Amplification and expansion of oncogenic pathways as metastatic traits

No Pathway Network information available for Amplification and expansion of oncogenic pathways as metastatic traits

Pathways in the Amplification and expansion of oncogenic pathways as metastatic traits SuperPath

#	Name	Source	Genes
1	Amplification and expansion of oncogenic pathways as metastatic traits	WikiPathways	CXCR4 CYTIP EPAS1 JAG1 LEF1 NOTCH1 PIK3CG POSTN SRC TCF7 TCF7L1 TCF7L2 TNC VCAM1 VEGFA VHL (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
2	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
3	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
5	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
6	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
7	TCF7	Transcription Factor 7	Protein Coding	1
8	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
9	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
10	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
11	NOTCH1	Notch Receptor 1	Protein Coding	1
12	TNC	Tenascin C	Protein Coding	1
13	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	1
14	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
15	POSTN	Periostin	Protein Coding	1
16	CYTIP	Cytohesin 1 Interacting Protein	Protein Coding	1

Disorders associated with Amplification and expansion of oncogenic pathways as metastatic traits SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1, VHL	4.71
2	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	3.38
3	Deafness, autosomal dominant 56	Enrichment	TNC	2.93
4	Whim syndrome 1	Enrichment	CXCR4	2.93
5	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.93
6	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.93
7	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.93
8	Erythrocytosis, familial, 4	Enrichment	EPAS1	2.93
9	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.93
10	Thrombocytopenia 6	Enrichment	SRC	2.93
11	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.93
12	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	2.93
13	Retinal hemangioblastoma	Enrichment	VHL	2.93
14	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.63
15	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.63
16	Split hand-foot malformation	Enrichment	LEF1	2.63
17	Erythrocytosis, familial, 3	Enrichment	EPAS1	2.63
18	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.63
19	Alagille syndrome 1	Enrichment	JAG1	2.45
20	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	2.45
21	Primary polycythemia	Enrichment	VHL	2.45
22	Keratoacanthoma	Enrichment	NOTCH1	2.45
23	Erythrocytosis, familial, 2	Enrichment	VHL	2.33
24	Au-kline syndrome	Enrichment	VHL	2.33
25	Middle aortic syndrome	Enrichment	JAG1	2.33
26	Fanconi anemia, complementation group d2	Enrichment	VHL	2.23
27	Von hippel-lindau syndrome	Enrichment	VHL	2.23
28	Split-hand/foot malformation 1	Enrichment	LEF1	2.15
29	Autosomal dominant secondary polycythemia	Enrichment	EPAS1	2.15
30	Myelofibrosis	Enrichment	SRC	2.08
31	Renal cell carcinoma, papillary, 1	Enrichment	VHL	2.08
32	Multiple enchondromatosis, maffucci type	Enrichment	VHL	2.08
33	Adams-oliver syndrome	Enrichment	NOTCH1	2.08
34	Hypoplastic left heart syndrome	Enrichment	NOTCH1	2.03
35	Aortic valve disease 1	Enrichment	NOTCH1	1.82
36	Osteoporosis	Enrichment	SRC	1.79
37	Pheochromocytoma	Enrichment	VHL	1.79
38	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.79
39	Renal cell carcinoma, nonpapillary	Enrichment	VHL	1.76
40	Heart, malformation of	Enrichment	JAG1	1.68
41	Hepatoblastoma	Enrichment	JAG1	1.61
42	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.61
43	Connective tissue disease	Enrichment	NOTCH1	1.43
44	Fanconi anemia, complementation group a	Enrichment	VHL	1.39
45	Type 2 diabetes mellitus	Enrichment	TCF7L2	1.31
46	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.30
47	Thrombocytopenia	Enrichment	SRC	1.26
48	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TNC	1.22
49	Autism	Enrichment	TCF7L2	1.09
50	Colorectal cancer	Enrichment	SRC	1.01
51	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.86
52	Inherited cancer-predisposing syndrome	Enrichment	VHL	0.84
53	Hereditary retinal dystrophy	Enrichment	JAG1	0.53
54	Fundus dystrophy	Enrichment	JAG1	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Amplification and expansion of oncogenic pathways as metastatic traits

Pathway Network for Amplification and expansion of oncogenic pathways as metastatic traits

Member Pathways for Amplification and expansion of oncogenic pathways as metastatic traits

Pathways in the Amplification and expansion of oncogenic pathways as metastatic traits SuperPath

Associated Genes for Amplification and expansion of oncogenic pathways as metastatic traits

Associated Disorders for Amplification and expansion of oncogenic pathways as metastatic traits

Disorders associated with Amplification and expansion of oncogenic pathways as metastatic traits SuperPath

STRING Interaction Network for Amplification and expansion of oncogenic pathways as metastatic traits

Sources for Amplification and expansion of oncogenic pathways as metastatic traits