichment	SMARCA4	1.40
229	Bladder cancer	Enrichment	ARID1A, TSC1	1.38
230	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.35
231	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.35
232	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.35
233	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.35
234	Carney complex variant	Enrichment	PRKAR1A	1.35
235	Myasthenic syndrome, congenital, 1b, fast-channel	Enrichment	CHRNA1	1.35
236	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.35
237	Malonyl-coa decarboxylase deficiency	Enrichment	MLYCD	1.35
238	Leptin deficiency or dysfunction	Enrichment	LEP	1.35
239	Achromatopsia 4	Enrichment	GNAI3	1.35
240	Neonatal diabetes mellitus	Enrichment	INS	1.35
241	Idiopathic bronchiectasis	Enrichment	CFTR	1.35
242	2p21 microdeletion syndrome	Enrichment	PPM1B	1.35
243	Digenic hemochromatosis	Enrichment	TFR2	1.35
244	Familial sick sinus syndrome	Enrichment	GNB2	1.35
245	Non-immune hydrops fetalis	Enrichment	ARID1A, CHRNA1	1.32
246	Capillary malformations, congenital	Enrichment	GNA11	1.26
247	Alzheimer disease 2	Enrichment	NOS3	1.26
248	Atrioventricular septal defect	Enrichment	SMARCAL1	1.26
249	Familial adenomatous polyposis 1	Enrichment	STK11	1.26
250	Mitochondrial complex iii deficiency, nuclear type 4	Enrichment	COX10	1.26
251	Cox deficiency, infantile mitochondrial myopathy	Enrichment	COX15	1.26
252	Pre-eclampsia	Enrichment	NOS3	1.26
253	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.26
254	Dystonia	Enrichment	GNAL, GNB1	1.23
255	Melanoma, uveal	Enrichment	GNA11	1.18
256	Type 1 diabetes mellitus	Enrichment	INS	1.18
257	Testicular germ cell tumor	Enrichment	STK11	1.18
258	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	1.18
259	Keratoconus	Enrichment	TSC1	1.18
260	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.18
261	Breast adenocarcinoma	Enrichment	AKT1	1.18
262	46,xy disorder of sex development	Enrichment	INSR	1.18
263	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.12
264	Myelofibrosis	Enrichment	SRC	1.12
265	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.12
266	Brachydactyly	Enrichment	GNAS	1.12
267	Polycystic kidney disease 1	Enrichment	TSC2	1.12
268	Megacolon	Enrichment	AKT3	1.12
269	Paroxysmal dystonia	Enrichment	SLC2A1	1.12
270	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1, STRADA	1.11
271	Centralopathic epilepsy	Enrichment	SLC2A1, STRADA	1.07
272	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.06
273	Hemochromatosis, type 1	Enrichment	TFR2	1.06
274	Multiple pterygium syndrome, lethal type	Enrichment	CHRNA1	1.06
275	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.06
276	Hypothyroidism	Enrichment	GNB1	1.06
277	Choreatic disease	Enrichment	GNAO1	1.06
278	Permanent neonatal diabetes mellitus	Enrichment	INS	1.06
279	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.01
280	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.01
281	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.01
282	Primary hyperaldosteronism	Enrichment	GNAS	1.01
283	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.01
284	Cowden syndrome	Enrichment	AKT1	1.01
285	Ovarian cancer	Enrichment	SMARCB1	1.00
286	Autism spectrum disorder	Enrichment	SMARCB1	0.97
287	Stroke, ischemic	Enrichment	NOS3	0.97
288	Neurodegeneration with brain iron accumulation	Enrichment	CRAT	0.97
289	Polymicrogyria	Enrichment	AKT3	0.97
290	Melanoma	Enrichment	STK11	0.97
291	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	0.97
292	Leukemia, acute lymphoblastic	Enrichment	GNB1	0.93
293	Myelodysplastic syndrome	Enrichment	GNB1	0.93
294	Combined immunodeficiency	Enrichment	TFRC	0.93
295	Movement disease	Enrichment	GNAO1	0.93
296	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	0.93
297	Diabetes mellitus	Enrichment	INS	0.93
298	Combined t and b cell immunodeficiency	Enrichment	TFRC	0.93
299	Septooptic dysplasia	Enrichment	ARID1A	0.90
300	Lip and oral cavity carcinoma	Enrichment	STK11	0.90
301	Acute promyelocytic leukemia	Enrichment	PRKAR1A	0.86
302	Osteoporosis	Enrichment	SRC	0.83
303	Congenital myasthenic syndrome	Enrichment	CHRNA1	0.83
304	Hereditary chronic pancreatitis	Enrichment	CFTR	0.83
305	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	0.81
306	Atypical hemolytic-uremic syndrome	Enrichment	SMARCAL1	0.81
307	Lynch syndrome	Enrichment	CFTR	0.81
308	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.81
309	Kidney disease	Enrichment	TSC1	0.81
310	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	ARID1A	0.78
311	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	0.78
312	Isolated congenital microcephaly	Enrichment	SMARCAL1	0.78
313	Alzheimer disease, familial, 1	Enrichment	NOS3	0.76
314	Melanoma, cutaneous malignant 1	Enrichment	STK11	0.76
315	Pancreatitis, hereditary	Enrichment	CFTR	0.76
316	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	0.73
317	Congenital myopathy	Enrichment	CHRNA1	0.71
318	Maturity-onset diabetes of the young	Enrichment	INS	0.69
319	Focal segmental glomerulosclerosis	Enrichment	SMARCAL1	0.69
320	Breast cancer	Enrichment	AKT1, GNG3	0.68
321	Centronuclear myopathy	Enrichment	CHRNA1	0.67
322	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.66
323	Malaria	Enrichment	NOS2	0.64
324	Congenital stationary night blindness	Enrichment	GNB3	0.64
325	Non-syndromic male infertility due to sperm motility disorder	Enrichment	AK7	0.64
326	Pancreatic cancer	Enrichment	STK11	0.61
327	Cystic fibrosis	Enrichment	CFTR	0.52
328	Peripheral nervous system disease	Enrichment	COX6A1	0.52
329	Neuropathy	Enrichment	COX6A1	0.52
330	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.51
331	Severe combined immunodeficiency	Enrichment	AK2	0.51
332	Male infertility	Enrichment	CFTR	0.49
333	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.47
334	Epilepsy	Enrichment	SLC2A1	0.44
335	Gastric cancer	Enrichment	STK11	0.41
336	Nephrotic syndrome	Enrichment	SMARCAL1	0.41
337	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.41
338	Hereditary breast carcinoma	Enrichment	AKT1	0.41
339	Complex neurodevelopmental disorder	Enrichment	GNB2, PPP2CA	0.39
340	Thrombocytopenia	Enrichment	SRC	0.38
341	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.36
342	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.36
343	Myeloma, multiple	Enrichment	PIK3R2	0.33
344	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.33
345	Primary ovarian insufficiency	Enrichment	NOS3	0.31
346	Leigh syndrome, nuclear	Enrichment	COX15	0.26
347	Autism	Enrichment	CHRNA1	0.25
348	Leigh disease	Enrichment	COX15	0.24
349	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

AMPK Enzyme Complex Pathway

Pathway Network for AMPK Enzyme Complex Pathway

Member Pathways for AMPK Enzyme Complex Pathway

Pathways in the AMPK Enzyme Complex Pathway SuperPath

Associated Genes for AMPK Enzyme Complex Pathway

Associated Disorders for AMPK Enzyme Complex Pathway

Disorders associated with AMPK Enzyme Complex Pathway SuperPath

STRING Interaction Network for AMPK Enzyme Complex Pathway

Sources for AMPK Enzyme Complex Pathway